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  1. Article ; Online: Driophlox, a new genus of cardinalid (Aves: Passeriformes: Cardinalidae).

    Scott, Benjamin F / Chesser, R Terry / Unitt, Philip / Burns, Kevin J

    Zootaxa

    2024  Volume 5406, Issue 3, Page(s) 497–500

    MeSH term(s) Animals ; Passeriformes ; Mites
    Language English
    Publishing date 2024-02-07
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5406.3.11
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  2. Article ; Online: Evaluating perspectives on well-being and burnout among emergency medicine program leaders.

    Agarwal, Anish K / Barrett, John R / Gonzales, Rachel / Deutsch, Amanda J / Scott, Kevin R

    The American journal of emergency medicine

    2023  Volume 77, Page(s) 223–225

    MeSH term(s) Humans ; Burnout, Psychological ; Burnout, Professional/epidemiology ; Emergency Medicine ; Surveys and Questionnaires
    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Letter
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2023.12.035
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    Zs.A 2005: Show issues Location:
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  3. Article ; Online: Proteome changes in larval zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) exposed to (±) anatoxin-a.

    Langan, Laura M / Lovin, Lea M / Taylor, Raegyn B / Scarlett, Kendall R / Kevin Chambliss, C / Chatterjee, Saurabh / Scott, J Thad / Brooks, Bryan W

    Environment international

    2024  Volume 185, Page(s) 108514

    Abstract: Anatoxin-a and its analogues are potent neurotoxins produced by several genera of cyanobacteria. Due in part to its high toxicity and potential presence in drinking water, these toxins pose threats to public health, companion animals and the environment. ...

    Abstract Anatoxin-a and its analogues are potent neurotoxins produced by several genera of cyanobacteria. Due in part to its high toxicity and potential presence in drinking water, these toxins pose threats to public health, companion animals and the environment. It primarily exerts toxicity as a cholinergic agonist, with high affinity at neuromuscular junctions, but molecular mechanisms by which it elicits toxicological responses are not fully understood. To advance understanding of this cyanobacteria, proteomic characterization (DIA shotgun proteomics) of two common fish models (zebrafish and fathead minnow) was performed following  (±) anatoxin-a exposure. Specifically, proteome changes were identified and quantified in larval fish exposed for 96 h (0.01-3 mg/L (±) anatoxin-a and caffeine (a methodological positive control) with environmentally relevant treatment levels examined based on environmental exposure distributions of surface water data. Proteomic concentration - response relationships revealed 48 and 29 proteins with concentration - response relationships curves for zebrafish and fathead minnow, respectively. In contrast, the highest number of differentially expressed proteins (DEPs) varied between zebrafish (n = 145) and fathead minnow (n = 300), with only fatheads displaying DEPs at all treatment levels. For both species, genes associated with reproduction were significantly downregulated, with pathways analysis that broadly clustered genes into groups associated with DNA repair mechanisms. Importantly, significant differences in proteome response between the species was also observed, consistent with prior observations of differences in response using both behavioral assays and gene expression, adding further support to model specific differences in organismal sensitivity and/or response. When DEPs were read across from humans to zebrafish, disease ontology enrichment identified diseases associated with cognition and muscle weakness consistent with the prior literature. Our observations highlight limited knowledge of how (±) anatoxin-a, a commonly used synthetic racemate surrogate, elicits responses at a molecular level and advances its toxicological understanding.
    MeSH term(s) Animals ; Humans ; Zebrafish/metabolism ; Proteome/metabolism ; Larva ; Proteomics ; Cyprinidae/metabolism ; Water Pollutants, Chemical/toxicity ; Cyanobacteria Toxins ; Tropanes
    Chemical Substances anatoxin a (80023A73NK) ; Proteome ; Water Pollutants, Chemical ; Cyanobacteria Toxins ; Tropanes
    Language English
    Publishing date 2024-02-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2024.108514
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    Zs.A 3131: Show issues Location:
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  4. Article ; Online: RNAi-mediated knockdown of two orphan G protein-coupled receptors reduces fecundity in the yellow fever mosquito

    Keyes-Scott, Nia I / Swade, Kyle R / Allen, Lena R / Vogel, Kevin J

    Frontiers in insect science

    2023  Volume 3, Page(s) 1197945

    Abstract: G protein-coupled receptors (GPCRs) control numerous physiological processes in insects, including reproduction. While many GPCRs have known ligands, orphan GPCRs do not have identified ligands in which they bind. Advances in genomic sequencing and ... ...

    Abstract G protein-coupled receptors (GPCRs) control numerous physiological processes in insects, including reproduction. While many GPCRs have known ligands, orphan GPCRs do not have identified ligands in which they bind. Advances in genomic sequencing and phylogenetics provide the ability to compare orphan receptor protein sequences to sequences of characterized GPCRs, and thus gain a better understanding of the potential functions of orphan GPCRs. Our study sought to investigate the functions of two orphan GPCRs, AAEL003647 and AAEL019988, in the yellow fever mosquito,
    Language English
    Publishing date 2023-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 3123819-1
    ISSN 2673-8600 ; 2673-8600
    ISSN (online) 2673-8600
    ISSN 2673-8600
    DOI 10.3389/finsc.2023.1197945
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  5. Article ; Online: Chordal Preservation Mitral Valve Replacement for Delayed MitraClip Failure.

    Greason, Kevin L / Spittell, Peter C / Wright, R Scott

    Texas Heart Institute journal

    2022  Volume 49, Issue 6

    Abstract: Mitral valve replacement may be indicated in delayed MitraClip (Abbott) failure. Although it would be best to preserve the chordal apparatus during surgical mitral valve replacement, this has not been reported for delayed MitraClip failure, probably ... ...

    Abstract Mitral valve replacement may be indicated in delayed MitraClip (Abbott) failure. Although it would be best to preserve the chordal apparatus during surgical mitral valve replacement, this has not been reported for delayed MitraClip failure, probably because there is almost always impressive inflammation around the MitraClip, which has likely precluded previous attempts at chordal preservation. A successful surgical chordal preservation mitral valve replacement in delayed MitraClip failure is reported here.
    MeSH term(s) Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604761-0
    ISSN 1526-6702 ; 0730-2347
    ISSN (online) 1526-6702
    ISSN 0730-2347
    DOI 10.14503/THIJ-21-7599
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    Zs.A 1452: Show issues Location:
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    Zs.MO 484: Show issues

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  6. Article ; Online: Consistent changes in muscle metabolism underlie dive performance across multiple lineages of diving ducks.

    Schell, Elizabeth R / McCracken, Kevin G / Scott, Graham R / White, Jeff / Lavretsky, Philip / Dawson, Neal J

    Proceedings. Biological sciences

    2023  Volume 290, Issue 2007, Page(s) 20231466

    Abstract: Diving animals must sustain high activity with limited ... ...

    Abstract Diving animals must sustain high activity with limited O
    MeSH term(s) Animals ; Ducks ; Locomotion ; Lipid Metabolism ; Anaerobiosis ; Pectoralis Muscles
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2023.1466
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    Zs.A 1364: Show issues Location:
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  7. Article ; Online: Selinexor therapy for multiple myeloma and non-Hodgkin lymphomas.

    Goldsmith, Scott R / Liu, Lawrence / Shiah, Kevin

    Current opinion in oncology

    2022  Volume 34, Issue 5, Page(s) 524–530

    Abstract: Purpose of review: In this review we highlight the most recent studies furthering the clinical development of selinexor, a novel exportin-1 inhibitor, for the treatment of multiple myeloma and non-Hodgkin lymphomas.: Recent findings: Three pivotal ... ...

    Abstract Purpose of review: In this review we highlight the most recent studies furthering the clinical development of selinexor, a novel exportin-1 inhibitor, for the treatment of multiple myeloma and non-Hodgkin lymphomas.
    Recent findings: Three pivotal trials, the SADAL trial for diffuse large B-cell lymphoma, and the BOSTON and selinexor treatment of refractory myeloma trials for multiple myeloma, have recently led to the regulatory approval of selinexor monotherapy or combination regimens. They are complemented by several earlier phase clinical trials with iterative combinations, adding selinexor to novel therapies and cytotoxic chemotherapy regimens at various stages in the disease courses. In some, selinexor appears synergistic, occasionally overcoming treatment refractoriness, whereas in other situations appears additive. Consistent issues with tolerability are seen across trials, although consensus guidelines on their preemption and management have recently been adopted which may improve treatment success. While comparative data are lacking, the efficacy of selinexor-based regimens does not approach that of contemporaneous cellular and immunotherapies.
    Summary: Selinexor is a novel and potentially synergistic therapy for lymphoid malignancies, although requires refined supportive measures and strategies to improve its efficacy. Likely, for continued success, it will need to identify niches that complement recent advances, such as bridging to cellular therapies or maintenance thereafter.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols ; Humans ; Hydrazines/pharmacology ; Hydrazines/therapeutic use ; Lymphoma, Non-Hodgkin/drug therapy ; Multiple Myeloma/drug therapy ; Multiple Myeloma/pathology ; Triazoles
    Chemical Substances Hydrazines ; Triazoles ; selinexor (31TZ62FO8F)
    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000866
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    Zs.A 3046: Show issues Location:
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  8. Article: Vaccination with

    Timm, Morgan R / Tamadonfar, Kevin O / Nye, Taylor M / Pinkner, Jerome S / Dodson, Karen W / Ellebedy, Ali H / Hultgren, Scott J

    Research square

    2023  

    Abstract: Catheter-associated urinary tract infections (CAUTIs) contribute greatly to the burden of healthcare associated infections. ...

    Abstract Catheter-associated urinary tract infections (CAUTIs) contribute greatly to the burden of healthcare associated infections.
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3213777/v1
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  9. Article ; Online: High risk and low prevalence diseases: Serotonin syndrome.

    Spadaro, Anthony / Scott, Kevin R / Koyfman, Alex / Long, Brit

    The American journal of emergency medicine

    2022  Volume 61, Page(s) 90–97

    Abstract: Introduction: Serotonin syndrome is a rare, frequently misdiagnosed, serious condition with high morbidity.: Objective: This review highlights the pearls and pitfalls of serotonin syndrome, including diagnosis, initial resuscitation, and management ... ...

    Abstract Introduction: Serotonin syndrome is a rare, frequently misdiagnosed, serious condition with high morbidity.
    Objective: This review highlights the pearls and pitfalls of serotonin syndrome, including diagnosis, initial resuscitation, and management in the emergency department (ED) based on current evidence.
    Discussion: Serotonin syndrome is a potentially deadly toxidrome marked by excess serotonin receptor activity or neurotransmission. Features of serotonin syndrome include 1) neuromuscular excitation such as tremor, hyperreflexia, and clonus; 2) autonomic dysfunction such as tachycardia, hypertension/hypotension, and hyperthermia; and 3) altered mental status such as agitation, delirium, and coma. Although serotonin syndrome may be more obvious in patients who have overdosed on serotonergic agents such as serotonin reuptake inhibitors (SSRIs), multiple other medications may also cause serotonin syndrome. Alternative diagnoses such as sepsis, neuroleptic malignant syndrome, and decompensated hyperthyroidism should be considered. The primary components of therapy include stopping the offending agent and supportive care, which focuses on agitation control, monitoring for and treating hyperthermia, and managing autonomic instability.
    Conclusions: An understanding of serotonin syndrome can assist emergency clinicians in diagnosing and managing this disease.
    MeSH term(s) Humans ; Serotonin Syndrome/diagnosis ; Serotonin Syndrome/epidemiology ; Serotonin Syndrome/therapy ; Selective Serotonin Reuptake Inhibitors/therapeutic use ; Prevalence ; Neuroleptic Malignant Syndrome ; Receptors, Serotonin
    Chemical Substances Serotonin Uptake Inhibitors ; Receptors, Serotonin
    Language English
    Publishing date 2022-08-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2022.08.030
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  10. Article ; Online: DNA-Compatible Conditions for the Formation of

    Zhang, Panpan / Koch, Grant / Zhang, Yankun / Yang, Kevin / Lokey, R Scott

    ACS omega

    2023  Volume 8, Issue 26, Page(s) 23477–23483

    Abstract: DNA-encoded libraries (DELs) are a powerful platform in drug discovery. Peptides have unique properties that make them attractive pharmaceutical candidates. N-methylation of the peptide backbone can confer beneficial properties such as increased ... ...

    Abstract DNA-encoded libraries (DELs) are a powerful platform in drug discovery. Peptides have unique properties that make them attractive pharmaceutical candidates. N-methylation of the peptide backbone can confer beneficial properties such as increased proteolytic stability and membrane permeability. Herein, we evaluate different DEL reaction systems and report a DNA-compatible protocol for forming N-methylated amide bonds. The DNA-compatible, bis(trichloromethyl)carbonate-mediated amide coupling is efficient for the formation of N-methyl peptide bonds, which promises to increase the opportunity to identify passively cell-permeable macrocyclic peptide hits by DNA-encoded technology.
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c00576
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