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Article ; Online: Delivery of Anticancer Drugs Using Microbubble-Assisted Ultrasound in a 3D Spheroid Model.

Roy, Marie / Alix, Corentin / Burlaud-Gaillard, Julien / Fouan, Damien / Raoul, William / Bouakaz, Ayache / Blanchard, Emmanuelle / Lecomte, Thierry / Viaud-Massuard, Marie-Claude / Sasaki, Noboru / Serrière, Sophie / Escoffre, Jean-Michel

Molecular pharmaceutics

2024 Volume 21, Issue 2, Page(s) 831–844

Abstract: Tumor spheroids are promising three-dimensional (3D) ...

Abstract	Tumor spheroids are promising three-dimensional (3D)
MeSH term(s)	Humans ; Irinotecan ; Microbubbles ; Antineoplastic Agents ; Doxorubicin/pharmacology ; Bleomycin ; Neoplasms ; Spheroids, Cellular ; Cell Line, Tumor
Chemical Substances	Irinotecan (7673326042) ; Antineoplastic Agents ; Doxorubicin (80168379AG) ; Bleomycin (11056-06-7)
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.3c00921
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Article: Population Genomics Reveals Molecular Determinants of Specialization to Tomato in the Polyphagous Fungal Pathogen

Mercier, Alex / Simon, Adeline / Lapalu, Nicolas / Giraud, Tatiana / Bardin, Marc / Walker, Anne-Sophie / Viaud, Muriel / Gladieux, Pierre

Phytopathology

2021 Volume 111, Issue 12, Page(s) 2355–2366

Abstract: Many fungal plant pathogens encompass multiple populations specialized on different plant species. Understanding the factors underlying pathogen adaptation to their hosts is a major challenge of evolutionary microbiology, and it should help to prevent ... ...

Abstract	Many fungal plant pathogens encompass multiple populations specialized on different plant species. Understanding the factors underlying pathogen adaptation to their hosts is a major challenge of evolutionary microbiology, and it should help to prevent the emergence of new specialized pathogens on novel hosts. Previous studies have shown that French populations of the gray mold pathogen
MeSH term(s)	Botrytis/genetics ; France ; Genetics, Population ; Lycopersicon esculentum/microbiology ; Metagenomics ; Plant Diseases/microbiology
Language	English
Publishing date	2021-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	208889-7
ISSN	1943-7684 ; 0031-949X
ISSN (online)	1943-7684
ISSN	0031-949X
DOI	10.1094/PHYTO-07-20-0302-FI
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Article ; Online: Human CD19-specific switchable CAR T-cells are efficacious as constitutively active CAR T-cells but cause less morbidity in a mouse model of human CD19

Pennell, Christopher A / Campbell, Heather / Storlie, Meghan D / Bolivar-Wagers, Sara / Osborn, Mark J / Refaeli, Yosef / Jensen, Michael / Viaud, Sophie / Young, Travis S / Blazar, Bruce R

Journal for immunotherapy of cancer

2022 Volume 10, Issue 12

Abstract: Current Food and Drug Administration (FDA)-approved CD19-specific chimeric antigen receptor (CAR) T-cell therapies for B-cell malignancies are constitutively active and while efficacious, can cause morbidity and mortality. Their toxicities might be ... ...

Abstract	Current Food and Drug Administration (FDA)-approved CD19-specific chimeric antigen receptor (CAR) T-cell therapies for B-cell malignancies are constitutively active and while efficacious, can cause morbidity and mortality. Their toxicities might be reduced if CAR T-cell activity was regulatable rather than constitutive. To test this, we compared the efficacies and morbidities of constitutively active (conventional) and regulatable (switchable) CAR (sCAR) T-cells specific for human CD19 (huCD19) in an immune-competent huCD19
MeSH term(s)	United States ; Humans ; Mice ; Animals ; Mice, Inbred C57BL ; Antigens, CD19 ; T-Lymphocytes ; Lymphoma, B-Cell/therapy ; Disease Models, Animal ; Mice, Transgenic ; Morbidity ; Weight Loss
Chemical Substances	CD19-specific chimeric antigen receptor ; Antigens, CD19
Language	English
Publishing date	2022-12-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2022-005934
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Article: Population Genomics Reveals Molecular Determinants of Specialization to Tomato in the Polyphagous Fungal Pathogen Botrytis cinerea in France

Mercier, Alex / Simon, Adeline / Lapalu, Nicolas / Giraud, Tatiana / Bardin, Marc / Walker, Anne-Sophie / Viaud, Muriel / Gladieux, Pierre

Phytopathology. 2021 Dec., v. 111, no. 12

2021

Abstract	Many fungal plant pathogens encompass multiple populations specialized on different plant species. Understanding the factors underlying pathogen adaptation to their hosts is a major challenge of evolutionary microbiology, and it should help to prevent the emergence of new specialized pathogens on novel hosts. Previous studies have shown that French populations of the gray mold pathogen Botrytis cinerea parasitizing tomato and grapevine are differentiated from each other, and have higher aggressiveness on their host of origin than on other hosts, indicating some degree of host specialization in this polyphagous pathogen. Here, we aimed at identifying the genomic features underlying the specialization of B. cinerea populations to tomato and grapevine. Based on whole genome sequences of 32 isolates, we confirmed the subdivision of B. cinerea pathogens into two genetic clusters on grapevine and another, single cluster on tomato. Levels of genetic variation in the different clusters were similar, suggesting that the tomato-specific cluster has not recently emerged following a bottleneck. Using genome scans for selective sweeps and divergent selection, tests of positive selection based on polymorphism and divergence at synonymous and nonsynonymous sites, and analyses of presence and absence variation, we identified several candidate genes that represent possible determinants of host specialization in the tomato-associated population. This work deepens our understanding of the genomic changes underlying the specialization of fungal pathogen populations.
Keywords	Botrytis cinerea ; Vitis ; genetic variation ; gray mold ; metagenomics ; plant pathology ; tomatoes ; France
Language	English
Dates of publication	2021-12
Size	p. 2355-2366.
Publishing place	The American Phytopathological Society
Document type	Article
ZDB-ID	208889-7
ISSN	1943-7684 ; 0031-949X
ISSN (online)	1943-7684
ISSN	0031-949X
DOI	10.1094/PHYTO-07-20-0302-FI
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Article ; Online: Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study.

Enaud, Raphaël / Cambos, Sophie / Viaud, Esther / Guichoux, Erwan / Chancerel, Emilie / Marighetto, Aline / Etchamendy, Nicole / Clark, Samantha / Mohammedi, Kamel / Cota, Daniela / Delhaes, Laurence / Gatta-Cherifi, Blandine

Nutrients

2021 Volume 13, Issue 11

Abstract: Patients with obesity are known to exhibit gut microbiota dysbiosis and memory deficits. Bariatric surgery (BS) is currently the most efficient anti-obesity treatment and may improve both gut dysbiosis and cognition. However, no study has investigated ... ...

Abstract	Patients with obesity are known to exhibit gut microbiota dysbiosis and memory deficits. Bariatric surgery (BS) is currently the most efficient anti-obesity treatment and may improve both gut dysbiosis and cognition. However, no study has investigated association between changes of gut microbiota and cognitive function after BS. We prospectively evaluated 13 obese patients on anthropometric data, memory functions, and gut microbiota-mycobiota before and six months after BS. The Rey Auditory Verbal Learning Test (AVLT) and the symbol span (SS) of the Weschler Memory Scale were used to assess verbal and working memory, respectively. Fecal microbiota and mycobiota were longitudinally analyzed by 16S and ITS2 rRNA sequencing respectively. AVLT and SS scores were significantly improved after BS (AVLT scores: 9.7 ± 1.7 vs. 11.2 ± 1.9,
MeSH term(s)	Adolescent ; Adult ; Aged ; Bacteria/classification ; Bacteria/growth & development ; Bariatric Surgery ; Feces/microbiology ; Female ; Fungi/growth & development ; Gastrointestinal Microbiome ; Humans ; Male ; Memory ; Middle Aged ; Mycobiome ; Obesity, Morbid/microbiology ; Obesity, Morbid/psychology ; Obesity, Morbid/surgery ; Pilot Projects ; Prospective Studies ; Young Adult
Language	English
Publishing date	2021-11-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13114061
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Article ; Online: The polyphagous plant pathogenic fungus Botrytis cinerea encompasses host-specialized and generalist populations.

Mercier, Alex / Carpentier, Florence / Duplaix, Clémentine / Auger, Annie / Pradier, Jean-Marc / Viaud, Muriel / Gladieux, Pierre / Walker, Anne-Sophie

Environmental microbiology

2019 Volume 21, Issue 12, Page(s) 4808–4821

Abstract: The host plant is often the main variable explaining population structure in fungal plant pathogens, because specialization contributes to reduce gene flow between populations associated with different hosts. Previous population genetic analysis revealed ...

Abstract	The host plant is often the main variable explaining population structure in fungal plant pathogens, because specialization contributes to reduce gene flow between populations associated with different hosts. Previous population genetic analysis revealed that French populations of the grey mould pathogen Botrytis cinerea were structured by hosts tomato and grapevine, suggesting host specialization in this highly polyphagous pathogen. However, these findings raised questions about the magnitude of this specialization and the possibility of specialization to other hosts. Here we report specialization of B. cinerea populations to tomato and grapevine hosts but not to other tested plants. Population genetic analysis revealed two pathogen clusters associated with tomato and grapevine, while the other clusters co-occurred on hydrangea, strawberry and bramble. Measurements of quantitative pathogenicity were consistent with host specialization of populations found on tomato, and to a lesser extent, populations found on grapevine. Pathogen populations from hydrangea and strawberry appeared to be generalist, while populations from bramble may be weakly specialized. Our results suggest that the polyphagous B. cinerea is more accurately described as a collection of generalist and specialist individuals in populations. This work opens new perspectives for grey mould management, while suggesting spatial optimization of crop organization within agricultural landscapes.
MeSH term(s)	Botrytis/genetics ; Botrytis/physiology ; Fragaria/microbiology ; Host Specificity ; Host-Pathogen Interactions ; Lycopersicon esculentum/microbiology ; Plant Diseases/microbiology ; Vitis/microbiology
Language	English
Publishing date	2019-11-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020213-1
ISSN	1462-2920 ; 1462-2912
ISSN (online)	1462-2920
ISSN	1462-2912
DOI	10.1111/1462-2920.14829
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Article: Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study

Nutrients. 2021 Nov. 13, v. 13, no. 11

2021

Abstract	Patients with obesity are known to exhibit gut microbiota dysbiosis and memory deficits. Bariatric surgery (BS) is currently the most efficient anti-obesity treatment and may improve both gut dysbiosis and cognition. However, no study has investigated association between changes of gut microbiota and cognitive function after BS. We prospectively evaluated 13 obese patients on anthropometric data, memory functions, and gut microbiota-mycobiota before and six months after BS. The Rey Auditory Verbal Learning Test (AVLT) and the symbol span (SS) of the Weschler Memory Scale were used to assess verbal and working memory, respectively. Fecal microbiota and mycobiota were longitudinally analyzed by 16S and ITS2 rRNA sequencing respectively. AVLT and SS scores were significantly improved after BS (AVLT scores: 9.7 ± 1.7 vs. 11.2 ± 1.9, p = 0.02, and SS scores: 9.7 ± 23.0 vs. 11.6 ± 2.9, p = 0.05). An increase in bacterial alpha-diversity, and Ruminococcaceae, Prevotella, Agaricus, Rhodotorula, Dipodascus, Malassezia, and Mucor were significantly associated with AVLT score improvement after BS, while an increase in Prevotella and a decrease in Clostridium, Akkermansia, Dipodascus and Candida were linked to SS scores improvement. We identified several changes in the microbial communities that differ according to the improvement of either the verbal or working memories, suggesting a complex gut-brain-axis that evolves after BS.
Keywords	Agaricus ; Candida ; Clostridium ; Dipodascus ; Malassezia ; Mucor ; Prevotella ; Rhodotorula ; Ruminococcaceae ; bariatric surgery ; cognition ; digestive system ; dysbiosis ; evolution ; intestinal microorganisms ; memory ; mycobiota ; obesity ; species diversity
Language	English
Dates of publication	2021-1113
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13114061
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Article: Impact of contouring methods on pre-treatment and post-treatment dosimetry for the prediction of tumor control and survival in HCC patients treated with selective internal radiation therapy.

Nodari, Guillaume / Popoff, Romain / Riedinger, Jean Marc / Lopez, Olivier / Pellegrinelli, Julie / Dygai-Cochet, Inna / Tabouret-Viaud, Claire / Presles, Benoit / Chevallier, Olivier / Gehin, Sophie / Gallet, Matthieu / Latournerie, Marianne / Manfredi, Sylvain / Loffroy, Romaric / Vrigneaud, Jean Marc / Cochet, Alexandre

EJNMMI research

2021 Volume 11, Issue 1, Page(s) 24

Abstract: Introduction: The aim of this study was to evaluate the impact of the contouring methods on dose metrics and their predictive value on tumor control and survival, in both situations of pre-treatment and post-treatment dosimetry, for patients with ... ...

Abstract	Introduction: The aim of this study was to evaluate the impact of the contouring methods on dose metrics and their predictive value on tumor control and survival, in both situations of pre-treatment and post-treatment dosimetry, for patients with advanced HCC treated with SIRT. Methods: Forty-eight patients who underwent SIRT between 2012 and 2020 were retrospectively included in this study. Target volumes were delineated using two methods: MRI-based contours manually drawn by a radiologist and then registered on SPECT/CT and PET/CT via deformable registration (Pre-C Results: No significant differences were found for Dm and TNR between pre- and post-treatment. TNR evaluated with radiologic contours (Pre-C Conclusion: In advanced HCC treated with SIRT, Dm and TNR determined with radiologic contours were predictive of tumor control and OS. This study shows that a rigorous clinical workflow (radiologic contours + registration on scintigraphic images) is feasible and should be prospectively considered for improving therapeutic strategy.
Language	English
Publishing date	2021-03-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2619892-7
ISSN	2191-219X
ISSN	2191-219X
DOI	10.1186/s13550-021-00766-x
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Article ; Online: Age at diagnosis in patients with chronic congenital endocrine conditions: a regional cohort study from a reference center for rare diseases.

Kallali, Wafa / Messiaen, Claude / Saïdi, Roumaisah / Lessim, Soucounda / Viaud, Magali / Dulon, Jerome / Nedelcu, Mariana / Samara, Dinane / Houang, Muriel / Donadille, Bruno / Courtillot, Carine / de Filippo, GianPaolo / Carel, Jean-Claude / Christin-Maitre, Sophie / Touraine, Philippe / Netchine, Irene / Polak, Michel / Léger, Juliane

Orphanet journal of rare diseases

2021 Volume 16, Issue 1, Page(s) 469

Abstract: Background: For chronic congenital endocrine conditions, age at diagnosis is a key issue with implications for optimal management and psychological concerns. These conditions are associated with an increase in the risk of comorbid conditions, ... ...

Abstract	Background: For chronic congenital endocrine conditions, age at diagnosis is a key issue with implications for optimal management and psychological concerns. These conditions are associated with an increase in the risk of comorbid conditions, particularly as it concerns growth, pubertal development and fertility potential. Clinical presentation and severity depend on the disorder and the patient's age, but diagnosis is often late. Objective: To evaluate age at diagnosis for the most frequent congenital endocrine diseases affecting growth and/or development. Patients and methods: This observational cohort study included all patients (n = 4379) with well-defined chronic congenital endocrine diseases-non-acquired isolated growth hormone deficiency (IGHD), isolated congenital hypogonadotropic hypogonadism (ICHH), ectopic neurohypophysis (NH), Turner syndrome (TS), McCune-Albright syndrome (MAS), complete androgen insensitivity syndrome (CAIS) and gonadal dysgenesis (GD)-included in the database of a single multisite reference center for rare endocrine growth and developmental disorders, over a period of 14 years. Patients with congenital hypothyroidism and adrenal hyperplasia were excluded as they are generally identified during neonatal screening. Results: Median age at diagnosis depended on the disease: first year of life for GD, before the age of five years for ectopic NH and MAS, 8-10 years for IGHD, TS (11% diagnosed antenatally) and CAIS and 17.4 years for ICHH. One third of the patients were diagnosed before the age of five years. Diagnosis occurred in adulthood in 22% of cases for CAIS, 11.6% for TS, 8.8% for GD, 0.8% for ectopic NH, and 0.4% for IGHD. A male predominance (2/3) was observed for IGHD, ectopic NH, ICHH and GD. Conclusion: The early recognition of growth/developmental failure during childhood is essential, to reduce time-to-diagnosis and improve outcomes.
MeSH term(s)	Adult ; Androgen-Insensitivity Syndrome ; Child, Preschool ; Cohort Studies ; Endocrine System Diseases/diagnosis ; Gonadal Dysgenesis ; Humans ; Infant, Newborn ; Male ; Rare Diseases/diagnosis
Language	English
Publishing date	2021-11-04
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ISSN	1750-1172
ISSN (online)	1750-1172
DOI	10.1186/s13023-021-02099-3
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Article ; Online: Cancer and the gut microbiota: an unexpected link.

Zitvogel, Laurence / Galluzzi, Lorenzo / Viaud, Sophie / Vétizou, Marie / Daillère, Romain / Merad, Miriam / Kroemer, Guido

Science translational medicine

2015 Volume 7, Issue 271, Page(s) 271ps1

Abstract: Changes in the interactions among the gut microbiota, intestinal epithelium, and host immune system are associated with many diseases, including cancer. We discuss how environmental factors infuence this cross-talk during oncogenesis and tumor ... ...

Abstract	Changes in the interactions among the gut microbiota, intestinal epithelium, and host immune system are associated with many diseases, including cancer. We discuss how environmental factors infuence this cross-talk during oncogenesis and tumor progression and how manipulations of the gut microbiota might improve the clinical activity of anticancer agents.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Carcinogenesis/pathology ; Dysbiosis ; Gastrointestinal Tract/microbiology ; Humans ; Microbiota ; Neoplasms/drug therapy ; Neoplasms/microbiology
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2015-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.3010473
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