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Article ; Online: Alveolar cleft closure using a triangular flap with an M-shaped incision.

Sakamoto, Yoshiaki / Miyamoto, Junpei / Kishi, Kazuo

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2019 Volume 72, Issue 12, Page(s) e3–e4

MeSH term(s)	Alveolar Bone Grafting/methods ; Alveoloplasty/methods ; Bone Regeneration/physiology ; Bone Transplantation/methods ; Child ; Cleft Lip/physiopathology ; Cleft Lip/surgery ; Humans ; Surgical Flaps
Language	English
Publishing date	2019-09-24
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2019.09.001
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Article ; Online: PCR-Based Rapid Identification System Using Bridged Nucleic Acids for Detection of Clarithromycin-Resistant Mycobacterium avium-M. intracellulare Complex Isolates.

Hirama, Takashi / Shiono, Ayako / Egashira, Hiroshi / Kishi, Etsuko / Hagiwara, Koichi / Nakamura, Hidetoshi / Kanazawa, Minoru / Nagata, Makoto

Journal of clinical microbiology

2016 Volume 54, Issue 3, Page(s) 699–704

Abstract: The nontuberculous mycobacteria (NTM) cause miscellaneous disorders in humans, especially in the lungs, which present with a variety of radiological features. To date, knowledge of the pathogenic role of the Mycobacterium avium-intracellulare complex ( ... ...

Abstract	The nontuberculous mycobacteria (NTM) cause miscellaneous disorders in humans, especially in the lungs, which present with a variety of radiological features. To date, knowledge of the pathogenic role of the Mycobacterium avium-intracellulare complex (MAC) in the human lung and the definitive criteria for initiating multidrug therapy are still lacking. However, there is little doubt that clarithromycin is the most efficacious drug among the various treatment regimens for lung NTM. In this study, with the use of a bridged nucleic acid (BNA) probe a detection system based on a real-time PCR (BNA-PCR) for the identification of the point mutations at position 2058 or 2059 in domain V of the 23S rRNA gene responsible for clarithromycin resistance was developed and has been assessed using MAC isolates from clinical samples. Out of 199 respiratory specimens, the drug susceptibility test demonstrated 12 strains resistant to clarithromycin, while the BNA-PCR showed 8 strains carrying the point mutation at position 2058 or 2059 of the 23S rRNA gene. This system revealed that there were mycobacterial strains resistant to clarithromycin which do not carry previously identified resistance genes. This paper documents a novel system for detecting clarithromycin-resistant strains and demonstrates that although these mutations are tacitly assumed to account for >90% of the reported resistant mutants, there is a significant fraction of resistant mutants that do not harbor these mutations. Therefore, unknown mechanisms affecting clarithromycin resistance remain to be elucidated.
MeSH term(s)	Adult ; Aged ; Anti-Bacterial Agents/pharmacology ; Clarithromycin/pharmacology ; Drug Resistance, Bacterial ; Female ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Mutation ; Mycobacterium avium Complex/classification ; Mycobacterium avium Complex/drug effects ; Mycobacterium avium Complex/genetics ; Mycobacterium avium-intracellulare Infection/diagnosis ; Mycobacterium avium-intracellulare Infection/microbiology ; Polymerase Chain Reaction ; RNA, Ribosomal, 23S/genetics ; Sensitivity and Specificity ; Sputum/microbiology
Chemical Substances	Anti-Bacterial Agents ; RNA, Ribosomal, 23S ; Clarithromycin (H1250JIK0A)
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.02954-15
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Article ; Online: Fluoreno[2,3-b]fluorene vs Indeno[2,1-b]fluorene: Unusual Relationship between the Number of π Electrons and Excitation Energy in m-Quinodimethane-Type Singlet Diradicaloids.

Miyoshi, Hirokazu / Miki, Masahito / Hirano, Shintaro / Shimizu, Akihiro / Kishi, Ryohei / Fukuda, Kotaro / Shiomi, Daisuke / Sato, Kazunobu / Takui, Takeji / Hisaki, Ichiro / Nakano, Masayoshi / Tobe, Yoshito

The Journal of organic chemistry

2017 Volume 82, Issue 3, Page(s) 1380–1388

Abstract: The dimesityl derivative of fluoreno[2,3-b]fluorene (6b) was synthesized and its structure and physical properties were investigated to elucidate the effects of its enhanced open-shell character, which was predicted theoretically in comparison with the ... ...

Abstract	The dimesityl derivative of fluoreno[2,3-b]fluorene (6b) was synthesized and its structure and physical properties were investigated to elucidate the effects of its enhanced open-shell character, which was predicted theoretically in comparison with the smaller congener indeno[2,1-b]fluorene (5b). All structural and physical properties are in accordance with the theoretical predictions and can be interpreted in terms of the resonance contributors. The most remarkable spectroscopic property is the larger excitation energy of 24π-electron hydrocarbon 6b than that of 20π-electron system 5b in their lowest energy absorption bands of electronic spectra, a trend that is contrary to the well-known feature for common, alternant aromatic hydrocarbons. The theoretical basis of this unusual behavior was elucidated on the basis of the balance between the diradical character, exchange integral, and HOMO-LUMO gap and was confirmed by a complete-active-space configuration-interaction method with two electrons in two orbitals for the corresponding parent hydrocarbons 5a and 6a.
Language	English
Publishing date	2017-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.6b02500
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Article ; Online: M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis.

Kubota, Yoshiaki / Takubo, Keiyo / Shimizu, Takatsune / Ohno, Hiroaki / Kishi, Kazuo / Shibuya, Masabumi / Saya, Hideyuki / Suda, Toshio

The Journal of experimental medicine

2009 Volume 206, Issue 5, Page(s) 1089–1102

Abstract: ... selective for pathological angiogenesis and lymphangiogenesis. Macrophage colony-stimulating factor (M-CSF ... vessel networks in tumors and therefore possesses therapeutic potential as an M-CSF inhibitor ... However, the physiological role of M-CSF in vascular and lymphatic development, as well as the precise mechanisms underlying ...

Abstract	Antiangiogenic therapy for the treatment of cancer and other neovascular diseases is desired to be selective for pathological angiogenesis and lymphangiogenesis. Macrophage colony-stimulating factor (M-CSF), a cytokine required for the differentiation of monocyte lineage cells, promotes the formation of high-density vessel networks in tumors and therefore possesses therapeutic potential as an M-CSF inhibitor. However, the physiological role of M-CSF in vascular and lymphatic development, as well as the precise mechanisms underlying the antiangiogenic effects of M-CSF inhibition, remains unclear. Moreover, therapeutic potential of M-CSF inhibition in other neovascular diseases has not yet been evaluated. We used osteopetrotic (op/op) mice to demonstrate that M-CSF deficiency reduces the abundance of LYVE-1(+) and LYVE1(-) macrophages, resulting in defects in vascular and lymphatic development. In ischemic retinopathy, M-CSF was required for pathological neovascularization but was not required for the recovery of normal vasculature. In mouse osteosarcoma, M-CSF inhibition effectively suppressed tumor angiogenesis and lymphangiogenesis, and it disorganized extracellular matrices. In contrast to VEGF blockade, interruption of M-CSF inhibition did not promote rapid vascular regrowth. Continuous M-CSF inhibition did not affect healthy vascular and lymphatic systems outside tumors. These results suggest that M-CSF-targeted therapy is an ideal strategy for treating ocular neovascular diseases and cancer.
MeSH term(s)	Animals ; Diabetic Retinopathy/drug therapy ; Humans ; Hyperoxia/drug therapy ; Immunohistochemistry ; Lymphangiogenesis/drug effects ; Macrophage Colony-Stimulating Factor/pharmacology ; Macrophage Colony-Stimulating Factor/therapeutic use ; Mice ; Neoplasms/blood supply ; Neoplasms/drug therapy ; Neovascularization, Pathologic/prevention & control ; Retinal Diseases/drug therapy ; Retinal Diseases/pathology ; Vascular Resistance/drug effects
Chemical Substances	Macrophage Colony-Stimulating Factor (81627-83-0)
Language	English
Publishing date	2009-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20081605
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Article ; Online: Synthesis and structure of two new mycolactones isolated from M. ulcerans subsp. shinshuense.

Hande, Sudhir M / Kazumi, Yuko / Lai, W George / Jackson, Katrina L / Maeda, Shinji / Kishi, Yoshito

Organic letters

2012 Volume 14, Issue 17, Page(s) 4618–4621

Abstract: Two new mycolactones, mycolactones S1 and S2, were isolated from culture agar of Mycobacterium ulcerans subsp. shinshuense. Their structures were established in a three-step procedure: (1) probable structures were speculated from MS analysis; (2) ... ...

Abstract	Two new mycolactones, mycolactones S1 and S2, were isolated from culture agar of Mycobacterium ulcerans subsp. shinshuense. Their structures were established in a three-step procedure: (1) probable structures were speculated from MS analysis; (2) candidates were synthesized; (3) HPLC profiles were established for identification of the natural products. Newly isolated mycolactones correspond to the "oxidized forms" of mycolactone A/B, the causative toxin of Buruli ulcer, isolated from Mycobacterium ulcerans.
MeSH term(s)	Buruli Ulcer/etiology ; Chromatography, High Pressure Liquid ; Macrolides/chemical synthesis ; Macrolides/chemistry ; Molecular Structure ; Mycobacterium ulcerans/chemistry
Chemical Substances	Macrolides ; mycolactone S1 ; mycolactone S2
Language	English
Publishing date	2012-09-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/ol302072b
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Article ; Online: Pneumatosis intestinalis induced by osimertinib in a patient with lung adenocarcinoma harbouring epidermal growth factor receptor gene mutation with simultaneously detected exon 19 deletion and T790 M point mutation: a case report.

Nukii, Yuki / Miyamoto, Atsushi / Mochizuki, Sayaka / Moriguchi, Shuhei / Takahashi, Yui / Ogawa, Kazumasa / Murase, Kyoko / Hanada, Shigeo / Uruga, Hironori / Takaya, Hisashi / Morokawa, Nasa / Kishi, Kazuma

BMC cancer

2019 Volume 19, Issue 1, Page(s) 186

Abstract: ... gene mutations, namely a deletion in exon 19 and a point mutation (T790 M) in exon 20. Osimertinib was started ...

Abstract	Background: Pneumatosis intestinalis is a rare adverse event that occurs in patients with lung cancer, especially those undergoing treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). Osimertinib is the most recently approved EGFR-TKI, and its usage is increasing in clinical practice for lung cancer patients who have mutations in the EGFR gene. Case presentation: A 74-year-old woman with clinical stage IV (T2aN2M1b) lung adenocarcinoma was determined to have EGFR gene mutations, namely a deletion in exon 19 and a point mutation (T790 M) in exon 20. Osimertinib was started as seventh-line therapy. Follow-up computed tomography on the 97th day after osimertinib administration incidentally demonstrated intra-mural air in the transverse colon, as well as intrahepatic portal vein gas. Pneumatosis intestinalis and portal vein gas improved by fasting and temporary interruption of osimertinib. Osimertinib was then restarted and continued without recurrence of pneumatosis intestinalis. Overall, following progression-free survival of 12.2 months, with an overall duration of administration of 19.4 months (581 days), osimertinib was continued during beyond-progressive disease status, until a few days before the patient died of lung cancer. Conclusions: Pneumatosis intestinalis should be noted as an important adverse event that can occur with administration of osimertinib; thus far, such an event has never been reported. This was a valuable case in which osimertinib was successfully restarted after complete recovery from pneumatosis intestinalis, such that further extended administration of osimertinib was achieved.
MeSH term(s)	Acrylamides ; Adenocarcinoma of Lung/complications ; Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/genetics ; Aged ; Aniline Compounds ; ErbB Receptors/genetics ; Exons ; Fatal Outcome ; Female ; Humans ; Mutation ; Piperazines/adverse effects ; Piperazines/therapeutic use ; Pneumatosis Cystoides Intestinalis/diagnosis ; Pneumatosis Cystoides Intestinalis/etiology ; Point Mutation ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; Radiography, Thoracic ; Sequence Deletion ; Tomography, X-Ray Computed
Chemical Substances	Acrylamides ; Aniline Compounds ; Piperazines ; Protein Kinase Inhibitors ; osimertinib (3C06JJ0Z2O) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2019-02-28
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-019-5399-5
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Article ; Online: Rapid and simple diagnosis of Chlamydophila pneumoniae pneumonia by an immunochromatographic test for detection of immunoglobulin M antibodies.

Miyashita, Naoyuki / Ouchi, Kazunobu / Kishi, Fumio / Tabuchi, Mitsuaki / Tsumura, Naoki / Bannai, Hisaichi / Iwata, Satoshi / Tanaka, Toshihiro / Oka, Mikio

Clinical and vaccine immunology : CVI

2008 Volume 15, Issue 7, Page(s) 1128–1131

Abstract: ... of Chlamydophila pneumoniae-specific immunoglobulin M antibodies, the results obtained by the MySet test were compared ...

Abstract	To evaluate a newly developed immunochromatographic test (the MySet test) for the detection of Chlamydophila pneumoniae-specific immunoglobulin M antibodies, the results obtained by the MySet test were compared with those obtained by two serological tests. The sensitivity and specificity of the MySet test were 100% and 92.9%, respectively. The MySet test is rapid and simple to use and is thought to be a useful tool for the selection of appropriate antibiotic therapy.
MeSH term(s)	Adolescent ; Adult ; Antibodies, Bacterial/blood ; Child ; Child, Preschool ; Chlamydophila Infections/diagnosis ; Chlamydophila Infections/immunology ; Chlamydophila Infections/microbiology ; Chlamydophila pneumoniae/immunology ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/immunology ; Female ; Humans ; Immunoassay/instrumentation ; Immunoassay/methods ; Immunoglobulin M/blood ; Male ; Middle Aged ; Pneumonia, Bacterial/diagnosis ; Pneumonia, Bacterial/immunology ; Sensitivity and Specificity
Chemical Substances	Antibodies, Bacterial ; Immunoglobulin M
Language	English
Publishing date	2008-05-14
Publishing country	United States
Document type	Comparative Study ; Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2221082-9
ISSN	1556-679X ; 1556-6811
ISSN (online)	1556-679X
ISSN	1556-6811
DOI	10.1128/CVI.00085-08
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Article: Synthesis and Structure of Two New Mycolactones Isolated from M. ulcerans subsp. shinshuense

Hande, Sudhir M / Kazumi Yuko / Lai W. George / Jackson Katrina L / Maeda Shinji / Kishi Yoshito

Organic letters. 2012 Sept. 07, v. 14, no. 17

2012

Abstract	Two new mycolactones, mycolactones S1 and S2, were isolated from culture agar of Mycobacterium ulcerans subsp. shinshuense. Their structures were established in a three-step procedure: (1) probable structures were speculated from MS analysis; (2) candidates were synthesized; (3) HPLC profiles were established for identification of the natural products. Newly isolated mycolactones correspond to the âoxidized formsâ of mycolactone A/B, the causative toxin of Buruli ulcer, isolated from Mycobacterium ulcerans.
Keywords	Mycobacterium ulcerans ; agar ; chemical structure ; high performance liquid chromatography ; organic compounds ; oxidation
Language	English
Dates of publication	2012-0907
Size	p. 4618-4621.
Publishing place	American Chemical Society
Document type	Article
ISSN	1523-7052
DOI	10.1021%2Fol302072b
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Synthesis of alcohols from m-fluorophenylsulfones and dialkylboranes: application to the C14-C35 building block of E7389.

Liu, Lei / Henderson, James A / Yamamoto, Akihiko / Brémond, Paul / Kishi, Yoshito

Organic letters

2012 Volume 14, Issue 9, Page(s) 2262–2265

Abstract: The reaction of m-fluorophenylsulfone anions with dialkylboranes, followed by alkaline ...

Abstract	The reaction of m-fluorophenylsulfone anions with dialkylboranes, followed by alkaline hydroperoxide oxidation, yields alcohols in high yields. Optimization of the process, scope and limitation, and application to the synthesis of one of the C14-C35 building blocks of E7389, a right half analogue of halichondrin B, are reported.
Language	English
Publishing date	2012-05-04
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/ol300672q
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Article: [Association between clustered strain of M. tuberculosis and infectiousness index of tuberculosis cases in a population-based IS6110-RFLP analysis].

Tsukishima, Eri / Mitsuhashi, Yuu / Yano, Koichi / Takase, Aiko / Kamada, Arisu / Amishima, Masaru / Akiyama, Yasushi / Fujino, Michihiro / Tobise, Katsuyuki / Kishi, Fujiya

Kekkaku : [Tuberculosis

2007 Volume 82, Issue 5, Page(s) 459–466

Abstract: Objective: Isolates of M. tuberculosis were analyzed for their DNA fingerprints to facilitate ...

Abstract	Objective: Isolates of M. tuberculosis were analyzed for their DNA fingerprints to facilitate understanding of ongoing transmission of tuberculosis in Sapporo (population 1.87 million), Japan, where the incidence rate of tuberculosis was 15.0 per 100,000 in 2004. Subject: Out of all tuberculosis patients registered in the city from November 1998 to December 2003, isolates from culture-positive respiratory tuberculosis cases for whom written informed consent had been obtained, were analyzed by restriction fragment length polymorphism (RFLP). The study included 345 cases (249 men and 96 women) whose isolates were available for DNA patterns. Method: Using standard IS6110-RFLP typing, cases whose isolates shared identical fingerprints were considered to belong to the same cluster. Proportions of clustered cases were evaluated according to their clinical and socio-economical characteristics. Results: Out of 345 cases, 207 (60.0%) were classified into 59 clusters, and 15% of clustered cases having definite epidemiological links. Multiple logistic regression analysis in men showed that age and infectiousness were significantly related to clustering. The adjusted odds ratios (OR) [95% confidence intervals (CI)] were 0.17 [0.03-0.79] for 30-59 years, 0.15 [0.03-0.69] for 60 years or over and 2.35 [1.17-4.70] for those cases assigned as the highest level of transmission of tuberculosis from the infectiousness index of cases. For women the final model showed the adjusted OR [95% CI] were 0.52 [0.22-1.22] for those with previous history of tuberculosis and 0.33 [0.06-1.85] for diabetics. In male cases with a previous history of tuberculosis, most highly infectious cases were significantly associated with clustering (OR [95% CI], 4.53 [1.16-17.68]). Conclusion: The results suggest that highly infectious male tuberculosis cases with endogenous reactivation have contributed to recent transmission of tuberculosis in the studied area.
MeSH term(s)	Cluster Analysis ; DNA Fingerprinting ; DNA, Bacterial/genetics ; Female ; Humans ; Incidence ; Japan/epidemiology ; Male ; Mycobacterium tuberculosis/genetics ; Odds Ratio ; Polymorphism, Restriction Fragment Length ; Tuberculosis, Pulmonary/epidemiology ; Tuberculosis, Pulmonary/microbiology ; Tuberculosis, Pulmonary/transmission
Chemical Substances	DNA, Bacterial
Language	Japanese
Publishing date	2007-05
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	131032-x
ISSN	1884-2410 ; 0022-9776
ISSN (online)	1884-2410
ISSN	0022-9776
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