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  1. Article: A Mental Health Survey of Medical Professionals Working During the COVID-19 Pandemic at Shaukat Khanum Cancer Hospital, Lahore.

    Chatha, Muhammad H / Khan, Sanaa A / Nazir Ahmed, Wajahat / Khan, Ahsun / Abu Bakar, Muhammad / Asif, Muhammad

    Cureus

    2022  Volume 14, Issue 9, Page(s) e28869

    Abstract: ... to assess the mental health burden amongst healthcare workers at Shaukat Khanum Memorial Cancer Hospital and ...

    Abstract Introduction The last months of 2019 saw the emergence of a novel coronavirus, SARS-COV-2, capable of causing widespread disease in humans. The rapid spread of this new disease culminated in one of the biggest pandemics in known history. The far-reaching social, economical, and health effects of this pandemic are still unfolding on a global scale. Given the interconnectedness of social, environmental, and biological factors in manifesting psychiatric illnesses, it is fair to assume that the profound effects of this pandemic would likely increase the strain on mental healthcare systems.  The objective of this study was to assess the mental health burden amongst healthcare workers at Shaukat Khanum Memorial Cancer Hospital and Research Center (SKMCH & RC) at the start of the COVID-19 pandemic and to identify any differences in the mental health scores of anxiety, depression, and sleep disturbance for professionals directly involved in the care of COVID-19 patients as compared to those who were not. Material and methods This was an observational cross-sectional clinical study that used self-reported questionnaires after approval from the hospital's ethical board. The sample size was calculated based on a study published previously by Huang using a 23.04% incidence of anxiety in medical staff. Depression was quantified using the Patient Health Questionnaire-9 score (PHQ-9), anxiety by the Beck Anxiety Inventory, and sleep quality using the Pittsburgh Sleep Quality Index checklist (PSQI). A total of 221 healthcare workers who completed the questionnaires were included in the study and the results were analyzed using SPSS Statistics v. 23 (IBM Corp., Armonk, NY). Levene's test was used to assess the equality of variances, and an independent sample t-test and chi-square test were applied for the comparison of means. A one-way ANOVA test was used to compare means across more than two groups. Results Of the 221 healthcare workers recruited in the study, 57% were males, and 43% were females. Among the sample, 43% of participants were doctors, 27.1% were nurses, and others were technicians and medical assistants. It was observed that 50% of males and 36% of female healthcare workers experienced moderate to severe depression at the onset of the pandemic. Furthermore, 35% of males and 25% of females suffered from moderate to severe anxiety, and more than 80% of our study population reported poor quality of sleep. Conclusion The present study reported a high prevalence of anxiety levels, depressive symptoms, and poor sleep quality among the healthcare professionals working in SKMCH & RC Lahore during the COVID-19 pandemic irrespective of direct contact with COVID-19 patients in a healthcare setting.
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.28869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A clinical study and treatment results of adrenocortical carcinoma patients presented in Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore.

    Khan, Muhammad Shadab / Ali, Azfar / Tariq, Irfan / Khan, Muhammad Attaullah / Bakar, Muhammad Abu / Anwar, Abdul Wahid

    JPMA. The Journal of the Pakistan Medical Association

    2019  Volume 69, Issue 5, Page(s) 717–719

    Abstract: Adrenocortical carcinoma is a rare and aggressive malignancy with an incidence of 0.5-2 per million per year and its overall prognosis is very poor. This study was aimed to point out the factors associated with tumour recurrence and patient's survival ... ...

    Abstract Adrenocortical carcinoma is a rare and aggressive malignancy with an incidence of 0.5-2 per million per year and its overall prognosis is very poor. This study was aimed to point out the factors associated with tumour recurrence and patient's survival after complete surgical resection of this aggressive malignancy. Patients admitted from January 2011 till December 2015 were retrospectively reviewed using case notes. In these five years 29 patients were admitted with adrenal tumour out of which 13 had adrenocortical carcinoma. On five year follow up, six (46.2%) patients developed recurrence. MEAN disease free survival was 31.0 ± 23.92 (2-63) months 53.8% while MEAN overall survival was 46.69 ± 22.81 (14-80) months 92.3%. Results concluded that hormonally active tumour on clinical presentation, positive surgical resection margins, positive nodal status and poorly differentiated tumour on histopathology are the factors associated with tumour recurrence and patient's survival.
    MeSH term(s) Adolescent ; Adrenal Cortex Hormones/metabolism ; Adrenal Cortex Neoplasms/metabolism ; Adrenal Cortex Neoplasms/pathology ; Adrenal Cortex Neoplasms/therapy ; Adrenalectomy ; Adrenocortical Carcinoma/metabolism ; Adrenocortical Carcinoma/pathology ; Adrenocortical Carcinoma/therapy ; Adult ; Aged ; Antineoplastic Agents, Hormonal/therapeutic use ; Chemotherapy, Adjuvant ; Child ; Child, Preschool ; Disease-Free Survival ; Female ; Humans ; Lymph Nodes/pathology ; Male ; Margins of Excision ; Middle Aged ; Mitotane/therapeutic use ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Pakistan ; Prognosis ; Retrospective Studies ; Survival Rate ; Young Adult
    Chemical Substances Adrenal Cortex Hormones ; Antineoplastic Agents, Hormonal ; Mitotane (78E4J5IB5J)
    Language English
    Publishing date 2019-05-20
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Prognostic significance of pre- and post-operative serum carcinoembryonic antigen levels in patients presented with rectal carcinoma; an experience from Shaukat Khanum Memorial Cancer Hospital and Research Center Lahore.

    Khan, Muhammad Shadab / Khan, Muhammad Attaullah / Akbar, Sana Amir / Bakar, Muhammad Abu / Khattak, Shahid / Syed, Aamir Ali

    JPMA. The Journal of the Pakistan Medical Association

    2019  Volume 69, Issue 10, Page(s) 1431–1436

    Abstract: ... in rectal carcinoma.: Methods: The retrospective study was conducted at Shaukat Khanum Memorial ...

    Abstract Objective: To explore the importance of serum carcinoembryonic antigen level as a tumour marker in rectal carcinoma.
    Methods: The retrospective study was conducted at Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan, and comprised data of patients with rectal carcinoma from January 1996 to December 2015. Serum carcinoembryonic antigen levels were analysed using immulite@2000 system analyser. On the basis of serum carcinoembryonic antigen levels, data of patients was divided into four groups. Group A had normal serum levels both before and after surgical resection; Group B had normal levels pre-surgery but post-surgery levels were raised; Group C had raised levels pre-surgery that went down to normal post-surgery; and Group D had raised levels both before and after surgery. SPSS 23 was used for data analysis.
    Results: Of the 401 patients, 267(66.6%) were males, and 204(50.9%) were aged <50 years. Group A had 267(66.6%) patients, Group B 26(6.5%), Group C 79(`9.7) and Group D had 29(7.2%) patients. Stage III disease was the most common 343(85.5%) and it was true across the groups. Overall recurrence was in 141(35.2%) patients. Group D had the highest recurrence rate 26(89.7%), while Group C had the lowest 18(22.8%).
    Conclusions: Fluctuating levels of carcinoembryonic antigen affected post-operative outcome.
    MeSH term(s) Biomarkers, Tumor/blood ; Carcinoembryonic Antigen/blood ; Carcinoma/blood ; Carcinoma/pathology ; Carcinoma/surgery ; Colonoscopy ; Disease-Free Survival ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Margins of Excision ; Middle Aged ; Neoplasm Staging ; Postoperative Period ; Preoperative Period ; Prognosis ; Rectal Neoplasms/blood ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery ; Retrospective Studies ; Tomography, X-Ray Computed
    Chemical Substances Biomarkers, Tumor ; Carcinoembryonic Antigen
    Language English
    Publishing date 2019-08-19
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Risk factors effecting development of metachronous liver metastasis in rectal cancer patients after curative surgical resection. Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore experience.

    Khan, Muhammad Shadab / Bakar, Muhammad Abu / Saba, Ayesha / Khan, Muhammad Attaullah / Akbar, Sana Amir / Islam Nasir, Irfan Ul

    JPMA. The Journal of the Pakistan Medical Association

    2019  Volume 69, Issue 2, Page(s) 201–204

    Abstract: ... conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, and comprised ...

    Abstract Objective: To determine risk factors affecting development of metachronous liver metastasis in rectal cancer patients after curative surgical resection.
    Methods: The retrospective cohort study was conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, and comprised data of patients with histologically proven rectal carcinoma admitted to the department of surgical oncology from January 2005 to December 2015. Clinical data of all patients, including age, gender, clinical presentation, clinical and pathological tumour-nodes-metastasis classification, neoadjuvant chemo-radiotherapy, surgery, adjuvant chemotherapy, pre- and postoperative carcinoembryonic antigen levels, histopathological findings and tumour recurrence were analysed. SPSS 23 was used for data analysis..
    Results: Of the 434 patients, 26(6%) developed liver metastasis. Of them, 18(69%) were male and 16(61.5%) were aged below 50 years. On clinical staging, 2(7.7%) patients had stage II disease, 22(84.6%) had stage III, and 2(7.7%) patients had stage IV disease. At last follow-up, 2(7.7%) patients were alive without disease, 7(27%) had expired, while 17(65.4%) were alive with disease..
    Conclusions: Tumour depth, lymph node metastasis, postoperative carcinoembryonic antigen levels, complete tumour response on histopathology were found to beresponsible for metachronous liver metastases in rectal cancer patients following curative resection.
    MeSH term(s) Adult ; Cancer Care Facilities/statistics & numerical data ; Carcinoma/epidemiology ; Carcinoma/pathology ; Carcinoma/therapy ; Colectomy/adverse effects ; Colectomy/methods ; Combined Modality Therapy/methods ; Combined Modality Therapy/statistics & numerical data ; Female ; Humans ; Liver Neoplasms/epidemiology ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary ; Male ; Middle Aged ; Neoplasm Staging ; Neoplasms, Second Primary/epidemiology ; Neoplasms, Second Primary/pathology ; Pakistan/epidemiology ; Rectal Neoplasms/epidemiology ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2019-02-25
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A retrospective study of cardiotoxicities induced by 5-fluouracil (5-FU) and 5-FU based chemotherapy regimens in Pakistani adult cancer patients at Shaukat Khanum Memorial Cancer Hospital & Research Center.

    Khan, Mansoor Ahmed / Masood, Nehal / Husain, Nawazishi / Ahmad, Bashir / Aziz, Tahir / Naeem, Anjum

    JPMA. The Journal of the Pakistan Medical Association

    2012  Volume 62, Issue 5, Page(s) 430–434

    Abstract: ... extracted from the medical records of all diagnosed cancer patients at Shaukat Khanum Memorial ...

    Abstract Objective: To study cardiotoxicities, especially bradycardia in cancer patients treated with 5-Fluouracil and 5-Fluouracil based chemotherapy regimens in Pakistani population.
    Methods: Data was extracted from the medical records of all diagnosed cancer patients at Shaukat Khanum Memorial Cancer Hospital and Research Center registered between January 2002 and December 2004 receiving 5- Fluouracil based chemotherapy regimens. The data was analysed retrospectively, including electrocardiogram and cardiac markers. Pearson's Correlation coefficient was calculated to see any possible correlation between 5-Fluouracil alone and 5-Fluouracil based regimens and cardiotoxicity, and other variables.
    Results: Symptomatic cardiotoxicity was observed in 60 (19.93%) out of 301 patients whose cases were part of the study. Bradycardia was the most common cardiotoxicity and was observed in 36 (11.96%) patients. Nine (2.99%) mortalities were also observed. The incidence of cardiotoxicity was not significantly different between the patients with and without pre-existing cardiovascular disease (p = 0.095) and having negative correlation - 0.305. Cardiotoxicities were more common with Continuous Infusion (CI) of 5-Fluouracil, radiotherapy concurrent with 5-Fluouracil and when 5-Fluouracil was used in combination with Cisplatinum (CDDP).
    Conclusion: Cardiotoxicities were more prevalent when 5-Fluouracil was used along with concurrent radiotherapy and with Cisplatinum and when administered in continuous infusion pattern. Hence, 5-Fluouracil and 5-Fluouracil based chemotherapy regimens cause cardiotoxicities, especially bradycardia, in a significant number of cancer patients in Pakistani population.
    MeSH term(s) Adult ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bradycardia/chemically induced ; Bradycardia/epidemiology ; Electrocardiography ; Female ; Fluorouracil/administration & dosage ; Fluorouracil/adverse effects ; Heart Diseases/chemically induced ; Heart Diseases/epidemiology ; Humans ; Incidence ; Male ; Neoplasms/drug therapy ; Pakistan/epidemiology ; Retrospective Studies ; Risk Factors ; Statistics, Nonparametric
    Chemical Substances Antimetabolites, Antineoplastic ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2012-05
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Aquifers

    Salik Javaid, Muhammad / Ali Khan, Shaukat

    Matrix and Fluids

    2018  

    Keywords Hydrology & the hydrosphere ; water, groundwater, water resources, electrical resistivity, isotopes, electromagnetic induction
    Language English
    Size 1 electronic resource (144 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030646833
    ISBN 9781838813703 ; 1838813705
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article: Carveol mitigates the development of the morphine anti-nociceptive tolerance, physical dependence, and conditioned place preference in mice.

    Badshah, Ismail / Qazi, Neelum Gul / Anwar, Maira / Shaukat, Bushra / Khan, Muhammad Imran / Murtaza, Babar

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27809

    Abstract: Emergence of analgesic tolerance and dependence to morphine is frequently the limiting factor in the use of this agent in the management of pain. Hence, this study aimed to investigate the beneficial effects of the natural compound carveol (CV) against ... ...

    Abstract Emergence of analgesic tolerance and dependence to morphine is frequently the limiting factor in the use of this agent in the management of pain. Hence, this study aimed to investigate the beneficial effects of the natural compound carveol (CV) against morphine antinociceptive tolerance, dependence and conditioned place preference (CPP) in mice. Behavioural paradigms included hot plate and tail-flick (for tolerance), observation of withdrawal signs (for dependence) while biochemical tests involved the assays for mRNA expression, nitrite levels, antioxidants, and immunohistochemistry studies. Behavioural tests indicated that treatment with CV significantly attenuated the morphine analgesic tolerance, physical dependence and CPP in mice. It was observed during biochemical analysis that CV-treated animals exhibited reduced mRNA expression of inducible nitric oxide synthase (iNOS) and NR2B (an NMDA subtype). In addition, decreased levels of nitrite were observed in mouse hippocampus following CV treatment than morphine administration only. Further, CV enhanced the neuronal innate antioxidants including Glutathione-S-Transferase (GST), glutathione (GSH) and catalase (CAT), while curtailed lipid peroxidase (LPO) levels in mice brain tissues. Moreover, CV exerted significant anti-inflammatory effects as evidenced by reduced expression of TNF-
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Wearable Printed Temperature Sensors: Short Review on Latest Advances for Biomedical Applications.

    Khan, Saleem / Ali, Shaukat / Khan, Arshad / Bermak, Amine

    IEEE reviews in biomedical engineering

    2023  Volume 16, Page(s) 152–170

    Abstract: The rapid growth in wearable biosensing devices is driven by the strong desire to monitor the human health data and to predict the symptoms of chronic diseases at an early stage. Different sensors are developed for continuous monitoring of various ... ...

    Abstract The rapid growth in wearable biosensing devices is driven by the strong desire to monitor the human health data and to predict the symptoms of chronic diseases at an early stage. Different sensors are developed for continuous monitoring of various biomarkers through wearable and implantable sensing patches. Temperature sensor has proved to be an important physiological parameter amongst the various wearable biosensing patches. This paper highlights the recent progresses made in printing of functional nanomaterials for developing wearable temperature sensors on polymeric substrates. A special focus is given to the advanced functional nanomaterials as well as their deposition through printing technologies. The geometric resolutions, shape, physical and electrical characteristics as well as sensing properties using different materials are compared and summarized. Wearability is the main concern of these newly developed sensors, which is summarized by discussing representative examples. Finally, the challenges concerning the stability, repeatability, reliability, sensitivity, linearity, ageing, and large-scale manufacturing are discussed with future outlook of the wearable systems.
    MeSH term(s) Humans ; Temperature ; Reproducibility of Results ; Wearable Electronic Devices ; Nanostructures ; Prostheses and Implants
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1941-1189
    ISSN (online) 1941-1189
    DOI 10.1109/RBME.2021.3121480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Exploring the Long-Term Disability Outcomes in Trauma Patients: Study Protocol.

    Shaukat, Natasha / Merchant, Asma Altaf Hussain / Sahibjan, Fazila / Abbasi, Ayesha / Jarrar, Zeerak / Ahmed, Tanweer / Atiq, Huba / Khan, Uzma Rahim / Khan, NadeemUllah / Mushtaq, Saima / Rasul, Shahid / Hyder, Adnan / Razzak, Junaid / Haider, Adil

    Research square

    2024  

    Abstract: ... ...

    Abstract Objectives
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-4238506/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: In vitro

    Arshad, Tahreem / Shoaib Khan, Haji Muhammad / Khan, Kashif-Ur-Rehman / Al-Roujayee, Abdulaziz S / Mohany, Mohamed / Ahmad, Maqsood / Maryam, Sana / Akram, Muhammad Bilal / Shaukat, Hasnain / Khursheed, Umair / Aboul-Soud, Mourad A M

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1352045

    Abstract: The bioactive extracts of traditional medicinal plants are rich in polyphenols and help to rejuvenate skin. The study was designed to assess the skin rejuvenating effects of a stable cream enriched with 4% ...

    Abstract The bioactive extracts of traditional medicinal plants are rich in polyphenols and help to rejuvenate skin. The study was designed to assess the skin rejuvenating effects of a stable cream enriched with 4%
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1352045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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