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Article ; Online: Contribution to the taxonomy of Lobellini (Collembola: Neanurinae) and investigations on luminous Collembola from Japan.

Ohira, Atsuko / Nakamori, Taizo / Matsumoto, Sachi / Bessho-Uehara, Manabu / Kato, Takumi / Oba, Yuichi

Zootaxa

2023 Volume 5325, Issue 1, Page(s) 63–89

Abstract: Lobella sauteri was redescribed based on the lectotype and specimens obtained from the type locality Bugenji, Yokohama, Kanagawa, as the true identity of the luminous Collembola, Lobella sp. Lobella sauteri has morphological traits characteristic of the ... ...

Abstract	Lobella sauteri was redescribed based on the lectotype and specimens obtained from the type locality Bugenji, Yokohama, Kanagawa, as the true identity of the luminous Collembola, Lobella sp. Lobella sauteri has morphological traits characteristic of the genus currently called Telobella. As L. sauteri is the type species of Lobella, the genus Telobella was synonymised with Lobella according to the principle of priority, and the genus Lobella was redefined to include both the species previously assigned to Telobella and those previously assigned to Lobella. A new species Lobella monstrum sp. nov. was described and new combinations were proposed for certain species in Lobellini. Light-emitting capacity was confirmed in L. sauteri and newly reported in Lobella yambaru comb. nov. Vitronura giselae and Vitronura kunigamiensis.
MeSH term(s)	Animals ; Japan ; Arthropods
Language	English
Publishing date	2023-08-07
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5325.1.4
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Article ; Online: Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells.

Asano, Satoshi / Ono, Ami / Baba, Kaede / Uehara, Teru / Sakamoto, Kotaro / Hayata-Takano, Atsuko / Nakazawa, Takanobu / Yanamoto, Souichi / Tanimoto, Kotaro / Hashimoto, Hitoshi / Ago, Yukio

Journal of pharmacological sciences

2024 Volume 154, Issue 3, Page(s) 139–147

Abstract: Vasoactive intestinal peptide (VIP) receptor 2 (VIPR2) is a G protein-coupled receptor that binds to Gαs, Gαi, and Gαq proteins to regulate various downstream signaling molecules, such as protein kinase A (PKA), phosphatidylinositol 3-kinase (PI3K), and ... ...

Abstract	Vasoactive intestinal peptide (VIP) receptor 2 (VIPR2) is a G protein-coupled receptor that binds to Gαs, Gαi, and Gαq proteins to regulate various downstream signaling molecules, such as protein kinase A (PKA), phosphatidylinositol 3-kinase (PI3K), and phospholipase C. In this study, we examined the role of VIPR2 in cell cycle progression. KS-133, a newly developed VIPR2-selective antagonist peptide, attenuated VIP-induced cell proliferation in MCF-7 cells. The percentage of cells in the S-M phase was decreased in MCF-7 cells treated with KS-133. KS-133 in the presence of VIP decreased the phosphorylation of extracellular signal-regulated kinase (ERK), AKT, and glycogen synthase kinase-3β (GSK3β), resulting in a decrease in cyclin D1 levels. In MCF-7 cells stably-expressing VIPR2, KS-133 decreased PI3K activity and cAMP levels. Treatment with the ERK-specific kinase (MEK) inhibitor U0126 and the class I PI3K inhibitor ZSTK474 decreased the percentage of cells in the S phase. KS-133 reduced the percentage of cells in the S phase more than treatment with U0126 or ZSTK474 alone and did not affect the effect of the mixture of these inhibitors. Our findings suggest that VIPR2 signaling regulates cyclin D1 levels through the cAMP/PKA/ERK and PI3K/AKT/GSK3β pathways, and mediates the G1/S transition to control cell proliferation.
MeSH term(s)	Humans ; Cyclin D1/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; MCF-7 Cells ; Receptors, Vasoactive Intestinal Peptide, Type II ; Phosphatidylinositol 3-Kinases/metabolism ; Glycogen Synthase Kinase 3 beta ; Cell Division ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Cell Proliferation ; Phosphatidylinositol 3-Kinase ; Butadienes ; Nitriles ; Peptides, Cyclic
Chemical Substances	U 0126 ; Cyclin D1 (136601-57-5) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Receptors, Vasoactive Intestinal Peptide, Type II ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; KS-133 ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; VIPR2 protein, human ; Butadienes ; Nitriles ; Peptides, Cyclic
Language	English
Publishing date	2024-01-05
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1016/j.jphs.2024.01.002
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Article ; Online: Proton-pump Inhibitor-induced Severe Hypomagnesemia and Hypocalcemia are Clinically Masked by Thiazide Diuretic.

Uehara, Atsuko / Kita, Yohei / Sumi, Hirofumi / Shibagaki, Yugo

Internal medicine (Tokyo, Japan)

2019 Volume 58, Issue 15, Page(s) 2201–2205

Abstract: Hypomagnesemia, a side effect of proton-pump inhibitors (PPIs), can be asymptomatic. The presence of hypocalcemia or hypokalemia is indicative of hypomagnesemia; however, the concomitant use of PPIs and thiazide may mask hypocalcemia. A 79-year-old woman ...

Abstract	Hypomagnesemia, a side effect of proton-pump inhibitors (PPIs), can be asymptomatic. The presence of hypocalcemia or hypokalemia is indicative of hypomagnesemia; however, the concomitant use of PPIs and thiazide may mask hypocalcemia. A 79-year-old woman with a history of chronic heart failure and chronic kidney disease developed symptomatic hypocalcemia and hypomagnesemia. Five weeks earlier, she had developed thiazide-induced hyponatremia, so thiazide had been discontinued. Reviewing the patient's charts revealed that three discontinued thiazide administrations in the clinical course had unmasked hypocalcemia. Our case demonstrates that thiazide-induced hypercalcemia can be so prominent as to mask PPI-induced hypocalcemia and hypomagnesemia.
MeSH term(s)	Aged ; Female ; Heart Failure/drug therapy ; Humans ; Hypercalcemia/chemically induced ; Hypocalcemia/chemically induced ; Hypokalemia/chemically induced ; Hyponatremia/chemically induced ; Magnesium Deficiency/chemically induced ; Proton Pump Inhibitors/adverse effects ; Proton Pump Inhibitors/therapeutic use ; Sodium Chloride Symporter Inhibitors/adverse effects
Chemical Substances	Proton Pump Inhibitors ; Sodium Chloride Symporter Inhibitors
Language	English
Publishing date	2019-04-17
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2608-18
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Article ; Online: 2-Deoxy-d-glucose induces deglycosylation of proinflammatory cytokine receptors and strongly reduces immunological responses in mouse models of inflammation.

Uehara, Ikuno / Kajita, Mitsuko / Tanimura, Atsuko / Hida, Shigeaki / Onda, Munehiko / Naito, Zenya / Taki, Shinsuke / Tanaka, Nobuyuki

Pharmacology research & perspectives

2022 Volume 10, Issue 2, Page(s) e00940

Abstract: Anti-proinflammatory cytokine therapies against interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1 are major advancements in treating inflammatory diseases, especially rheumatoid arthritis. Such therapies are mainly performed by injection of ... ...

Abstract	Anti-proinflammatory cytokine therapies against interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1 are major advancements in treating inflammatory diseases, especially rheumatoid arthritis. Such therapies are mainly performed by injection of antibodies against cytokines or cytokine receptors. We initially found that the glycolytic inhibitor 2-deoxy-d-glucose (2-DG), a simple monosaccharide, attenuated cellular responses to IL-6 by inhibiting N-linked glycosylation of the IL-6 receptor gp130. Aglycoforms of gp130 did not bind to IL-6 or activate downstream intracellular signals that included Janus kinases. 2-DG completely inhibited dextran sodium sulfate-induced colitis, a mouse model for inflammatory bowel disease, and alleviated laminarin-induced arthritis in the SKG mouse, an experimental model for human rheumatoid arthritis. These diseases have been shown to be partially dependent on IL-6. We also found that 2-DG inhibited signals for other proinflammatory cytokines such as TNF-α, IL-1β, and interferon -γ, and accordingly, prevented death by another inflammatory disease, lipopolysaccharide (LPS) shock. Furthermore, 2-DG prevented LPS shock, a model for a cytokine storm, and LPS-induced pulmonary inflammation, a model for acute respiratory distress syndrome of coronavirus disease 2019 (COVID-19). These results suggest that targeted therapies that inhibit cytokine receptor glycosylation are effective for treatment of various inflammatory diseases.
MeSH term(s)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Cells, Cultured ; Cytokine Receptor gp130/antagonists & inhibitors ; Cytokine Receptor gp130/metabolism ; Cytokine Release Syndrome/prevention & control ; Cytokines/metabolism ; Deoxyglucose/pharmacology ; Glycosylation/drug effects ; Inflammation/chemically induced ; Inflammation/prevention & control ; Janus Kinases/drug effects ; Lipopolysaccharides ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Cytokine/drug effects ; Receptors, Cytokine/immunology ; Receptors, Cytokine/metabolism ; Receptors, Interleukin-6/antagonists & inhibitors ; Receptors, Interleukin-6/genetics ; Receptors, Interleukin-6/metabolism
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Cytokines ; Il6ra protein, mouse ; Il6st protein, mouse ; Lipopolysaccharides ; Receptors, Cytokine ; Receptors, Interleukin-6 ; Cytokine Receptor gp130 (133483-10-0) ; Deoxyglucose (9G2MP84A8W) ; Janus Kinases (EC 2.7.10.2)
Language	English
Publishing date	2022-02-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2740389-0
ISSN	2052-1707 ; 2052-1707
ISSN (online)	2052-1707
ISSN	2052-1707
DOI	10.1002/prp2.940
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Article: A case of fulminant

Fukui, Sayato / Kogawa, Rikitake / Hojo, Atsuko / Kawamura, Wataru / Kura, Yoshimasa / Monma, Chie / Uehara, Yuki / Sawada, Umihiko

IDCases

2021 Volume 24, Page(s) e01112

Abstract: A 69-year-old man was brought to our hospital by ambulance with a fever. The translucent pink color of the serum sample suggested severe hemolysis. His blood pressure dropped rapidly, and he later suffered a cardiopulmonary arrest and died approximately ... ...

Abstract	A 69-year-old man was brought to our hospital by ambulance with a fever. The translucent pink color of the serum sample suggested severe hemolysis. His blood pressure dropped rapidly, and he later suffered a cardiopulmonary arrest and died approximately 30 h after arriving at our hospital. The day after the patient's death,
Language	English
Publishing date	2021-04-06
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2021.e01112
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Article ; Online: Isolation of Aspergillus oryzae mutants producing low levels of 2,4,6-trichloroanisole.

Endo, Michiko / Ito, Ren / Ise, Ayaka / Ueta, Shinya / Yamamura, Mei / Uehara, Yurina / Fujii, Yuzo / Kanda, Ryoko / Fujita, Akiko / Isogai, Atsuko / Fujii, Tsutomu / Yamada, Osamu

The Journal of general and applied microbiology

2022 Volume 68, Issue 1, Page(s) 24–29

Abstract: Musty or moldy off-odor in sake severely reduces its quality. Such off-odor is caused by 2,4,6-trichloroanisole (TCA), a compound that is produced by Aspergillus oryzae during sake production by O-methylating the precursor 2,4,6-trichlorophenol (TCP). ... ...

Abstract	Musty or moldy off-odor in sake severely reduces its quality. Such off-odor is caused by 2,4,6-trichloroanisole (TCA), a compound that is produced by Aspergillus oryzae during sake production by O-methylating the precursor 2,4,6-trichlorophenol (TCP). TCP suppresses the growth of fungi, including A. oryzae, although TCA does not. Therefore, strains that are unable to convert TCP to TCA should be sensitive to TCP in the medium. Nevertheless, A. oryzae with a disrupted O-methyltransferase gene (ΔomtT) grew in a medium containing TCP. In agar medium, we observed no growth difference between the ΔomtT strain and a non-disrupted transformant; however, a significant growth delay was observed with the ΔomtT strain grown in liquid medium containing 0.5 µg/mL of TCP. This strain was more sensitive to low concentrations of TCP, suggesting that omtT contributes to the conversion (detoxification) of TCP in liquid culture. We generated A. oryzae RIB 40 mutants by ultraviolet irradiation and then cultured them in liquid medium containing TCP to obtain strains that did not produce moldy odor. The slow-growing strains were cultured in agar plates and then used to make koji with added TCP. We obtained three strains with lower TCA-producing ability and with sufficient hydrolase activities for sake brewing.
MeSH term(s)	Agar ; Alcoholic Beverages ; Anisoles ; Aspergillus oryzae/genetics ; Chlorophenols ; Fermentation ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins
Chemical Substances	Anisoles ; Chlorophenols ; Saccharomyces cerevisiae Proteins ; 2,4,6-trichloroanisole (31O3X41254) ; Agar (9002-18-0)
Language	English
Publishing date	2022-04-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	218355-9
ISSN	1349-8037 ; 0022-1260
ISSN (online)	1349-8037
ISSN	0022-1260
DOI	10.2323/jgam.2021.09.002
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Article: Denosumab for treatment of immobilization-related hypercalcemia in a patient with end-stage renal disease.

Uehara, Atsuko / Yazawa, Masahiko / Kawata, Atsumi / Hachisuka, Rina / Shibagaki, Yugo

CEN case reports

2017 Volume 6, Issue 1, Page(s) 111–114

Abstract: The efficacy and safety of denosumab for the treatment of immobilization-related hypercalcemia in end-stage renal disease remain uncertain. We describe the case of a hemodialysis patient with immobilization-related hypercalcemia who was successfully ... ...

Abstract	The efficacy and safety of denosumab for the treatment of immobilization-related hypercalcemia in end-stage renal disease remain uncertain. We describe the case of a hemodialysis patient with immobilization-related hypercalcemia who was successfully treated with denosumab. A 79-year-old man admitted for hemodialysis after sustaining an acute kidney injury developed immobilization-related hypercalcemia due to the impairment resulting from an acute myocardial infarction, acute heart failure, and catheter-related bloodstream infection. After admission, the patient's corrected serum calcium rose to 12.9 from 8.8 mg/dL. A bisphosphonate (alendronate) was administered, but it was ineffective. Subsequently, treatment with denosumab proved to be effective and his corrected serum calcium level declined to 9.3 mg/dL within 1 week. Hypocalcemia, which is an adverse effect of denosumab, was prevented using active vitamin D and calcium supplementation, and his calcium level stabilized. Thus, our case demonstrates that denosumab is a viable therapeutic option for dialysis patients experiencing immobilization-related hypercalcemia.
Language	English
Publishing date	2017-05
Publishing country	Japan
Document type	Journal Article
ISSN	2192-4449
ISSN	2192-4449
DOI	10.1007/s13730-017-0254-5
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Article ; Online: Nintedanib-induced glomerular microangiopathy: a case report.

Hasegawa, Masataka / Uehara, Atsuko / Suzuki, Tomo / Sekine, Reio / Yazawa, Masahiko / Ichikawa, Daisuke / Koike, Junki / Shibagaki, Yugo

CEN case reports

2020 Volume 9, Issue 4, Page(s) 295–300

Abstract: Nintedanib, a triple tyrosine kinase inhibitor of vascular endothelial growth factor receptor, platelet-derived growth factor receptor, and fibroblast growth factor receptor, has been used in idiopathic pulmonary fibrosis and adenocarcinoma in advanced ... ...

Abstract	Nintedanib, a triple tyrosine kinase inhibitor of vascular endothelial growth factor receptor, platelet-derived growth factor receptor, and fibroblast growth factor receptor, has been used in idiopathic pulmonary fibrosis and adenocarcinoma in advanced non-small cell lung cancer. Although vascular endothelial growth factor inhibitors have been reported to cause endothelial injury and glomerular microangiopathy, nintedanib-induced glomerular microangiopathy has not been reported. A 68-year-old man with a history of primary aldosteronism, idiopathic pulmonary fibrosis, and pleomorphic carcinoma of the lung developed proteinuria and leg edema after nintedanib initiation. Kidney biopsy revealed prominent endothelial and mesangial injury. Proteinuria improved after nintedanib withdrawal. To the best of our knowledge, this is the second case report of nintedanib-induced glomerular microangiopathy. Although the incidence of nephropathy among patients receiving nintedanib is unknown at this moment, we recommend monitoring urinary protein excretion and blood pressure in patients receiving nintedanib and performing kidney biopsy to determine any histopathological change.
MeSH term(s)	Aged ; Carcinoma/diagnosis ; Carcinoma/drug therapy ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/injuries ; Glomerular Mesangium/blood supply ; Glomerular Mesangium/drug effects ; Glomerular Mesangium/injuries ; Humans ; Hyperaldosteronism/drug therapy ; Idiopathic Pulmonary Fibrosis/drug therapy ; Indoles/administration & dosage ; Indoles/adverse effects ; Indoles/therapeutic use ; Kidney/blood supply ; Kidney/drug effects ; Kidney Diseases/chemically induced ; Kidney Diseases/pathology ; Lung Neoplasms/pathology ; Male ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; Proteinuria/chemically induced ; Receptors, Fibroblast Growth Factor/drug effects ; Receptors, Platelet-Derived Growth Factor/drug effects ; Receptors, Vascular Endothelial Growth Factor/drug effects ; Thrombotic Microangiopathies/chemically induced ; Thrombotic Microangiopathies/diagnosis ; Withholding Treatment
Chemical Substances	Indoles ; Protein Kinase Inhibitors ; Receptors, Fibroblast Growth Factor ; Receptors, Platelet-Derived Growth Factor (EC 2.7.10.1) ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1) ; nintedanib (G6HRD2P839)
Language	English
Publishing date	2020-04-11
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2660492-9
ISSN	2192-4449 ; 2192-4449
ISSN (online)	2192-4449
ISSN	2192-4449
DOI	10.1007/s13730-020-00474-w
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Article ; Online: A Functional Parathyroid Cyst from the Hemorrhagic Degeneration of a Parathyroid Adenoma.

Uehara, Atsuko / Suzuki, Tomo / Yamamoto, Yutaro / Hasegawa, Masataka / Koitabashi, Kenichiro / Yazawa, Masahiko / Koike, Junki / Shibagaki, Yugo

Internal medicine (Tokyo, Japan)

2019 Volume 59, Issue 3, Page(s) 389–394

Abstract: A 77-year-old man with a history of hypertension, prostate hyperplasia, and urolithiasis was admitted for acute kidney injury caused by hypercalcemia. Neck ultrasonography showed a large cyst adjacent to the right lower thyroid lobe. Although ... ...

Abstract	A 77-year-old man with a history of hypertension, prostate hyperplasia, and urolithiasis was admitted for acute kidney injury caused by hypercalcemia. Neck ultrasonography showed a large cyst adjacent to the right lower thyroid lobe. Although a
MeSH term(s)	Adenoma/etiology ; Adenoma/physiopathology ; Adenoma/surgery ; Aged ; Calcimimetic Agents/therapeutic use ; Cinacalcet/therapeutic use ; Cysts/physiopathology ; Cysts/surgery ; Humans ; Hypercalcemia/complications ; Hyperparathyroidism/drug therapy ; Male ; Parathyroid Glands/physiopathology ; Parathyroid Glands/surgery ; Parathyroid Neoplasms/etiology ; Parathyroid Neoplasms/physiopathology ; Parathyroid Neoplasms/surgery ; Parathyroidectomy ; Treatment Outcome
Chemical Substances	Calcimimetic Agents ; Cinacalcet (UAZ6V7728S)
Language	English
Publishing date	2019-10-07
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.3319-19
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Article: Tetraploidy-associated centrosome overduplication in mouse early embryos.

Yaguchi, Kan / Yamamoto, Takahiro / Matsui, Ryo / Shimada, Masaya / Shibanuma, Atsuko / Kamimura, Keiko / Koda, Toshiaki / Uehara, Ryota

Communicative & integrative biology

2018 Volume 11, Issue 4, Page(s) e1526605

Abstract: Recently, we observed that tetraploidization of certain types of human cancer cells resulted in upregulation of centrosome duplication cycles and chronic generation of the extra centrosome. Here, we investigated whether tetraploidy-linked upregulation of ...

Abstract	Recently, we observed that tetraploidization of certain types of human cancer cells resulted in upregulation of centrosome duplication cycles and chronic generation of the extra centrosome. Here, we investigated whether tetraploidy-linked upregulation of centrosome duplication also occurs in non-cancer cells using tetraploidized parthenogenetic mouse embryos. Cytokinesis blockage at early embryonic stage before de novo centriole biogenesis provided the unique opportunity in which tetraploidization can be induced without transient doubling of centrosome number. The extra numbers of the centrioles and the centrosomes were observed more frequently in tetraploidized embryos during the blastocyst stage than in their diploid counterparts, demonstrating the generality of the newly found tetraploidy-driven centrosome overduplication in mammalian non-cancer systems.
Language	English
Publishing date	2018-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2451097-X
ISSN	1942-0889
ISSN	1942-0889
DOI	10.1080/19420889.2018.1526605
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