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  1. Article ; Online: Trends in orthopaedic surgery for spondyloarthritis: outcomes from a National Hospitalised Patient Registry (MBDS) over a 17-year period (1999-2015).TREND-EspA study.

    Mazzucchelli, Ramón / Almodóvar, Raquel / Turrado-Crespí, Paula / Crespí-Villarías, Natalia / Pérez-Fernández, Elia / García-Zamora, Elena / García-Vadillo, Alberto

    RMD open

    2022  Volume 8, Issue 1

    Abstract: Objective: To assess the incidence of orthopaedic surgery (OS) (including total hip arthroplasty (THA), total knee arthroplasty, upper limb arthroplasty, arthrodesis and spinal surgery) and associated trends in patients with spondyloarthritis (SpA) over ...

    Abstract Objective: To assess the incidence of orthopaedic surgery (OS) (including total hip arthroplasty (THA), total knee arthroplasty, upper limb arthroplasty, arthrodesis and spinal surgery) and associated trends in patients with spondyloarthritis (SpA) over a long period (17 years).
    Methods: An observational, retrospective, population-based, serial cross-sectional study was conducted. All hospital admissions of patients with SpA reported between 1999 and 2015 were analysed, and a control group was selected and matched by age, sex and year of admission. Incidence rates for OS (and subtypes) were calculated. Generalised linear models were used to analyse trends; unconditional logistic regression models were used to calculate crude and adjusted ORs (aORs) with the aim of evaluating the association between OS and SpA.
    Results: The study database contained data on 214 280 hospital admissions (SpA/non-SpA 1:1 ratio). In the SpA cohort, 5 382 admissions (5.02%) had undergone OS compared with 3 533 in the non-SpA cohort (3.29%) (AOR 1.64; 95% CI 1.57 to 1.72). OS rates increased for both cohorts (+4.92% per year vs +8.41%). The trend in OS, THA, arthrodesis and spinal surgery decreased or stabilised in patients under age 60 in the SpA cohort, while the non-SpA cohort remained stable. In the SpA cohort, the mean age was 53.68 years (SD 13.65) in 1999, increasing to 62.76 years (SD 12.74) in 2015. In the non-SpA cohort, the mean age remained stable at around 63 years.
    Conclusions: A 9-year difference in the age of patients undergoing OS was observed in patients with SpA. The incidence of OS, THA and arthrodesis decreased in patients under age 60, and the incidence of spinal surgery decreased in patients under age 40. Our findings suggest that these patients are increasingly able to defer surgical interventions.
    MeSH term(s) Adult ; Arthroplasty, Replacement, Hip/adverse effects ; Cross-Sectional Studies ; Humans ; Middle Aged ; Orthopedic Procedures ; Registries ; Retrospective Studies ; Spondylarthritis/epidemiology ; Spondylarthritis/surgery
    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2021-002107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Association of oral bisphosphonates with cardioembolic ischemic stroke: a nested case-control study.

    Rodríguez-Martín, Sara / Barreira-Hernández, Diana / Mazzucchelli, Ramón / Gil, Miguel / García-Lledó, Alberto / Izquierdo-Esteban, Laura / Pérez-Gómez, Ana / Rodríguez-Miguel, Antonio / De Abajo, Francisco J

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1197238

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1197238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Trends in orthopaedic surgery for spondyloarthritis

    Raquel Almodovar / Ramón Mazzucchelli / Natalia Crespí-Villarías / Elia Pérez-Fernández / Elena García-Zamora / Paula Turrado-Crespí / Alberto García-Vadillo

    RMD Open, Vol 8, Iss

    outcomes from a National Hospitalised Patient Registry (MBDS) over a 17-year period (1999–2015).TREND-EspA study

    2022  Volume 1

    Keywords Medicine ; R
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Risk of Ischemic Stroke Associated with Calcium Supplements and Interaction with Oral Bisphosphonates: A Nested Case-Control Study.

    Barreira-Hernández, Diana / Rodríguez-Martín, Sara / Gil, Miguel / Mazzucchelli, Ramón / Izquierdo-Esteban, Laura / García-Lledó, Alberto / Pérez-Gómez, Ana / Rodríguez-Miguel, Antonio / de Abajo, Francisco J

    Journal of clinical medicine

    2023  Volume 12, Issue 16

    Abstract: Conflicting results about the association of calcium supplements (CS) with ischemic stroke (IS) have been reported. We tested this hypothesis by differentiating between CS alone (CaM) and CS with vitamin D (CaD) and between cardioembolic and non- ... ...

    Abstract Conflicting results about the association of calcium supplements (CS) with ischemic stroke (IS) have been reported. We tested this hypothesis by differentiating between CS alone (CaM) and CS with vitamin D (CaD) and between cardioembolic and non-cardioembolic IS. We examined the potential interaction with oral bisphosphonates (oBs). A nested case-control study was carried out. We identified incident IS cases aged 40-90 and randomly sampled five controls per case matched by age, sex, and index date. Current users were compared to non-users. An adjusted odds ratios (AOR) and 95% CI were computed through conditional logistic regression. Only new users were considered. We included 13,267 cases (4400 cardioembolic, 8867 non-cardioembolic) and 61,378 controls (20,147 and 41,231, respectively). CaM use was associated with an increased risk of cardioembolic IS (AOR = 1.88; 95% CI: 1.21-2.90) in a duration-dependent manner, while it showed no association with non-cardioembolic IS (AOR = 1.05; 95% CI: 0.74-1.50); its combination with oBs increased the risk of cardioembolic IS considerably (AOR = 2.54; 95% CI: 1.28-5.04), showing no effect on non-cardioembolic. CaD use was not associated with either cardioembolic (AOR = 1.08; 95% CI: 0.88-1.31) or non-cardioembolic IS (AOR = 0.98; 95% CI: 0.84-1.13) but showed a small association with cardioembolic IS when combined with oBs (AOR = 1.35; 95% CI: 1.03-1.76). The results support the hypothesis that CS increases the risk of cardioembolic IS, primarily when used concomitantly with oBs.
    Language English
    Publishing date 2023-08-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12165294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Democracia y mortalidad por Covid-19 en Europa.

    Mazzucchelli, Ramón / Agudo Dieguez, Alberto / Dieguez Costa, Elisa M / Crespí Villarías, Natalia

    Revista espanola de salud publica

    2020  Volume 94

    Abstract: Objective: In Europe there is a great variability in mortality by Covid-19 among different countries. While some countries, such as Greece, Belarus or Ukraine, have a mortality rate of less than 5 cases/100,000 inhabitants, other countries such as ... ...

    Title translation Democracy and Covid-19 mortality in Europe.
    Abstract Objective: In Europe there is a great variability in mortality by Covid-19 among different countries. While some countries, such as Greece, Belarus or Ukraine, have a mortality rate of less than 5 cases/100,000 inhabitants, other countries such as Belgium, Spain or the United Kingdom have a mortality rate of well over 50 cases/100,000 inhabitants. It is generally considered that the reason for this variability is multifactorial (including political reasons), but there are few studies that associate factors related to this variability. The objective of this work was to analyse political risk factors/markers that could explain the variability in mortality due to Covid-19 among different European countries.
    Methods: This is a retrospective, multinational, ecological study based on the exploitation of the database provided by the European Centre for Disease Prevention and Control which collects daily information worldwide on new cases and deaths. The accumulated mortality of Covid-19 in European countries (with more than 100 deaths on 01/05/2020) was calculated up to 29/05/2020. Political variables were compiled from different sources in the countries included in the study. The variables analysed were: the democracy index and the different factors included in it, the country's political system and the country's corruption index. On the other hand, specific political measures implemented in the different countries were collected, such as the number of days elapsed from the notification of the first infected person to 100 infected persons, to lockdown, to the closure of schools or the cancelation of meetings. The number of people infected up to the date of lockdown was also registered. For the statistical analysis of the association between the dependent variable (mortality) and the factors studied, correlation index were calculated, and the association was studied through univariate and multivariate linear regression models.
    Results: At May 1 2020, 27 European countries had at least 100 deaths. The mean mortality was 19.83 cases/100,000 inhabitants (SD 22.4) and a median of 7.95. Mortality varied from a minimum of 1.49 cases/100,000 population in Ukraine to 82.19 cases/100,000 population in Belgium. About factors analyzed both the democracy index (as well as the factors included in it), the political system (full democracy vs. no) and the corruption index were statistically associated with mortality. Also, the time until the implementation of the political measures was associated with mortality.
    Conclusions: In Europe, there is a west to east (from highest to lowest) gradient in the mortality of Covid-19. Some of the observed mortality variability can be explained by political factors.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/mortality ; Democracy ; Europe/epidemiology ; Humans ; International Cooperation ; Pandemics ; Pneumonia, Viral/mortality ; Politics ; Quarantine ; Retrospective Studies ; SARS-CoV-2
    Keywords covid19
    Language Spanish
    Publishing date 2020-06-24
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1288657-9
    ISSN 2173-9110 ; 0034-8899 ; 1135-5727
    ISSN (online) 2173-9110
    ISSN 0034-8899 ; 1135-5727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association of spondyloarthritis and sarcoidosis: A retrospective observational population-based matched cohort study.

    Mazzucchelli, Ramón / Almodovar, Raquel / Dieguez-Costa, Elisa / Crespí Villarías, Natalia / Pérez Fernandez, Elia / García Vadillo, Alberto

    Joint bone spine

    2021  Volume 89, Issue 2, Page(s) 105290

    Abstract: Objectives: To investigate the association between spondyloarthritis (SpA) and sarcoidosis.: Methods: An observational retrospective population-based matched cohort study was conducted. Using data from the Spanish Minimum Basic Data Set. All the ... ...

    Abstract Objectives: To investigate the association between spondyloarthritis (SpA) and sarcoidosis.
    Methods: An observational retrospective population-based matched cohort study was conducted. Using data from the Spanish Minimum Basic Data Set. All the admissions of patients with SpA reported between 1999 and 2015 were analysed and a control group matched by age, sex and year of admission was selected. Crude and age- and sex-adjusted incidence rates for sarcoidosis were calculated. Generalized linear models were used for trend analysis and unconditional logistic regression models for calculating crude and adjusted odds ratios (ORs) to assess the association between sarcoidosis and SpA.
    Results: The study database contained data on 214,280 hospitalisations: 107,140 admissions of patients with SpA and 107,140 of patients without SpA. Overall, 220 of the admissions were of patients with sarcoidosis: 133 (0.12%) in the SpA group and 87 (0.08%) in the non-SpA group (P<0.05). The incidence rates of sarcoidosis were 2.68 and 1.64 per 100,000 per year in the SpA and non-SpA groups, respectively. The trend was similar in the two cohorts. Regarding potential associations between SpA and sarcoidosis, the crude and adjusted ORs were 1.52 (95% CI: 1.16-2.01) and 1.50 (95% CI: 1.14-1.97) overall in patients with SpA, with adjusted ORs of 1.42 (95% CI: 1.03-1.94) and 1.81 (95% CI: 1.29-2.55) in patients with ankylosing spondylitis and psoriatic arthritis, respectively.
    Conclusions: There is a relationship that is not due to chance between sarcoidosis and SpA and specifically that sarcoidosis is significantly associated with ankylosing spondylitis and psoriatic arthritis.
    MeSH term(s) Arthritis, Psoriatic/epidemiology ; Cohort Studies ; Humans ; Retrospective Studies ; Sarcoidosis/complications ; Sarcoidosis/diagnosis ; Sarcoidosis/epidemiology ; Spondylarthritis/complications ; Spondylarthritis/diagnosis ; Spondylarthritis/epidemiology ; Spondylitis, Ankylosing/complications ; Spondylitis, Ankylosing/epidemiology
    Language English
    Publishing date 2021-10-12
    Publishing country France
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2021.105290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Trends in amyloidosis in spondyloarthritis

    Ramón Mazzucchelli / Natalia Crespí-Villarías / Alberto García Vadillo / Raquel Almodovar-González / Elisa Dieguez-Costa / Elia Pérez-Fernández / Elena García-Zamora

    RMD Open, Vol 7, Iss

    results from the Spanish National Inpatient Registry over a 17-year period (1999–2015)—TREND-EspA study

    2021  Volume 3

    Keywords Medicine ; R
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Trends in amyloidosis in spondyloarthritis: results from the Spanish National Inpatient Registry over a 17-year period (1999-2015)-TREND-EspA study.

    Mazzucchelli, Ramon / Almodovar-González, Raquel / Dieguez-Costa, Elisa / Crespí-Villarías, Natalia / Pérez-Fernández, Elia / García-Zamora, Elena / Garcia Vadillo, Alberto

    RMD open

    2021  Volume 7, Issue 3

    Abstract: Objective: To assess the incidence of amyloidosis and trends therein in patients with spondyloarthritis (SpA) over a long period (17 years).: Methods: An observational retrospective population-based matched cohort study was conducted. All the ... ...

    Abstract Objective: To assess the incidence of amyloidosis and trends therein in patients with spondyloarthritis (SpA) over a long period (17 years).
    Methods: An observational retrospective population-based matched cohort study was conducted. All the admissions of patients with SpA, including ankylosing spondylitis (AS), psoriatic arthritis (PsA), arthritis associated with inflammatory bowel disease (SpA-IBD) and reactive arthritis (ReA), reported between 1999 and 2015, were analysed and a control group matched by age, sex and year of admission was selected. Incidence rates for amyloidosis were calculated. Generalised linear models were used for trend analysis and unconditional logistic regression for calculating crude and adjusted ORs (AOR) to assess the association between amyloidosis and SpA.
    Results: The study database contained data on 107 140 admissions in each group. Between 1999 and 2015, 792 patients in the SpA cohort (0.7% of all admissions) had a diagnosis of amyloidosis versus 68 in the non-SpA cohort (0.1%) (p<0.001). From 1999 to 2015, incidence rates of amyloidosis tended to decrease in the SpA cohort (-4.63%/year overall), while they increased in the Non-SpA cohort (+10.25%/year overall). We found strong associations of amyloidosis with all SpAs (AOR 10.4; 95% CI 8.2 to 13.3) and with each type studied (AORs 10.05 (7.84 to 12. 88) for AS, 9.5 (7.3 to 12.4) for PsA, 22.9 (16.6 to 31.7) for SpA-IBD and 10.1 (6.1 to 16.7) for ReA).
    Conclusions: Incidence of amyloidosis among patients with SpA has strongly decreased in Spain. Amyloidosis is most strongly associated with SpA-IBD while the strength of association with PsA and ReA is similar to that with AS.
    MeSH term(s) Amyloidosis/epidemiology ; Cohort Studies ; Humans ; Inpatients ; Registries ; Retrospective Studies ; Spondylarthritis/diagnosis ; Spondylarthritis/epidemiology
    Language English
    Publishing date 2021-09-30
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2021-001782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Trends in fractures in patients with spondyloarthritis: a nationwide population-based study (TREND-EspA study).

    Mazzucchelli, Ramon / Almodovar, Raquel / Dieguez-Costa, Elisa / Crespi Villarias, Natalia / Pérez-Fernandez, Elia / García-Vadillo, Alberto

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2021  Volume 33, Issue 1, Page(s) 149–159

    Abstract: Our aim was to analyze trends in fracture rates in SpA patients over an extended time period. Only an increase of axial fractures, more specifically vertebral fractures, is observed in SpA.: Purpose: To analyze fracture incidence and trend in patients ...

    Abstract Our aim was to analyze trends in fracture rates in SpA patients over an extended time period. Only an increase of axial fractures, more specifically vertebral fractures, is observed in SpA.
    Purpose: To analyze fracture incidence and trend in patients with spondyloarthritis (SpA) over an extended time period.
    Methods: Retrospective observational population-based study with matched cohorts. Data from the Minimum Basic Data Set (MBDS) of Spain were reviewed. All SpA patient hospitalizations reported from 1999 to 2015 (SpA cohort) were analyzed. A control cohort (non-SpA cohort) matched by age, sex, region, and year of hospitalization was recruited. The age and sex-adjusted crude incidence rate was calculated for any fractures (axial and peripheral). Generalized linear models (GLM) were used for trend analysis. Association between fracture type and SpA (and its subtypes) was assessed using unconditional logistic regression models.
    Results: In the SpA cohort, the age and sex-adjusted rates per 100,000 inhabitants/year of total fracture and different types of fracture were 45.72 any fractures, 17.64 axial, and 28.02 peripheral; 29.42 osteoporotic (12.67 vertebra, 12.29 hip, 1.50 pelvis, 1.82 humerus and 2.09 radius). In the non-SpA cohort, they were 65.79 any, 12.08 axial, 51.52 peripheral; 31.17 osteoporotic (4.94 vertebra, 16.15 hip, 2.29 pelvis, 3.64 humerus, 5.38 radius). Between 1999 and 2015, the trend in incidence rate for total fracture and different types of fracture increased similarly for both cohorts. In the SpA cohort, an increase of axial fractures was found (AOR 1.444; 95%CI 1.297-1.609), and specifically of vertebral fractures (AOR 2.440; 95%CI 2.097-2.839). Other types of fractures did not increase.
    Conclusions: Only an increase of axial fractures, more specifically vertebral fractures, is observed in SpA. Trend in incidence is similar in both cohorts.
    MeSH term(s) Hip Fractures ; Humans ; Incidence ; Osteoporotic Fractures/epidemiology ; Retrospective Studies ; Spinal Fractures/epidemiology ; Spinal Fractures/etiology ; Spondylarthritis/epidemiology
    Language English
    Publishing date 2021-08-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-021-06079-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Democracy and Covid-19 mortality in Europe.]

    Mazzucchelli, Ramón / Agudo Dieguez, Alberto / Dieguez Costa, Elisa M. / Crespí Villarías, Natalia

    Revista espanola de salud publica

    Abstract: OBJECTIVE: In Europe there is a great variability in mortality by Covid-19 among different countries While some countries, such as Greece, Belarus or Ukraine, have a mortality rate of less than 5 cases/100,000 inhabitants, other countries such as Belgium, ...

    Abstract OBJECTIVE: In Europe there is a great variability in mortality by Covid-19 among different countries While some countries, such as Greece, Belarus or Ukraine, have a mortality rate of less than 5 cases/100,000 inhabitants, other countries such as Belgium, Spain or the United Kingdom have a mortality rate of well over 50 cases/100,000 inhabitants It is generally considered that the reason for this variability is multifactorial (including political reasons), but there are few studies that associate factors related to this variability The objective of this work was to analyse political risk factors/markers that could explain the variability in mortality due to Covid-19 among different European countries METHODS: This is a retrospective, multinational, ecological study based on the exploitation of the database provided by the European Centre for Disease Prevention and Control which collects daily information worldwide on new cases and deaths The accumulated mortality of Covid-19 in European countries (with more than 100 deaths on 01/05/2020) was calculated up to 29/05/2020 Political variables were compiled from different sources in the countries included in the study The variables analysed were: the democracy index and the different factors included in it, the country's political system and the country's corruption index On the other hand, specific political measures implemented in the different countries were collected, such as the number of days elapsed from the notification of the first infected person to 100 infected persons, to lockdown, to the closure of schools or the cancelation of meetings The number of people infected up to the date of lockdown was also registered For the statistical analysis of the association between the dependent variable (mortality) and the factors studied, correlation index were calculated, and the association was studied through univariate and multivariate linear regression models RESULTS: At May 1 2020, 27 European countries had at least 100 deaths The mean mortality was 19 83 cases/100,000 inhabitants (SD 22 4) and a median of 7 95 Mortality varied from a minimum of 1 49 cases/100,000 population in Ukraine to 82 19 cases/100,000 population in Belgium About factors analyzed both the democracy index (as well as the factors included in it), the political system (full democracy vs no) and the corruption index were statistically associated with mortality Also, the time until the implementation of the political measures was associated with mortality CONCLUSIONS: In Europe, there is a west to east (from highest to lowest) gradient in the mortality of Covid-19 Some of the observed mortality variability can be explained by political factors
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #613460
    Database COVID19

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