Article ; Online: (R)-[
European journal of medicinal chemistry
2019 Volume 176, Page(s) 410–418
Abstract: ... of the established TSPO PET tracer (R)-[ ...
Abstract | Positron emission tomography (PET) imaging of the 18 kDa translocator protein (TSPO), has a high diagnostic potential in neurodegenerative disorders and cancer. However, TSPO is considered a challenge for molecular imaging due to the poor availability of suitable radiotracers with adequate pharmacokinetic properties. Here, we describe the development of a radiofluorinated pyridinyl isoquinoline analogue of the established TSPO PET tracer (R)-[ |
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MeSH term(s) | Animals ; Female ; Fluorine Radioisotopes/chemistry ; Humans ; Isoquinolines/chemical synthesis ; Isoquinolines/chemistry ; Isoquinolines/metabolism ; Isoquinolines/pharmacokinetics ; Isotope Labeling ; Mice, Inbred C57BL ; Microsomes, Liver/metabolism ; Positron-Emission Tomography/methods ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Pyridines/metabolism ; Pyridines/pharmacokinetics ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/metabolism ; Radiopharmaceuticals/pharmacokinetics ; Receptors, GABA/metabolism ; Tissue Distribution |
Chemical Substances | Bzrp protein, mouse ; Fluorine Radioisotopes ; Isoquinolines ; Pyridines ; Radiopharmaceuticals ; Receptors, GABA ; Fluorine-18 (GZ5I74KB8G) |
Language | English |
Publishing date | 2019-05-10 |
Publishing country | France |
Document type | Journal Article |
ZDB-ID | 188597-2 |
ISSN | 1768-3254 ; 0009-4374 ; 0223-5234 |
ISSN (online) | 1768-3254 |
ISSN | 0009-4374 ; 0223-5234 |
DOI | 10.1016/j.ejmech.2019.05.008 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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