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  1. Article: Human liver myofibroblasts during development and diseases with a focus on portal (myo)fibroblasts.

    Lepreux, Sébastien / Desmoulière, Alexis

    Frontiers in physiology

    2015  Volume 6, Page(s) 173

    Abstract: Myofibroblasts are stromal cells mainly involved in tissue repair. These cells present contractile properties and play a major role in extracellular matrix deposition and remodeling. In liver, myofibroblasts are found in two critical situations. First, ... ...

    Abstract Myofibroblasts are stromal cells mainly involved in tissue repair. These cells present contractile properties and play a major role in extracellular matrix deposition and remodeling. In liver, myofibroblasts are found in two critical situations. First, during fetal liver development, especially in portal tracts, myofibroblasts surround vessels and bile ducts during their maturation. After complete development of the liver, myofibroblasts disappear and are replaced in portal tracts by portal fibroblasts. Second, during liver injury, myofibroblasts re-appear principally deriving from the activation of local stromal cells such as portal fibroblasts and hepatic stellate cells or can sometimes emerge by an epithelial-mesenchymal transition process. After acute injury, myofibroblasts play also a major role during liver regeneration. While myofibroblastic precursor cells are well known, the spectrum of activation and the fate of myofibroblasts during disease evolution are not fully understood. Some data are in accordance with a possible deactivation, at least partial, or a disappearance by apoptosis. Despite these shadows, liver is definitively a pertinent model showing that myofibroblasts are pivotal cells for extracellular matrix control during morphogenesis, repair and fibrous scarring.
    Language English
    Publishing date 2015-06-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2015.00173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Varicella-zoster virus in actively spreading segmental vitiligo skin: Pathological, immunochemical, and ultrastructural findings (a first and preliminary study).

    Gauthier, Yvon / Lepreux, Sebastien / Cario-Andre, Muriel / Rambert, Jérome / Dakdaki, Adrien / Lafon, Marie-Edith / Abouqal, Redouane / Benzekri, Laila

    Pigment cell & melanoma research

    2022  Volume 36, Issue 1, Page(s) 78–85

    Abstract: Segmental vitiligo (SV) is a unilateral subtype of vitiligo which is clinically characterized by a cutaneous depigmentation and histologically by a melanocyte loss from the epidermis and hair follicle reservoirs. To date, its pathogenesis remains a ... ...

    Abstract Segmental vitiligo (SV) is a unilateral subtype of vitiligo which is clinically characterized by a cutaneous depigmentation and histologically by a melanocyte loss from the epidermis and hair follicle reservoirs. To date, its pathogenesis remains a mystery. In many cases, this skin depigmentation shares several clinical features and dysfunctions with herpes zoster (HZ). So, for the first time, we examined whether any nucleus and cell fusion associated with a positive immunolabelling of varicella-zoster virus (VZV) and VZV mature virions could be found in SV skin samples as in herpes zoster (HZ). A total of 40 SV samples were used for histological and immunochemical studies. Control samples were obtained from three HZ, and 10 generalized vitiligo lesions. For ultrastructural study, three recent SV and one HZ as controls were recruited. Here, we report that nuclear fusion in epidermal cells were statistically associated with recent SV (p < .001), whereas syncytia formation was associated with long-lasting SV (p = .001). A positive detection of VZV antigen was statistically associated in the epidermis with recent SV and in the dermis with long-lasting SV (p = .001). Finally, the discovery of mature virions in 3/3 recent SV samples provides additional arguments for our viral hypothesis.
    MeSH term(s) Humans ; Herpesvirus 3, Human ; Vitiligo ; Skin ; Herpes Zoster ; Melanocytes
    Language English
    Publishing date 2022-10-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2409570-9
    ISSN 1755-148X ; 1600-0749 ; 0893-5785 ; 1755-1471
    ISSN (online) 1755-148X ; 1600-0749
    ISSN 0893-5785 ; 1755-1471
    DOI 10.1111/pcmr.13064
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    Zs.A 2444: Show issues Location:
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  3. Article: Idiopathic inflammatory myopathies overlapping with systemic diseases.

    Lepreux, Sébastien / Hainfellner, Johannes A / Vital, Anne

    Clinical neuropathology

    2017  Volume 37, Issue 1, Page(s) 6–15

    Abstract: A muscle biopsy is currently requested to assess the diagnosis of an idiopathic inflammatory myopathy overlapping with a systemic disease. During the past few years, the classification of inflammatory myopathy subtypes has been revisited progressively on ...

    Abstract A muscle biopsy is currently requested to assess the diagnosis of an idiopathic inflammatory myopathy overlapping with a systemic disease. During the past few years, the classification of inflammatory myopathy subtypes has been revisited progressively on the basis of correlations between clinical phenotypes, autoantibodies and histological data. Several syndromic entities are now more clearly defined, and the aim of the present review is to clarify the contribution of muscle biopsy in a setting of idiopathic inflammatory myopathies overlapping with systemic diseases.
.
    MeSH term(s) Animals ; Autoantibodies/immunology ; Biopsy/methods ; Humans ; Inflammation/diagnosis ; Inflammation/pathology ; Muscles/pathology ; Myositis/pathology ; Phenotype
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2017-11-14
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 603167-5
    ISSN 0722-5091
    ISSN 0722-5091
    DOI 10.5414/NP301077
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    Zs.A 1745: Show issues Location:
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  4. Article ; Online: Erdheim-Chester Disease: An Unusual Cause of Intracranial Vasculitis and Progressive Leukoencephalopathy.

    Sagnier, Sharmila / Debruxelles, Sabrina / Lepreux, Sébastien / Sibon, Igor

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2016  Volume 25, Issue 5, Page(s) e63–e65

    Abstract: Erdheim-Chester disease (ECD) is a non-Langerhans histiocytosis affecting multiple organs. Stroke as symptom onset of ECD with intracranial vasculitis is unusual. We report the case of a 64-year-old man who presented with an acute ischemic stroke ... ...

    Abstract Erdheim-Chester disease (ECD) is a non-Langerhans histiocytosis affecting multiple organs. Stroke as symptom onset of ECD with intracranial vasculitis is unusual. We report the case of a 64-year-old man who presented with an acute ischemic stroke associated with a moderate leukoencephalopathy and intracranial arteries stenosis. Four years later, he developed movement disorders with dysarthria and cognitive impairment. Neuroradiological findings demonstrated a rapidly progressive and diffuse leukoencephalopathy associated with brain atrophy and infiltration of the intracranial vertebral artery wall. Brain postmortem evaluation confirmed the diagnosis of ECD. This diagnosis should be evoked in patients with cryptogenic stroke, progressive leukoencephalopathy, and infiltration of the arterial wall.
    MeSH term(s) Atrophy ; Autopsy ; Biopsy ; Brain/pathology ; Cause of Death ; Diffusion Magnetic Resonance Imaging ; Disease Progression ; Erdheim-Chester Disease/complications ; Erdheim-Chester Disease/diagnostic imaging ; Erdheim-Chester Disease/pathology ; Fatal Outcome ; Humans ; Immunohistochemistry ; Infarction, Middle Cerebral Artery/diagnostic imaging ; Infarction, Middle Cerebral Artery/etiology ; Infarction, Middle Cerebral Artery/pathology ; Leukoencephalopathy, Progressive Multifocal/diagnostic imaging ; Leukoencephalopathy, Progressive Multifocal/etiology ; Leukoencephalopathy, Progressive Multifocal/pathology ; Male ; Middle Aged ; Positron-Emission Tomography ; Vasculitis, Central Nervous System/diagnostic imaging ; Vasculitis, Central Nervous System/etiology ; Vasculitis, Central Nervous System/pathology
    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2016.01.042
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    Zs.A 3519: Show issues Location:
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  5. Article ; Online: Purpura fébrile et protéinurie chez une patiente de 71 ans.

    Lepreux, Sébastien / Deminière, Colette

    Nephrologie & therapeutique

    2012  Volume 8, Issue 3, Page(s) 177–178

    Title translation Febrile purpura and proteinuria in a 71-year-old female patient.
    MeSH term(s) Aged ; Female ; Fever/etiology ; Humans ; Parvoviridae Infections/complications ; Parvoviridae Infections/diagnosis ; Parvovirus B19, Human ; Proteinuria/etiology ; Purpura/etiology
    Language French
    Publishing date 2012-06
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2011.10.006
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    Zs.A 6298: Show issues Location:
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  6. Article ; Online: Malignant triton tumor: Grand Round presentation of a rare aggressive case thoracolumbar spine tumor.

    Ghailane, Soufiane / Fauquier, Sandra / Lepreux, Sébastien / Le Huec, Jean-Charles

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2017  Volume 28, Issue 6, Page(s) 1448–1452

    Abstract: Introduction: We report a rare and aggressive case of malignant triton tumor (MTT) at the thoracolumbar junction with foraminal extension mistreated as schwannoma.: Materials and methods: A 70-year-old man with a 2-year history of lower back pain and ...

    Abstract Introduction: We report a rare and aggressive case of malignant triton tumor (MTT) at the thoracolumbar junction with foraminal extension mistreated as schwannoma.
    Materials and methods: A 70-year-old man with a 2-year history of lower back pain and left L4 radiculopathy with no history of neurofibromatosis.
    Results: Pre-operative MRI suggested a typical schwannoma. Upon complete marginal resection, histological findings revealed a MTT. The patient presented with a local and regional recurrence and died 10 months after surgery. MTTs are a subgroup of malignant peripheral nerve sheath tumors, which develop from Schwann cells of peripheral nerves or within existing neurofibromas, and display rhabdomyoblastic differentiation.
    Conclusion: Based on the Grand Round case and relevant literature, we present a case of a highly aggressive and fast-growing tumor with a very high local and distant recurrence. There is no consensus treatment plan available and patients usually die shortly after diagnosis.
    MeSH term(s) Aged ; Diagnostic Errors ; Fatal Outcome ; Humans ; Male ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Nerve Sheath Neoplasms/pathology ; Nerve Sheath Neoplasms/surgery ; Neurilemmoma ; Spinal Neoplasms/pathology ; Spinal Neoplasms/surgery
    Language English
    Publishing date 2017-09-18
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-017-5277-2
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    Zs.A 3437: Show issues Location:
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  7. Article ; Online: CD154 Induces Interleukin-6 Secretion by Kidney Tubular Epithelial Cells under Hypoxic Conditions: Inhibition by Chloroquine.

    Dewitte, Antoine / Villeneuve, Julien / Lepreux, Sébastien / Bouchecareilh, Marion / Gauthereau, Xavier / Rigothier, Claire / Combe, Christian / Ouattara, Alexandre / Ripoche, Jean

    Mediators of inflammation

    2020  Volume 2020, Page(s) 6357046

    Abstract: Inflammation is a major contributor to tubular epithelium injury in kidney disorders, and the involvement of blood platelets in driving inflammation is increasingly stressed. CD154, the ligand of CD40, is one of the mediators supporting platelet ... ...

    Abstract Inflammation is a major contributor to tubular epithelium injury in kidney disorders, and the involvement of blood platelets in driving inflammation is increasingly stressed. CD154, the ligand of CD40, is one of the mediators supporting platelet proinflammatory properties. Although hypoxia is an essential constituent of the inflammatory reaction, if and how platelets and CD154 regulate inflammation in hypoxic conditions remain unclear. Here, we studied the control by CD154 of the proinflammatory cytokine interleukin- (IL-) 6 secretion in short-term oxygen (O
    MeSH term(s) Apoptosis ; Blotting, Western ; CD40 Ligand/pharmacology ; Cell Hypoxia/physiology ; Cell Line ; Cell Proliferation ; Cell Survival ; Chloroquine/pharmacology ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Flow Cytometry ; Humans ; Interleukin-6/metabolism ; Kidney Tubules/cytology ; Microscopy, Fluorescence ; Real-Time Polymerase Chain Reaction
    Chemical Substances Interleukin-6 ; CD40 Ligand (147205-72-9) ; Chloroquine (886U3H6UFF)
    Language English
    Publishing date 2020-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2020/6357046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3575: Show issues Location:
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  8. Article: Correction to: Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critically ill patients?

    Dewitte, Antoine / Lepreux, Sébastien / Villeneuve, Julien / Rigothier, Claire / Combe, Christian / Ouattara, Alexandre / Ripoche, Jean

    Annals of intensive care

    2018  Volume 8, Issue 1, Page(s) 32

    Abstract: Upon publication of the original article [1], it was noticed that the title was incorrect. Instead of 'critical', it should read 'critically', and therefore, the correct title should be. ...

    Abstract Upon publication of the original article [1], it was noticed that the title was incorrect. Instead of 'critical', it should read 'critically', and therefore, the correct title should be.
    Language English
    Publishing date 2018-02-28
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-018-0378-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Périneuriome réticulaire du nerf tibial.

    Gaumond, Stéphanie / Poussange, Nicolas / Fabre, Thierry / Vital, Anne / Lepreux, Sébastien

    Annales de pathologie

    2016  Volume 36, Issue 3, Page(s) 210–213

    Abstract: Reticular (retiform) perineurioma is a rare variant of soft tissue perineurioma developed from the perineurium. This benign tumor is characterized by strands of spindle cells in a fibro-myxoid matrix surrounding pseudocystic mucoid spaces. We report a ... ...

    Title translation Reticular perineurioma of the tibial nerve.
    Abstract Reticular (retiform) perineurioma is a rare variant of soft tissue perineurioma developed from the perineurium. This benign tumor is characterized by strands of spindle cells in a fibro-myxoid matrix surrounding pseudocystic mucoid spaces. We report a tibial nerve reticular perineurioma in a 35-year-old patient.
    Language French
    Publishing date 2016-06
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 225720-8
    ISSN 0242-6498
    ISSN 0242-6498
    DOI 10.1016/j.annpat.2016.01.006
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    Zs.A 1652: Show issues Location:
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  10. Article: In vitro and pilot in vivo imaging of 18 kDa translocator protein (TSPO) in inflammatory vascular disease.

    Schollhammer, Romain / Lepreux, Sébastien / Barthe, Nicole / Vimont, Delphine / Rullier, Anne / Sibon, Igor / Berard, Xavier / Zhang, Andrea / Kimura, Yasuyuki / Fujita, Masahiro / Innis, Robert B / Zanotti-Fregonara, Paolo / Morgat, Clément

    EJNMMI research

    2021  Volume 11, Issue 1, Page(s) 45

    Abstract: Background: Inflammatory vascular disease of the arteries, such as inflamed atheromatous plaques or arteritis, may cause aneurysms or ischemic strokes. In this context, using positron emission tomography (PET) to image inflammation may help select ... ...

    Abstract Background: Inflammatory vascular disease of the arteries, such as inflamed atheromatous plaques or arteritis, may cause aneurysms or ischemic strokes. In this context, using positron emission tomography (PET) to image inflammation may help select patients who would benefit from appropriate therapeutic interventions. This study sought to assess the usefulness of the 18 kDa translocator protein (TSPO) tracers [
    Results: All in vitro sections showed specific binding of [
    Conclusion: Despite good uptake on surgical samples in vitro, [
    Trial registration: NCT02513589, registered 31 July 2015 and NCT00547976, registered 23 October 2007. https://clinicaltrials.gov .
    Language English
    Publishing date 2021-05-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2619892-7
    ISSN 2191-219X
    ISSN 2191-219X
    DOI 10.1186/s13550-021-00786-7
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