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  1. Article ; Online: Polymeric Nanoparticles for Biomedical Applications.

    Andrade, Stéphanie / Ramalho, Maria J / Loureiro, Joana A

    Polymers

    2024  Volume 16, Issue 2

    Abstract: Polymeric nanoparticles (NPs), utilized extensively in biomedical applications, have received increasing interest in the preceding years and today represent an established part of the nanotechnology field [ ... ]. ...

    Abstract Polymeric nanoparticles (NPs), utilized extensively in biomedical applications, have received increasing interest in the preceding years and today represent an established part of the nanotechnology field [...].
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16020249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Latent profiles of emotion regulation among university students: links to repetitive negative thinking, internet addiction, and subjective wellbeing.

    Oliveira, Joana / Pedras, Susana / Inman, Richard A / Ramalho, Sofia Marques

    Frontiers in psychology

    2024  Volume 15, Page(s) 1272643

    Abstract: Recent years have seen a deterioration in the mental health of university students and notable surge in the need for psychological support. Due to its links to psychopathology and high-risk behaviors, difficulty in emotion regulation frequently serves as ...

    Abstract Recent years have seen a deterioration in the mental health of university students and notable surge in the need for psychological support. Due to its links to psychopathology and high-risk behaviors, difficulty in emotion regulation frequently serves as a transdiagnostic dimension. This cross-sectional study used a person-centered analytical approach (latent profile analysis; LPA) to identify groups of Portuguese university students with similar profiles of emotion regulation difficulties (
    Language English
    Publishing date 2024-04-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2024.1272643
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  3. Article ; Online: An Unusual Cause of Dysphagia.

    Tomé, Sónia / Almeida, Joana / Pereira, Vítor Costa / Pinto, Luísa Viana / Ramalho, Joana / Engenheiro, Gonçalo / Carvalho, João / Branco, Catarina Aguiar

    Dysphagia

    2023  Volume 38, Issue 4, Page(s) 1264–1266

    MeSH term(s) Humans ; Deglutition Disorders/etiology
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 632764-3
    ISSN 1432-0460 ; 0179-051X
    ISSN (online) 1432-0460
    ISSN 0179-051X
    DOI 10.1007/s00455-022-10552-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2130: Show issues Location:
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  4. Article ; Online: Intrathecal baclofen for the management of hereditary spastic paraparesis: a systematic review.

    Viana Pinto, Luisa / Romeiro, Isabel / Gouveia, Filipa / Ramalho, Joana / Ribeiro Silva, Sara / Táboas Simões, Maria Inês / Rodrigues Leal, Joana

    International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation

    2024  Volume 47, Issue 1, Page(s) 3–9

    Abstract: This systematic review aims to evaluate the use of intrathecal baclofen (ITB) for hereditary spastic paraparesis (HSP) treatment. An extensive search in two electronical databases was performed. We identified articles published between 1990 and 2022 ( ... ...

    Abstract This systematic review aims to evaluate the use of intrathecal baclofen (ITB) for hereditary spastic paraparesis (HSP) treatment. An extensive search in two electronical databases was performed. We identified articles published between 1990 and 2022 (PubMed, Scopus), and applied the following inclusion criteria: diagnosis of HSP at the time of the intervention, either familial or sporadic; report on the effect of ITB in patients with HSP; test trial via either bolus injections or continuous infusion tests; and ITB pump implantation. A data extraction sheet based on the Cochrane Consumers and Communication Review Group's data extraction template was created and adapted to collect relevant data. A qualitative analysis was performed to present the results in narrative summary fashion. A total of 6 studies met our inclusion criteria. 51 patients with HSP had a pre-implantation ITB trial. The time since the diagnosis until the pump implantation ranged from 5 to 30 years. The initial bolus ranged from 20 to 50 μg and the mean doses used at steady state ranged from 65 to 705 μg. An improvement in spasticity was observed on the modified Ashworth Scale in patients treated with ITB. Although all studies reported a subjective gait improvement, not all found an objective improvement in gait. The most common side effect reported was catheter-related problems. The findings of this review support the use of ITB as an effective and a viable option for the treatment of spasticity in HSP refractory to conservative therapies.
    MeSH term(s) Humans ; Baclofen/adverse effects ; Paraparesis, Spastic/chemically induced ; Paraparesis, Spastic/drug therapy ; Infusion Pumps, Implantable ; Injections, Spinal ; Muscle Spasticity/drug therapy
    Chemical Substances Baclofen (H789N3FKE8)
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 533323-4
    ISSN 1473-5660 ; 0342-5282
    ISSN (online) 1473-5660
    ISSN 0342-5282
    DOI 10.1097/MRR.0000000000000607
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1326: Show issues Location:
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  5. Article ; Online: Horseback Riding-Related Injuries in Portugal and Prevention Strategies.

    Pinto, Luísa V / Gouveia, Filipa C / Ramalho, Joana F / Silva, Sara R / Silva, Joana R

    Journal of sport rehabilitation

    2023  Volume 32, Issue 4, Page(s) 409–414

    Abstract: Context: Horse riding (HR) has gain popularity in Portugal, thereby increasing the number of related injuries. This study identifies frequently occurring injuries in Portuguese riders, the conditions under which they occur, and preventive measures.: ... ...

    Abstract Context: Horse riding (HR) has gain popularity in Portugal, thereby increasing the number of related injuries. This study identifies frequently occurring injuries in Portuguese riders, the conditions under which they occur, and preventive measures.
    Design: A retrospective cohort study.
    Methods: We included 216 Portuguese riders practicing HR at the time of the study with ≥1 year of experience. Data were obtained from a questionnaire that characterized first and second rider injuries; we opted for a systematic method to assess the riders' injuries, in a temporal order. Questions regarding demographic data, sports-related background, systematic training workload, number and characteristics of the first 2 injuries, and the need for treatment were included in the questionnaire.
    Results: Most first and second injuries were musculoskeletal, occurred from falling off the horse during training, and primarily affected the lower limb. Rehabilitation was required in almost 50% of all cases. The occurrence of injury was significantly associated with the number of days of training per week, years of experience, height and weight of the rider, and practice of another sport. Riding different horses was also significantly associated with the number of injuries.
    Conclusions: The most frequently occurring injuries during HR are musculoskeletal and in the extremities. Injury prevention is essential in HR, as most riders have at least one injury while practicing. Rehabilitation should involve a physiatrist and core strengthening exercises.
    MeSH term(s) Humans ; Horses ; Animals ; Athletic Injuries/epidemiology ; Athletic Injuries/prevention & control ; Portugal/epidemiology ; Retrospective Studies ; Sports ; Surveys and Questionnaires ; Reinjuries
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1106769-x
    ISSN 1543-3072 ; 1056-6716
    ISSN (online) 1543-3072
    ISSN 1056-6716
    DOI 10.1123/jsr.2022-0101
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    Zs.A 3780: Show issues Location:
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  6. Article ; Online: Transferrin-Conjugated PLGA Nanoparticles for Co-Delivery of Temozolomide and Bortezomib to Glioblastoma Cells.

    Ramalho, Maria João / Torres, Inês David / Loureiro, Joana Angélica / Lima, Jorge / Pereira, Maria Carmo

    ACS applied nano materials

    2023  Volume 6, Issue 15, Page(s) 14191–14203

    Abstract: Glioblastoma (GBM) represents almost half of primary brain tumors, and its standard treatment with the alkylating agent temozolomide (TMZ) is not curative. Treatment failure is partially related to intrinsic resistance mechanisms mediated by the O6- ... ...

    Abstract Glioblastoma (GBM) represents almost half of primary brain tumors, and its standard treatment with the alkylating agent temozolomide (TMZ) is not curative. Treatment failure is partially related to intrinsic resistance mechanisms mediated by the O6-methylguanine-DNA methyltransferase (MGMT) protein, frequently overexpressed in GBM patients. Clinical trials have shown that the anticancer agent bortezomib (BTZ) can increase TMZ's therapeutic efficacy in GBM patients by downregulating MGMT expression. However, the clinical application of this therapeutic strategy has been stalled due to the high toxicity of the combined therapy. The co-delivery of TMZ and BTZ through nanoparticles (NPs) of poly(lactic-
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Journal Article
    ISSN 2574-0970
    ISSN (online) 2574-0970
    DOI 10.1021/acsanm.3c02122
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  7. Article ; Online: How Compassionate Abilities Influence the Experience of Loneliness and Quality of Life of People with and without Chronic Physical Disease?

    Ramalho, Tânia / Pereira, Joana / Ferreira, Cláudia

    The Journal of psychology

    2021  Volume 155, Issue 8, Page(s) 679–694

    Abstract: The current study aimed to test whether individuals with and without a chronic physical disease differ in levels of compassionate abilities, loneliness and quality of life (QoL); and to examine whether loneliness mediated the impact of self-compassion ... ...

    Abstract The current study aimed to test whether individuals with and without a chronic physical disease differ in levels of compassionate abilities, loneliness and quality of life (QoL); and to examine whether loneliness mediated the impact of self-compassion and of receiving compassion from others in physical, psychological, and social QoL. In this cross-sectional study, individuals with (
    MeSH term(s) Chronic Disease ; Cross-Sectional Studies ; Empathy ; Humans ; Loneliness ; Quality of Life
    Language English
    Publishing date 2021-08-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3126-4
    ISSN 1940-1019 ; 0022-3980
    ISSN (online) 1940-1019
    ISSN 0022-3980
    DOI 10.1080/00223980.2021.1952922
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1702: Show issues Location:
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  8. Article: Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials.

    Andrade, Stéphanie / Nunes, Débora / Dabur, Meghna / Ramalho, Maria J / Pereira, Maria C / Loureiro, Joana A

    Pharmaceutics

    2023  Volume 15, Issue 1

    Abstract: Neurodegenerative diseases are caused by the gradual loss of neurons' function. These neurological illnesses remain incurable, and current medicines only alleviate the symptoms. Given the social and economic burden caused by the rising frequency of ... ...

    Abstract Neurodegenerative diseases are caused by the gradual loss of neurons' function. These neurological illnesses remain incurable, and current medicines only alleviate the symptoms. Given the social and economic burden caused by the rising frequency of neurodegenerative diseases, there is an urgent need for the development of appropriate therapeutics. Natural compounds are gaining popularity as alternatives to synthetic drugs due to their neuroprotective properties and higher biocompatibility. While natural compounds' therapeutic effects for neurodegenerative disease treatment have been investigated in numerous in vitro and in vivo studies, only few have moved to clinical trials. This article provides the first systematic review of the clinical trials evaluating natural compounds' safety and efficacy for the treatment of the five most prevalent neurodegenerative disorders: Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease.
    Language English
    Publishing date 2023-01-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15010212
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  9. Article ; Online: Gadolinium-Based Contrast Agents: Associated Adverse Reactions.

    Ramalho, Miguel / Ramalho, Joana

    Magnetic resonance imaging clinics of North America

    2017  Volume 25, Issue 4, Page(s) 755–764

    Abstract: Gadolinium-based contrast agents have been considered extremely safe drugs with a low incidence of acute adverse reactions. Most of the reactions are mild and physiologic. However, despite being extremely rare, acute severe adverse reactions, including ... ...

    Abstract Gadolinium-based contrast agents have been considered extremely safe drugs with a low incidence of acute adverse reactions. Most of the reactions are mild and physiologic. However, despite being extremely rare, acute severe adverse reactions, including anaphylaxis, may occur. In this article adverse reactions are discussed with regard to their classification, pathophysiology, symptoms, and risk factors.
    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196851-5
    ISSN 1557-9786 ; 1064-9689
    ISSN (online) 1557-9786
    ISSN 1064-9689
    DOI 10.1016/j.mric.2017.06.006
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  10. Article ; Online: Gadolinium Deposition and Chronic Toxicity.

    Ramalho, Joana / Ramalho, Miguel

    Magnetic resonance imaging clinics of North America

    2017  Volume 25, Issue 4, Page(s) 765–778

    Abstract: Clinicians, radiologists, and patients should be aware of the most up-to-date data on the risks of gadolinium-based contrast agent (GBCA) administration. In this review, we discuss in vivo gadolinium retention, particularly brain tissue retention, and ... ...

    Abstract Clinicians, radiologists, and patients should be aware of the most up-to-date data on the risks of gadolinium-based contrast agent (GBCA) administration. In this review, we discuss in vivo gadolinium retention, particularly brain tissue retention, and potential toxic effects. GBCA pharmacokinetics and biodistribution are reviewed briefly. Based on the more recent published literature and society guidelines, general safety recommendations for clinical practice are provided.
    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196851-5
    ISSN 1557-9786 ; 1064-9689
    ISSN (online) 1557-9786
    ISSN 1064-9689
    DOI 10.1016/j.mric.2017.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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