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Book: Clinical manual of Alzheimer disease and other dementias

Weiner, Myron F. / Lipton, Anne M.

2012

Author's details	ed. by Myron F. Weiner ; Anne M. Lipton
Keywords	Alzheimer Disease ; Dementia
Language	English
Size	XXXIV, 428 S., [3] Bl. : Ill., graph. Darst.
Edition	1. ed.
Publisher	American Psychiatric Publ
Publishing place	Washington, DC u.a.
Publishing country	United States
Document type	Book
Note	Neuropsychiatric assessment and diagnosis / Myron F. Weiner, Robert Garrett, Mary E. Bret -- Medical and neurological evaluation and diagnosis / Anne M. Lipton, Craig D. Rubin -- Neuropsychological assessment / C. Munro Cullum, Laura H. Lacritz -- Neuroimaging / Norman L. Foster -- Alzheimer disease / David S. Geldmacher -- Mild cognitive impairment / Yonas E. Geda, Ronald C. Petersen -- Vascular cognitive disorder / Cassandra E.I. Szoeke ... [et al.] -- Dementia with lewy bodies and other synucleinopathies / Rawan Tarawneh, James E. Galvin -- Frontotemporal dementia and other tauopathies / Anne. M. Lipton, Adam Boxer -- Traumatic brain injury / Erin D. Bigler -- Other causes of dementia / Edward Y. Zamrini, Mary Quiceno -- Treatment of psychiatric disorders in people with dementia / Martin Steinberg, Constantine G. Lyketsos -- Pharmacological treatment of neuropsychiatric symptoms / Roy Yaari, Pierre N. Tariot, Danielle F. Richards -- Pharmacological treatment of alzheimer disease and mild cognitive impairment / Martin R. Farlow, Malaz Boustani -- Supporting family caregivers / Kristin Martin-Cook, Myron F. Weiner
HBZ-ID	HT017337911
ISBN	978-1-58562-422-5 ; 1-58562-422-5
Database	Catalogue ZB MED Medicine, Health

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2012 A 3459	order for loan	Magazin

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Article: Evaluation of the Hydrophilic, Cohesive, and Physical Properties of Eight Hyaluronic Acid Fillers: Clinical Implications of Gel Differentiation.

Enright, Kaitlyn M / Weiner, Steven F / Durairaj, Kalpna K / Gilardino, Mirko S / Nikolis, Andreas

Clinical, cosmetic and investigational dermatology

2024 Volume 17, Page(s) 89–101

Abstract: Background: Hyaluronic acid (HA) fillers are used to treat an array of aesthetic indications. Proper filler selection is paramount for successful patient outcomes. However, many important physiochemical and physical properties that impact HA gel ... ...

Abstract	Background: Hyaluronic acid (HA) fillers are used to treat an array of aesthetic indications. Proper filler selection is paramount for successful patient outcomes. However, many important physiochemical and physical properties that impact HA gel behavior remain undefined. Purpose: To evaluate the hydrophilicity, cohesivity and particle size of eight commercial HA fillers manufactured by either Non-Animal Stabilized Hyaluronic Acid (NASHA) or Optimal Balance Technology (OBT) techniques. Methods and materials: Three individual in vitro experiments were performed to assess HA swelling capacity, cohesion, and particle size. Image analyses, blinded evaluation using the Gavard-Sundaram Cohesivity Scale, and laser diffraction technology were utilized, respectively. Results: Compared to fillers manufactured with NASHA technology, OBT products demonstrated greater swelling capacity, cohesion, and wider particle size distributions. Strong positive correlations between swelling factor, degree of cohesivity, and increasing widths of the particle size distributions were observed. Conclusions: The hydrophilicity, cohesivity and particle size distributions vary among HA fillers manufactured with different techniques. The creation of new labels identifying products based on their unique combination of physiochemical and physical characteristics may help guide appropriate selection of HA fillers to optimize patient outcomes.
Language	English
Publishing date	2024-01-12
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S446429
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Article ; Online: Reproduction dynamics of planktonic microbial eukaryotes in the open ocean.

Weinkauf, Manuel F G / Siccha, Michael / Weiner, Agnes K M

Journal of the Royal Society, Interface

2022 Volume 19, Issue 187, Page(s) 20210860

Abstract: Understanding the biology of reproduction of an organismal lineage is important for retracing key evolutionary processes, yet gaining detailed insights often poses major challenges. Planktonic Foraminifera are globally distributed marine microbial ... ...

Abstract	Understanding the biology of reproduction of an organismal lineage is important for retracing key evolutionary processes, yet gaining detailed insights often poses major challenges. Planktonic Foraminifera are globally distributed marine microbial eukaryotes and important contributors to the global carbon cycle. They cannot routinely be cultured under laboratory conditions across generations, and thus details of their life cycle remain incomplete. The production of flagellated gametes has long been taken as an indication of exclusively sexual reproduction, but recent research suggests the existence of an additional asexual generation in the life cycle. To gain a better understanding of the reproductive biology of planktonic Foraminifera, we applied a dynamic, individual-based modelling approach with parameters based on laboratory and field observations to test if sexual reproduction is sufficient for maintaining viable populations. We show that temporal synchronization and potentially spatial concentration of gamete release seems inevitable for maintenance of the population under sexual reproduction. We hypothesize that sexual reproduction is likely beneficial during the adaptation to new environments, while population sustenance in stable environments can be ensured through asexual reproduction.
MeSH term(s)	Biological Evolution ; Eukaryota ; Oceans and Seas ; Plankton ; Reproduction ; Reproduction, Asexual
Language	English
Publishing date	2022-02-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2156283-0
ISSN	1742-5662 ; 1742-5689
ISSN (online)	1742-5662
ISSN	1742-5689
DOI	10.1098/rsif.2021.0860
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Article ; Online: Compassion-focused therapy (CFT) for the reduction of the self-stigma of mental disorders: the COMpassion for Psychiatric disorders, Autism and Self-Stigma (COMPASS) study protocol for a randomized controlled study.

Riebel, M / Rohmer, O / Charles, E / Lefebvre, F / Weibel, S / Weiner, L

Trials

2023 Volume 24, Issue 1, Page(s) 393

Abstract: Background: People with mental disorders face frequent stigmatizing attitudes and behaviors from others. Importantly, they can internalize such negative attitudes and thus self-stigmatize. Self-stigma is involved in diminished coping skills leading to ... ...

Abstract	Background: People with mental disorders face frequent stigmatizing attitudes and behaviors from others. Importantly, they can internalize such negative attitudes and thus self-stigmatize. Self-stigma is involved in diminished coping skills leading to social avoidance and difficulties in adhering to care. Reducing self-stigma and its emotional corollary, shame, is thus crucial to attenuate the negative outcomes associated with mental illness. Compassion-focused therapy (CFT) is a third-wave cognitive behavioral therapy that targets shame reduction and hostile self-to-self relationship and allows for symptom improvement while increasing self-compassion. Although shame is a prominent part of the concept of self-stigma, the efficacy of CFT has never been evaluated in individuals with high levels of self-stigma. The purpose of this study is to evaluate the efficacy and acceptability of a group-based CFT program on self-stigma, compared to a psychoeducation program for self-stigma (Ending Self-Stigma) and to treatment as usual (TAU). We hypothesize that diminished shame and emotional dysregulation and increased self-compassion will mediate the relationship between self-stigma improvements post-therapy in the experimental group. Methods: This seven-center trial will involve 336 participants diagnosed with a severe mental illness and/or autism spectrum disorder and reporting high levels of self-stigma. Participants will be randomized into one of three treatment arms: 12 week-treatment of compassion-focused therapy (experimental arm), 12 week-treatment of Psychoeducation (active control arm), and TAU (treatment as usual-passive control arm). The primary outcome is the decrease of self-stigma scores on a self-report scale, i.e., ISMI, at 12 weeks. Secondary endpoints include sustainability of self-stigma scores (ISMI) and self-reported scores regarding target psychological dimensions, e.g., shame and emotional regulation, social functioning, and psychiatric symptoms. Assessments are scheduled at pretreatment, post-treatment (at 12 weeks), and at 6-month follow-up. Acceptability will be evaluated via (i) the Credibility and Expectancy Questionnaire at T0, (ii) the Consumer Satisfaction Questionnaire for Psychotherapeutic Services posttreatment and at 6-month follow-up, (iii) attendance, and (iv) dropout rates. Discussion: This study will evaluate the potential efficacy and acceptability of a group-based CFT program on the decrease of self-stigma and thereby contribute to the continuing development of evidence-based therapeutic interventions for the internalized stigma of mental and neurodevelopmental disorders. Trial registration: ClinicalTrials.gov NCT05698589. Registered on January 26, 2023.
MeSH term(s)	Humans ; Autistic Disorder ; Empathy ; Autism Spectrum Disorder ; Mental Disorders ; Social Stigma ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-023-07393-y
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Article ; Online: The history of the use of intrathecal prostigmine to achieve fertility in men with spinal cord injuries.

Silver, J R / Weiner, M-F

Spinal cord series and cases

2019 Volume 5, Page(s) 37

MeSH term(s)	Cholinesterase Inhibitors/administration & dosage ; Cholinesterase Inhibitors/history ; Cholinesterase Inhibitors/therapeutic use ; History, 20th Century ; Humans ; Infertility, Male/drug therapy ; Male ; Neostigmine/administration & dosage ; Neostigmine/history ; Neostigmine/therapeutic use ; Spinal Cord Injuries/complications
Chemical Substances	Cholinesterase Inhibitors ; Neostigmine (3982TWQ96G)
Keywords	covid19
Language	English
Publishing date	2019-05-01
Publishing country	England
Document type	Historical Article ; Journal Article ; Review
ISSN	2058-6124
ISSN (online)	2058-6124
DOI	10.1038/s41394-019-0183-y
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Article ; Online: Urtication (flogging with stinging nettles) and flagellation (beating with rods) in the treatment of paralysis.

Silver, J R / Weiner, M-F

Spinal cord series and cases

2019 Volume 5, Page(s) 79

Abstract: Urtication and flagellation were used as a last resort in the treatment of paralysis when all other means were exhausted, and very few cases are reported in the literature. Two cases were identified and reviewed, one of urtication (flogging with nettles) ...

Abstract	Urtication and flagellation were used as a last resort in the treatment of paralysis when all other means were exhausted, and very few cases are reported in the literature. Two cases were identified and reviewed, one of urtication (flogging with nettles) and one of flagellation (beating with rods). In both cases the symptoms were alleviated, but there was insufficient detail to evaluate the therapeutic value of each treatment.
MeSH term(s)	Animals ; History, 15th Century ; History, 16th Century ; History, 17th Century ; History, 18th Century ; History, Ancient ; History, Medieval ; Humans ; Neurology/history ; Paralysis/history ; Paralysis/therapy ; Urtica dioica ; Violence
Keywords	covid19
Language	English
Publishing date	2019-09-26
Publishing country	England
Document type	Historical Article ; Journal Article ; Review
ISSN	2058-6124
ISSN (online)	2058-6124
DOI	10.1038/s41394-019-0222-8
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Article ; Online: Cognitive effects of electroconvulsive therapy in depressed adolescents.

Ghaziuddin, Neera / McClintock, Shawn M / Maixner, Daniel F / Miller, Leslie R / Husain, Mustafa / Wachtel, Lee E / Siddiqi, Shan H / Flood, Michael / Weinstein, Sally / Frye, Mark A / Weiner, Richard D

Journal of affective disorders

2024 Volume 356, Page(s) 32–33

Language	English
Publishing date	2024-03-11
Publishing country	Netherlands
Document type	Letter
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2024.03.050
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Zs.A 1485: Show issues

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Article ; Online: Validation of a zebrafish developmental defects assay as a qualified alternative test for its regulatory use following the ICH S5(R3) guideline.

Weiner, A M J / Irijalba, I / Gallego, M P / Ibarburu, I / Sainz, L / Goñi-de-Cerio, F / Quevedo, C / Muriana, A

Reproductive toxicology (Elmsford, N.Y.)

2023 Volume 123, Page(s) 108513

Abstract: Zebrafish is a popular toxicology model and provides an ethically acceptable small-scale analysis system with the complexity of a complete organism. Our goal is to further validate this model for its regulatory use for reproductive and developmental ... ...

Abstract	Zebrafish is a popular toxicology model and provides an ethically acceptable small-scale analysis system with the complexity of a complete organism. Our goal is to further validate this model for its regulatory use for reproductive and developmental defects by testing the compounds indicated in the "Guideline on detection of reproductive and developmental toxicity for human pharmaceuticals" (ICH S5(R3) guideline.) To determine the embryotoxic and developmental risk of the 32 reference compounds listed in the ICH S5(R3) guideline, the presence of morphological alterations in zebrafish embryos was analyzed at two different stages to calculateLC50 and EC50 values for each stage. Teratogenic Indexes were established as the ratio between LC50 and EC50 critical for the proper compound classification as teratogenic when it is ≥ 2. A total of three biological replicates have been conducted to study the reproducibility of the assay. The chemicals' concentration in the medium and internally in the zebrafish embryos was evaluated. In this study, the 3 negative compounds were properly categorized while 23 compounds out of the 29 reference ones (sensitivity of 79.31%) were classified as teratogenic in zebrafish. The 6 that had false-negative results were classified 4 as inconclusive, 1 as not toxic, and 1 compound resulted toxic for zebrafish embryos under testing conditions. After the bioavailability experiments, some of the obtained inconclusive results were refined. The developmental defects assay in zebrafish gives an accuracy of 89.66%, sensitivity of 88.46%, specificity and repeatability of 100% compared to mammals; therefore, this is a well-integrated strategy using New Alternative Methods, to minimize the use of animals in developmental toxicity studies.
MeSH term(s)	Animals ; Humans ; Zebrafish ; Reproducibility of Results ; Embryo, Nonmammalian ; Teratogens/toxicity ; Teratogenesis ; Mammals
Chemical Substances	Teratogens
Language	English
Publishing date	2023-11-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	639342-1
ISSN	1873-1708 ; 0890-6238
ISSN (online)	1873-1708
ISSN	0890-6238
DOI	10.1016/j.reprotox.2023.108513
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Zs.A 2316: Show issues

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Article ; Online: The Scottish Women's Hospital at Royaumont, France 1914-1919.

Weiner, M-F

The journal of the Royal College of Physicians of Edinburgh

2014 Volume 44, Issue 4, Page(s) 328–336

Abstract: In 1915, under the aegis of the French Red Cross, volunteer medical women from the Scottish Women's Hospital Service for Foreign Service established a hospital at Royaumont Abbey in France, to treat casualties of the First World War. By working as a team ...

Abstract	In 1915, under the aegis of the French Red Cross, volunteer medical women from the Scottish Women's Hospital Service for Foreign Service established a hospital at Royaumont Abbey in France, to treat casualties of the First World War. By working as a team comprised of radiologists, bacteriologists and surgeons, they were able to combat gas gangrene and record remarkable results. The circumstances and the way in which the doctors were portrayed in France and Britain prevented them from actively promoting their results to gain wider acceptance. After the War, medical women lost their training and employment opportunities and many left the profession.
MeSH term(s)	Female ; France ; Gas Gangrene/history ; Gas Gangrene/therapy ; History, 20th Century ; Hospitals, Voluntary/history ; Humans ; Male ; Military Personnel/history ; Physicians, Women/history ; Red Cross/history ; Scotland ; World War I
Language	English
Publishing date	2014
Publishing country	Scotland
Document type	Historical Article ; Journal Article
ZDB-ID	2866363-9
ISSN	2042-8189 ; 0953-0932
ISSN (online)	2042-8189
ISSN	0953-0932
DOI	10.4997/JRCPE.2014.418
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Zs.A 3088 -Suppl.-: Show issues

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Article ; Online: George Riddoch (1888-1947): the driving force behind the treatment of spinal injuries in the UK during the Second World War.

Silver, J R / Weiner, M-F

The journal of the Royal College of Physicians of Edinburgh

2018 Volume 48, Issue 3, Page(s) 264–271

Abstract: The development of the successful treatment of spinal injuries has been inextricably linked to Sir Ludwig Guttmann and Stoke Mandeville Hospital. The role of George Riddoch has largely been ignored or mentioned merely in relation to Ludwig Guttmann and ... ...

Abstract	The development of the successful treatment of spinal injuries has been inextricably linked to Sir Ludwig Guttmann and Stoke Mandeville Hospital. The role of George Riddoch has largely been ignored or mentioned merely in relation to Ludwig Guttmann and his appointment as the first Resident Medical Officer at Stoke Mandeville Hospital. Riddoch's contribution was far more significant. New material, comprising Riddoch's letters and memoranda written between 1939 and 1944, reveals his paramount involvement in the setting up of spinal injury units across the UK between 1941 and 1944, and his skill as an administrator and a clinician. Riddoch must be given credit for finding and appointing Ludwig Guttmann.
MeSH term(s)	History, 20th Century ; Hospital Units/history ; Hospital Units/organization & administration ; Neurology/history ; Neurology/organization & administration ; Orthopedics/history ; Orthopedics/organization & administration ; Spinal Cord Injuries/history ; Spinal Cord Injuries/therapy ; Spinal Injuries/history ; Spinal Injuries/therapy ; United Kingdom ; World War II
Language	English
Publishing date	2018-10-09
Publishing country	Scotland
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	2866363-9
ISSN	2042-8189 ; 0953-0932
ISSN (online)	2042-8189
ISSN	0953-0932
DOI	10.4997/JRCPE.2018.314
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