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  1. Article ; Online: Engraftment of adult hematopoietic stem and progenitor cells in a novel model of humanized mice.

    Yu, Chun I / Maser, Rick / Marches, Florentina / Banchereau, Jacques / Palucka, Karolina

    iScience

    2024  Volume 27, Issue 3, Page(s) 109238

    Abstract: Pre-clinical use of humanized mice transplanted with ... ...

    Abstract Pre-clinical use of humanized mice transplanted with CD34
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mouse models for immuno-oncology.

    Bosenberg, Marcus / Liu, Edison T / Yu, Chun I / Palucka, Karolina

    Trends in cancer

    2023  Volume 9, Issue 7, Page(s) 578–590

    Abstract: Realizing the clinical promise of cancer immunotherapy is hindered by gaps in our knowledge of in vivo mechanisms underlying treatment response as well as treatment limiting toxicity. Preclinical in vivo model systems and technologies are required to ... ...

    Abstract Realizing the clinical promise of cancer immunotherapy is hindered by gaps in our knowledge of in vivo mechanisms underlying treatment response as well as treatment limiting toxicity. Preclinical in vivo model systems and technologies are required to address these knowledge gaps and to surmount the challenges faced in the clinical application of immunotherapy. Mice are commonly used for basic and translational research to support development and testing of immune interventions, including for cancer. Here, we discuss the advantages and the limitations of current models as well as future developments.
    MeSH term(s) Animals ; Mice ; Neoplasms/drug therapy ; Medical Oncology ; Disease Models, Animal ; Translational Research, Biomedical ; Immunotherapy
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2023.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Long-term engraftment of adult hematopoietic progenitors in a novel model of humanized mice.

    Yu, Chun I / Maser, Rick / Marches, Florentina / Banchereau, Jacques / Palucka, Karolina

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Pre-clinical use of humanized mice transplanted with CD34 : Summary: Pre-clinical use of humanized mice is limited by insufficient engraftment with adult hematopoietic progenitor cells (HPCs). Here, we developed a novel immunodeficient mice which ... ...

    Abstract Pre-clinical use of humanized mice transplanted with CD34
    Summary: Pre-clinical use of humanized mice is limited by insufficient engraftment with adult hematopoietic progenitor cells (HPCs). Here, we developed a novel immunodeficient mice which support long-term engraftment with adult bone marrow HPCs and facilitate building autologous models for immuno-oncology studies.
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.02.560534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Q&A: Evidence presenter. Interview by Marian Turner.

    Palucka, Karolina

    Nature

    2013  Volume 504, Issue 7480, Page(s) S9

    MeSH term(s) Antigens, Neoplasm/immunology ; Cancer Vaccines/immunology ; Cancer Vaccines/therapeutic use ; Clinical Trials as Topic/trends ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Dendritic Cells/transplantation ; GPI-Linked Proteins/immunology ; Humans ; Immunotherapy ; Male ; Pancreatic Neoplasms/immunology ; Pancreatic Neoplasms/therapy ; Precision Medicine/trends ; Treatment Outcome
    Chemical Substances Antigens, Neoplasm ; Cancer Vaccines ; GPI-Linked Proteins ; mesothelin
    Language English
    Publishing date 2013-12-19
    Publishing country England
    Document type Interview
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/504S9a
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  5. Book: Dendritic cells and macrophages in cancer therapy

    Palucka, Karolina

    Dr. Jekyll and Mr. Hyde

    2015  

    Abstract: CIT): Immunology Interest Group Dr. Karolina Palucka is an internationally recognized ... and associate director of cancer immunology in 2014. Prior to joining JAX, Karolina was the Michael ... sciences and clinical immunology at Mt. Sinai School of Medicine in New York. Karolina is a leader ...

    Institution National Institutes of Health (U.S.). / Immunology Interest Group,
    Author's details Karolina Palucka ; Immunology Interest Group
    Abstract (CIT): Immunology Interest Group Dr. Karolina Palucka is an internationally recognized clinical oncologist and cancer immunologist. She joined The Jackson Laboratory for Genomic Medicine (JAX) as professor and associate director of cancer immunology in 2014. Prior to joining JAX, Karolina was the Michael A.E. Ramsay Chair for Cancer Immunology Research and director of the Ralph M. Steinman Center for Cancer Vaccines at the Baylor Institute for Immunology Research in Dallas, where she was principal investigator of a large research award from the Human Immunology Project Consortium. She is also professor of oncological sciences and clinical immunology at Mt. Sinai School of Medicine in New York. Karolina is a leader in the field of cancer immunotherapy. Her research exploits dendritic cells, which control the body"s immune response to tumors, as the basis for new vaccines against melanomas and other human cancers. By combining outstanding cutting-edge immunology and experimental models, including humanized mice, with human trials, she is advancing the field of cancer immunotherapy and her talks bring together basic and translational work into an exciting whole.
    MeSH term(s) Neoplasms/therapy ; Cancer Vaccines ; Neoplasms/immunology ; Dendritic Cells/immunology ; Macrophages/immunology
    Language English
    Size 1 online resource (1 streaming video file (1 hr., 5 min.)) :, color, sound
    Document type Book
    Note Closed-captioned. ; Access restricted to HHS only.
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Article ; Online: Diversity and collaboration for effective immunotherapy.

    Palucka, Karolina / Banchereau, Jacques

    Nature medicine

    2016  Volume 22, Issue 12, Page(s) 1390–1391

    Language English
    Publishing date 2016-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm.4249
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  7. Article ; Online: Immunotherapy: Cancer vaccines on the move.

    Banchereau, Jacques / Palucka, Karolina

    Nature reviews. Clinical oncology

    2017  Volume 15, Issue 1, Page(s) 9–10

    MeSH term(s) Cancer Vaccines/immunology ; Cancer Vaccines/therapeutic use ; Humans ; Immunologic Factors ; Immunotherapy/trends ; Neoplasms/immunology ; Neoplasms/therapy
    Chemical Substances Cancer Vaccines ; Immunologic Factors
    Language English
    Publishing date 2017-09-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/nrclinonc.2017.149
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    Zs.A 6029: Show issues Location:
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  8. Article: Computational immune synapse analysis reveals T-cell interactions in distinct tumor microenvironments.

    Wang, Victor / Liu, Zichao / Martinek, Jan / Zhou, Jie / Boruchov, Hannah / Ray, Kelly / Palucka, Karolina / Chuang, Jeffrey

    Research square

    2023  

    Abstract: The tumor microenvironment (TME) and the cellular interactions within it can be critical to tumor progression and treatment response. Although technologies to generate multiplex images of the TME are advancing, the many ways in which TME imaging data can ...

    Abstract The tumor microenvironment (TME) and the cellular interactions within it can be critical to tumor progression and treatment response. Although technologies to generate multiplex images of the TME are advancing, the many ways in which TME imaging data can be mined to elucidate cellular interactions are only beginning to be realized. Here, we present a novel approach for multipronged computational immune synapse analysis (CISA) that reveals T-cell synaptic interactions from multiplex images. CISA enables automated discovery and quantification of immune synapse interactions based on the localization of proteins on cell membranes. We first demonstrate the ability of CISA to detect T-cell:APC (antigen presenting cell) synaptic interactions in two independent human melanoma imaging mass cytometry (IMC) tissue microarray datasets. We then generate melanoma histocytometry whole slide images and verify that CISA can detect similar interactions across data modalities. Interestingly, CISA histoctyometry analysis also reveals that T-cell:macrophage synapse formation is associated with T-cell proliferation. We next show the generality of CISA by extending it to breast cancer IMC images, finding that CISA quantifications of T-cell:B-cell synapses are predictive of improved patient survival. Our work demonstrates the biological and clinical significance of spatially resolving cell-cell synaptic interactions in the TME and provides a robust method to do so across imaging modalities and cancer types.
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2968528/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Developing and validating model systems for immuno-oncology.

    McCarthy, Claire E / Zahir, Nastaran / Eljanne, Mariam / Sharon, Elad / Voest, Emile E / Palucka, Karolina

    Cancer cell

    2021  Volume 39, Issue 8, Page(s) 1018–1022

    Abstract: Owing to clinical success of immune-checkpoint blockade, immunotherapy is becoming a cornerstone of modern oncology, and immuno-oncology is at the forefront of basic cancer research. This commentary outlines future opportunities for immuno-oncology ... ...

    Abstract Owing to clinical success of immune-checkpoint blockade, immunotherapy is becoming a cornerstone of modern oncology, and immuno-oncology is at the forefront of basic cancer research. This commentary outlines future opportunities for immuno-oncology modeling.
    MeSH term(s) Aging/immunology ; Animals ; Databases, Factual ; Dogs ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immunotherapy/methods ; Medical Oncology/methods ; Mice ; Neoplasms/immunology ; Neoplasms/therapy ; Neoplasms, Experimental ; Organ Culture Techniques ; Translational Research, Biomedical/methods
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2021-06-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2021.05.017
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  10. Article ; Online: Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults.

    Ravichandran, Sathyabaarathi / Erra-Diaz, Fernando / Karakaslar, Onur E / Marches, Radu / Kenyon-Pesce, Lisa / Rossi, Robert / Chaussabel, Damien / Nehar-Belaid, Djamel / LaFon, David C / Pascual, Virginia / Palucka, Karolina / Paust, Silke / Nahm, Moon H / Kuchel, George A / Banchereau, Jacques / Ucar, Duygu

    Nature immunology

    2024  Volume 25, Issue 2, Page(s) 316–329

    Abstract: Pneumococcal infections cause serious illness and death among older adults. The capsular polysaccharide vaccine PPSV23 and conjugated alternative PCV13 can prevent these infections; yet, underlying immunological responses and baseline predictors remain ... ...

    Abstract Pneumococcal infections cause serious illness and death among older adults. The capsular polysaccharide vaccine PPSV23 and conjugated alternative PCV13 can prevent these infections; yet, underlying immunological responses and baseline predictors remain unknown. We vaccinated 39 older adults (>60 years) with PPSV23 or PCV13 and observed comparable antibody responses (day 28) and plasmablast transcriptional responses (day 10); however, the baseline predictors were distinct. Analyses of baseline flow cytometry and bulk and single-cell RNA-sequencing data revealed a baseline phenotype specifically associated with weaker PCV13 responses, which was characterized by increased expression of cytotoxicity-associated genes, increased frequencies of CD16
    MeSH term(s) Male ; Humans ; Female ; Aged ; Vaccines, Conjugate ; Antibodies, Bacterial ; Double-Blind Method ; Streptococcus pneumoniae ; Vaccination ; Pneumococcal Vaccines ; Polysaccharides
    Chemical Substances Vaccines, Conjugate ; Antibodies, Bacterial ; Pneumococcal Vaccines ; Polysaccharides
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01717-5
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