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Article ; Online: Association Between Muscle Wasting and Muscle Strength in Patients Who Developed Severe Sepsis And Septic Shock.

Borges, Rodrigo Cerqueira / Soriano, Francisco Garcia

2018 Volume 51, Issue 3, Page(s) 312–320

Abstract: Purpose: To evaluate the association between the rectus femoris cross-sectional area (RFCSA) and the muscular strength obtained at the bedside in patients forwarded to the intensive care unit (ICU) for severe sepsis and septic shock.: Methods: An ... ...

Abstract	Purpose: To evaluate the association between the rectus femoris cross-sectional area (RFCSA) and the muscular strength obtained at the bedside in patients forwarded to the intensive care unit (ICU) for severe sepsis and septic shock. Methods: An observational study of prospective cohort. RFCSA was assessed by ultrasound on the following day of the ICU admission and monitored during hospitalization. The patients performed clinical tests of muscle strength (Medical Research Council (MRC) scale and handgrip dynamometry), when they could understand the verbal commands of the examiners. Results: In 37 patients hospitalized for sepsis there was a significant decline in RFCSA of 5.18 (4.49-5.96) cm on the 2nd day of ICU for 4.37 (3.71-5.02) cm at hospital discharge. Differently, the handgrip strength showed an increase from the awakening of 12.00 (7.00-20.00) Kgf to 19.00 (14.00-26.00) Kgf until hospital discharge. Patients in mechanical ventilation had a greater tendency to decline in the RFCSA compared with patients who did not receive mechanical ventilation, however without being significant (P = 0.08). There was a negative association between RFCSA delta (2nd day of ICU-ICU discharge) and handgrip strength (r = 0.51, P < 0.05), and a male and Sepsis-related Organ Failure Assessment score positive association with the RFCSA delta. Conclusion: There was an association of RFCSA with clinical muscle strength tests. In addition, it has been shown that sepsis can lead to short-term muscle degradation, regardless of whether they are submitted to mechanical ventilation or not.
MeSH term(s)	Aged ; Female ; Hand Strength ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Muscular Atrophy/physiopathology ; Muscular Atrophy/therapy ; Prospective Studies ; Respiration, Artificial ; Shock, Septic/physiopathology ; Shock, Septic/therapy
Language	English
Publishing date	2018-04-24
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Observational Study
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000001183
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Article ; Online: Dendritic cells in COVID-19 immunopathogenesis: insights for a possible role in determining disease outcome.

Borges, Rodrigo Cerqueira / Hohmann, Miriam Sayuri / Borghi, Sergio Marques

International reviews of immunology

2020 Volume 40, Issue 1-2, Page(s) 108–125

Abstract: SARS-CoV-2 is the causative agent of the COVID-19 pandemic. This novel coronavirus emerged in China, quickly spreading to more than 200 countries worldwide. Although most patients are only mildly ill or even asymptomatic, some develop severe pneumonia ... ...

Abstract	SARS-CoV-2 is the causative agent of the COVID-19 pandemic. This novel coronavirus emerged in China, quickly spreading to more than 200 countries worldwide. Although most patients are only mildly ill or even asymptomatic, some develop severe pneumonia and become critically ill. One of the biggest unanswered questions is why some develop severe disease, whilst others do not. Insight on the interaction between SARS-CoV-2 and the immune system and the contribution of dysfunctional immune responses to disease progression will be instrumental to the understanding of COVID-19 pathogenesis, risk factors for worst outcome, and rational design of effective therapies and vaccines. In this review we have gathered the knowledge available thus far on the epidemiology of SARS-COV-2 infection, focusing on the susceptibility of older individuals, SARS-CoV-2-host cell interaction during infection and the immune response directed at SARS-CoV-2. Dendritic cells act as crucial messengers linking innate and adaptative immunity against viral infections. Thus, this review also brings a focused discussion on the role of dendritic cells and their immune functions during SARS-CoV-2 infection and how immune evasion strategies of SARS-CoV-2 and advancing age mediate dendritic cell dysfunctions that contribute to COVID-19 pathogenesis and increased susceptibility to worst outcomes. This review brings to light the hypothesis that concomitant occurrence of dendritic cell dysfunction/cytopathic effects induced by SARS-CoV-2 and/or aging may influence disease outcome in the elderly. Lastly, a detailed discussion on the effects and mechanisms of action of drugs currently being tested for COVID-19 on the function of dendritic cells is also provided.
MeSH term(s)	Adaptive Immunity/immunology ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/immunology ; COVID-19/pathology ; Dendritic Cells/immunology ; Humans ; Immune Evasion/immunology ; Immunity, Innate/immunology ; Middle Aged ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; Severity of Illness Index ; Young Adult
Chemical Substances	Antiviral Agents
Keywords	covid19
Language	English
Publishing date	2020-11-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	632825-8
ISSN	1563-5244 ; 1545-5858 ; 0883-0185
ISSN (online)	1563-5244 ; 1545-5858
ISSN	0883-0185
DOI	10.1080/08830185.2020.1844195
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Article ; Online: Evidence for Monocyte Reprogramming in a Long-Term Postsepsis Study.

Gritte, Raquel Bragante / Souza-Siqueira, Talita / Borges da Silva, Eliane / Dos Santos de Oliveira, Laiane Cristina / Cerqueira Borges, Rodrigo / Alves, Heloísa H de Oliveira / Masi, Laureane Nunes / Murata, Gilson Masahiro / Gorjão, Renata / Levada-Pires, Adriana Cristina / Nogueira, Antônio Carlos / Pithon-Curi, Tânia Cristina / de Azevedo, Ricardo Bentes / Soriano, Francisco Garcia / Curi, Rui / Machado, Marcel Cerqueira Cesar

Critical care explorations

2022 Volume 4, Issue 8, Page(s) e0734

Abstract: This study sought to identify monocyte alterations from septic patients after hospital discharge by evaluating gene expression of inflammatory mediators and monocyte polarization markers. It was hypothesized that sepsis reprograms the inflammatory state ... ...

Abstract	This study sought to identify monocyte alterations from septic patients after hospital discharge by evaluating gene expression of inflammatory mediators and monocyte polarization markers. It was hypothesized that sepsis reprograms the inflammatory state of monocytes, causing effects that persist after hospital discharge and influencing patient outcomes. Design: The gene expression patterns of inflammatory receptors, M1 and M2 macrophage polarization markers, NLRP3 inflammasome components, and pro- and anti-inflammatory cytokines in monocytes were assessed. Patients: Thirty-four patients from the University of São Paulo Hospital, during the acute sepsis phase (phase A), immediately after ICU discharge (phase B), and 3 months (phase C), 6 months (phase D), 1 year (phase E), and 3 years (phase F) after discharge, were included. Patients that died during phases A and B were grouped separately, and the remaining patients were collectively termed the survivor group. Measurements and main results: The gene expression of toll-like receptor ( Conclusions: Sepsis reprograms the inflammatory state of monocytes, probably contributing to postsepsis syndrome development and mortality.
Language	English
Publishing date	2022-07-29
Publishing country	United States
Document type	Journal Article
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000000734
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Article ; Online: Muscle degradation, vitamin D and systemic inflammation in hospitalized septic patients.

Borges, Rodrigo Cerqueira / Barbeiro, Hermes Vieira / Barbeiro, Denise Frediani / Soriano, Francisco Garcia

Journal of critical care

2019 Volume 56, Page(s) 125–131

Abstract: Purpose: To date, the relationship between systemic inflammation and muscle changes observed by ultrasonography in septic patients in clinical studies is not known. Furthermore, the role of vitamin D on muscle changes in these patients needs to be ... ...

Abstract	Purpose: To date, the relationship between systemic inflammation and muscle changes observed by ultrasonography in septic patients in clinical studies is not known. Furthermore, the role of vitamin D on muscle changes in these patients needs to be investigated. Materials and methods: Forty-five patients admitted to the ICU due to severe sepsis or septic shock. Blood samples were collected to evaluate systemic inflammation (interleukin (IL)-10, IL-1β, IL-1α, IL-6, IL-8 and tumor necrosis factor-α(TNF-α)) and vitamin D. Muscle mass was evaluated by ultrasound during hospitalization. Clinical tests of muscle strength (Medical Research Council (MRC) scale and handgrip) were performed after the awakening of patients. Results: There was a reduction in day 2 values to hospital discharge on TNF-alpha, IL-8, IL-6 and IL-10 (p < .05). The muscle mass showed a significant decline from day 6 of the ICU. After awakening, the patients had a significant increase in muscle strength (p < .05). There was a positive association between muscle mass variation (day 2 - ICU) with absolute values of IL-8 (r = 0.38 p = .05). For muscle strength, there was a negative association between handgrip strength with IL-8 (r = -0.36 p < .05) on ICU discharge. The vitamin D showed a positive association with the handgrip strength of the day 1 of the awakening (r = 0.51 p < .05). Conclusions: In septic patients, there is an association between inflammation and changes in muscle mass and strength during ICU stay, which is similar to those observed in experimental studies. In addition, there was an association of vitamin D with recovery of muscle strength during hospitalization.
MeSH term(s)	Adult ; Aged ; Cytokines/metabolism ; Female ; Hand Strength ; Hospitalization ; Humans ; Inflammation/pathology ; Intensive Care Units ; Middle Aged ; Muscle, Skeletal/physiopathology ; Muscular Atrophy/diagnostic imaging ; Muscular Atrophy/physiopathology ; Prospective Studies ; Quadriceps Muscle/diagnostic imaging ; Quadriceps Muscle/physiopathology ; Sepsis/physiopathology ; Shock, Septic/physiopathology ; Ultrasonography ; Vitamin D/blood ; Vitamins
Chemical Substances	Cytokines ; Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2019-12-21
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2019.12.017
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Zs.A 2152: Show issues

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Article ; Online: Factors associated with COVID-19 vaccination among pregnant women in Rio De Janeiro City, Brazil.

Borges, Moara Alves Santa Bárbara / Florentino, Pilar Tavares Veras / Cerqueira-Silva, Thiago / de Carvalho, Luciana Freire / de Araújo Oliveira, Vinícius / Aguilar, Gislani Mateus Oliveira / Prado, Rodrigo de Sousa / Soranz, Daniel / Werneck, Guilherme Loureiro / Pescarini, Julia M / da Costa, Paulo Sérgio Sucasas / Barreto, Mauricio Lima / de Oliveira Garcia, Márcio Henrique / Penna, Gerson Oliveira / Barral-Netto, Manoel / Paixão, Enny S

Scientific reports

2023 Volume 13, Issue 1, Page(s) 18235

Abstract: COVID-19 vaccination during pregnancy is safe and effective in reducing the risk of complications. However, the uptake is still below targets worldwide. This study aimed to explore the factors associated with COVID-19 vaccination uptake among pregnant ... ...

Abstract	COVID-19 vaccination during pregnancy is safe and effective in reducing the risk of complications. However, the uptake is still below targets worldwide. This study aimed to explore the factors associated with COVID-19 vaccination uptake among pregnant women since data on this topic is scarce in low-to-middle-income countries. A retrospective cohort study included linked data on COVID-19 vaccination and pregnant women who delivered a singleton live birth from August 1, 2021, to July 31, 2022, in Rio de Janeiro City, Brazil. Multiple logistic regression was performed to identify factors associated with vaccination during pregnancy, applying a hierarchical model and describing odds ratio with 95% confidence intervals. Of 65,304 pregnant women included in the study, 53.0% (95% CI, 52-53%) received at least one dose of COVID-19 vaccine during pregnancy. Higher uptake was observed among women aged older than 34 (aOR 1.21, 95%CI 1.15-1.28), black (aOR 1.10, 1.04-1.16), or parda/brown skin colour (aOR 1.05, 1.01-1.09), with less than eight years of education (aOR 1.09, 1.02-1.17), living without a partner (aOR 2.24, 2.16-2.34), more than six antenatal care appointments (aOR 1.92, 1.75-2.09), and having a previous child loss (OR 1.06, 1.02-1.11). These results highlight the need for targeted educational campaigns, trustful communication, and accessibility strategies for specific populations to improve vaccination uptake during pregnancy.
MeSH term(s)	Female ; Humans ; Pregnancy ; Brazil/epidemiology ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Pregnant Women ; Retrospective Studies ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-10-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-44370-6
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Article ; Online: Factors associated with COVID-19 vaccination among pregnant women in Rio De Janeiro City, Brazil

Moara Alves Santa Bárbara Borges / Pilar Tavares Veras Florentino / Thiago Cerqueira-Silva / Luciana Freire de Carvalho / Vinícius de Araújo Oliveira / Gislani Mateus Oliveira Aguilar / Rodrigo de Sousa Prado / Daniel Soranz / Guilherme Loureiro Werneck / Julia M. Pescarini / Paulo Sérgio Sucasas da Costa / Mauricio Lima Barreto / Márcio Henrique de Oliveira Garcia / Gerson Oliveira Penna / Manoel Barral-Netto / Enny S. Paixão

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 9

Abstract: Abstract COVID-19 vaccination during pregnancy is safe and effective in reducing the risk of complications. However, the uptake is still below targets worldwide. This study aimed to explore the factors associated with COVID-19 vaccination uptake among ... ...

Abstract	Abstract COVID-19 vaccination during pregnancy is safe and effective in reducing the risk of complications. However, the uptake is still below targets worldwide. This study aimed to explore the factors associated with COVID-19 vaccination uptake among pregnant women since data on this topic is scarce in low-to-middle-income countries. A retrospective cohort study included linked data on COVID-19 vaccination and pregnant women who delivered a singleton live birth from August 1, 2021, to July 31, 2022, in Rio de Janeiro City, Brazil. Multiple logistic regression was performed to identify factors associated with vaccination during pregnancy, applying a hierarchical model and describing odds ratio with 95% confidence intervals. Of 65,304 pregnant women included in the study, 53.0% (95% CI, 52–53%) received at least one dose of COVID-19 vaccine during pregnancy. Higher uptake was observed among women aged older than 34 (aOR 1.21, 95%CI 1.15–1.28), black (aOR 1.10, 1.04–1.16), or parda/brown skin colour (aOR 1.05, 1.01–1.09), with less than eight years of education (aOR 1.09, 1.02–1.17), living without a partner (aOR 2.24, 2.16–2.34), more than six antenatal care appointments (aOR 1.92, 1.75–2.09), and having a previous child loss (OR 1.06, 1.02–1.11). These results highlight the need for targeted educational campaigns, trustful communication, and accessibility strategies for specific populations to improve vaccination uptake during pregnancy.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Physical activity in daily life in Brazilian COPD patients during and after exacerbation.

Borges, Rodrigo Cerqueira / Carvalho, Celso Ricardo Fernandes

COPD

2012 Volume 9, Issue 6, Page(s) 596–602

Abstract: Background: Although hospitalization is recognized as an important cause of reduction in physical activity in daily life (PADL) in COPD, there is only one study evaluating this effect, and it was performed in European COPD patients who have a lower PADL ...

Abstract	Background: Although hospitalization is recognized as an important cause of reduction in physical activity in daily life (PADL) in COPD, there is only one study evaluating this effect, and it was performed in European COPD patients who have a lower PADL than that of South American COPD patients. Objectives: To investigate the effect of hospitalization due to acute exacerbation of PADL in Brazilian COPD patients and to evaluate the factors that determines the physical activity levels during hospitalization and after discharge. Methods: PADL was quantified using a 3-axis accelerometer on the 3rd day of hospitalization and 1 month after discharge in Brazilian COPD patients who were hospitalized due to disease exacerbation. Six-minute walking distance (6MWD), lower limb strength and pulmonary function were also evaluated. Results: A total of 20 patients completed the study. During hospitalization, patients spent most of the time (87%) lying down or sitting; however, 1 month after they were walking >40 min/day. In addition, patients with prior hospitalization had a lower level of physical activity compared to those without a previous history of hospitalization. The time spent walking during hospitalization was significantly explained by the quadriceps strength (r(2) = 0.29; p < 0.05), while 1 month after, the time spent walking was only significantly explained by the 6MWD (r(2) = 0.51; p = 0.02). Conclusions: Brazilian COPD patients are inactive during hospitalization but become active 1 month after discharge. Previously hospitalized are more inactive both during and after exacerbation. The quadriceps strength and 6MWD explain the physical activity levels during hospitalization and at home, respectively.
MeSH term(s)	Accelerometry ; Activities of Daily Living ; Aged ; Brazil ; Combined Modality Therapy ; Disease Progression ; Exercise Test ; Female ; Hospitalization ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Motor Activity ; Muscle Strength ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Disease, Chronic Obstructive/therapy ; Quadriceps Muscle/physiology ; Spirometry ; Treatment Outcome ; Walking
Language	English
Publishing date	2012-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2171107-0
ISSN	1541-2563 ; 1541-2555
ISSN (online)	1541-2563
ISSN	1541-2555
DOI	10.3109/15412555.2012.705364
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Zs.A 5990: Show issues

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Article ; Online: Position Statement on the Use of Myocardial Strain in Cardiology Routines by the Brazilian Society of Cardiology's Department Of Cardiovascular Imaging - 2023.

Almeida, André Luiz Cerqueira / Melo, Marcelo Dantas Tavares de / Bihan, David Costa de Souza Le / Vieira, Marcelo Luiz Campos / Pena, José Luiz Barros / Del Castillo, José Maria / Abensur, Henry / Hortegal, Renato de Aguiar / Otto, Maria Estefania Bosco / Piveta, Rafael Bonafim / Dantas, Maria Rosa / Assef, Jorge Eduardo / Beck, Adenalva Lima de Souza / Santo, Thais Harada Campos Espirito / Silva, Tonnison de Oliveira / Salemi, Vera Maria Cury / Rocon, Camila / Lima, Márcio Silva Miguel / Barberato, Silvio Henrique /

Rodrigues, Ana Clara / Rabschkowisky, Arnaldo / Frota, Daniela do Carmo Rassi / Gripp, Eliza de Almeida / Barretto, Rodrigo Bellio de Mattos / Silva, Sandra Marques E / Cauduro, Sanderson Antonio / Pinheiro, Aurélio Carvalho / Araujo, Salustiano Pereira de / Tressino, Cintia Galhardo / Silva, Carlos Eduardo Suaide / Monaco, Claudia Gianini / Paiva, Marcelo Goulart / Fisher, Cláudio Henrique / Alves, Marco Stephan Lofrano / Grau, Cláudia R Pinheiro de Castro / Santos, Maria Veronica Camara Dos / Guimarães, Isabel Cristina Britto / Morhy, Samira Saady / Leal, Gabriela Nunes / Soares, Andressa Mussi / Cruz, Cecilia Beatriz Bittencourt Viana / Guimarães Filho, Fabio Villaça / Assunção, Bruna Morhy Borges Leal / Fernandes, Rafael Modesto / Saraiva, Roberto Magalhães / Tsutsui, Jeane Mike / Soares, Fábio Luis de Jesus / Falcão, Sandra Nívea Dos Reis Saraiva / Hotta, Viviane Tiemi / Armstrong, Anderson da Costa / Hygidio, Daniel de Andrade / Miglioranza, Marcelo Haertel / Camarozano, Ana Cristina / Lopes, Marly Maria Uellendahl / Cerci, Rodrigo Julio / Siqueira, Maria Eduarda Menezes de / Torreão, Jorge Andion / Rochitte, Carlos Eduardo / Felix, Alex

Arquivos brasileiros de cardiologia

2024 Volume 120, Issue 12, Page(s) e20230646

Abstract: Central Illustration : Position Statement on the Use of Myocardial Strain in Cardiology Routines by the Brazilian Society of Cardiology's Department Of Cardiovascular Imaging - 2023 Proposal for including strain in the integrated diastolic function ... ...

Title translation	Posicionamento do Departamento de Imagem Cardiovascular da Sociedade Brasileira de Cardiologia sobre o Uso do Strain Miocárdico na Rotina do Cardiologista – 2023.
Abstract	Central Illustration : Position Statement on the Use of Myocardial Strain in Cardiology Routines by the Brazilian Society of Cardiology's Department Of Cardiovascular Imaging - 2023 Proposal for including strain in the integrated diastolic function assessment algorithm, adapted from Nagueh et al.67 Am: mitral A-wave duration; Ap: reverse pulmonary A-wave duration; DD: diastolic dysfunction; LA: left atrium; LASr: LA strain reserve; LVGLS: left ventricular global longitudinal strain; TI: tricuspid insufficiency. Confirm concentric remodeling with LVGLS. In LVEF, mitral E wave deceleration time < 160 ms and pulmonary S-wave < D-wave are also parameters of increased filling pressure. This algorithm does not apply to patients with atrial fibrillation (AF), mitral annulus calcification, > mild mitral valve disease, left bundle branch block, paced rhythm, prosthetic valves, or severe primary pulmonary hypertension.
MeSH term(s)	Humans ; Echocardiography, Doppler ; Brazil ; Atrial Fibrillation/diagnostic imaging ; Heart Atria/diagnostic imaging ; Cardiology ; Ventricular Function, Left ; Ventricular Dysfunction, Left
Language	English
Publishing date	2024-01-15
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20230646
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Article ; Online: Physical activity, muscle strength, and exercise capacity 3 months after severe sepsis and septic shock.

Borges, Rodrigo Cerqueira / Carvalho, Celso R F / Colombo, Alexandra Siqueira / da Silva Borges, Mariucha Pereira / Soriano, Francisco Garcia

Intensive care medicine

2015 Volume 41, Issue 8, Page(s) 1433–1444

Abstract: Purpose: To quantify the physical activity in daily life (PADL), muscle strength, and exercise capacity in the short and medium term in survivors of severe sepsis and septic shock.: Methods: Prospective cohort study with a follow-up from hospital ... ...

Abstract	Purpose: To quantify the physical activity in daily life (PADL), muscle strength, and exercise capacity in the short and medium term in survivors of severe sepsis and septic shock. Methods: Prospective cohort study with a follow-up from hospital admission to 3 months after hospital discharge. Seventy-two patients admitted to the ICU for severe sepsis or septic shock and a control group of healthy sedentary subjects (n = 50) were enrolled. All patients had their PADL quantified by an accelerometer during their hospital stay and 3 months after. Exercise capacity and handgrip and quadriceps muscle strength were also evaluated. Results: During hospitalization, patients spent the majority of their time inactive in a lying or sitting position (90 ± 34% of daily time). Physical inactivity was partially reduced 3 months after (58 ± 20% of daily time). However, the time patients spent walking was only 63% of the time reported for healthy subjects. Patients also showed lower movement intensity when compared with controls (2.1 ± 0.3 vs 2.5 ± 0.4 m/s(2)). At hospital discharge, muscle strength and exercise capacity were approximately 54% of the predicted value, and these parameters showed significant increase in patients 3 months after (70% of predicted value). Multivariable analysis demonstrated that the use of systemic corticosteroids and hospitalization time negatively influenced quadriceps strength and exercise capacity at the time of hospital discharge. Conclusion: Our results suggest that survivors of sepsis admitted to the ICU have a substantial reduction in physical activity, exercise capacity, and muscle strength compared to healthy subjects that persist even 3 months after hospital discharge.
MeSH term(s)	Accelerometry ; Activities of Daily Living ; Adult ; Aged ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Motor Activity/physiology ; Muscle Strength/physiology ; Prospective Studies ; Recovery of Function ; Sepsis/physiopathology ; Shock, Septic/physiopathology
Language	English
Publishing date	2015-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-015-3914-y
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Article: Pregabalin to improve postoperative recovery in bariatric surgery: a parallel, randomized, double-blinded, placebo-controlled study.

Martins, Marcelo J / Martins, Caroline Paiva Matos Oliveira / Castro-Alves, Lucas J / Jesus, Gabriel Nascimento / Campos, Guilherme Oliveira / Sacramento, Breno Barbosa Cerqueira / Borges, Leonardo Ferrari / Mello, Carlos Augusto Bastos / Alves, Rodrigo Leal / Módolo, Norma Sueli Pinheiro

Journal of pain research

2018 Volume 11, Page(s) 2407–2415

Abstract: Purpose: Obesity has been considered as a major public health problem in developed countries for which bariatric surgery has become an important treatment strategy. Postoperative pain, however, is a frequent problem in postoperative management. ... ...

Abstract	Purpose: Obesity has been considered as a major public health problem in developed countries for which bariatric surgery has become an important treatment strategy. Postoperative pain, however, is a frequent problem in postoperative management. Pregabalin blocks the development of hyperalgesia and central pain sensitization. The objective of this randomized, placebo-controlled, double-blinded trial was to evaluate the effect of a single dose of preoperative pregabalin vs placebo on the quality of postoperative recovery in patients undergoing bariatric surgery. Patients and methods: A total of 70 patients undergoing abdominal gastroplasty were randomly assigned to receive oral pregabalin (75 mg) or an identical placebo 1 hour before surgery. The primary outcome was Quality of Recovery-40 (QoR-40) score at 24 hours. Secondary outcomes included opioid consumption and postoperative pain scores. Results: In all, 60 of the 70 patients completed the study. The mean (SD) global recovery scores (QoR-40) 24 hours after surgery in the pregabalin and control groups were 183.7 (9) and 182.1 (12), respectively (mean difference=1.6, 95% CI -7.36 to 4.2, Conclusion: In patients who underwent bariatric surgery, a single preoperative dose of pregabalin (75 mg) did not improve pain relief, quality of postoperative recovery, or reduction in opioid consumption. Clinical trial registration: http://www.ensaiosclinicos.gov.br (identifier: RBR-2g89x8).
Language	English
Publishing date	2018-10-17
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S176468
Database	MEDical Literature Analysis and Retrieval System OnLINE

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