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  1. Book ; Online: Chapter Use of RPAS to monitor coastal dune systems and beach erosion in Guardamar del Segura, Spain

    Pagán, José Ignacio / Bañón, Luis / ORTIZ GARCIA, PABLO / Aragonés, Luis / López, Isabel

    (Monitoring of Mediterranean Coastal Areas: Problems and Measurement Techniques)

    2022  

    Series title Monitoring of Mediterranean Coastal Areas: Problems and Measurement Techniques
    Keywords The environment ; RPAS ; Monitor ; Dune ; Changes ; Guardamar del Segura ; Erosion
    Language English
    Size 1 electronic resource (9 pages)
    Publisher Firenze University Press
    Publishing place Florence
    Document type Book ; Online
    Note English
    HBZ-ID HT030375881
    ISBN 9791221500301
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The effect of changes in saddle height on coordination and its variability during pedalling cycle.

    García-López, Juan / Ferrer-Roca, Ventura / Floría, Pablo

    Sports biomechanics

    2022  , Page(s) 1–14

    Abstract: Modifications in saddle height affect the range of movement of the lower limb's joints during pedalling. Although its effect on movement patterns is poorly understood. The purpose of this study was to analyse the acute effects of small changes in bicycle ...

    Abstract Modifications in saddle height affect the range of movement of the lower limb's joints during pedalling. Although its effect on movement patterns is poorly understood. The purpose of this study was to analyse the acute effects of small changes in bicycle saddle height on pedalling coordination and its variability. Lower extremity kinematic data were collected in random order for ten well-trained cyclists while pedalling at three different saddle heights: preferred, 2% higher and 2% lower than preferred position. A dynamical systems approach was used to quantify the coordination and its variability for selected joint couplings. Modifications in saddle height produced large changes in the frequency of movement patterns, although they were not enough to alter the coordination classification. Lowering the saddle height increased the frequency of the proximal coordinative hip-ankle pattern (
    Language English
    Publishing date 2022-08-09
    Publishing country England
    Document type Journal Article
    ISSN 1752-6116
    ISSN (online) 1752-6116
    DOI 10.1080/14763141.2022.2109510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in

    García-López, Miriam / Hernández, Pablo / Megias, Diego / Ferrándiz, María-José / Campa, Adela G de la

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: Topoisomerase I (TopoI) ... ...

    Abstract Topoisomerase I (TopoI) in
    MeSH term(s) Transcriptome ; DNA Topoisomerases, Type I/genetics ; DNA Topoisomerases, Type I/metabolism ; Streptococcus pneumoniae/genetics ; DNA Gyrase/genetics ; DNA Gyrase/metabolism ; Anti-Bacterial Agents/pharmacology
    Chemical Substances DNA Topoisomerases, Type I (EC 5.99.1.2) ; DNA Gyrase (EC 5.99.1.3) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Training Characteristics and Competitive Demands in Women Road Cyclists: A Systematic Review.

    Herrero-Molleda, Alba / Álvarez-Álvarez, María José / Floría, Pablo / García-López, Juan

    International journal of sports physiology and performance

    2023  Volume 18, Issue 8, Page(s) 794–804

    Abstract: Purpose: To identify the main training characteristics and competitive demands in women's road cycling.: Methods: A systematic search was conducted on 5 databases according to PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) ...

    Abstract Purpose: To identify the main training characteristics and competitive demands in women's road cycling.
    Methods: A systematic search was conducted on 5 databases according to PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. The articles had to be primary studies, written after 1990 with a sample of competitive women between the ages of 15 and 50. The Quality Assessment Tool for Quantitative Studies and the Oxford Levels of Evidence scales were used.
    Results: The search yielded 1713 articles, of which 20 were included. Studies on training and competitive demands (n = 5) found that both external and internal loads are higher in women than in men. Studies on strength and endurance training (n = 5) showed that both velocity-based and heavy-load strength training programs performed at least 2 days per week and including 3 to 4 lower-body exercises improved performance. Altitude-training studies (n = 3) found that "Live High-Train Low" was effective to increase performance during the first 9 days after the training camp. The 7 remaining studies focused on a range of topics. The methodological quality was strong for 12 studies and moderate for 8. In contrast, the level of evidence was high in 7 and low in the other 13.
    Conclusions: Endurance training and competitive demands in women's road cycling are higher than those of men. Strength training is effective in women when the frequency, intensity, and number of exercises are appropriate, while altitude training should be completed a few days before competing. Further studies are warranted to better define the participants' competitive level, using a methodological design with a higher level of evidence.
    MeSH term(s) Adolescent ; Adult ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Bicycling ; Databases, Factual ; Endurance Training ; Exercise ; Resistance Training
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ISSN 1555-0273
    ISSN (online) 1555-0273
    DOI 10.1123/ijspp.2023-0038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: MicroRNAs in Gingival Crevicular Fluid: An Observational Case-Control Study of Differential Expression in Periodontitis.

    Almiñana-Pastor, Pedro J / Alpiste-Illueca, Francisco M / Micó-Martinez, Pablo / García-Giménez, Jose Luis / García-López, Eva / López-Roldán, Andrés

    Non-coding RNA

    2023  Volume 9, Issue 6

    Abstract: Objectives: microRNAs (miRNAs) present in the gingival crevicular fluid (GCF) of patients with chronic periodontitis may serve as biomarkers of periodontal disease. The aim of this study was to perform a miRNA-sequencing study of all miRNAs present in ... ...

    Abstract Objectives: microRNAs (miRNAs) present in the gingival crevicular fluid (GCF) of patients with chronic periodontitis may serve as biomarkers of periodontal disease. The aim of this study was to perform a miRNA-sequencing study of all miRNAs present in GCF, comparing miRNA expression level profiles between advanced chronic periodontitis (CP) patients and healthy subjects (HS).
    Materials and methods: GCF samples were collected from the single-rooted teeth of patients with severe CP (
    Results: Of all the sequenced miRNAs, miR-199, miR-146a, miR-30a, and miR-338 were identified as best representing the CP patient samples. The validation study identified miR-199 as the most powerful biomarker used to define periodontitis.
    Conclusions: Upon sequencing all known miRNAs in GCF for the first time, we uncovered several potential biomarkers to define periodontitis. Identifying miRNAS in the GCF using high-throughput approaches will clarify the role of these molecules in periodontitis and provide biomarkers with potential applications.
    Language English
    Publishing date 2023-11-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813993-8
    ISSN 2311-553X ; 2311-553X
    ISSN (online) 2311-553X
    ISSN 2311-553X
    DOI 10.3390/ncrna9060073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Resurfacing of atrophic facial acne scars with a multimodality CO

    García, Pablo Naranjo / Andrino, Rodolfo Lopez

    Journal of cosmetic dermatology

    2024  Volume 23 Suppl 1, Page(s) 13–18

    Abstract: Background: Scarring is one of the most prevalent long-term complications of acne vulgaris and has cosmetic, psychological, and social burdens. Contemporary management programs integrate multiple modalities to best address the multiple factors ... ...

    Abstract Background: Scarring is one of the most prevalent long-term complications of acne vulgaris and has cosmetic, psychological, and social burdens. Contemporary management programs integrate multiple modalities to best address the multiple factors underlying their development and persistence. This work assessed the impact of sequential multimodal laser therapy on acne scar geometrics and texture.
    Methods: Adult patients (n = 16) with Fitzpatrick skin type II-IV and presenting with facial acne scars, underwent three combination ablative (CO
    Results: At baseline, all patients had both box and rolling scars, while only three had icepick scars. Six months following treatment, mean scar volume improved from 5.7 ± 5.2 mm
    Conclusion: Multimodal CO
    MeSH term(s) Adult ; Humans ; Cicatrix/etiology ; Cicatrix/radiotherapy ; Carbon Dioxide ; Laser Therapy/adverse effects ; Treatment Outcome ; Acne Vulgaris/etiology ; Atrophy/etiology ; Skin Abnormalities
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.16283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6539: Show issues Location:
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  7. Article: Design and Validation of a Clinical Outcome Measure for Adolescents and Adult Patients with Spinal Muscular Atrophy: SMA Life Study Protocol.

    Rebollo, Pablo / García-López, Sofía / Povedano, Mónica / Cattinari, María G / Martínez-Moreno, Mercedes / Terrancle, Ángeles / Cabello-Moruno, Rosana / Vázquez-Costa, Juan F

    Neurology and therapy

    2024  Volume 13, Issue 1, Page(s) 233–249

    Abstract: Introduction: The objective of this study is to develop a clinical tool for the evaluation and follow-up of adolescent and adult patients with 5q spinal muscular atrophy (SMA) and to design its validation.: Methods: This prospective, non- ... ...

    Abstract Introduction: The objective of this study is to develop a clinical tool for the evaluation and follow-up of adolescent and adult patients with 5q spinal muscular atrophy (SMA) and to design its validation.
    Methods: This prospective, non-interventional study will be carried out at five centres in Spain and will include patients aged 16 years or older with a confirmed diagnosis of 5q SMA (biallelic mutation of the survival motor neuron 1 [SMN1] gene). A panel of experts made up of neurologists, physiatrists and Spanish patients' association (FundAME), participated in the design of the clinical tool. Physicians will administer the tool at three time points (baseline, 12 months and 24 months). Additionally, data from other questionnaires and scales will be collected. Once recruitment is achieved, an interim statistical analysis will be performed to assess its psychometric properties by applying Rasch analysis and classical statistical tests.
    Results: The tool will consist of up to 53 items to assess functional status from a clinical perspective in seven key dimensions (bulbar, respiratory, axial, lower, upper, fatigability and other symptoms), which will be collected together with objective clinical measures (body mass index, forced vital capacity, pinch strength and 6-minute walk test).
    Conclusions: The validation of this tool will facilitate the clinical evaluation of adult and adolescent patients with SMA and the quantification of their response to new treatments in both clinical practice and research.
    Language English
    Publishing date 2024-01-05
    Publishing country New Zealand
    Document type Journal Article
    ISSN 2193-8253
    ISSN 2193-8253
    DOI 10.1007/s40120-023-00571-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Feasibility and Safety of Using Combined Light-Emitting Diodes Versus Intense Pulsed Light Technology for the Improvement of Facial Hypervascularization in Adult Patients.

    García, Pablo Naranjo / Andrino, Rodolfo López

    Photobiomodulation, photomedicine, and laser surgery

    2023  Volume 41, Issue 2, Page(s) 64–72

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Female ; Humans ; Male ; Face ; Feasibility Studies ; Intense Pulsed Light Therapy ; Low-Level Light Therapy/adverse effects ; Pain/etiology ; Skin ; Proof of Concept Study ; Prospective Studies
    Language English
    Publishing date 2023-02-11
    Publishing country United States
    Document type Journal Article
    ISSN 2578-5478
    ISSN (online) 2578-5478
    DOI 10.1089/photob.2022.0079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in Streptococcus pneumoniae

    Miriam García-López / Pablo Hernández / Diego Megias / María-José Ferrándiz / Adela G. de la Campa

    International Journal of Molecular Sciences, Vol 24, Iss 21, p

    2023  Volume 15800

    Abstract: Topoisomerase I (TopoI) in Streptococcus pneumoniae , encoded by topA , is a suitable target for drug development. Seconeolitsine (SCN) is a new antibiotic that specifically blocks this enzyme. We obtained the topARA mutant, which encodes an enzyme less ... ...

    Abstract Topoisomerase I (TopoI) in Streptococcus pneumoniae , encoded by topA , is a suitable target for drug development. Seconeolitsine (SCN) is a new antibiotic that specifically blocks this enzyme. We obtained the topARA mutant, which encodes an enzyme less active than the wild type ( topAWT ) and more resistant to SCN inhibition. Likely due to the essentiality of TopoI, we were unable to replace the topAWT allele by the mutant topARA version. We compared the in vivo activity of TopoIRA and TopoIWT using regulated overexpression strains, whose genes were either under the control of a moderately (P Zn ) or a highly active promoter (P Mal ). Overproduction of TopoIRA impaired growth, increased SCN resistance and, in the presence of the gyrase inhibitor novobiocin (NOV), caused lower relaxation than TopoIWT. Differential transcriptomes were observed when the topAWT and topARA expression levels were increased about 5-fold. However, higher increases (10–15 times), produced a similar transcriptome, affecting about 52% of the genome, and correlating with a high DNA relaxation level with most responsive genes locating in topological domains. These results confirmed that TopoI is indeed the target of SCN in S. pneumoniae and show the important role of TopoI in global transcription, supporting its suitability as an antibiotic target.
    Keywords DNA supercoiling ; DNA topoisomerase I ; seconeolitsine ; regulation of supercoiling ; transcriptional domains ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 572
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Correction to:  Identifcation and management of tomato brown rugose fruit virus in greenhouses in Mexico.

    Vargas-Mejía, Pablo / Rodríguez-Gómez, Gustavo / Salas-Aranda, Daniel A / García-López, Irving J / Pérez-Alfaro, Ruth S / de Dios, Emmanuel Ávila / Santoyo-Villa, J Natzul / Briseño, Ricardo I Alcalá / Silva-Rosales, Laura

    Archives of virology

    2023  Volume 168, Issue 5, Page(s) 151

    Language English
    Publishing date 2023-05-04
    Publishing country Austria
    Document type Published Erratum
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-023-05772-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.110: Show issues Location:
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