LIVIVO - Search results -

Search results

Result 1 - 10 of total 26

Search options

Article ; Online: Challenges and opportunities for modeling aging and cancer.

Anczuków, Olga / Airhart, Susie / Chuang, Jeffrey H / Coussens, Lisa M / Kuchel, George A / Korstanje, Ron / Li, Sheng / Lucido, Anna Lisa / McAllister, Sandra S / Politi, Katerina / Polyak, Kornelia / Ratliff, Timothy / Ren, Gary / Trowbridge, Jennifer J / Ucar, Duygu / Palucka, Karolina

Cancer cell

2023 Volume 41, Issue 4, Page(s) 641–645

Abstract: Age is among the main risk factors for cancer, and any cancer study in adults is faced with an aging tissue and organism. Yet, pre-clinical studies are carried out using young mice and are not able to address the impact of aging and associated ... ...

Abstract	Age is among the main risk factors for cancer, and any cancer study in adults is faced with an aging tissue and organism. Yet, pre-clinical studies are carried out using young mice and are not able to address the impact of aging and associated comorbidities on disease biology and treatment outcomes. Here, we discuss the limitations of current mouse cancer models and suggest strategies for developing novel models to address these major gaps in knowledge and experimental approaches.
MeSH term(s)	Animals ; Mice ; Aging ; Neoplasms/genetics ; Disease Models, Animal ; Risk Factors
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2078448-X
ISSN	1878-3686 ; 1535-6108
ISSN (online)	1878-3686
ISSN	1535-6108
DOI	10.1016/j.ccell.2023.03.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5650: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 104: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mapping systemic lupus erythematosus heterogeneity at the single-cell level.

Nehar-Belaid, Djamel / Hong, Seunghee / Marches, Radu / Chen, Guo / Bolisetty, Mohan / Baisch, Jeanine / Walters, Lynnette / Punaro, Marilynn / Rossi, Robert J / Chung, Cheng-Han / Huynh, Richie P / Singh, Prashant / Flynn, William F / Tabanor-Gayle, Joy-Ann / Kuchipudi, Navya / Mejias, Asuncion / Collet, Magalie A / Lucido, Anna Lisa / Palucka, Karolina /

Robson, Paul / Lakshminarayanan, Santhanam / Ramilo, Octavio / Wright, Tracey / Pascual, Virginia / Banchereau, Jacques F

Nature immunology

2020 Volume 21, Issue 9, Page(s) 1094–1106

Abstract: Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled ~276,000 peripheral blood mononuclear cells from 33 children with SLE with ... ...

Abstract	Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled ~276,000 peripheral blood mononuclear cells from 33 children with SLE with different degrees of disease activity and 11 matched controls. Increased expression of interferon-stimulated genes (ISGs) distinguished cells from children with SLE from healthy control cells. The high ISG expression signature (ISG
MeSH term(s)	Adolescent ; Adult ; Cells, Cultured ; Child ; Cohort Studies ; Disease Progression ; Female ; Gene Expression Profiling ; Humans ; Interferons/genetics ; Leukocytes, Mononuclear/physiology ; Lupus Erythematosus, Systemic/genetics ; Male ; Sequence Analysis, RNA ; Severity of Illness Index ; Single-Cell Analysis/methods ; Transcriptome
Chemical Substances	Interferons (9008-11-1)
Language	English
Publishing date	2020-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-020-0743-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Therapeutic management and care provided for neonates at the borderline of viability

Anna Bogusława Pilewska-Kozak / Beata Dobrowolska / Celina Łepecka–Klusek / Agnieszka Bałanda–Bałdyga / Agnieszka Konstancja Pawłowska-Muc / Grażyna Stadnicka / Klaudia Pałucka / Karolina Depa

Journal of Education, Health and Sport, Vol 7, Iss 3, Pp 258-

opinions of medical school students

2017 Volume 272

Abstract: Technological advances in the 20th c. and development of neonatology have created a chance to survive for the infants born before term, underdeveloped and unable to survive outside the mother’s womb. The triumph of reason over nature has given newborns a ...

Abstract	Technological advances in the 20th c. and development of neonatology have created a chance to survive for the infants born before term, underdeveloped and unable to survive outside the mother’s womb. The triumph of reason over nature has given newborns a chance of undisturbed development, however there are infants who have no hopes to function independently, whose life is overburdened with pain and suffering. From the ethical point of view all activities undertaken by the medical staff require respect for the human being and individualized management. The issues like decision as to continue or withheld resuscitation, differentiation between persistant therapy and euthanasia, withdrawal from persistant life supporting therapy and treatment, the limits of decision making are the main dilemmas of the medical staff and parents. The purpose of study was to present opinions of the medical school students on the care of neonates born at the borderline of viability. The study was carried out in the group of 360 students of medical schools, 211 (58.6%) from the Medical University of Lublin, and 149 (41.4%) students of theMedicalUniversityinWrocław. The respondents were diagnostically surveyed by means of a questionnaire developed by the authors and evaluated by competent judges. The study was approved by the Ethical Board, Medical University of Lublin, No KE – 0254/180/2013. The results revealed that over half respondents stated that it is impassible to define the limit of neonate’s viability, i.e. maturity to live outsider the mother’s womb and that each baby should be approached individually. The majority of students believed that resuscitation of a newborn on the verge of viability is the right approach. Almost every fourth student thought that the question should consider parental opinion, and 1/3 believed that once started, the treatment should be continued in any situation.
Keywords	premature baby ; care ; resuscitation ; persistant life sustaining therapy ; Education ; L ; Sports ; GV557-1198.995 ; Medicine ; R
Subject code	170
Language	English
Publishing date	2017-02-01T00:00:00Z
Publisher	Kazimierz Wielki University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Therapeutic management and care provided for neonates at the borderline of viability

Journal of Education, Health and Sport, Vol 7, Iss

opinions of medical school students

2017 Volume 3

Abstract	Technological advances in the 20th c. and development of neonatology have created a chance to survive for the infants born before term, underdeveloped and unable to survive outside the mother’s womb. The triumph of reason over nature has given newborns a chance of undisturbed development, however there are infants who have no hopes to function independently, whose life is overburdened with pain and suffering. From the ethical point of view all activities undertaken by the medical staff require respect for the human being and individualized management. The issues like decision as to continue or withheld resuscitation, differentiation between persistant therapy and euthanasia, withdrawal from persistant life supporting therapy and treatment, the limits of decision making are the main dilemmas of the medical staff and parents. The purpose of study was to present opinions of the medical school students on the care of neonates born at the borderline of viability. The study was carried out in the group of 360 students of medical schools, 211 (58.6%) from the Medical University of Lublin, and 149 (41.4%) students of theMedicalUniversityinWrocław. The respondents were diagnostically surveyed by means of a questionnaire developed by the authors and evaluated by competent judges. The study was approved by the Ethical Board, Medical University of Lublin, No KE – 0254/180/2013. The results revealed that over half respondents stated that it is impassible to define the limit of neonate’s viability, i.e. maturity to live outsider the mother’s womb and that each baby should be approached individually. The majority of students believed that resuscitation of a newborn on the verge of viability is the right approach. Almost every fourth student thought that the question should consider parental opinion, and 1/3 believed that once started, the treatment should be continued in any situation.
Keywords	premature baby ; care ; resuscitation ; persistant life sustaining therapy ; Education ; L ; Sports ; GV557-1198.995 ; Medicine ; R
Subject code	170
Language	English
Publishing date	2017-02-01T00:00:00Z
Publisher	Kazimierz Wielki University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Dendritic cells: a critical player in cancer therapy?

Palucka, Anna Karolina / Ueno, Hideki / Fay, Joseph / Banchereau, Jacques

Journal of immunotherapy (Hagerstown, Md. : 1997)

2008 Volume 31, Issue 9, Page(s) 793–805

Abstract: Cancer immunotherapy seeks to mobilize a patient's immune system for therapeutic benefit. It can be passive, that is, transfer of immune effector cells (T cells) or proteins (antibodies), or active, that is, vaccination. Early clinical trials testing ... ...

Abstract	Cancer immunotherapy seeks to mobilize a patient's immune system for therapeutic benefit. It can be passive, that is, transfer of immune effector cells (T cells) or proteins (antibodies), or active, that is, vaccination. Early clinical trials testing vaccination with ex vivo generated dendritic cells (DCs) pulsed with tumor antigens provide a proof-of-principle that therapeutic immunity can be elicited. Yet, the clinical benefit measured by regression of established tumors in patients with stage IV cancer has been observed in a fraction of patients only. The next generation of DC vaccines is expected to generate large numbers of high avidity effector CD8 T cells and to overcome regulatory T cells and suppressive environment established by tumors, a major obstacle in metastatic disease. Therapeutic vaccination protocols will combine improved DC vaccines with chemotherapy to exploit immunogenic chemotherapy regimens. We foresee adjuvant vaccination in patients with resected tumors but at high risk of relapse to be based on in vivo targeting of DCs with fusion proteins containing anti-DCs antibodies, antigens from tumor stem/propagating cells, and DC activators.
MeSH term(s)	Animals ; Antigens, Neoplasm/immunology ; Antigens, Neoplasm/metabolism ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cancer Vaccines/therapeutic use ; Combined Modality Therapy ; Dendritic Cells/metabolism ; Dendritic Cells/pathology ; Humans ; Immunotherapy ; Neoplasm Staging ; Neoplasms/pathology ; Neoplasms/therapy ; T-Lymphocyte Subsets/metabolism ; T-Lymphocyte Subsets/pathology ; Tumor Escape/immunology
Chemical Substances	Antigens, Neoplasm ; Cancer Vaccines
Language	English
Publishing date	2008-10-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1064067-8
ISSN	1537-4513 ; 1053-8550 ; 1524-9557
ISSN (online)	1537-4513
ISSN	1053-8550 ; 1524-9557
DOI	10.1097/CJI.0b013e31818403bc
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1778: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: IFN priming is necessary but not sufficient to turn on a migratory dendritic cell program in lupus monocytes.

Rodriguez-Pla, Alicia / Patel, Pinakeen / Maecker, Holden T / Rossello-Urgell, Jose / Baldwin, Nicole / Bennett, Lynda / Cantrell, Victoria / Baisch, Jeanine / Punaro, Marilynn / Gotte, Alisa / Nassi, Lorien / Wright, Tracey / Palucka, Anna Karolina / Banchereau, Jacques / Pascual, Virginia

Journal of immunology (Baltimore, Md. : 1950)

2014 Volume 192, Issue 12, Page(s) 5586–5598

Abstract: Blood monocytes from children with systemic lupus erythematosus (SLE) behave similar to dendritic cells (DCs), and SLE serum induces healthy monocytes to differentiate into DCs in a type I IFN-dependent manner. In this study, we found that these ... ...

Abstract	Blood monocytes from children with systemic lupus erythematosus (SLE) behave similar to dendritic cells (DCs), and SLE serum induces healthy monocytes to differentiate into DCs in a type I IFN-dependent manner. In this study, we found that these monocytes display significant transcriptional changes, including a prominent IFN signature, compared with healthy controls. Few of those changes, however, explain DC function. Exposure to allogeneic T cells in vitro reprograms SLE monocytes to acquire DC phenotype and function, and this correlates with both IFN-inducible (IP10) and proinflammatory cytokine (IL-1β and IL6) expression. Furthermore, we found that both IFN and SLE serum induce the upregulation of CCR7 transcription in these cells. CCR7 protein expression, however, requires a second signal provided by TLR agonists such as LPS. Thus, SLE serum "primes" a subset of monocytes to readily (<24 h) respond to TLR agonists and acquire migratory DC properties. Our findings might explain how microbial infections exacerbate lupus.
MeSH term(s)	Adolescent ; Adult ; Cell Movement/immunology ; Child ; Cytokines/immunology ; Dendritic Cells/immunology ; Dendritic Cells/pathology ; Female ; Humans ; Interferon Type I/immunology ; Lipopolysaccharides/pharmacology ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/pathology ; Receptors, CCR7/immunology ; Toll-Like Receptors/agonists ; Toll-Like Receptors/immunology
Chemical Substances	CCR7 protein, human ; Cytokines ; Interferon Type I ; Lipopolysaccharides ; Receptors, CCR7 ; Toll-Like Receptors
Language	English
Publishing date	2014-05-14
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1301319
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition.

Immunity

2016 Volume 44, Issue 4, Page(s) 924–938

Abstract: Large numbers of melanoma lesions develop resistance to targeted inhibition of mutant BRAF or fail to respond to checkpoint blockade. We explored whether modulation of intratumoral antigen-presenting cells (APCs) could increase responses to these ... ...

Abstract	Large numbers of melanoma lesions develop resistance to targeted inhibition of mutant BRAF or fail to respond to checkpoint blockade. We explored whether modulation of intratumoral antigen-presenting cells (APCs) could increase responses to these therapies. Using mouse melanoma models, we found that CD103(+) dendritic cells (DCs) were the only APCs transporting intact antigens to the lymph nodes and priming tumor-specific CD8(+) T cells. CD103(+) DCs were required to promote anti-tumoral effects upon blockade of the checkpoint ligand PD-L1; however, PD-L1 inhibition only led to partial responses. Systemic administration of the growth factor FLT3L followed by intratumoral poly I:C injections expanded and activated CD103(+) DC progenitors in the tumor, enhancing responses to BRAF and PD-L1 blockade and protecting mice from tumor rechallenge. Thus, the paucity of activated CD103(+) DCs in tumors limits checkpoint-blockade efficacy and combined FLT3L and poly I:C therapy can enhance tumor responses to checkpoint and BRAF blockade.
MeSH term(s)	Animals ; Antigen Presentation/immunology ; Antigens, CD/metabolism ; B7-H1 Antigen/antagonists & inhibitors ; CD8-Positive T-Lymphocytes/immunology ; Cell Line, Tumor ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Integrin alpha Chains/metabolism ; Melanoma, Experimental/immunology ; Mice, Inbred C57BL ; Mice, Knockout ; Poly I-C/pharmacology ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; fms-Like Tyrosine Kinase 3/pharmacology
Chemical Substances	Antigens, CD ; B7-H1 Antigen ; Cd274 protein, mouse ; Integrin alpha Chains ; alpha E integrins ; Flt3 protein, mouse (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1) ; Braf protein, mouse (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Poly I-C (O84C90HH2L)
Language	English
Publishing date	2016-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2016.03.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors.

Piqueras, Bernard / Connolly, John / Freitas, Heidi / Palucka, Anna Karolina / Banchereau, Jacques

Blood

2005 Volume 107, Issue 7, Page(s) 2613–2618

Abstract: Host response to viral infection involves distinct effectors of innate and adaptive immunity, whose mobilization needs to be coordinated to ensure protection. Here we show that influenza virus triggers, in human blood dendritic-cell (DC) subsets (ie, ... ...

Abstract	Host response to viral infection involves distinct effectors of innate and adaptive immunity, whose mobilization needs to be coordinated to ensure protection. Here we show that influenza virus triggers, in human blood dendritic-cell (DC) subsets (ie, plasmacytoid and myeloid DCs), a coordinated chemokine (CK) secretion program with 3 successive waves. The first one, occurring at early time points (2 to 4 hours), includes CKs potentially attracting effector cells such as neutrophils, cytotoxic T cells, and natural killer (NK) cells (CXCL16, CXCL1, CXCL2, and CXCL3). The second one occurs within 8 to 12 hours and includes CKs attracting effector memory T cells (CXCL8, CCL3, CCL4, CCL5, CXCL9, CXCL10, and CXCL11). The third wave, which occurs after 24 to 48 hours, when DCs have reached the lymphoid organs, includes CCL19, CCL22, and CXCL13, which attract naive T and B lymphocytes. Thus, human blood DC subsets carry a common program of CK production, which allows for a coordinated attraction of the different immune effectors in response to viral infection.
MeSH term(s)	Antigen-Presenting Cells/immunology ; CD4-Positive T-Lymphocytes/immunology ; Cell Movement ; Cytokines/classification ; Cytokines/genetics ; Dendritic Cells/classification ; Dendritic Cells/immunology ; Dendritic Cells/virology ; Epithelial Cells/immunology ; Humans ; Immunologic Memory ; Kinetics ; Oligonucleotide Array Sequence Analysis ; Orthomyxoviridae/immunology ; Transcription, Genetic
Chemical Substances	Cytokines
Language	English
Publishing date	2005-11-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2005-07-2965
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells.

Li, Dapeng / Romain, Gabrielle / Flamar, Anne-Laure / Duluc, Dorothée / Dullaers, Melissa / Li, Xiao-Hua / Zurawski, Sandra / Bosquet, Nathalie / Palucka, Anna Karolina / Le Grand, Roger / O'Garra, Anne / Zurawski, Gerard / Banchereau, Jacques / Oh, Sangkon

The Journal of experimental medicine

2012 Volume 209, Issue 1, Page(s) 109–121

Abstract: Dendritic cells (DCs) can initiate and shape host immune responses toward either immunity or tolerance by their effects on antigen-specific CD4(+) T cells. DC-asialoglycoprotein receptor (DC-ASGPR), a lectinlike receptor, is a known scavenger receptor. ... ...

Abstract	Dendritic cells (DCs) can initiate and shape host immune responses toward either immunity or tolerance by their effects on antigen-specific CD4(+) T cells. DC-asialoglycoprotein receptor (DC-ASGPR), a lectinlike receptor, is a known scavenger receptor. Here, we report that targeting antigens to human DCs via DC-ASGPR, but not lectin-like oxidized-LDL receptor, Dectin-1, or DC-specific ICAM-3-grabbing nonintegrin favors the generation of antigen-specific suppressive CD4(+) T cells that produce interleukin 10 (IL-10). These findings apply to both self- and foreign antigens, as well as memory and naive CD4(+) T cells. The generation of such IL-10-producing CD4(+) T cells requires p38/extracellular signal-regulated kinase phosphorylation and IL-10 induction in DCs. We further demonstrate that immunization of nonhuman primates with antigens fused to anti-DC-ASGPR monoclonal antibody generates antigen-specific CD4(+) T cells that produce IL-10 in vivo. This study provides a new strategy for the establishment of antigen-specific IL-10-producing suppressive T cells in vivo by targeting whole protein antigens to DCs via DC-ASGPR.
MeSH term(s)	Animals ; Antigens/immunology ; Antigens/metabolism ; Asialoglycoprotein Receptor/metabolism ; CD4-Positive T-Lymphocytes/immunology ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Interleukin-10/biosynthesis ; Ligands ; Macaca ; Male ; Scavenger Receptors, Class E/metabolism ; Signal Transduction
Chemical Substances	Antigens ; Asialoglycoprotein Receptor ; Ligands ; OLR1 protein, human ; Scavenger Receptors, Class E ; Interleukin-10 (130068-27-8) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
Language	English
Publishing date	2012-01-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20110399
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 45: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Glioma progression is shaped by genetic evolution and microenvironment interactions

Varn, Frederick S. / Johnson, Kevin C. / Martínek, Jan / Huse, Jason T. / Nasrallah, MacLean P. / Wesseling, Pieter / Cooper, Lee A.D. / Malta, Tathiane M. / Wade, Taylor E. / Sabedot, Thais S. / Brat, Daniel / Gould, Peter V. / Wöehrer, Adelheid / Aldape, Kenneth / Ismail, Azzam / Sivajothi, Santhosh K. / Barthel, Floris P. / Kim, Hun / Kocakavuk, Emre /

Ahmed, Nazia / White, Kieron / Datta, Indrani / Moon, Hyo-Eun / Pollock, Steven / Goldfarb, Christine / Lee, Ga-Hyun / Garofano, Luciano / Anderson, Kevin J. / Nehar-Belaid, Djamel / Barnholtz-Sloan, Jill S. / Bakas, Spyridon / Byrne, Annette T. / D’Angelo, Fulvio / Gan, Hui K. / Khasraw, Mustafa / Migliozzi, Simona / Ormond, D. Ryan / Paek, Sun Ha / Van Meir, Erwin G. / Walenkamp, Annemiek M.E. / Watts, Colin / Weiss, Tobias / Weller, Michael / Palucka, Karolina / Stead, Lucy F. / Poisson, Laila M. / Noushmehr, Houtan / Iavarone, Antonio / Verhaak, Roel G.W. / Martinek, Jan / Ryan Ormond, D. / Ha Paek, Sun / Alfaro, Kristin D. / Amin, Samirkumar B. / Ashley, David M. / Bock, Christoph / Brodbelt, Andrew / Bulsara, Ketan R. / Castro, Ana Valeria / Connelly, Jennifer M. / Costello, Joseph F. / de Groot, John F. / Finocchiaro, Gaetano / French, Pim J. / Golebiewska, Anna / Hau, Ann C. / Hong, Chibo / Horbinski, Craig / Kannan, Kasthuri S. / Kouwenhoven, Mathilde CM. / Lasorella, Anna / LaViolette, Peter S. / Ligon, Keith L. / Lowman, Allison K. / Mehta, Shwetal / Miletic, Hrvoje / Molinaro, Annette M. / Ng, Ho Keung / Niclou, Simone P. / Niers, Johanna M. / Phillips, Joanna J. / Rabadán, Raúl / Rao, Ganesh / Reifenberger, Guido / Sanai, Nader / Short, Susan C. / Sillevis Smitt, Peter / Sloan, Andrew E. / Smits, Marion / Snyder, James M. / Suzuki, Hiromichi / Tabatabai, Ghazaleh / Tanner, Georgette / Tomaszewski, William H. / Wells, Michael / Westerman, Bart A. / Wheeler, Helen / Xie, Jichun / Alfred Yung, W.K. / Zadeh, Gelareh / Zhao, Junfei / Verhaak, Roel GW.

Elsevier Inc. Cell. 2022 June 09, v. 185, no. 12 p.2184-2199.e16

2022

Abstract: The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients ... ...

Institution	The GLASS Consortium
Abstract	The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant glioma. Tumors recurred in distinct manners that were dependent on IDH mutation status and attributable to changes in histological feature composition, somatic alterations, and microenvironment interactions. Hypermutation and acquired CDKN2A deletions were associated with an increase in proliferating neoplastic cells at recurrence in both glioma subtypes, reflecting active tumor growth. IDH-wild-type tumors were more invasive at recurrence, and their neoplastic cells exhibited increased expression of neuronal signaling programs that reflected a possible role for neuronal interactions in promoting glioma progression. Mesenchymal transition was associated with the presence of a myeloid cell state defined by specific ligand-receptor interactions with neoplastic cells. Collectively, these recurrence-associated phenotypes represent potential targets to alter disease progression.
Keywords	DNA ; RNA ; adults ; disease progression ; evolution ; glioma ; histology ; isocitrate dehydrogenase ; mutation ; neurons ; therapeutics ; glioblastoma ; genomics ; treatment resistance ; microenvironment ; hypermutation ; macrophages ; single-cell ; spatial imaging
Language	English
Dates of publication	2022-0609
Size	p. 2184-2199.e16.
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2022.04.038
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 75/702: Show issues
Z 93: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED