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  1. Article ; Online: Autonomous Face Classification Online Self-Training System Using Pretrained ResNet50 and Multinomial Naïve Bayes.

    Maciura, Łukasz / Cieplak, Tomasz / Pliszczuk, Damian / Maj, Michał / Rymarczyk, Tomasz

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 12

    Abstract: This paper presents a novel, autonomous learning system working in real-time for face recognition. Multiple convolutional neural networks for face recognition tasks are available; however, these networks need training data and a relatively long training ... ...

    Abstract This paper presents a novel, autonomous learning system working in real-time for face recognition. Multiple convolutional neural networks for face recognition tasks are available; however, these networks need training data and a relatively long training process as the training speed depends on hardware characteristics. Pretrained convolutional neural networks could be useful for encoding face images (after classifier layers are removed). This system uses a pretrained ResNet50 model to encode face images from a camera and the Multinomial Naïve Bayes for autonomous training in the real-time classification of persons. Faces of several persons visible in a camera are tracked using special cognitive tracking agents who deal with machine learning models. After a face in a new position of the frame appears (in a place where there was no face in the previous frames), the system checks if it is novel or not using a novelty detection algorithm based on an SVM classifier; if it is unknown, the system automatically starts training. As a result of the conducted experiments, one can conclude that good conditions provide assurance that the system can learn the faces of a new person who appears in the frame correctly. Based on our research, we can conclude that the critical element of this system working is the novelty detection algorithm. If false novelty detection works, the system can assign two or more different identities or classify a new person into one of the existing groups.
    MeSH term(s) Humans ; Bayes Theorem ; Neural Networks, Computer ; Algorithms ; Machine Learning
    Language English
    Publishing date 2023-06-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23125554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rewiring regulatory T cells for tumour killing.

    Maj, Tomasz / Zou, Weiping

    Nature biomedical engineering

    2019  Volume 3, Issue 10, Page(s) 766–767

    MeSH term(s) Animals ; B7-H1 Antigen/metabolism ; CARD Signaling Adaptor Proteins/genetics ; Cytokines/metabolism ; Disease Models, Animal ; Forkhead Transcription Factors/genetics ; Histocompatibility Antigens Class I ; Humans ; Interferon-gamma/metabolism ; Lymph Nodes ; Male ; Mice ; Mice, Knockout ; Neoplasms/immunology ; Phenotype ; T-Lymphocytes/metabolism ; T-Lymphocytes, Regulatory/immunology ; Thymus Gland
    Chemical Substances B7-H1 Antigen ; CARD Signaling Adaptor Proteins ; Card11 protein, mouse ; Cd274 protein, mouse ; Cytokines ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Histocompatibility Antigens Class I ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2019-08-05
    Publishing country England
    Document type Journal Article
    ISSN 2157-846X
    ISSN (online) 2157-846X
    DOI 10.1038/s41551-019-0443-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Long noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population.

    Olesiński, Tomasz / Lutkowska, Anna / Balcerek, Adam / Sowińska, Anna / Piotrowski, P / Trzeciak, Tomasz / Maj, Tomasz / Hevelke, Piotr / Jagodziński, Pawel P

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 15369

    Abstract: The role of the long noncoding RNA CCAT1 NC_000008.10:g.128220661C > T (rs67085638) in the development of colon cancer has been reported. Therefore, we assessed the prevalence of rs67085638 in patients with gastric cancer (GC). We also evaluated the ... ...

    Abstract The role of the long noncoding RNA CCAT1 NC_000008.10:g.128220661C > T (rs67085638) in the development of colon cancer has been reported. Therefore, we assessed the prevalence of rs67085638 in patients with gastric cancer (GC). We also evaluated the effect of rs67085638 on B-cell-specific Moloney leukaemia virus insertion site 1 (BMI1) transcripts in primary GC and counterpart histopathologically confirmed disease-free margin tissue. Using high-resolution melting analysis, we evaluated rs67085638 frequency in patients with the GC genotype (n = 214) and controls (n = 502) in a Polish Caucasian population. qRT-PCR was used to determine BMI1 transcripts. We observed the trend of rs67085638 association in all patients with GC (p
    MeSH term(s) Adult ; Cell Proliferation/genetics ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Genetic Predisposition to Disease ; Genotype ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Polycomb Repressive Complex 1/genetics ; Polymorphism, Single Nucleotide/genetics ; RNA, Long Noncoding/genetics ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology
    Chemical Substances BMI1 protein, human ; CCAT1 long noncoding RNA, human ; RNA, Long Noncoding ; Polycomb Repressive Complex 1 (EC 2.3.2.27)
    Language English
    Publishing date 2021-07-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-94576-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Long noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population

    Tomasz Olesiński / Anna Lutkowska / Adam Balcerek / Anna Sowińska / P Piotrowski / Tomasz Trzeciak / Tomasz Maj / Piotr Hevelke / Pawel P. Jagodziński

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: Abstract The role of the long noncoding RNA CCAT1 NC_000008.10:g.128220661C > T (rs67085638) in the development of colon cancer has been reported. Therefore, we assessed the prevalence of rs67085638 in patients with gastric cancer (GC). We also evaluated ...

    Abstract Abstract The role of the long noncoding RNA CCAT1 NC_000008.10:g.128220661C > T (rs67085638) in the development of colon cancer has been reported. Therefore, we assessed the prevalence of rs67085638 in patients with gastric cancer (GC). We also evaluated the effect of rs67085638 on B-cell-specific Moloney leukaemia virus insertion site 1 (BMI1) transcripts in primary GC and counterpart histopathologically confirmed disease-free margin tissue. Using high-resolution melting analysis, we evaluated rs67085638 frequency in patients with the GC genotype (n = 214) and controls (n = 502) in a Polish Caucasian population. qRT-PCR was used to determine BMI1 transcripts. We observed the trend of rs67085638 association in all patients with GC (p trend = 0.028), a strong risk of the GC genotype in male (p trend = 0.035) but not female (p trend = 0.747) patients, and the association with non-cardia GC (p trend = 0.041), tumour stages T3 (p trend = 0.014) and T4 (p trend = 0.032), differentiation grading G3 (p trend = 0.009), lymph node metastasis stage N3 (p trend = 0.0005) and metastasis stage M0 (p trend = 0.027). We found that significantly increased BMI1 transcripts were associated with the primary GC genotype classified as grade G3 (p = 0.011) and as lymph node metastasis N3 (p = 0.010) and counterpart marginal tissues (p = 0.026, p = 0.040, respectively) from carriers of the T/T versus C/C genotypes. rs67085638 may contribute to increased BMI1 transcripts and the progression and rapid growth of GC.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Bladder Cancer Cells Exert Pleiotropic Effects on Human Adipose-Derived Stem Cells.

    Maj, Małgorzata / Kaźmierski, Łukasz / Balik, Karolina / Kowalska, Karolina / Gackowska, Lidia / Bajek, Anna / Drewa, Tomasz

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 4

    Abstract: Stem cell-based therapies are considered one of the most promising disciplines in biomedicine. Bladder cancer patients could benefit from therapies directed to promote healing after invasive surgeries or to lessen urinary incontinence, a common side ... ...

    Abstract Stem cell-based therapies are considered one of the most promising disciplines in biomedicine. Bladder cancer patients could benefit from therapies directed to promote healing after invasive surgeries or to lessen urinary incontinence, a common side effect of both cancer itself and the treatment. However, the local delivery of cells producing large amounts of paracrine factors may alter interactions within the microenvironment. For this reason, reconstructive cellular therapies for patients with a history of cancer carry a potential risk of tumor reactivation. We used an indirect co-culture model to characterize the interplay between adipose-derived stem cells and bladder cancer cells. Incubation with ASCs increased MCP-1 secretion by bladder cancer cells (from 2.1-fold to 8.1-fold, depending on the cell line). Cancer cell-derived factors altered ASC morphology. Cells with atypical shapes and significantly enlarged volumes appeared within the monolayer. Incubation in a conditioned medium (CM) containing soluble mediators secreted by 5637 and HB-CLS-1 bladder cancer cell lines decreased ASC numbers by 47.5% and 45.7%. A significant increase in adhesion to ECM components, accompanied by reduced motility and sheet migration, was also observed after incubation in CM from 5637 and HB-CLS-1 cells. No differences were observed when ASCs were co-cultured with HT-1376 cells. Our previous and present results indicate that soluble mediators secreted by ASCs and bladder cancer cells induce opposite effects influencing cells that represent the non-muscle-invasive urinary bladder.
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12040549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Long-Term Management of Seizures after Surgical Treatment of Supratentorial Cavernous Malformations : A Retrospective Single Centre Study.

    Dziedzic, Tomasz A / Koczyk, Kacper / Nowak, Arkadiusz / Maj, Edyta / Marchel, Andrzej

    Journal of Korean Neurosurgical Society

    2022  Volume 65, Issue 3, Page(s) 415–421

    Abstract: Objective: Seizure recurrence after the first-ever seizure in patients with a supratentorial cerebral cavernous malformation (CCM) is almost certain, so the diagnosis and treatment of epilepsy is justified. The optimal method of management of these ... ...

    Abstract Objective: Seizure recurrence after the first-ever seizure in patients with a supratentorial cerebral cavernous malformation (CCM) is almost certain, so the diagnosis and treatment of epilepsy is justified. The optimal method of management of these patients is still a matter of debate. The aim of our study was to identify factors associated with postoperative seizure control and assess the surgical morbidity rate.
    Methods: We retrospectively analysed 45 consecutive patients with a supratentorial CCM and symptomatic epilepsy in a single centre. Pre- and postoperative epidemiological data, seizure-related patient histories, neuroimaging results, surgery details and outcomes were obtained from hospital medical records. Seizure outcomes were assessed at least 12 months after surgery.
    Results: Thirty-five patients (77.8%) were seizure free at the long-term follow-up (Engel class I); six (13,3%) had rare, nocturnal seizures (Engel class II); and four (8.9%) showed meaningful improvement (Engel class III). In 15 patients (33%) in the Engel I group; it was possible to discontinue antiepileptic medication. Although there was not statistical significance, our results suggest that patients can benefit from early surgery. No deaths occurred in our study, and mild postoperative neurologic deficits were observed in two patients (4%) at the long-term follow-up.
    Conclusion: Surgical resection of CCMs should be considered in all patients with a supratentorial malformation and epilepsy due to the favourable surgical results in terms of the epileptic seizure control rate and low postoperative morbidity risk, despite the use of different predictors for the seizure outcome.
    Language English
    Publishing date 2022-04-29
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2253817-3
    ISSN 1598-7876 ; 2005-3711 ; 1225-8245
    ISSN (online) 1598-7876
    ISSN 2005-3711 ; 1225-8245
    DOI 10.3340/jkns.2020.0224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Differences in diffusion tensor imaging parameters of brain white matter tracts between patients with myotonic dystrophy type 1 and type 2 - a retrospective single-centre study.

    Maj, Edyta / Wolak, Tomasz / de Meulder, Joanna / Janiszewska, Katarzyna / Wojtaszek, Mikołaj / Kostera-Pruszczyk, Anna / Gołębiowski, Marek / Łusakowska, Anna

    Neurologia i neurochirurgia polska

    2023  Volume 57, Issue 5, Page(s) 430–437

    Abstract: Introduction: The main aim of our study was to compare diffusion tensor imaging (DTI) parameters in patients with myotonic dystrophy types 1 and 2 (DM1 and DM2).: Clinical rationale for the study: To ascertain whether DTI could be used to assess the ... ...

    Abstract Introduction: The main aim of our study was to compare diffusion tensor imaging (DTI) parameters in patients with myotonic dystrophy types 1 and 2 (DM1 and DM2).
    Clinical rationale for the study: To ascertain whether DTI could be used to assess the integrity of white matter tracts in the brain and identify any abnormalities or disruptions in connectivity between different brain regions in patients with DM. By providing a more detailed understanding of the structural changes in the brain associated with DM, could DTI potentially be used to develop more effective treatments for the cognitive and neurological symptoms of the disorder?
    Material and methods: We retrospectively compared MRI scans of 19 patients with DM1 to those of 23 healthy, matched controls, and of 16 patients with DM2 to those of 20 healthy, matched controls, and finally compared the DM1 and DM2 samples. Fraction anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) values were assessed using Tract Based Spatial Statistics (TBSS).
    Results: In patients with DM1, a statistically significant decrease in the values of the FA parameter was revealed in 45/48 white matter tracts compared to patients with DM2. There was no statistically significant decrease in the values of the FA parameter in patients with DM2 compared to DM1. The values of MD and RD were significantly higher in 47 tracts in DM1 patients compared to DM2 patients. AD values were significantly higher in all 48 tracts in DM1 patients compared to DM2 patients. There were no tracts with increased MD, AD, or RD values in DM2 patients compared to DM1.
    Conclusions: Our results indicate diffuse disintegration of white matter pathways in DM patients, especially in the DM1 group. The damage to all types of fibres (association, commissural, and projection) may explain the diversity of clinical symptoms, which were more severe in the DM1 group of patients than in the DM2 group.
    Clinical implications: DTI in patients with DM may help us to understand the neural mechanisms underlying brain involvement during the disease. In future, it may help to identify biomarkers for disease progression and treatment response.
    MeSH term(s) Humans ; White Matter/diagnostic imaging ; Diffusion Tensor Imaging/methods ; Myotonic Dystrophy/diagnostic imaging ; Retrospective Studies ; Brain/diagnostic imaging
    Language English
    Publishing date 2023-09-14
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 415519-1
    ISSN 1897-4260 ; 0028-3843
    ISSN (online) 1897-4260
    ISSN 0028-3843
    DOI 10.5603/pjnns.95587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Acute coronary syndrome due to extrinsic left main compression.

    Maj, Dominik / Kopiec, Tomasz / Wieteska, Małgorzata / Gąsecka, Aleksandra / Rymuza, Bartosz / Pietrasik, Arkadiusz

    Kardiologia polska

    2021  Volume 79, Issue 9, Page(s) 1034–1035

    MeSH term(s) Acute Coronary Syndrome/diagnostic imaging ; Acute Coronary Syndrome/etiology ; Coronary Angiography ; Coronary Stenosis ; Coronary Vessels ; Humans ; Pulmonary Artery
    Language English
    Publishing date 2021-06-24
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2021.0045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: To push or to pull? A clinical audit on the efficacy and safety of the pull and push percutaneous endoscopic gastrostomy techniques in oncological patients.

    Kucha, Piotr / Zorniak, Michal / Szmit, Mateusz / Lipczynski, Rafal / Wieszczy-Szczepanik, Paulina / Kapala, Aleksandra / Wojciechowska, Urszula / Didkowska, Joanna / Rupinski, Maciej / Olesinski, Tomasz / Maj, Tomasz / Regula, Jaroslaw / Kaminski, Michal F / Januszewicz, Wladyslaw

    United European gastroenterology journal

    2023  Volume 11, Issue 10, Page(s) 951–959

    Abstract: Background: The peroral "pull" technique and the direct "push" procedure are the two main methods for percutaneous endoscopic gastrostomy (PEG) placement. Although pull-PEG is generally recommended as the first-line modality, many oncological patients ... ...

    Abstract Background: The peroral "pull" technique and the direct "push" procedure are the two main methods for percutaneous endoscopic gastrostomy (PEG) placement. Although pull-PEG is generally recommended as the first-line modality, many oncological patients require a push-PEG approach to prevent tumor seeding or overcome tumor-related obstruction.
    Objective: We aimed to compare the efficacy and safety of both PEG procedures in cancer patients.
    Methods: We retrospectively analyzed all consecutive PEG procedures within a tertiary oncological center. Patients were followed up with the hospital databases and National Cancer Registry to assess the technical success rate for PEG placement, the rate of minor and major adverse events (AEs), and 30-day mortality rates. We compared those outcomes between the two PEG techniques. Finally, risk factors for PEG-related adverse events were analyzed using a multivariable Cox proportional-hazard regression model adjusted for patients' sex, age, performance status (ECOG), Body Mass Index (BMI), diabetes, chemoradiotherapy (CRT) status (pre-/current-/post-treatment), and type of PEG.
    Results: We included 1055 PEG procedures (58.7% push-PEG/41.4% pull-PEG) performed in 994 patients between 2014 and 2021 (mean age 62.0 [±10.7] yrs.; 70.2% males; indication: head-and-neck cancer 75.9%/other cancer 24.1%). The overall technical success for PEG placement was 96.5%. Although the "push" technique had a higher rate of all AEs (21.4% vs. 7.1%, Hazard Ratio [HR]  = 2.9; 95% CI = 1.9-4.3, p < 0.001), most of these constituted minor AEs (71.9%), such as tube dislodgement. The methods had no significant difference regarding major AEs and 30-day mortality rates. Previous CRT was associated with an increased risk of major AEs (hazard ratio = 2.7, 95% CI = 1.0-7.2, p = 0.042).
    Conclusion: The risk of major AEs was comparable between the push- and pull-PEG techniques in cancer patients. Due to frequent tube dislodgement in push-PEG, the pull technique may be more suitable for long-term feeding. Previous CRT increases the risk of major AEs, favoring early ("prophylactic") PEG placement when such treatment is expected.
    MeSH term(s) Male ; Humans ; Middle Aged ; Female ; Gastrostomy/adverse effects ; Gastrostomy/methods ; Retrospective Studies ; Head and Neck Neoplasms/surgery ; Head and Neck Neoplasms/etiology ; Clinical Audit
    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Spinal Epidural Venous Plexus Enlargement as a Cause of Neurologic Symptoms: Vascular Anatomy and MRI Findings.

    Wnuk, Emilia / Maj, Edyta / Dziedzic, Tomasz / Podlecka Piętowska, Aleksandra

    Neurology India

    2020  Volume 68, Issue 5, Page(s) 1238–1241

    Abstract: Pathology of the spinal venous system, unlike that of the spinal arterial system, is rarely considered as a possible cause of clinical symptoms. As the imaging features of the spinal venous anatomy and its diseases are not well-known, related pathologies ...

    Abstract Pathology of the spinal venous system, unlike that of the spinal arterial system, is rarely considered as a possible cause of clinical symptoms. As the imaging features of the spinal venous anatomy and its diseases are not well-known, related pathologies may be overlooked or misdiagnosed. The major noninvasive technique enabling optimal visualization of spinal venous plexuses is magnetic resonance imaging (MRI). We report MRI findings from three cases of spinal venous plexus engorgement of different etiologies that resulted in neurologic symptoms, including radiculopathy and/or back pain. These cases are discussed in the context of the relevant anatomic and pathophysiologic background.
    MeSH term(s) Back Pain ; Epidural Space ; Humans ; Magnetic Resonance Imaging ; Radiculopathy
    Language English
    Publishing date 2020-10-24
    Publishing country India
    Document type Case Reports
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.294546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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