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  1. Article ; Online: Basophils orchestrate kidney fibrosis.

    Chauvin, Camille / Bayry, Jagadeesh

    Cell research

    2022  Volume 32, Issue 8, Page(s) 713–714

    MeSH term(s) Basophils ; Fibrosis ; Humans ; Kidney
    Language English
    Publishing date 2022-06-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-022-00683-1
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  2. Book ; Online: Access to health care for vulnerable groups in the European Union in 2012

    Chauvin, Pierre / Mestre, Marie-Camille / Simonnot, Nathalie

    an overview of the condition of persons excluded from healthcare systems in the EU

    2012  

    Author's details [authors Pierre Chauvin ; Marie-Camille Mestre ; Nathalie Simonnot]
    Subject code 610
    Language English
    Size 21 S. : Ill., graph. Darst.
    Publisher Médecins du Monde
    Publishing place Paris u.a.
    Publishing country France
    Document type Book ; Online
    HBZ-ID HT018305062
    DOI 10.4126/38m-005650535
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  3. Article ; Online: Obesity negatively impacts maintenance of antibody response to COVID-19 vaccines.

    Chauvin, Camille / Retnakumar, Sruthi Vijaya / Bayry, Jagadeesh

    Cell reports. Medicine

    2023  Volume 4, Issue 7, Page(s) 101117

    Abstract: Severe obesity accelerates the decline of neutralizing antibodies to COVID-19 vaccines contributing to increased risk of hospitalization from breakthrough SARS-CoV-2 infections. ...

    Abstract Severe obesity accelerates the decline of neutralizing antibodies to COVID-19 vaccines contributing to increased risk of hospitalization from breakthrough SARS-CoV-2 infections.
    MeSH term(s) Humans ; Antibody Formation ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; Obesity ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2023.101117
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  4. Article ; Online: The implication of anti-PD-1 therapy in cancer patients for the vaccination against viral and other infectious diseases.

    Retnakumar, Sruthi Vijaya / Chauvin, Camille / Bayry, Jagadeesh

    Pharmacology & therapeutics

    2023  Volume 245, Page(s) 108399

    Abstract: The phenomenon of 'T cell exhaustion', a state of T cell dysfunction observed during chronic infections and cancers, has been a major obstacle in mounting appropriate immune responses against infectious agents or tumor antigens. The exhausted T cells are ...

    Abstract The phenomenon of 'T cell exhaustion', a state of T cell dysfunction observed during chronic infections and cancers, has been a major obstacle in mounting appropriate immune responses against infectious agents or tumor antigens. The exhausted T cells are characterized by poor effector functions mainly due to the overexpression of inhibitory receptors such as programmed cell death protein 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), T cell immunoglobulin and mucin-domain containing 3 (TIM3), lymphocyte activation gene 3 (LAG3), and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT), commonly referred to as immune checkpoint (ICP) molecules. ICP blockade, especially of PD-1 that can potentially reverse T cell exhaustion and thereby re-stimulate the impaired immune system, is widely used in clinics as a promising therapeutic strategy for various cancers and is more recently being investigated in infectious diseases as well. In fact, cancer patients represent a population of immunocompromised individuals who are more susceptible to infections and associated complications, and thus the need for protective vaccinations against these diseases is of prime importance in this category. When it comes to vaccinating anti-PD-1-treated cancer patients against infectious diseases including COVID-19 and influenza, a special focus should be brought on the revived immune cells, which could be dynamically affected by the antigenic stimulation. However, since cancer patients are not generally included in clinical trials for designing vaccines against infectious diseases, the possible interaction between vaccine immune responses and ICP therapy is largely unexplored. Mechanistically, the reversal of T cell exhaustion by ICP in an otherwise immunocompromised population could be beneficial for the vaccine's efficacy, helping the immune system to mount a robust immune response. Nevertheless, patients with cancer undergoing anti-PD-1 blockade are known to experience immune-related adverse effects (irAEs). The risk of increasing the irAEs due to the overstimulation of the immune system during vaccination is a major concern. Therefore, while routine vaccination is indispensable for the protection of cancer patients, the impact of PD-1 blockade on vaccine responses against infectious agents requires careful consideration to avoid undesirable adverse effects that could impair the efficacy of anti-cancer treatment.
    MeSH term(s) Humans ; COVID-19/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Communicable Diseases/metabolism ; T-Lymphocytes ; Vaccination ; Immunotherapy
    Language English
    Publishing date 2023-03-30
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2023.108399
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  5. Article ; Online: Gasdermin D as a cellular switch to orientate immune responses via IL-33 or IL-1β.

    Chauvin, Camille / Retnakumar, Sruthi Vijaya / Bayry, Jagadeesh

    Cellular & molecular immunology

    2022  Volume 20, Issue 1, Page(s) 8–10

    MeSH term(s) Gasdermins ; Interleukin-33 ; Pyroptosis ; Cells, Cultured ; Immunity ; Interleukin-1beta/metabolism ; Inflammasomes/metabolism
    Chemical Substances Gasdermins ; Interleukin-33 ; Interleukin-1beta ; Inflammasomes
    Language English
    Publishing date 2022-11-15
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-022-00950-6
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  6. Article ; Online: IFN-γ Induces PD-L1 Expression in Primed Human Basophils.

    Bonam, Srinivasa Reddy / Chauvin, Camille / Mathew, Mano J / Bayry, Jagadeesh

    Cells

    2022  Volume 11, Issue 5

    Abstract: Programmed death-ligand 1 (PD-L1) plays a key role in maintaining immune tolerance and also in immune evasion of cancers and pathogens. Though the identity of stimuli that induce PD-L1 in various human innate cells and their function are relatively well ... ...

    Abstract Programmed death-ligand 1 (PD-L1) plays a key role in maintaining immune tolerance and also in immune evasion of cancers and pathogens. Though the identity of stimuli that induce PD-L1 in various human innate cells and their function are relatively well studied, data on the basophils remain scarce. In this study, we have identified one of the factors, such as IFN-γ, that induces PD-L1 expression in human basophils. Interestingly, we found that basophil priming by IL-3 is indispensable for IFN-γ-induced PD-L1 expression in human basophils. However, priming by other cytokines including granulocyte-macrophage colony-stimulating factor (GM-CSF) and thymic stromal lymphopoietin (TSLP) was dispensable. Analyses of a published microarray data set on IL-3-treated basophils indicated that IL-3 enhances
    MeSH term(s) B7-H1 Antigen ; Basophils ; Humans ; Interferon-gamma/pharmacology ; Interleukin-3/pharmacology ; Leukocyte Count
    Chemical Substances B7-H1 Antigen ; CD274 protein, human ; Interleukin-3 ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2022-02-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11050801
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  7. Article: Syndemic analysis of the pandemic COVID-19 crisis: a multidisciplinary "Understand-Anticipate - Propose" meta-method.

    Lepelletier, Didier / Souhard, Camille / Chidiac, Christian / Chauvin, Franck / Mansour, Zeina

    Archives of public health = Archives belges de sante publique

    2022  Volume 80, Issue 1, Page(s) 193

    Abstract: Background: In order to understand the pandemic COVID-19 crisis in a forward-looking way, the French High Council for public health (HCSP) has designed a conceptual scheme for public health planning based on L. Green's model in order to better ... ...

    Abstract Background: In order to understand the pandemic COVID-19 crisis in a forward-looking way, the French High Council for public health (HCSP) has designed a conceptual scheme for public health planning based on L. Green's model in order to better understand the issues at stake, by identifying dangers and levers for action. The final aim was to establish priorities and guidelines in order to anticipate the collateral consequences of the management of the crisis and be better prepared for the next one.
    Method: A public health conceptual framework PRECEDE-PROCEED adapted to the Covid-19 health crisis was developed using both a graphic (concept map) and analytic (to make the conceptual scheme functional) approaches. Then, a "meta-method" was applied using three distinct cognitive stages: understanding, anticipation and proposals of action.
    Results: The conceptual framework was broken down into 10 technical sheets covering essential diagnoses and integrating different public health determinants. Each of these was broken down into three cognitive stages, allowing for a diagnosis of understanding, a scenario of anticipation and a strategic analysis of action according to the chronology: understand-anticipate-propose. From these 10 technical sheets, 32 guidelines have been proposed.
    Conclusion: This work is intended to allow reflections on public health approaches to strengthen and anticipate health crisis management and health planning by politic managers working at national or sub-national level.
    Language English
    Publishing date 2022-08-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1117688-x
    ISSN 2049-3258 ; 0778-7367 ; 0003-9578
    ISSN (online) 2049-3258
    ISSN 0778-7367 ; 0003-9578
    DOI 10.1186/s13690-022-00951-x
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    Zs.A 147: Show issues Location:
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  8. Article ; Online: IFN-γ Induces PD-L1 Expression in Primed Human Basophils

    Srinivasa Reddy Bonam / Camille Chauvin / Mano J. Mathew / Jagadeesh Bayry

    Cells, Vol 11, Iss 801, p

    2022  Volume 801

    Abstract: Programmed death-ligand 1 (PD-L1) plays a key role in maintaining immune tolerance and also in immune evasion of cancers and pathogens. Though the identity of stimuli that induce PD-L1 in various human innate cells and their function are relatively well ... ...

    Abstract Programmed death-ligand 1 (PD-L1) plays a key role in maintaining immune tolerance and also in immune evasion of cancers and pathogens. Though the identity of stimuli that induce PD-L1 in various human innate cells and their function are relatively well studied, data on the basophils remain scarce. In this study, we have identified one of the factors, such as IFN-γ, that induces PD-L1 expression in human basophils. Interestingly, we found that basophil priming by IL-3 is indispensable for IFN-γ-induced PD-L1 expression in human basophils. However, priming by other cytokines including granulocyte-macrophage colony-stimulating factor (GM-CSF) and thymic stromal lymphopoietin (TSLP) was dispensable. Analyses of a published microarray data set on IL-3-treated basophils indicated that IL-3 enhances IFNGR2 , one of the chains of the IFNGR heterodimer complex, and CD274 , thus providing a mechanistic insight into the role of IL-3 priming in IFN-γ-induced PD-L1 expression in human basophils.
    Keywords human basophils ; PD-L1 ; IFN-γ ; IL-3 ; IL-4 ; IL-13 ; Biology (General) ; QH301-705.5
    Subject code 570 ; 616
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  9. Article: Angiœdème et anaphylaxie, une histoire de famille.

    Martinet, Camille / Gherri, Nadia / Laborde, Léon / Gil-Jardine, Cédric / Chauvin, Anthony / Lefort, Hugues

    Revue de l'infirmiere

    2022  Volume 71, Issue 282, Page(s) 27–29

    Abstract: Non-allergic angioedema has a worrying morbidity. Clinical examination is central, as C1-esterase inhibitor deficiency will not be documented in the acute phase. In the case of anaphylaxis that does not respond to adrenaline, an early diagnosis can ... ...

    Title translation Angioedema and anaphylaxis, a family story.
    Abstract Non-allergic angioedema has a worrying morbidity. Clinical examination is central, as C1-esterase inhibitor deficiency will not be documented in the acute phase. In the case of anaphylaxis that does not respond to adrenaline, an early diagnosis can optimise referral of the patient to a reference healthcare establishment for a specific therapeutic protocol (icatibant, C1 inhibitor) recently updated by recommendations.
    MeSH term(s) Anaphylaxis/diagnosis ; Anaphylaxis/therapy ; Angioedema/drug therapy ; Angioedema/therapy ; Angioedemas, Hereditary/diagnosis ; Angioedemas, Hereditary/drug therapy ; Epinephrine/therapeutic use ; Esterases/therapeutic use ; Humans
    Chemical Substances Esterases (EC 3.1.-) ; Epinephrine (YKH834O4BH)
    Language French
    Publishing date 2022-05-26
    Publishing country France
    Document type Journal Article
    ZDB-ID 632538-5
    ISSN 1293-8505 ; 0397-7900
    ISSN 1293-8505 ; 0397-7900
    DOI 10.1016/j.revinf.2022.05.010
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  10. Article ; Online: SARS-CoV-2 Induces Cytokine Responses in Human Basophils.

    Bonam, Srinivasa Reddy / Chauvin, Camille / Levillayer, Laurine / Mathew, Mano Joseph / Sakuntabhai, Anavaj / Bayry, Jagadeesh

    Frontiers in immunology

    2022  Volume 13, Page(s) 838448

    Abstract: Basophils play a key role in the orientation of immune responses. Though the interaction of SARS-CoV-2 with various immune cells has been relatively well studied, the response of basophils to this pandemic virus is not characterized yet. In this study, ... ...

    Abstract Basophils play a key role in the orientation of immune responses. Though the interaction of SARS-CoV-2 with various immune cells has been relatively well studied, the response of basophils to this pandemic virus is not characterized yet. In this study, we report that SARS-CoV-2 induces cytokine responses and in particular IL-13, in both resting and IL-3 primed basophils. The response was prominent under IL-3 primed condition. However, either SARS-CoV-2 or SARS-CoV-2-infected epithelial cells did not alter the expression of surface markers associated with the activation of basophils, such as CD69, CD13 and/or degranulation marker CD107a. We also validate that human basophils are not permissive to SARS-CoV-2 replication. Though increased expression of immune checkpoint molecule PD-L1 has been reported on the basophils from COVID-19 patients, we observed that SARS-CoV-2 does not induce PD-L1 on the basophils. Our data suggest that basophil cytokine responses to SARS-CoV-2 might help in reducing the inflammation and also to promote antibody responses to the virus.
    MeSH term(s) B7-H1 Antigen/metabolism ; Basophils/immunology ; Biomarkers/metabolism ; COVID-19/immunology ; Cells, Cultured ; Humans ; Interleukin-13/metabolism ; Interleukin-3/metabolism ; SARS-CoV-2/physiology ; Virus Replication
    Chemical Substances B7-H1 Antigen ; Biomarkers ; Interleukin-13 ; Interleukin-3
    Language English
    Publishing date 2022-02-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.838448
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