LIVIVO - Search results -

Search results

Result 1 - 10 of total 93

Search options

Article ; Online: Lactobacillus paracasei

Yamazaki, Takahiro / Yamada, Sayuri / Ohshio, Konomi / Sugamata, Miho / Morita, Yuji

International journal of molecular sciences

2022 Volume 23, Issue 3

Abstract: Lactobacillus ... ...

Abstract	Lactobacillus paracasei
MeSH term(s)	Animals ; Anti-Inflammatory Agents/metabolism ; Cell Line ; Gene Expression Regulation/drug effects ; Interleukin-10/metabolism ; Lactobacillus paracasei/physiology ; Lipopolysaccharides/adverse effects ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/metabolism ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Oxidative Stress/drug effects ; Probiotics ; Pyroptosis/drug effects
Chemical Substances	Anti-Inflammatory Agents ; IL10 protein, mouse ; Lipopolysaccharides ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2022-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23031443
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Lactobacillus paracasei KW3110 Prevents Inflammatory-Stress-Induced Mitochondrial Dysfunction in Mouse Macrophages

Takahiro Yamazaki / Sayuri Yamada / Konomi Ohshio / Miho Sugamata / Yuji Morita

International Journal of Molecular Sciences, Vol 23, Iss 1443, p

2022 Volume 1443

Abstract: Lactobacillus paracasei KW3110 (KW3110) has anti-inflammatory effects, including the prevention of blue light exposure induced retinal inflammation and ageing-related chronic inflammation in mice. The mechanism involves the promotion of anti-inflammatory ...

Abstract	Lactobacillus paracasei KW3110 (KW3110) has anti-inflammatory effects, including the prevention of blue light exposure induced retinal inflammation and ageing-related chronic inflammation in mice. The mechanism involves the promotion of anti-inflammatory cytokine interleukin (IL)-10 production by KW3110, leading to reduced pro-inflammatory cytokine IL-1β production. Although various stress-induced mitochondrial damages are associated with excessive inflammatory responses, the effect of KW3110 on inflammatory-stress-induced mitochondrial damage remains unknown. In this study, we investigated the effect of KW3110 on inflammatory stress-induced mitochondrial damage using the murine macrophage-like cell line J774A.1. KW3110 treatment suppressed lipopolysaccharide (LPS)-induced mitochondrial dysfunction, including downregulation of membrane potential, induction of reactive oxygen species, and respiratory dysfunction. In addition, KW3110 prevented LPS-induced disruption of mitochondrial morphology including cristae structures. IL-10 treatment also ameliorated LPS-induced mitochondrial dysfunction and morphology disruption. These results suggest that KW3110 prevents LPS-induced mitochondrial dysfunction, potentially via promoting IL-10 production in mouse macrophages. We are the first to reveal a suppressive effect of lactic acid bacteria on mitochondrial morphology disruption in inflammatory-stressed macrophages. Our findings contribute to understanding inflammatory-stress-induced mitochondrial damage and developing food ingredients with preventive effects on mitochondrial-damage-derived inflammatory conditions.
Keywords	lactic acid bacteria ; probiotics ; inflammation ; mitochondria ; macrophage ; interleukin-10 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Long days restore regular estrous cyclicity in mice lacking circadian rhythms.

Nakamura, Takahiro J / Takasu, Nana N / Sakazume, Sayuri / Matsumoto, Yu / Kawano, Natsuko / Pendergast, Julie S / Yamazaki, Shin / Nakamura, Wataru

Heliyon

2023 Volume 9, Issue 6, Page(s) e16970

Abstract: Many female mammals have recurring cycles of ovulation and sexual behaviors that are regulated by reproductive hormones and confer reproductive success. In addition to sexual behaviors, circadian behavioral rhythms of locomotor activity also fluctuate ... ...

Abstract	Many female mammals have recurring cycles of ovulation and sexual behaviors that are regulated by reproductive hormones and confer reproductive success. In addition to sexual behaviors, circadian behavioral rhythms of locomotor activity also fluctuate across the estrous cycle in rodents. Moreover, there is a bidirectional relationship between circadian rhythms and estrous cyclicity since mice with disrupted circadian rhythms also have compromised estrous cycles resulting in fewer pregnancies. In the present study, we assessed whether extending day length, which alters circadian rhythms, normalizes estrous cyclicity in mice. We found that
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e16970
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Long days restore regular estrous cyclicity in mice lacking circadian rhythms

Takahiro J. Nakamura / Nana N. Takasu / Sayuri Sakazume / Yu Matsumoto / Natsuko Kawano / Julie S. Pendergast / Shin Yamazaki / Wataru Nakamura

Heliyon, Vol 9, Iss 6, Pp e16970- (2023)

2023

Abstract	Many female mammals have recurring cycles of ovulation and sexual behaviors that are regulated by reproductive hormones and confer reproductive success. In addition to sexual behaviors, circadian behavioral rhythms of locomotor activity also fluctuate across the estrous cycle in rodents. Moreover, there is a bidirectional relationship between circadian rhythms and estrous cyclicity since mice with disrupted circadian rhythms also have compromised estrous cycles resulting in fewer pregnancies. In the present study, we assessed whether extending day length, which alters circadian rhythms, normalizes estrous cyclicity in mice. We found that Period (Per) 1/2/3 triple knockout (KO) mice, that have disabled canonical molecular circadian clocks, have markedly disrupted estrous cycles. Surprisingly, extending the day length by only 2 h per day restored regular 4- or 5-day estrous cycles to Per1/2/3 KO mice. Longer days also induced consistent 4-day, rather than 5-day, estrous cycles in wild-type C57BL/6J mice. These data demonstrate that extending daytime light exposure could be used for enhancing reproductive success.
Keywords	Breeding efficiency ; Clock gene ; C57BL/6J mice ; Photoperiod ; Seasonal breeder ; Wheel-running ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Rhamphocottus nagaakii (Cottoidea: Rhamphocottidae), a new species of grunt sculpin from the northwestern Pacific, with notes on the phylogeography of the genus Rhamphocottus [Correction: Apr. 2023, 70(2), p. 286]

Munehara, Hiroyuki / Togashi, Kouji / Yamada, Sayuri / Higashimura, Takushi / Yamazaki, Aya / Suzuki, Shota / Abe, Takuzo / Awata, Satoshi / Koya, Yasunori / Tsuruoka, Osamu

Ichthyol Res. 2023 Apr., v. 70, no. 2, p. 268-285

2023 , Page(s) 268–285

Abstract: A new species of grunt sculpin, Rhamphocottus nagaakii inhabiting the northwestern Pacific, previously identified as Rhamphocottus richardsonii Günther 1874, is described based on genetic evidence and morphological differences. The new species can be ... ...

Abstract	A new species of grunt sculpin, Rhamphocottus nagaakii inhabiting the northwestern Pacific, previously identified as Rhamphocottus richardsonii Günther 1874, is described based on genetic evidence and morphological differences. The new species can be distinguished based on morphometric characters related to the head, including head length [45.3–54.6% of standard length (SL)], postorbital head length (18.8–25.5% SL) and the length of pectoral-fin base (15.8–20.7% SL), which are smaller than in R. richardsonii (53.6–60.5% SL, 26.2–31.7% SL, and 19.5–25.2% SL, respectively). Genetic differences between two species markedly exceed levels for intra-specific differences. Rhamphocottus nagaakii is considered to have arisen from a common ancestor of the two species, which probably inhabited somewhere the North Pacific Rim around the Aleutian Archipelago. During a period of cooling in the Pliocene or the Miocene, R. nagaakii and R. richardsonii became separated to the southern regions of the northwestern and northeastern Pacific, and subsequently underwent speciation.
Keywords	Miocene epoch ; Pliocene epoch ; Rhamphocottus ; ancestry ; fins ; head ; morphometry ; new species ; phylogeography ; Aleutian Islands ; Pacific Rim
Language	English
Dates of publication	2023-04
Size	p. 268-285
Publishing place	Springer Japan
Document type	Article ; Online
ZDB-ID	2048252-8
ISSN	1616-3915 ; 1341-8998
ISSN (online)	1616-3915
ISSN	1341-8998
DOI	10.1007/s10228-022-00885-y
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: The real-world safety of atezolizumab as second-line or later treatment in Japanese patients with non-small-cell lung cancer: a post-marketing surveillance study.

Ohe, Yuichiro / Yamazaki, Naoya / Yamamoto, Nobuyuki / Murakami, Haruyasu / Yoh, Kiyotaka / Kitano, Shigehisa / Hashimoto, Hideyuki / Murayama, Ayako / Nakane, Sayuri / Gemma, Akihiko

Japanese journal of clinical oncology

2022 Volume 52, Issue 6, Page(s) 623–632

Abstract: Background: We conducted a post-marketing surveillance study to evaluate the clinical tolerability and safety of atezolizumab in Japanese patients with non-small-cell lung cancer (NSCLC).: Methods: This prospective, observational post-marketing ... ...

Abstract	Background: We conducted a post-marketing surveillance study to evaluate the clinical tolerability and safety of atezolizumab in Japanese patients with non-small-cell lung cancer (NSCLC). Methods: This prospective, observational post-marketing cohort study was conducted in NSCLC patients who received atezolizumab 1200 mg every 3 weeks at 770 facilities in Japan between April 18, 2018, and March 31, 2020 (study number UMIN000031978). Case report forms were completed, recording patient characteristics, treatment details, adverse events, adverse drug reactions (ADRs), their severity, onset and outcomes. Follow-up was for 12 months or until atezolizumab discontinuation. Results: Overall, 2570 patients were included, median age was 69.0 years, and 69.9% were males. ADRs were reported in 29.1% of patients, most commonly pyrexia (4.2%). Grade ≥ 3 ADRs occurred in 9.7% of patients aged <75 and 9.7% of those aged ≥75 years. The incidence of Grade ≥ 3 ADRs was not affected by the number of lines of previous treatment or the presence or history of an autoimmune disorder. Immune-related ADRs of interest that occurred in >1% of patients were interstitial lung disease (ILD; 4.4%), endocrine disorder (4.3%), and hepatic dysfunction (2.8%). ILD was significantly more common in patients with a history of, or concurrent, ILD versus those without (P ≤ 0.001). Risk factors of Grade ≥ 3 ADRs were a history of, or concurrent, ILD. Grade 5 ADRs occurred in 35 patients, 11 of whom had concurrent ILD. Conclusions: This large cohort study confirmed the clinical tolerability of atezolizumab in a real-world group of Japanese patients with NSCLC.
MeSH term(s)	Aged ; Antibodies, Monoclonal, Humanized ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Cohort Studies ; Drug-Related Side Effects and Adverse Reactions ; Female ; Humans ; Japan/epidemiology ; Lung Diseases, Interstitial/epidemiology ; Lung Neoplasms/drug therapy ; Male ; Marketing ; Product Surveillance, Postmarketing ; Prospective Studies
Chemical Substances	Antibodies, Monoclonal, Humanized ; atezolizumab (52CMI0WC3Y)
Language	English
Publishing date	2022-03-24
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyac024
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1298: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Lactobacillus paracasei

Yamazaki, Takahiro / Suzuki, Hiroaki / Yamada, Sayuri / Ohshio, Konomi / Sugamata, Miho / Yamada, Takahiro / Morita, Yuji

International journal of molecular sciences

2020 Volume 21, Issue 14

Abstract: Lactobacillus ... ...

Abstract	Lactobacillus paracasei
MeSH term(s)	Adenosine Triphosphate/toxicity ; Adult ; Animals ; Cell Cycle Checkpoints/drug effects ; Cell Death/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Cellular Senescence/drug effects ; Cytokines/metabolism ; Escherichia coli ; Eye Diseases/drug therapy ; Female ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Interleukin-10/metabolism ; Lactobacillus paracasei ; Lipopolysaccharides/toxicity ; Macrophages/drug effects ; Male ; Mice ; Middle Aged ; Probiotics/therapeutic use ; Retina/drug effects ; Retina/immunology ; Retina/pathology ; Retinal Pigment Epithelium/cytology ; Retinal Pigment Epithelium/drug effects ; Retinal Pigment Epithelium/immunology ; Retinal Pigment Epithelium/pathology ; Tight Junctions/metabolism
Chemical Substances	Cytokines ; Lipopolysaccharides ; Interleukin-10 (130068-27-8) ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2020-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21145091
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Lactobacillus paracasei KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans

Takahiro Yamazaki / Hiroaki Suzuki / Sayuri Yamada / Konomi Ohshio / Miho Sugamata / Takahiro Yamada / Yuji Morita

International Journal of Molecular Sciences, Vol 21, Iss 5091, p

2020 Volume 5091

Abstract: Lactobacillus paracasei KW3110 (KW3110) has anti-inflammatory effects and mitigates retinal pigment epithelium (RPE) cell damage caused by blue-light exposure. We investigated whether KW3110 suppresses chronic inflammatory stress-induced RPE cell damage ... ...

Abstract	Lactobacillus paracasei KW3110 (KW3110) has anti-inflammatory effects and mitigates retinal pigment epithelium (RPE) cell damage caused by blue-light exposure. We investigated whether KW3110 suppresses chronic inflammatory stress-induced RPE cell damage by modulating immune cell activity and whether it improves ocular disorders in healthy humans. First, we showed that KW3110 treatment of mouse macrophages (J774A.1) produced significantly higher levels of interleukin-10 as compared with other lactic acid bacterium strains (all p < 0.01). Transferring supernatant from KW3110- and E. coli 0111:B4 strain and adenosine 5′-triphosphate (LPS/ATP)-stimulated J774A.1 cells to human retinal pigment epithelium (ARPE-19) cells suppressed senescence-associated phenotypes, including proliferation arrest, abnormal appearance, cell cycle arrest, and upregulation of cytokines, and also suppressed expression of tight junction molecule claudin-1. A randomized, double-blind, placebo-controlled parallel-group study of healthy subjects ( n = 88; 35 to below 50 years) ingesting placebo or KW3110-containing supplements for 8 weeks showed that changes in critical flicker frequency, an indicator of eye fatigue, from the week-0 value were significantly larger in the KW3110 group at weeks 4 ( p = 0.040) and 8 ( p = 0.036). These results suggest that KW3110 protects ARPE-19 cells against premature senescence and aberrant expression of tight junction molecules caused by chronic inflammatory stress, and may improve chronic eye disorders including eye fatigue.
Keywords	lactic acid bacteria ; probiotics ; inflammation ; cellular senescence ; retina ; eye fatigue ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Reply to Slominski et al.: UVB irradiation induces proenkephalin

Shime, Hiroaki / Odanaka, Mizuyu / Tsuiji, Makoto / Matoba, Takuma / Imai, Masaki / Yasumizu, Yoshiaki / Uraki, Ryuta / Minohara, Kiyoshi / Watanabe, Maiko / Bonito, Anthony John / Fukuyama, Hidehiro / Ohkura, Naganari / Sakaguchi, Shimon / Morita, Akimichi / Yamazaki, Sayuri

Proceedings of the National Academy of Sciences of the United States of America

2021 Volume 118, Issue 3

MeSH term(s)	Enkephalins ; Homeostasis ; Protein Precursors ; Skin ; T-Lymphocytes, Regulatory ; Ultraviolet Rays
Chemical Substances	Enkephalins ; Protein Precursors ; proenkephalin
Language	English
Publishing date	2021-01-07
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2021919118
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer.

Minohara, Kiyoshi / Imai, Masaki / Matoba, Takuma / Wing, James Badger / Shime, Hiroaki / Odanaka, Mizuyu / Uraki, Ryuta / Kawakita, Daisuke / Toyama, Tatsuya / Takahashi, Satoru / Morita, Akimichi / Murakami, Shingo / Ohkura, Naganari / Sakaguchi, Shimon / Iwasaki, Shinichi / Yamazaki, Sayuri

Cancer science

2023 Volume 114, Issue 4, Page(s) 1256–1269

Abstract: We previously reported that regulatory T (Treg) cells expressing CTLA-4 on the cell surface are abundant in head and neck squamous cell carcinoma (HNSCC). The role of expanded Treg cells in the tumor microenvironment of HNSCC remains unclear. In this ... ...

Abstract	We previously reported that regulatory T (Treg) cells expressing CTLA-4 on the cell surface are abundant in head and neck squamous cell carcinoma (HNSCC). The role of expanded Treg cells in the tumor microenvironment of HNSCC remains unclear. In this study, we reveal that the tumor microenvironment of HNSCC is characterized by the high expression of genes related to Treg cells, dendritic cells (DCs), and interleukin (IL)-17-related molecules. Increased expression of IL17A, IL17F, or IL23A contributes to a favorable prognosis of HNSCC. In the tumor microenvironment of HNSCC, IL23A and IL12B are expressed in mature dendritic cells enriched in regulatory molecules (mregDCs). The mregDCs in HNSCC are a migratory and mature phenotype; their signature genes strongly correlate with Treg signature genes in HNSCC. We also observed that IL17A was highly expressed in Th17 cells and exhausted CD8
MeSH term(s)	Humans ; T-Lymphocytes, Regulatory ; Squamous Cell Carcinoma of Head and Neck/metabolism ; CD8-Positive T-Lymphocytes ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Prognosis ; Dendritic Cells ; Tumor Microenvironment
Language	English
Publishing date	2023-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.15698
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito