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Book: Dengue virus

Rothman, Alan L.

(Current topics in microbiology and immunology ; 338)

2010

Author's details	Alan L. Rothman, ed
Series title	Current topics in microbiology and immunology ; 338
Collection
Keywords	Denguevirus ; Denguefieber
Subject	Dengue ; Dandy-Fieber ; Dengue fever ; Pokalfieber
Language	English
Size	XV, 161 S. : graph. Darst.
Publisher	Springer
Publishing place	Heidelberg u.a.
Publishing country	Germany
Document type	Book
HBZ-ID	HT016123986
ISBN	978-3-642-02214-2 ; 9783642022159 ; 3-642-02214-6 ; 3642022154
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Viral Suppression of RIPK1-Mediated Signaling.

Udawatte, Darshika J / Rothman, Alan L

mBio

2021 Volume 12, Issue 4, Page(s) e0172321

Abstract: Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) has emerged as a key upstream regulator of cell death and inflammation. RIPK1-mediated signaling governs the outcome of signaling pathways initiated by tumor necrosis factor receptor 1 (TNFR1) ...

Abstract	Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) has emerged as a key upstream regulator of cell death and inflammation. RIPK1-mediated signaling governs the outcome of signaling pathways initiated by tumor necrosis factor receptor 1 (TNFR1), Toll-like receptor 3 (TLR3), TLR4, retinoic acid-inducible gene 1 (RIG-I)/melanoma differentiation-associated protein 5 (MDA-5), and Z-binding protein 1 (ZBP1) by signaling for NF-κB activation, mitogen-associated protein kinase (MAPK) and interferon regulatory factor 3/7 (IRF3/7) phosphorylation, and cell death via apoptosis and necroptosis. Both cell death and inflammatory responses play a major role in controlling virus infections. Therefore, viruses have evolved multifaceted mechanisms to exploit host immune responses by targeting RIPK1. This review focuses on the current understanding of RIPK1-mediated inflammatory and cell death pathways and multiple mechanisms by which viruses manipulate these pathways by targeting RIPK1. We also discuss gaps in our knowledge regarding RIPK1-mediated signaling pathways and highlight potential avenues for future research.
MeSH term(s)	Animals ; Apoptosis ; Cell Death ; Humans ; Inflammation/immunology ; Inflammation/pathology ; Mice ; NF-kappa B/metabolism ; Phosphorylation ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; Receptor-Interacting Protein Serine-Threonine Kinases/immunology ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Signal Transduction ; Virus Diseases/immunology
Chemical Substances	NF-kappa B ; Receptors, Tumor Necrosis Factor, Type I ; TNFRSF1A protein, human ; RIPK1 protein, human (EC 2.7.11.1) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2021-08-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mBio.01723-21
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immune-Based Interventions Against Infectious Disease - Impact of a Phase I Center for Biomedical Research Excellence in Translational Infectious Diseases Immunology.

Rothman, Alan L / Friedman, Jennifer / Kurtis, Jonathan D

Rhode Island medical journal (2013)

2021 Volume 104, Issue 2, Page(s) 34–38

Abstract: In 2011, faculty from the University of Rhode Island (URI)'s Institute for Immunology and Informatics and Lifespan's Center for International Health Research collaborated to develop a successful application for a Phase I Center of Biomedical Research ... ...

Abstract	In 2011, faculty from the University of Rhode Island (URI)'s Institute for Immunology and Informatics and Lifespan's Center for International Health Research collaborated to develop a successful application for a Phase I Center of Biomedical Research Excellence around the scientific theme of translational infectious diseases immunology. From 2013 to 2020, this COBRE supported significant discoveries in research on dengue, HIV, and malaria, among other diseases, and facilitated the career development of several independent Rhode Island (RI)-based early-stage investigators. Our experience illustrates both the potential and challenges for investigators with shared scientific interests to leverage the NIH COBRE program to enhance cross-institutional interactions.
MeSH term(s)	Biomedical Research ; Communicable Diseases/therapy ; Faculty ; Global Health ; Humans ; Rhode Island
Language	English
Publishing date	2021-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	419430-5
ISSN	2327-2228 ; 0363-7913
ISSN (online)	2327-2228
ISSN	0363-7913
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Article ; Online: DHIM supporting immunologic investigations and the identification of immune correlates of protection.

Rothman, Alan L

The Journal of infectious diseases

2014 Volume 209 Suppl 2, Page(s) S61–5

Abstract: Evidence suggesting that immune responses to dengue virus (DENV) have the potential for both beneficial and detrimental effects on the outcome of infection is a concern for dengue vaccine development. There is thus a great need to define measures of DENV- ...

Abstract	Evidence suggesting that immune responses to dengue virus (DENV) have the potential for both beneficial and detrimental effects on the outcome of infection is a concern for dengue vaccine development. There is thus a great need to define measures of DENV-specific immune responses that reliably indicate when immunity is protective. The existence of 4 main DENV serotypes and the difficulty in defining which individuals have been exposed and to which viruses present challenges to defining immune correlates of protective immunity against DENV in field efficacy studies; experimental infection studies in humans offer a pathway to address these challenges.
MeSH term(s)	Adaptive Immunity ; Animals ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Dengue/immunology ; Dengue/prevention & control ; Dengue Virus/classification ; Dengue Virus/immunology ; Humans ; Models, Biological
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2014-05-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiu111
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Article ; Online: The Injury Prevention Program to Reduce Early Childhood Injuries: A Cluster Randomized Trial.

Perrin, Eliana M / Skinner, Asheley C / Sanders, Lee M / Rothman, Russell L / Schildcrout, Jonathan S / Bian, Aihua / Barkin, Shari L / Coyne-Beasley, Tamera / Delamater, Alan M / Flower, Kori B / Heerman, William J / Steiner, Michael J / Yin, H Shonna

Pediatrics

2024

Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2023-062966
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Article ; Online: Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1.

Udawatte, Darshika J / Lang, Diane M / Currier, Jeffrey R / Medin, Carey L / Rothman, Alan L

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 926036

Abstract: Dengue virus (DENV) infection is the most prevalent arthropod-borne virus disease and is endemic in more than 100 countries. Several DENV proteins have been shown to target crucial human host proteins to evade innate immune responses and establish a ... ...

Abstract	Dengue virus (DENV) infection is the most prevalent arthropod-borne virus disease and is endemic in more than 100 countries. Several DENV proteins have been shown to target crucial human host proteins to evade innate immune responses and establish a productive infection. Here we report that the DENV NS3 protein targets RIPK1 (Receptor Interacting Protein Kinase I), a central mediator of inflammation and cell death, and decreases intracellular RIPK1 levels during DENV infection. The interaction of NS3 with RIPK1 results in the inhibition of NF-κB activation in response to TNFR or TLR3 stimulation. Also, we observed that the effects of NS3 on RIPK1 were independent of NS3 protease activity. Our data demonstrate a novel mechanism by which DENV suppresses normal cellular functions to evade host innate immune responses.
MeSH term(s)	Humans ; Dengue Virus ; NF-kappa B/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Signal Transduction ; Toll-Like Receptor 3/metabolism
Chemical Substances	NF-kappa B ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Receptors, Tumor Necrosis Factor, Type I ; RIPK1 protein, human (EC 2.7.11.1) ; TLR3 protein, human ; Toll-Like Receptor 3 ; TNFRSF1A protein, human
Language	English
Publishing date	2022-10-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.926036
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: T lymphocyte responses to flaviviruses - diverse cell populations affect tendency toward protection and disease.

Sanchez Vargas, Luis Alberto / Mathew, Anuja / Rothman, Alan L

Current opinion in virology

2020 Volume 43, Page(s) 28–34

Abstract: Dengue virus (DENV), Yellow Fever virus, West Nile virus, Japanese encephalitis virus and Zika virus are medically important flaviviruses transmitted to humans by mosquitoes and circulate in overlapping geographic areas. Cross-reactive immune responses ... ...

Abstract	Dengue virus (DENV), Yellow Fever virus, West Nile virus, Japanese encephalitis virus and Zika virus are medically important flaviviruses transmitted to humans by mosquitoes and circulate in overlapping geographic areas. Cross-reactive immune responses have been demonstrated among the flaviviruses, particularly the four DENV serotypes. The immunological imprint left by a flavivirus infection can therefore have profound effects on the responses to subsequent infections. In this review we summarize recent research focusing on T cell responses to DENV using clinical samples from prospective cohort studies in Asia. These data suggest that durability of different T cell populations after natural infection or vaccination is an important consideration for the outcome of subsequent flavivirus exposures and we argue for continued investigation in the context of longitudinal cohort studies.
MeSH term(s)	Animals ; Antibodies, Viral/immunology ; Cross Reactions ; Culicidae/physiology ; Culicidae/virology ; Flavivirus/genetics ; Flavivirus/immunology ; Flavivirus/physiology ; Flavivirus Infections/immunology ; Flavivirus Infections/prevention & control ; Flavivirus Infections/transmission ; Flavivirus Infections/virology ; Humans ; T-Lymphocytes/immunology
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2020-08-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2611378-8
ISSN	1879-6265 ; 1879-6257
ISSN (online)	1879-6265
ISSN	1879-6257
DOI	10.1016/j.coviro.2020.07.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Staging and clean room: Constructs designed to facilitate transparency and reduce bias in comparative analyses of real-world data.

Muntner, Paul / Hernandez, Rohini K / Kent, Shia T / Browning, James E / Gilbertson, David T / Hurwitz, Kathleen E / Jick, Susan S / Lai, Edward C / Lash, Timothy L / Monda, Keri L / Rothman, Kenneth J / Bradbury, Brian D / Brookhart, M Alan

Pharmacoepidemiology and drug safety

2024 Volume 33, Issue 3, Page(s) e5770

Abstract: Purpose: We describe constructs designed to protect the integrity of the results from comparative analyses using real-world data (RWD): staging and clean room.: Methods: Staging involves performing sequential preliminary analyses and evaluating the ... ...

Abstract	Purpose: We describe constructs designed to protect the integrity of the results from comparative analyses using real-world data (RWD): staging and clean room. Methods: Staging involves performing sequential preliminary analyses and evaluating the population size available and potential bias before conducting comparative analyses. A clean room involves restricted access to data and preliminary results, policies governing exploratory analyses and protocol deviations, and audit trail. These constructs are intended to allow decisions about protocol deviations, such as changes to design or model specification, to be made without knowledge of how they might affect subsequent analyses. We describe an example for implementing staging with a clean room. Results: Stage 1 may involve selecting a data source, developing and registering a protocol, establishing a clean room, and applying inclusion/exclusion criteria. Stage 2 may involve attempting to achieve covariate balance, often through propensity score models. Stage 3 may involve evaluating the presence of residual confounding using negative control outcomes. After each stage, check points may be implemented when a team of statisticians, epidemiologists and clinicians masked to how their decisions may affect study outcomes, reviews the results. This review team may be tasked with making recommendations for protocol deviations to address study precision or bias. They may recommend proceeding to the next stage, conducting additional analyses to address bias, or terminating the study. Stage 4 may involve conducting the comparative analyses. Conclusions: The staging and clean room constructs are intended to protect the integrity and enhance confidence in the results of analyses of RWD.
MeSH term(s)	Humans ; Bias ; Policy
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1099748-9
ISSN	1099-1557 ; 1053-8569
ISSN (online)	1099-1557
ISSN	1053-8569
DOI	10.1002/pds.5770
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Article ; Online: Language Disparities in Caregiver Satisfaction with Physician Communication at Well Visits from 0-2 Years.

Gutierrez-Wu, Jennifer C / Ritter, Victor / McMahon, Ellen L / Heerman, William J / Rothman, Russell L / Perrin, Eliana M / Shonna Yin, H / Sanders, Lee M / Delamater, Alan M / Flower, Kori B

Academic pediatrics

2024

Abstract: Objective: This study aimed to describe caregiver satisfaction with physician communication over the first two years of life and examine differences by preferred language and the relationship to physician continuity.: Methods: Longitudinal data were ... ...

Abstract	Objective: This study aimed to describe caregiver satisfaction with physician communication over the first two years of life and examine differences by preferred language and the relationship to physician continuity. Methods: Longitudinal data were collected at well visits (2 months to 2 years) from participants in a randomized controlled trial to prevent childhood obesity. Satisfaction with communication was assessed using the validated Communication Assessment Tool (CAT) questionnaire. Changes in the odds of optimal scores were estimated in mixed-effects logistic regression models to evaluate the associations between satisfaction over time and language, interpreter use, and physician continuity. Results: Of 865 caregivers, 35% were Spanish-speaking. Spanish-speaking caregivers without interpreters had lower odds of an optimal satisfaction score compared with English speakers during the first 2 years, beginning at 2 months [OR 0.64 (95% CI: 0.43, 0.95)]. There was no significant difference in satisfaction between English-speaking caregivers and Spanish-speaking caregivers with an interpreter. The odds of optimal satisfaction scores increased over time for both language groups. For both language groups, odds of an optimal satisfaction score decreased each time a new physician was seen for a visit [OR 0.82 (95% CI: 0.69, 0.97)]. Conclusion: Caregiver satisfaction with physician communication improves over the first two years of well-child visits for both English- and Spanish-speakers. A loss of physician continuity over time was also associated with lower satisfaction. Future interventions to ameliorate communication disparities should ensure adequate interpreter use for primarily Spanish-speaking patients and address continuity issues to improve communication satisfaction.
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2483385-X
ISSN	1876-2867 ; 1876-2859
ISSN (online)	1876-2867
ISSN	1876-2859
DOI	10.1016/j.acap.2024.03.004
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Article ; Online: Zika Virus: The Agent and Its Biology, With Relevance to Pathology.

Medin, Carey L / Rothman, Alan L

Archives of pathology & laboratory medicine

2017 Volume 141, Issue 1, Page(s) 33–42

Abstract: Once obscure, Zika virus (ZIKV) has attracted significant medical and scientific attention in the past year because of large outbreaks associated with the recent introduction of this virus into the Western hemisphere. In particular, the occurrence of ... ...

Abstract	Once obscure, Zika virus (ZIKV) has attracted significant medical and scientific attention in the past year because of large outbreaks associated with the recent introduction of this virus into the Western hemisphere. In particular, the occurrence of severe congenital infections and cases of Guillain-Barré syndrome has placed this virus squarely in the eyes of clinical and anatomic pathologists. This review article provides a basic introduction to ZIKV, its genetics, its structural characteristics, and its biology. A multidisciplinary effort will be essential to establish clinicopathologic correlations of the basic virology of ZIKV in order to advance development of diagnostics, therapeutics, and vaccines.
MeSH term(s)	Brazil/epidemiology ; Disease Outbreaks ; Genome, Viral/genetics ; Guillain-Barre Syndrome/complications ; Guillain-Barre Syndrome/epidemiology ; Humans ; Microcephaly/complications ; Microcephaly/epidemiology ; Polynesia/epidemiology ; Uganda/epidemiology ; Zika Virus/genetics ; Zika Virus/isolation & purification ; Zika Virus/physiology ; Zika Virus Infection/complications ; Zika Virus Infection/epidemiology ; Zika Virus Infection/virology
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/arpa.2016-0409-RA
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