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  1. Article ; Online: Angina, a preoperative clinical sign for the development of delirium after transcatheter aortic valve implantation.

    Takeuchi, Masashi / Suzuki, Hideaki / Miyata, Satoshi / Ebihara, Satoru / Satoshi, Yasuda

    Geriatrics & gerontology international

    2023  Volume 23, Issue 12, Page(s) 971–972

    MeSH term(s) Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Risk Factors ; Risk Assessment ; Delirium/diagnosis ; Delirium/etiology ; Treatment Outcome ; Heart Valve Prosthesis Implantation
    Language English
    Publishing date 2023-10-31
    Publishing country Japan
    Document type Letter
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14707
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    Zs.A 5801: Show issues Location:
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  2. Article: Low-energy Ar

    Yoshimura, Satoru / Sugimoto, Satoshi / Takeuchi, Takae / Kiuchi, Masato

    Heliyon

    2023  Volume 9, Issue 4, Page(s) e14643

    Abstract: This study was conducted to determine whether the simultaneous injections of ... ...

    Abstract This study was conducted to determine whether the simultaneous injections of Ar
    Language English
    Publishing date 2023-03-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e14643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Spatial and Functional Crosstalk between the Mitochondrial Na

    Takeuchi, Ayako / Matsuoka, Satoshi

    International journal of molecular sciences

    2022  Volume 23, Issue 14

    Abstract: The mitochondrial ... ...

    Abstract The mitochondrial Na
    MeSH term(s) Calcium/metabolism ; HEK293 Cells ; Humans ; Mitochondria/metabolism ; Myocytes, Cardiac/metabolism ; Sarcoplasmic Reticulum/metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism ; Sodium-Calcium Exchanger/metabolism
    Chemical Substances Sodium-Calcium Exchanger ; Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23147948
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  4. Article ; Online: Long-Term Safety and Effectiveness of Tacrolimus in Patients With Lupus Nephritis in Japan: 10-Year Analysis of the Real-World TRUST Study.

    Takeuchi, Tsutomu / Wakasugi, Naoko / Hashida, Tetsuji / Uno, Satoshi / Makino, Hirofumi

    The Journal of rheumatology

    2024  

    Abstract: Objective: To assess the long-term safety and effectiveness of tacrolimus as maintenance therapy in patients with lupus nephritis (LN) receiving treatment in real-world clinical settings in Japan.: Methods: An open-label, noncomparative, ... ...

    Abstract Objective: To assess the long-term safety and effectiveness of tacrolimus as maintenance therapy in patients with lupus nephritis (LN) receiving treatment in real-world clinical settings in Japan.
    Methods: An open-label, noncomparative, observational, prospective postmarketing surveillance study was conducted in 1395 patients with LN receiving maintenance treatment with tacrolimus at 278 medical institutions across Japan over a period of 10 years. Tacrolimus continuation rate and cumulative incidence of adverse drug reactions (ADRs), relapse, progression to renal failure, and progression to dialysis were calculated using Kaplan-Meier analysis.
    Results: Safety data were available for 1355 patients, almost half (49.3%) of whom remained on tacrolimus for the full 10 years of follow-up. A significant reduction in mean (SD) daily oral corticosteroid dose was observed from 16.0 (9.7) mg/day at 4 weeks after initiation of tacrolimus treatment to 7.2 (4.4) mg/day at year 10 (
    Conclusion: Tacrolimus was effective and generally well tolerated as maintenance therapy for LN in a large cohort of patients in Japan followed for 10 years, almost half of whom remained on therapy for the entire duration of follow-up. (ClinicalTrials.gov: NCT01410747).
    Language English
    Publishing date 2024-04-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.2023-0210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1168: Show issues Location:
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    Zs.MO 135: Show issues

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  5. Article ; Online: Polyglucuronic acids prepared from α-(1 → 3)-glucan by TEMPO-catalytic oxidation.

    Chitbanyong, Korawit / Hou, Gaoyuan / Shibata, Izumi / Takeuchi, Miyuki / Kimura, Satoshi / Isogai, Akira

    Carbohydrate polymers

    2024  Volume 330, Page(s) 121813

    Abstract: 2,2,6,6-Tetramethylpiperidine-1-oxyl radical (TEMPO)-catalytic oxidation was applied to a water-insoluble α-(1 → 3)-glucan in water at pH 10 and room temperature (∼24 °C), with solid NaOCl· ... ...

    Abstract 2,2,6,6-Tetramethylpiperidine-1-oxyl radical (TEMPO)-catalytic oxidation was applied to a water-insoluble α-(1 → 3)-glucan in water at pH 10 and room temperature (∼24 °C), with solid NaOCl·5H
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2024.121813
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  6. Article ; Online: Photoexcited Plasmon-Driven Ultrafast Dynamics of the Adsorbate Probed by Femtosecond Time-Resolved Surface-Enhanced Time-Domain Raman Spectroscopy.

    Kumar, Pardeep / Kuramochi, Hikaru / Takeuchi, Satoshi / Tahara, Tahei

    The journal of physical chemistry letters

    2023  Volume 14, Issue 11, Page(s) 2845–2853

    Abstract: Metal nanoparticles have high potential in light-harvesting applications by transferring absorbed photon energy to the adsorbates. However, photoexcited plasmon-driven ultrafast dynamics of the adsorbate on metal nanoparticles have not been clearly ... ...

    Abstract Metal nanoparticles have high potential in light-harvesting applications by transferring absorbed photon energy to the adsorbates. However, photoexcited plasmon-driven ultrafast dynamics of the adsorbate on metal nanoparticles have not been clearly understood. We studied ultrafast plasmon-driven processes of trans-1,2-bis(4-pyridyl)ethylene (BPE) adsorbed on gold nanoparticle assemblies (GNAs) using time-resolved surface-enhanced impulsive stimulated Raman spectroscopy (TR-SE-ISRS). After photoexciting the localized surface plasmon resonance (LSPR) band of the GNAs, we measured femtosecond time-resolved surface-enhanced Raman spectra of the adsorbate, which exhibited transient bleach in the Raman signal and following biphasic recovery that proceeds on the time scale of a few tens of picoseconds. The TR-SE-ISRS data were analyzed with singular value decomposition, and the obtained species-associated Raman spectra indicated that photoexcitation of the LSPR band alters chemical interaction between BPE and the GNAs on an ultrafast time scale; initial steady-state BPE is recovered through a precursor state that has weaker interaction with the GNAs.
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.2c03813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Spatial and Functional Crosstalk between the Mitochondrial Na + -Ca 2+ Exchanger NCLX and the Sarcoplasmic Reticulum Ca 2+ Pump SERCA in Cardiomyocytes

    Ayako Takeuchi / Satoshi Matsuoka

    International Journal of Molecular Sciences, Vol 23, Iss 14, p

    2022  Volume 7948

    Abstract: The mitochondrial Na + -Ca 2+ exchanger, NCLX, was reported to supply Ca 2+ to sarcoplasmic reticulum (SR)/endoplasmic reticulum, thereby modulating various cellular functions such as the rhythmicity of cardiomyocytes, and cellular Ca 2+ signaling upon ... ...

    Abstract The mitochondrial Na + -Ca 2+ exchanger, NCLX, was reported to supply Ca 2+ to sarcoplasmic reticulum (SR)/endoplasmic reticulum, thereby modulating various cellular functions such as the rhythmicity of cardiomyocytes, and cellular Ca 2+ signaling upon antigen receptor stimulation and chemotaxis in B lymphocytes; however, there is little information on the spatial relationships of NCLX with SR Ca 2+ handling proteins, and their physiological impact. Here we examined the issue, focusing on the interaction of NCLX with an SR Ca 2+ pump SERCA in cardiomyocytes. A bimolecular fluorescence complementation assay using HEK293 cells revealed that the exogenously expressed NCLX was localized in close proximity to four exogenously expressed SERCA isoforms. Immunofluorescence analyses of isolated ventricular myocytes showed that the NCLX was localized to the edges of the mitochondria, forming a striped pattern. The co-localization coefficients in the super-resolution images were higher for NCLX–SERCA2, than for NCLX–ryanodine receptor and NCLX–Na + /K + ATPase α-1 subunit, confirming the close localization of endogenous NCLX and SERCA2 in cardiomyocytes. The mathematical model implemented with the spatial and functional coupling of NCLX and SERCA well reproduced the NCLX inhibition-mediated modulations of SR Ca 2+ reuptake in HL-1 cardiomyocytes. Taken together, these results indicated that NCLX and SERCA are spatially and functionally coupled in cardiomyocytes.
    Keywords mitochondria ; sarcoplasmic reticulum ; NCLX ; SERCA ; Ca 2+ signaling ; cardiomyocyte ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 333
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Minor contribution of NCX to Na

    Takeuchi, Ayako / Matsuoka, Satoshi

    Cell calcium

    2021  Volume 96, Page(s) 102386

    Abstract: NCLX was identified as a mitochondrial ... ...

    Abstract NCLX was identified as a mitochondrial Na
    MeSH term(s) Animals ; Brain/drug effects ; Brain/metabolism ; Cells, Cultured ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Mitochondria/metabolism ; Ruthenium Compounds/pharmacology ; Sodium-Calcium Exchanger/antagonists & inhibitors ; Sodium-Calcium Exchanger/metabolism
    Chemical Substances NCX1 protein, mouse ; Ru 360 ; Ruthenium Compounds ; Slc8b1protein, mouse ; Sodium-Calcium Exchanger
    Language English
    Publishing date 2021-03-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2021.102386
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1596: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Optogenetic control of medaka behavior with channelrhodopsin.

    Seki, Takahide / Takeuchi, Hideaki / Ansai, Satoshi

    Development, growth & differentiation

    2023  Volume 65, Issue 6, Page(s) 288–299

    Abstract: Optogenetics enables the manipulation of neural activity with high spatiotemporal resolution in genetically defined neurons. The method is widely used in various model animals in the neuroscience and physiology fields. Channelrhodopsins are robust tools ... ...

    Abstract Optogenetics enables the manipulation of neural activity with high spatiotemporal resolution in genetically defined neurons. The method is widely used in various model animals in the neuroscience and physiology fields. Channelrhodopsins are robust tools for optogenetic manipulation, but they have not yet been used for studies in medaka. In the present study, we used the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated knock-in approach to establish a transgenic medaka strain expressing the Chloromonas oogama channelrhodopsin (CoChR) in the ISL LIM homeobox 1 (isl1) locus. We demonstrated that light stimuli elicited specific behavioral responses, such as bending or turning locomotion in the embryos and pectoral fin movements in the larvae and adults. The response probabilities and intensities of these movements could be controlled by adjusting the intensity, duration, or wavelength of each light stimulus. Furthermore, we demonstrated that the pectoral fin movements in the adult stage could be elicited using a laser pointer to irradiate region including the caudal hind brain and the rostral spinal cord. Our results indicate that CoChR allows for manipulation of medaka behaviors by activating targeted neurons, which will further our understanding of the detailed neural mechanisms of motor control or social behaviors in medaka.
    MeSH term(s) Animals ; Channelrhodopsins/genetics ; Optogenetics/methods ; Oryzias/genetics ; Animals, Genetically Modified ; Light
    Chemical Substances Channelrhodopsins
    Language English
    Publishing date 2023-07-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 280433-5
    ISSN 1440-169X ; 0012-1592
    ISSN (online) 1440-169X
    ISSN 0012-1592
    DOI 10.1111/dgd.12872
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    Zs.A 194: Show issues Location:
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  10. Article ; Online: Physiological and Pathophysiological Roles of Mitochondrial Na

    Takeuchi, Ayako / Matsuoka, Satoshi

    Biomolecules

    2021  Volume 11, Issue 12

    Abstract: It has been over 10 years ... ...

    Abstract It has been over 10 years since
    MeSH term(s) Animals ; Energy Metabolism ; Humans ; Mitochondria, Heart/metabolism ; Mitochondrial Permeability Transition Pore ; Mitochondrial Proteins/chemistry ; Mitochondrial Proteins/metabolism ; Models, Molecular ; Myocytes, Cardiac/metabolism ; Protein Conformation ; Reactive Oxygen Species/metabolism ; Sodium-Calcium Exchanger/chemistry ; Sodium-Calcium Exchanger/metabolism
    Chemical Substances Mitochondrial Permeability Transition Pore ; Mitochondrial Proteins ; Reactive Oxygen Species ; SLC8B1 protein, human ; Sodium-Calcium Exchanger
    Language English
    Publishing date 2021-12-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11121876
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