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Article: Author's response.

Lipscomb, Mary F

2024 Volume 11, Issue 1, Page(s) 100105

Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819382-9
ISSN	2374-2895
ISSN	2374-2895
DOI	10.1016/j.acpath.2023.100105
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Lung macrophages and dendritic cells in health and disease

Lipscomb, Mary F.

(Lung biology in health and disease ; 102)

1997

Author's details	ed. by Mary F. Lipscomb
Series title	Lung biology in health and disease ; 102
Collection
Keywords	Lung Diseases / immunology ; Macrophages, Alveolar / immunology ; Dendritic cells / immunology ; Lunge ; Makrophage ; Dendritische Zelle ; Immunreaktion ; Alveolarphagozyt
Subject	Makrozyt ; Makrocyt ; Makrophagen ; Abwehrreaktion ; Immunantwort ; Immunoreaktivität ; Immunabwehr ; Alveolarmakrophage ; Macrophagocytus alveolaris ; Pulmo
Language	English
Size	XXIII, 855 S. : Ill., graph. Darst.
Edition	1. print.
Publisher	Dekker
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT007530793
ISBN	0-8247-9817-1 ; 978-0-8247-9817-8
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
1997 A 6086	order for loan	Magazin

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Article: Gender differences in appointments to pathology department interim chair positions and subsequent advancement to permanent chair positions.

Lipscomb, Mary F / Joste, Nancy E / Markwood, Madeleine / Bailey, David N / Hansel, Donna E / Jorda, Merce / Leonard, Debra G B / Powell, Deborah / Rojiani, Amyn M / Shin, Sandra J / Thor, Ann

Academic pathology

2023 Volume 10, Issue 2, Page(s) 100082

Abstract: Females are under-represented as departmental chairs in academic medical centers and identifying ways to increase their numbers in this position would be useful. A previous study of women chairs of pathology showed that 35% of permanent chairs had ... ...

Abstract	Females are under-represented as departmental chairs in academic medical centers and identifying ways to increase their numbers in this position would be useful. A previous study of women chairs of pathology showed that 35% of permanent chairs had previously been interim chairs, suggesting that the interim position was a common pathway for women to advance to a permanent chair position. We sought to determine whether it might also be true for males and if not, possible reasons for the difference. Between January 2016 and June 2022, the Association of Pathology Chairs identified 50 people who had served as interim pathology department chairs. Males served as interim chairs more often than females (66% vs 34%), but, within this time frame, female interim chairs were more likely to become permanent chairs than males (47% of females compared to 27% of males). To better understand the difference in the rate of advancement from interim to permanent chair, we surveyed the 50 individuals who had served as interim chairs to explore gender differences in backgrounds, reasons for serving as interim chairs and reasons for seeking or not seeking the permanent chair position. No significant gender differences were found except that male interim chairs were older (59.2 years) than female interim chairs (50.4 years). This study affirms that serving as an interim chair is a common pathway for females to become permanent chairs, while it is less so for males, although the reasons for this difference could not be determined.
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819382-9
ISSN	2374-2895
ISSN	2374-2895
DOI	10.1016/j.acpath.2023.100082
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Article: What Advice Current Pathology Chairs Seek From Former Chairs.

Bailey, David N / Cohen, Stanley / Gotlieb, Avrum / Lipscomb, Mary F / Sanfilippo, Fred

Academic pathology

2018 Volume 5, Page(s) 2374289518807397

Abstract: The 2018 Association of Pathology Chairs annual meeting included a panel discussion of Association of Pathology Chairs senior fellows (former chairs of academic departments of pathology who have remained active in Association of Pathology Chairs) about ... ...

Abstract	The 2018 Association of Pathology Chairs annual meeting included a panel discussion of Association of Pathology Chairs senior fellows (former chairs of academic departments of pathology who have remained active in Association of Pathology Chairs) about the type of advice that current (sitting) pathology chairs ask them. To inform the panel discussion, information was obtained from the senior fellows by e-mail and subsequent conference call. Of the 33 respondents, 24 (73%) had provided consultation advice (9, <5; 11, 5-10; 2, 10-20; and 2, >20). Most (>75%) of the consultations were provided face-to-face and outside the framework of Association of Pathology Chairs, with 70% of those seeking advice being well known by the consultant(s). Of the senior fellows providing advice, 71% had themselves sought consultation from former pathology chairs and 75% from nonpathology chairs. Modest correlation was found between the number of consultations senior fellows sought when they were chairs and the number of consultations they subsequently provided. The most frequent topics of consultation were strategic planning, balancing the missions, setting department priorities, recruitment of faculty and staff, conflict management, issues specific to new chairs, and resource (money/space) issues. Those who had provided such advice the longest and to the most people indicated that there was no significant change in the type of questions asked over time. Former department chairs can be a valuable source of counseling for current chairs, and organizations of department chairs should consider formalizing the use of these individuals as consultants to sitting chairs.
Language	English
Publishing date	2018-10-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819382-9
ISSN	2374-2895
ISSN	2374-2895
DOI	10.1177/2374289518807397
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Life After Being a Pathology Department Chair II: Lessons Learned.

Bailey, David N / Lipscomb, Mary F / Gorstein, Fred / Wilkinson, David / Sanfilippo, Fred

Academic pathology

2017 Volume 4, Page(s) 2374289517733734

Abstract: The 2016 Association of Pathology Chairs annual meeting featured a discussion group of Association of Pathology Chairs senior fellows (former chairs of academic departments of pathology who have remained active in Association of Pathology Chairs) that ... ...

Abstract	The 2016 Association of Pathology Chairs annual meeting featured a discussion group of Association of Pathology Chairs senior fellows (former chairs of academic departments of pathology who have remained active in Association of Pathology Chairs) that focused on how they decided to transition from the chair, how they prepared for such transition, and what they did after the transition. At the 2017 annual meeting, the senior fellows (encompassing 481 years of chair service) discussed lessons they learned from service as chair. These lessons included preparation for the chairship, what they would have done differently as chair, critical factors for success as chair, factors associated with failures, stress reduction techniques for themselves and for their faculty and staff, mechanisms for dealing with and avoiding problems, and the satisfaction they derived from their service as chair. It is reasonable to assume that these lessons may be representative of those learned by chairs of other specialties as well as by higher-level academic administrators such as deans, vice presidents, and chief executive officers. Although the environment for serving as a department chair has been changing dramatically, many of the lessons learned by former chairs are still valuable for current chairs of any length of tenure.
Language	English
Publishing date	2017-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819382-9
ISSN	2374-2895
ISSN	2374-2895
DOI	10.1177/2374289517733734
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Article: Life After Being a Pathology Department Chair III: Reflections on the "Afterlife".

Bailey, David N / Buja, L Maximilian / Gorstein, Fred / Gotlieb, Avrum / Green, Ralph / Kane, Agnes / Lipscomb, Mary F / Sanfilippo, Fred

Academic pathology

2019 Volume 6, Page(s) 2374289519846068

Abstract: The Association of Pathology Chairs Senior Fellows Group provided reflections on activities that have kept them engaged and inspired after stepping down as chair. They offered advice to current chairs who were considering leaving their positions and also ...

Abstract	The Association of Pathology Chairs Senior Fellows Group provided reflections on activities that have kept them engaged and inspired after stepping down as chair. They offered advice to current chairs who were considering leaving their positions and also to individuals contemplating becoming pathology chairs. A majority (35/41) responded: 60% maintained teaching/mentoring activities; 43% engaged in hobbies; 40% took other administrative positions including deans, medical center chief executive officers, and residency program directors; 31% continued research; 28% wrote books; 20% performed community service; 14% led professional organizations; 14% developed specialized programs; 11% engaged in clinical service; and 11% performed entrepreneurial activities. Most individuals had several of these activities. One-third indicated that those considering becoming chair should be able to place faculty and department needs before their own. One-fourth emphasized the need to know why one wants to become chair, the need to develop clear goals, and the need to know what one wants to accomplish as chair before applying for and accepting the position. More than half (57%) indicated that before stepping down as chair, one should have a clear plan and/or professional goals that can be served by stepping down. Some even suggested that this be in place before applying for the chair. Almost two-thirds (63%) indicated they had no regrets stepping down as chair. These findings may be valuable to those contemplating stepping down from or stepping into any department chair position or other academic leadership role.
Language	English
Publishing date	2019-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819382-9
ISSN	2374-2895
ISSN	2374-2895
DOI	10.1177/2374289519846068
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Article: Women in Academic Pathology: Pathways to Department Chair.

Lipscomb, Mary F / Bailey, David N / Howell, Lydia P / Johnson, Rebecca / Joste, Nancy / Leonard, Debra G B / Markwood, Priscilla / Pinn, Vivian W / Powell, Deborah / Thornburg, MarieAnn / Zander, Dani S

Academic pathology

2021 Volume 8, Page(s) 23742895211010322

Abstract: The Association of Pathology Chairs, an organization of American and Canadian academic pathology departments, has a record percent of women department chairs in its ranks (31%), although still not representative of the percent of women pathology faculty ( ...

Abstract	The Association of Pathology Chairs, an organization of American and Canadian academic pathology departments, has a record percent of women department chairs in its ranks (31%), although still not representative of the percent of women pathology faculty (43%). These women chairs were surveyed to determine what had impeded and what had facilitated their academic advancement before becoming chairs. The 2 most frequently identified impediments to their career advancement were heavy clinical loads and the lack of time, training, and/or funding to pursue research. Related to the second impediment, only one respondent became chair of a department which was in a top 25 National Institutes of Health-sponsored research medical school. Eighty-nine percent of respondents said that they had experienced gender bias during their careers in pathology, and 31% identified gender bias as an important impediment to advancement. The top facilitator of career advancement before becoming chairs was a supportive family. Strikingly, 98% of respondents have a spouse or partner, 75% have children, and 38% had children younger than 18 when becoming chairs. Additional top facilitators were opportunities to attend national meetings and opportunities to participate in leadership. Previous leadership experiences included directing a clinical service, a residency training program, and/or a medical student education program. These results suggest important ways to increase the success of women in academic pathology and increasing the percent of women department chairs, including supporting a family life and providing time, encouragement and resources for research, attending national meetings, and taking on departmental leadership positions.
Language	English
Publishing date	2021-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819382-9
ISSN	2374-2895
ISSN	2374-2895
DOI	10.1177/23742895211010322
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Article: Life After Being a Pathology Department Chair: Issues and Opportunities.

Bailey, David N / Lipscomb, Mary F / Gorstein, Fred / Wilkinson, David / Sanfilippo, Fred

Academic pathology

2016 Volume 3, Page(s) 2374289516673651

Abstract: Although there is a considerable literature on transition of faculty members to the position of department chair, there is a dearth of publications about transitioning from the chair to other activities including retirement. The Association of Pathology ... ...

Abstract	Although there is a considerable literature on transition of faculty members to the position of department chair, there is a dearth of publications about transitioning from the chair to other activities including retirement. The Association of Pathology Chairs senior fellows (all of whom are former chairs of academic departments of pathology) made this topic a focus of discussion at the Association of Pathology Chairs 2016 Annual Meeting. Of the 33 senior fellows engaged in this discussion, following their time as chairs, a small majority (18) transitioned to other administrative posts within or outside the university, while the others either returned to the active faculty (7) or retired (8). The motivating factors and influences for transitioning from the chair were probed along with the processes used in executing the transition, such as the development of transition plans. The reasons for selecting the specific type of postchair activity were also investigated. There was extraordinary diversity in the type of post-chair activities pursued. To our knowledge, no other medical specialty has examined these issues, which may be potentially relevant for the career planning of active chairs.
Language	English
Publishing date	2016-10-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819382-9
ISSN	2374-2895
ISSN	2374-2895
DOI	10.1177/2374289516673651
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Article: Effect of Bacillus anthracis virulence factors on human dendritic cell activation.

Hahn, Andrew C / Lyons, C Rick / Lipscomb, Mary F

Human immunology

2008 Volume 69, Issue 9, Page(s) 552–561

Abstract: Bacillus anthracis possesses three primary virulence factors: capsule, lethal toxin (LT), and edema toxin (ET). Dendritic cells (DCs) are critical to innate and acquired immunity and represent potential targets for these factors. We examined the ability ... ...

Abstract	Bacillus anthracis possesses three primary virulence factors: capsule, lethal toxin (LT), and edema toxin (ET). Dendritic cells (DCs) are critical to innate and acquired immunity and represent potential targets for these factors. We examined the ability of B. anthracis spores and bacilli to stimulate human monocyte-derived DC (MDDC), primary myeloid DC (mDC), and plasmacytoid DC (pDC) cytokine secretion. Exposure of MDDCs and mDCs to spores or vegetative bacilli of the genetically complete strain UT500 induced significantly increased cytokine secretion. Spores lacking genes required for capsule biosynthesis stimulated significantly higher cytokine secretion than UT500 spores from mDCs, but not MDDCs. In contrast, bacilli lacking capsule stimulated significantly higher cytokine secretion than UT500 bacilli in both MDDCs and mDCs. Spores or bacilli lacking both LT and ET stimulated significantly higher cytokine secretion than UT500 spores or bacilli, respectively, in both mDCs and MDDCs. pDCs exposed to spores or bacilli did not produce significant amounts of cytokines even when virulence factors were absent. In conclusion, B. anthracis employs toxins as well as capsule to inhibit human MDDC and mDC cytokine secretion, whereas human pDCs respond poorly even when capsule or both toxins are absent.
MeSH term(s)	Bacillus anthracis/metabolism ; Bacillus anthracis/pathogenicity ; Cytokines/biosynthesis ; Cytokines/immunology ; Cytokines/metabolism ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Humans ; Spores, Bacterial/metabolism ; Spores, Bacterial/pathogenicity ; Virulence Factors/immunology ; Virulence Factors/metabolism
Chemical Substances	Cytokines ; Virulence Factors
Language	English
Publishing date	2008-07-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	801524-7
ISSN	1879-1166 ; 0198-8859
ISSN (online)	1879-1166
ISSN	0198-8859
DOI	10.1016/j.humimm.2008.06.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dendritic cells: immune regulators in health and disease.

Lipscomb, Mary F / Masten, Barbara J

Physiological reviews

2002 Volume 82, Issue 1, Page(s) 97–130

Abstract: Dendritic cells (DCs) are bone marrow-derived cells of both lymphoid and myeloid stem cell origin that populate all lymphoid organs including the thymus, spleen, and lymph nodes, as well as nearly all nonlymphoid tissues and organs. Although DCs are a ... ...

Abstract	Dendritic cells (DCs) are bone marrow-derived cells of both lymphoid and myeloid stem cell origin that populate all lymphoid organs including the thymus, spleen, and lymph nodes, as well as nearly all nonlymphoid tissues and organs. Although DCs are a moderately diverse set of cells, they all have potent antigen-presenting capacity for stimulating naive, memory, and effector T cells. DCs are members of the innate immune system in that they can respond to dangers in the host environment by immediately generating protective cytokines. Most important, immature DCs respond to danger signals in the microenvironment by maturing, i.e., differentiating, and acquiring the capacity to direct the development of primary immune responses appropriate to the type of danger perceived. The powerful adjuvant activity that DCs possess in stimulating specific CD4 and CD8 T cell responses has made them targets in vaccine development strategies for the prevention and treatment of infections, allograft reactions, allergic and autoimmune diseases, and cancer. This review addresses the origins and migration of DCs to their sites of activity, their basic biology as antigen-presenting cells, their roles in important human diseases and, finally, selected strategies being pursued to harness their potent antigen-stimulating activity.
MeSH term(s)	Animals ; Dendritic Cells/physiology ; Humans ; Immune System/physiology ; Immune System/physiopathology ; Immune System Diseases/physiopathology ; Neoplasms/physiopathology ; Reference Values
Language	English
Publishing date	2002-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	209902-0
ISSN	1522-1210 ; 0031-9333
ISSN (online)	1522-1210
ISSN	0031-9333
DOI	10.1152/physrev.00023.2001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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