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  1. Article ; Online: Inhalative as well as Intravenous Administration of H

    Scheid, Stefanie / Goeller, Max / Baar, Wolfgang / Wollborn, Jakob / Buerkle, Hartmut / Schlunck, Günther / Lagrèze, Wolf / Goebel, Ulrich / Ulbrich, Felix

    International journal of molecular sciences

    2022  Volume 23, Issue 10

    Abstract: ... Hydrogen sulfide (H: Methods: Ischemia-reperfusion injury was induced in rats by a temporary increase ... in intraocular pressure (1 h). H: Results: Both inhalative and intravenously delivered H: Conclusion ... and inflammation. Both inhalative H ...

    Abstract Background: Neuronal ischemia-reperfusion injury (IRI), such as it can occur in glaucoma or strokes, is associated with neuronal cell death and irreversible loss of function of the affected tissue. Hydrogen sulfide (H
    Methods: Ischemia-reperfusion injury was induced in rats by a temporary increase in intraocular pressure (1 h). H
    Results: Both inhalative and intravenously delivered H
    Conclusion: Hydrogen sulfide acts, at least in part, via the mitogen-activated protein kinase (MAPK) ERK1/2 to reduce apoptosis and inflammation. Both inhalative H
    MeSH term(s) Administration, Intravenous ; Animals ; Hydrogen Sulfide/metabolism ; Hydrogen Sulfide/pharmacology ; Hydrogen Sulfide/therapeutic use ; Ischemia/metabolism ; Neuroprotection ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/metabolism ; Retina/metabolism ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Vascular Endothelial Growth Factor A ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2022-05-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23105519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: C-H Fluoromethoxylation of Arenes by Photoredox Catalysis.

    Bertoli, Giulia / Martínez, Ángel Manu / Goebel, Jonas F / Belmonte, Debora / Sivendran, Nardana / Gooßen, Lukas J

    Angewandte Chemie (International ed. in English)

    2022  Volume 62, Issue 5, Page(s) e202215920

    Abstract: ... monofluoromethoxylation reagents, enabling the photocatalytic C-H functionalization of arenes. Thus, irradiation of 1-(OCH ...

    Abstract Redox-active N-(fluoromethoxy)benzotriazoles were made accessible from fluoroacetic acid and hydroxybenzotriazoles via electrodecarboxylative coupling. After alkylation, they become effective monofluoromethoxylation reagents, enabling the photocatalytic C-H functionalization of arenes. Thus, irradiation of 1-(OCH
    Language English
    Publishing date 2022-12-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202215920
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  3. Article ; Online: Manganese(I) Catalyzed ortho C-H Allylation of Benzoic Acids.

    Goebel, Jonas F / Stemmer, Johanna / Belitz, Florian / Gooßen, Lukas J

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 24, Page(s) e202301839

    Abstract: The 3d-metal catalyst Mn(CO) ...

    Abstract The 3d-metal catalyst Mn(CO)
    Language English
    Publishing date 2023-05-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202301839
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  4. Article ; Online: Ru-Catalyzed C-H Arylation of Acrylic Acids with Aryl Bromides.

    Belitz, Florian / Seitz, Ann-Katrin / Goebel, Jonas F / Hu, Zhiyong / Gooßen, Lukas J

    Organic letters

    2022  Volume 24, Issue 19, Page(s) 3466–3470

    Abstract: In the presence of a [Ru( ...

    Abstract In the presence of a [Ru(
    MeSH term(s) Bromides ; Catalysis ; Palladium
    Chemical Substances Bromides ; Palladium (5TWQ1V240M)
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c01043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Palladium-Catalyzed para-C-H Arylation of Anilines with Aromatic Halides.

    Lichte, Dominik / Pirkl, Nico / Heinrich, Gregor / Dutta, Sayan / Goebel, Jonas F / Koley, Debasis / Gooßen, Lukas J

    Angewandte Chemie (International ed. in English)

    2022  Volume 61, Issue 47, Page(s) e202210009

    Abstract: Controlling regioselectivity in C-H functionalizations is a key challenge in chemical method ... development. In arenes, functionalizations are most difficult to direct towards the C-H group furthest away ... from a substituent, in its para position. We herein demonstrate how the para-C-H arylation of anilines with non ...

    Abstract Controlling regioselectivity in C-H functionalizations is a key challenge in chemical method development. In arenes, functionalizations are most difficult to direct towards the C-H group furthest away from a substituent, in its para position. We herein demonstrate how the para-C-H arylation of anilines with non-activated aryl halides, elusive to date, is achieved by a base-assisted "metalla-tautomerism" approach. A proton is abstracted from the aniline substrate and replaced by an arylpalladium species, generated from the aryl halide coupling partner. In this step, the palladium is directed away from the N- to the tautomeric para-C-H position by a large phosphine ligand combined with a triphenylmethyl shielding group. The triphenylmethyl group is easily installed and removed, and can be recycled.
    Language English
    Publishing date 2022-10-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202210009
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  6. Article ; Online: Growth of C-S-H phases on different metallic surfaces.

    Schleiting, Maximilian / Wetzel, Alexander / Göbel, Daniela / Krooß, Philipp / Frenck, Johanna-Maria / Niendorf, Thomas / Middendorf, Bernhard

    Journal of microscopy

    2022  Volume 286, Issue 2, Page(s) 148–153

    Abstract: ... the growth of C-S-H phases on stainless steel and on cold drawn steel. This growth process was realised ...

    Abstract The influence of reinforcement, especially fibre reinforcement in ultra-high performance concrete is strongly dependent on the bonding (adhesive, shear and friction bond) between metallic surface and cementitious matrix. As usually straight fibres are used for fibre reinforcement and, thus, no significant mechanical bonding is existent, the adhesive bond is particularly important. Previous studies stated that the adhesive bonding behaviour between metallic materials and cementitious matrix strongly depends on the chemical composition of metallic alloys. Therefore, in order to address this topic, the present study investigates the growth of C-S-H phases on stainless steel and on cold drawn steel. This growth process was realised by a surface treatment of the metallic alloys using a synthetically manufactured Tricalciumsilicate (C
    Language English
    Publishing date 2022-02-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 219263-9
    ISSN 1365-2818 ; 0022-2720
    ISSN (online) 1365-2818
    ISSN 0022-2720
    DOI 10.1111/jmi.13089
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 838: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Ru-Catalyzed C–H Arylation of Acrylic Acids with Aryl Bromides

    Belitz, Florian / Seitz, Ann-Katrin / Goebel, Jonas F. / Hu, Zhiyong / Gooßen, Lukas J.

    Organic letters. 2022 May 04, v. 24, no. 19

    2022  

    Abstract: ... acids. This vinylic C–H functionalization proceeds in high yields of up to 94% and (Z/E)-ratios of up ... to 99:1, tolerating a wide range of functional groups. Mechanistic studies indicate that the vinylic C–H ...

    Abstract In the presence of a [Ru(p-cymene)Cl₂]₂/triethylphosphine/lithium carbonate catalyst system, aryl bromides undergo (Z)-selective couplings with unprotected 2-arylacrylic acids to form (Z)-diarylacrylic acids. This vinylic C–H functionalization proceeds in high yields of up to 94% and (Z/E)-ratios of up to 99:1, tolerating a wide range of functional groups. Mechanistic studies indicate that the vinylic C–H activation proceeds via base-assisted cyclometalation rather than via a Heck-type mechanism, which explains its orthogonal stereoselectivity.
    Keywords arylation ; carbon-hydrogen bond activation ; carbonates ; catalysts ; lithium ; p-cymene ; stereoselectivity
    Language English
    Dates of publication 2022-0504
    Size p. 3466-3470.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.2c01043
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Biaryl Synthesis via Electrooxidative Transition-Metal-Catalyzed C–H Activation

    Goebel, Jonas F. / Zeng, Zhongyi / Gooßen, Lukas J.

    Synthesis

    2021  Volume 54, Issue 03, Page(s) 565–569

    Abstract: ... for the development of sustainable C–H functionalization reactions. Herein we summarize recent advances in the synthesis of biaryls ... through electrooxidative processes involving transition-metal-catalyzed ortho -directed C–H activation. A particular focus ... is set on electrooxidative C–H/C–M couplings and dehydrogenative couplingsy as a. 1 ...

    Abstract The use of electricity as an inexpensive and waste-free oxidant opens up new opportunities for the development of sustainable C–H functionalization reactions. Herein we summarize recent advances in the synthesis of biaryls through electrooxidative processes involving transition-metal-catalyzed ortho -directed C–H activation. A particular focus is set on electrooxidative C–H/C–M couplings and dehydrogenative couplings. 1

    Introduction 2

    Electrooxidative C–H/C–M Couplings 3

    Electrooxidative C–H/C–H Couplings 4

    Conclusion and Outlook
    Keywords electrochemistry ; C–H activation ; directing groups ; transition-metal catalysis ; biaryls
    Language English
    Publishing date 2021-09-17
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2033062-5
    ISSN 1437-210X ; 0039-7881
    ISSN (online) 1437-210X
    ISSN 0039-7881
    DOI 10.1055/a-1648-2821
    Database Thieme publisher's database

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  9. Article ; Online: Nuclear smears observed in H&E-stained thrombus sections are neutrophil extracellular traps.

    de Boer, Onno J / Li, Xiaofei / Goebel, Heike / van der Wal, Allard C

    Journal of clinical pathology

    2016  Volume 69, Issue 2, Page(s) 181–182

    MeSH term(s) Artifacts ; Cell Nucleus/chemistry ; Cell Nucleus/pathology ; Coloring Agents ; Eosine Yellowish-(YS) ; Extracellular Traps/chemistry ; Hematoxylin ; Humans ; Immunohistochemistry ; Predictive Value of Tests ; Staining and Labeling/methods ; Thrombosis/metabolism ; Thrombosis/pathology
    Chemical Substances Coloring Agents ; Eosine Yellowish-(YS) (TDQ283MPCW) ; Hematoxylin (YKM8PY2Z55)
    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Letter
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2015-203019
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.139: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Inhalative as well as Intravenous Administration of H 2 S Provides Neuroprotection after Ischemia and Reperfusion Injury in the Rats’ Retina

    Stefanie Scheid / Max Goeller / Wolfgang Baar / Jakob Wollborn / Hartmut Buerkle / Günther Schlunck / Wolf Lagrèze / Ulrich Goebel / Felix Ulbrich

    International Journal of Molecular Sciences, Vol 23, Iss 5519, p

    2022  Volume 5519

    Abstract: ... Hydrogen sulfide (H 2 S) is considered a potentially neuroprotective substance, but the most effective route ... induced in rats by a temporary increase in intraocular pressure (1 h). H 2 S was then applied ... by inhalation (80 ppm at 0, 1.5, and 3 h after reperfusion) or by intravenous administration ...

    Abstract Background: Neuronal ischemia-reperfusion injury (IRI), such as it can occur in glaucoma or strokes, is associated with neuronal cell death and irreversible loss of function of the affected tissue. Hydrogen sulfide (H 2 S) is considered a potentially neuroprotective substance, but the most effective route of application and the underlying mechanism remain to be determined. Methods: Ischemia-reperfusion injury was induced in rats by a temporary increase in intraocular pressure (1 h). H 2 S was then applied by inhalation (80 ppm at 0, 1.5, and 3 h after reperfusion) or by intravenous administration of the slow-releasing H 2 S donor GYY 4137. After 24 h, the retinas were harvested for Western blotting, qPCR, and immunohistochemical staining. Retinal ganglion cell survival was evaluated 7 days after ischemia. Results: Both inhalative and intravenously delivered H 2 S reduced retinal ganglion cell death with a better result from inhalative application. H 2 S inhalation for 1.5 h, as well as GYY 4137 treatment, increased p38 phosphorylation. Both forms of application enhanced the extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation, and inhalation showed a significant increase at all three time points. H 2 S treatment also reduced apoptotic and inflammatory markers, such as caspase-3, intracellular adhesion molecule 1 (ICAM-1), vascular endothelial growth factor (VEGF), and inducible nitric oxide synthase (iNOS). The protective effect of H 2 S was partly abolished by the ERK1/2 inhibitor PD98059. Inhalative H 2 S also reduced the heat shock response including heme oxygenase (HO-1) and heat shock protein 70 (HSP-70) and the expression of radical scavengers such as superoxide dismutases (SOD1, SOD2) and catalase. Conclusion: Hydrogen sulfide acts, at least in part, via the mitogen-activated protein kinase (MAPK) ERK1/2 to reduce apoptosis and inflammation. Both inhalative H 2 S and intravenous GYY 4137 administrations can improve neuronal cell survival.
    Keywords hydrogen sulfide ; H 2 S ; GYY 4137 ; ischemia-reperfusion injury ; apoptosis ; inflammation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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