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  1. Article: Possible Efficacy of Vedolizumab, an Anti-α4β7 Integrin Antibody, in Palmoplantar Pustulosis.

    Terui, Hitoshi / Moroi, Rintaro / Masamune, Atsushi / Aiba, Setsuya / Yamasaki, Kenshi

    Case reports in dermatology

    2023  Volume 15, Issue 1, Page(s) 22–25

    Abstract: Palmoplantar pustulosis (PPP) is a chronic skin inflammatory disease in which blisters and pustules repeatedly develop on palms and soles. PPP is often refractory to topical therapy, oral therapy, phototherapy, and biologics that are usually applied for ... ...

    Abstract Palmoplantar pustulosis (PPP) is a chronic skin inflammatory disease in which blisters and pustules repeatedly develop on palms and soles. PPP is often refractory to topical therapy, oral therapy, phototherapy, and biologics that are usually applied for PPP. We report a patient with PPP improved by vedolizumab (anti-α4β7 integrin antibody) treatment for ulcerative colitis, suggesting the possibility of a new molecular target for PPP therapy.
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2505300-0
    ISSN 1662-6567
    ISSN 1662-6567
    DOI 10.1159/000529080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Author reply to antibiotics in SAPHO syndrome.

    Terui, Hitoshi / Segawa, Yuichiro / Otake, Eika / Omori, Ryoko / Tsuchiyama, Kenichiro / Kikuchi, Katsuko / Yamasaki, Kenshi / Aiba, Setsuya / Asano, Yoshihide

    The Journal of dermatology

    2023  Volume 51, Issue 1, Page(s) e26

    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Significance of Immunosuppressive Cells as a Target for Immunotherapies in Melanoma and Non-Melanoma Skin Cancers.

    Fujimura, Taku / Aiba, Setsuya

    Biomolecules

    2020  Volume 10, Issue 8

    Abstract: Tumor-associated macrophages (TAMs) have been detected in most skin cancers. TAMs produce various chemokines and angiogenic factors that promote tumor development, along with other immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs), ...

    Abstract Tumor-associated macrophages (TAMs) have been detected in most skin cancers. TAMs produce various chemokines and angiogenic factors that promote tumor development, along with other immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated neutrophils. TAMs generated from monocytes develop into functional, fully activated macrophages, and TAMs obtain various immunosuppressive functions to maintain the tumor microenvironment. Since TAMs express PD1 to maintain the immunosuppressive M2 phenotype by PD1/PD-L1 signaling from tumor cells, and the blockade of PD1/PD-L1 signaling by anti-PD1 antibodies (Abs) activate and re-polarize TAMs into immunoreactive M1 phenotypes, TAMs represent a potential target for anti-PD1 Abs. The main population of TAMs comprises CD163
    MeSH term(s) Humans ; Immunotherapy/methods ; Macrophages/immunology ; Melanoma/immunology ; Melanoma/therapy ; Myeloid-Derived Suppressor Cells/immunology ; Neutrophils/immunology ; Signal Transduction/immunology ; Skin Neoplasms/immunology ; Skin Neoplasms/therapy ; T-Lymphocytes, Regulatory/immunology ; Tumor Microenvironment/immunology
    Language English
    Publishing date 2020-07-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom10081087
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  4. Article ; Online: Phosphor-signal transducers and activator of transcription 1 signaling in mucosal lichen planus developing from metastatic bladder cancer treated with pembrolizumab.

    Tamabuchi, Erika / Fujimura, Taku / Lyu, Chunbing / Aiba, Setsuya

    Dermatologic therapy

    2021  Volume 34, Issue 4, Page(s) e14961

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Humans ; Lichen Planus/chemically induced ; Lichen Planus/drug therapy ; Transducers ; Urinary Bladder Neoplasms/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.14961
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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Topical and Systemic Formulation Options for Cutaneous T Cell Lymphomas.

    Fujimura, Taku / Amagai, Ryo / Kambayashi, Yumi / Aiba, Setsuya

    Pharmaceutics

    2021  Volume 13, Issue 2

    Abstract: Although various anti-cutaneous T-cell lymphoma (CTCL) therapies are available for clinical use, appropriate chemotherapy lines for the treatment of CTCLs have yet to be established. Therefore, to date, various clinical trials for the treatment of ... ...

    Abstract Although various anti-cutaneous T-cell lymphoma (CTCL) therapies are available for clinical use, appropriate chemotherapy lines for the treatment of CTCLs have yet to be established. Therefore, to date, various clinical trials for the treatment of advanced CTCLs are ongoing. In this review, we evaluate the therapeutic options that are available in clinical practice for treatment of early- and advanced-stage CTCLs (targeted therapies, histone deacetylase (HDAC) inhibitors, retinoids, interferons, cytotoxic drugs, etc.). We also examine clinical trials of novel regimens for the treatment of CTCLs.
    Language English
    Publishing date 2021-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13020200
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  6. Article ; Online: The Antimicrobial Peptide Cathelicidin Exerts Immunomodulatory Effects via Scavenger Receptors.

    Amagai, Ryo / Takahashi, Toshiya / Terui, Hitoshi / Fujimura, Taku / Yamasaki, Kenshi / Aiba, Setsuya / Asano, Yoshihide

    International journal of molecular sciences

    2023  Volume 24, Issue 1

    Abstract: An active form of cathelicidin antimicrobial peptide, LL-37, has immunomodulatory and stimulatory effects, though the specific pathways are not clear. The purpose of this study was to identify the cellular pathways by which LL-37 amplifies the ... ...

    Abstract An active form of cathelicidin antimicrobial peptide, LL-37, has immunomodulatory and stimulatory effects, though the specific pathways are not clear. The purpose of this study was to identify the cellular pathways by which LL-37 amplifies the inflammation induced by damage-associated molecular patterns (DAMPs). We performed DNA microarray, reverse transcription polymerase chain reaction, immunoblotting, and proximity ligation assays using cultured keratinocytes treated with LL-37 and/or the DAMP poly(I:C), a synthetic double-stranded RNA. In contrast to the combination of LL-37 and poly(I:C), LL-37 alone induced genes related to biological metabolic processes such as VEGFA and PTGS2 (COX-2). Inhibition of FPR2, a known receptor for cathelicidin, partially suppressed the induction of VEGFA and PTGS2. Importantly, VEGFA and PTGS2 induced by LL-37 alone were diminished by the knockdown of scavenger receptors including SCARB1 (SR-B1), OLR1 (SR-E1), and AGER (SR-J1). Moreover, LL-37 alone, as well as the combination of LL-37 and poly(I:C), showed proximity to the scavenger receptors, indicating that LL-37 acts via scavenger receptors and intermediates between them and poly(I:C). These results showed that the broad function of cathelicidin is generally dependent on scavenger receptors. Therefore, inhibitors of scavenger receptors or non-functional mock cathelicidin peptides may serve as new anti-inflammatory and immunosuppressive agents.
    MeSH term(s) Cathelicidins/immunology ; Cathelicidins/pharmacology ; Cyclooxygenase 2/genetics ; Poly I-C ; Receptors, Scavenger/immunology ; Humans ; Immunomodulation/genetics ; Immunomodulation/immunology
    Chemical Substances Cathelicidins ; Cyclooxygenase 2 (EC 1.14.99.1) ; Poly I-C (O84C90HH2L) ; Receptors, Scavenger ; CAMP protein, human
    Language English
    Publishing date 2023-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24010875
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  7. Article ; Online: Multiple angiolymphoid hyperplasia with eosinophilia on the right arm showing unusual presentation.

    Tamabuchi, Erika / Fujimura, Taku / Lyu, Chinbing / Aiba, Setsuya

    Dermatologic therapy

    2020  Volume 33, Issue 6, Page(s) e14314

    MeSH term(s) Angiolymphoid Hyperplasia with Eosinophilia/diagnosis ; Arm ; Humans ; Leukocyte Disorders
    Language English
    Publishing date 2020-09-28
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.14314
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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: The Antimicrobial Peptide Cathelicidin Exerts Immunomodulatory Effects via Scavenger Receptors

    Ryo Amagai / Toshiya Takahashi / Hitoshi Terui / Taku Fujimura / Kenshi Yamasaki / Setsuya Aiba / Yoshihide Asano

    International Journal of Molecular Sciences, Vol 24, Iss 1, p

    2023  Volume 875

    Abstract: An active form of cathelicidin antimicrobial peptide, LL-37, has immunomodulatory and stimulatory effects, though the specific pathways are not clear. The purpose of this study was to identify the cellular pathways by which LL-37 amplifies the ... ...

    Abstract An active form of cathelicidin antimicrobial peptide, LL-37, has immunomodulatory and stimulatory effects, though the specific pathways are not clear. The purpose of this study was to identify the cellular pathways by which LL-37 amplifies the inflammation induced by damage-associated molecular patterns (DAMPs). We performed DNA microarray, reverse transcription polymerase chain reaction, immunoblotting, and proximity ligation assays using cultured keratinocytes treated with LL-37 and/or the DAMP poly(I:C), a synthetic double-stranded RNA. In contrast to the combination of LL-37 and poly(I:C), LL-37 alone induced genes related to biological metabolic processes such as VEGFA and PTGS2 (COX-2). Inhibition of FPR2, a known receptor for cathelicidin, partially suppressed the induction of VEGFA and PTGS2. Importantly, VEGFA and PTGS2 induced by LL-37 alone were diminished by the knockdown of scavenger receptors including SCARB1 (SR-B1), OLR1 (SR-E1), and AGER (SR-J1). Moreover, LL-37 alone, as well as the combination of LL-37 and poly(I:C), showed proximity to the scavenger receptors, indicating that LL-37 acts via scavenger receptors and intermediates between them and poly(I:C). These results showed that the broad function of cathelicidin is generally dependent on scavenger receptors. Therefore, inhibitors of scavenger receptors or non-functional mock cathelicidin peptides may serve as new anti-inflammatory and immunosuppressive agents.
    Keywords cathelicidin ; scavenger receptors ; damage-associated molecular patterns (DAMPs) ; psoriasis ; innate immunity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Neutrophil Extracellular Traps as a Possible Pathomechanism of Generalized Acquired Cutis Laxa Associated with IgA-lamda Monoclonal Gammopathy of Undetermined Significance.

    Terui, Hitoshi / Yamasaki, Kenshi / Tamabuchi, Erika / Tsuchiyama, Kenichiro / Aiba, Setsuya

    Acta dermato-venereologica

    2021  Volume 101, Issue 9, Page(s) adv00536

    MeSH term(s) Cutis Laxa/diagnosis ; Extracellular Traps ; Humans ; Immunoglobulin A ; Monoclonal Gammopathy of Undetermined Significance ; Paraproteinemias/diagnosis
    Chemical Substances Immunoglobulin A
    Language English
    Publishing date 2021-09-03
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-3894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The IL-1 promoter-driven luciferase reporter cell line THP-G1b can efficiently predict skin-sensitising chemicals.

    Terui, Hitoshi / Kimura, Yutaka / Fujimura, Chizu / Aiba, Setsuya

    Archives of toxicology

    2021  Volume 95, Issue 5, Page(s) 1647–1657

    Abstract: IL-1 functions as an essential pro-inflammatory mediator for the sensitisation of allergic contact dermatitis (ACD). However, studies conducted to date have typically used a limited number of haptens and examined their effects only on murine ACD or ... ...

    Abstract IL-1 functions as an essential pro-inflammatory mediator for the sensitisation of allergic contact dermatitis (ACD). However, studies conducted to date have typically used a limited number of haptens and examined their effects only on murine ACD or murine dendritic cells (DCs). It therefore remains unclear whether IL-1α and/or IL-1β is produced in ACD induced by haptens other than those commonly used in mouse ACD models, and whether they are essential for sensitisation leading to ACD in humans. In addition, it is unclear whether human DCs also produce IL-1α or IL-1β after stimulation by haptens in general. Here, we first demonstrated that 10 haptens (3 extreme, 1 strong, 3 moderate and 3 weak) increased both IL-1α mRNA and IL-1β mRNA expression by the human monocyte cell line THP-1, a commonly used surrogate of DCs in in vitro skin sensitisation tests. Next, we constructed an in vitro skin sensitisation test using a stable IL-1β reporter cell line, THP-G1b, and evaluated whether 88 haptens and 34 non-haptens increase IL-1β reporter activity. We found that 94% of 77 haptens evaluated after considering their applicability domain and solubility in the chosen media stimulated reporter activity. These studies demonstrated that most haptens, irrespective of their potency, increased IL-1β mRNA expression by THP-1 cells, confirming that human DCs also produce IL-1β after stimulation by most haptens. The luciferase assay using THP-G1b cells is thus another skin sensitisation test based on the adverse outcome pathway with reasonable performance.
    MeSH term(s) Allergens ; Animal Testing Alternatives ; Animals ; Cell Line ; Dendritic Cells ; Dermatitis, Allergic Contact/diagnosis ; Haptens ; Humans ; In Vitro Techniques ; Interleukin-1alpha/metabolism ; Interleukin-8 ; Luciferases/metabolism ; Mice ; Monocytes ; Promoter Regions, Genetic ; Skin ; Skin Tests ; THP-1 Cells
    Chemical Substances Allergens ; Haptens ; IL1A protein, human ; Interleukin-1alpha ; Interleukin-8 ; Luciferases (EC 1.13.12.-)
    Language English
    Publishing date 2021-03-13
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 124992-7
    ISSN 1432-0738 ; 0340-5761
    ISSN (online) 1432-0738
    ISSN 0340-5761
    DOI 10.1007/s00204-021-03022-2
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