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  1. Book ; Online: Epilepsy Topics

    Holmes, Mark D.

    2014  

    Keywords Neurosciences
    Size 1 electronic resource (272 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021049292
    ISBN 9789535172178 ; 9535172174
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Decrease in phase slip rates and phase cone structures during seizure evolution and epileptogenic activities derived from microgrid ECoG data.

    Ramon, Ceon / Doud, Alexander / Holmes, Mark D

    Current research in neurobiology

    2024  Volume 6, Page(s) 100126

    Abstract: Sudden phase changes are related to cortical phase transitions, which likely change in frequency and spatial distribution as epileptogenic activity evolves. A 100 s long section of micro-ECoG data obtained before and during a seizure was selected and ... ...

    Abstract Sudden phase changes are related to cortical phase transitions, which likely change in frequency and spatial distribution as epileptogenic activity evolves. A 100 s long section of micro-ECoG data obtained before and during a seizure was selected and analyzed. In addition, nine other short-duration epileptic events were also examined. The data was collected at 420 Hz, imported into MATLAB, downsampled to 200 Hz, and filtered in the 1-50 Hz band. The Hilbert transform was applied to compute the analytic phase, which was then unwrapped, and detrended to look for sudden phase changes. The phase slip rate (counts/s) and its acceleration (counts/s
    Language English
    Publishing date 2024-02-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2665-945X
    ISSN (online) 2665-945X
    DOI 10.1016/j.crneur.2024.100126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluation of Chitosans as Coagulants-Flocculants to Improve Sand Filtration for Drinking Water Treatment.

    Holmes, Eleanor B / Oza, Hemali H / Bailey, Emily S / Sobsey, Mark D

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: The World Health Organization (WHO) reports that two billion people worldwide lack access to safely managed water sources, including 1.2 billion who already have access to improved water sources. In many countries, household point-of-use (POU) water- ... ...

    Abstract The World Health Organization (WHO) reports that two billion people worldwide lack access to safely managed water sources, including 1.2 billion who already have access to improved water sources. In many countries, household point-of-use (POU) water-treatment options are used to remove or deactivate microorganisms in water, but not all POU technologies meet WHO performance requirements to achieve safe drinking water. To improve the effectiveness of POU technologies, the use of multiple treatment barriers should be used as a way to increase overall treatment performance. The focus of this research is to evaluate multiple barrier treatment using chitosan, an organic coagulant−flocculant, to improve microbial and turbidity reductions in combination with sand filtration. Bench-scale intermittently operated sand filters with 16 cm layers of sands of two different grain sizes representing slow and rapid sand filters were dosed daily over 57 days with microbially spiked surface water volumes corresponding to household use. E. coli bacteria and MS2 coliphage virus reductions were quantified biweekly (N = 17) using culture methods. Bacteria and virus removals were significantly improved over sand filtration without chitosan pretreatment (Wilcoxon Rank-Sum, p < 0.05). When water was pretreated at an optimal chitosan dose of 10 mg/L followed by sand filtration, log10 reductions in bacteria and viruses met the two-star WHO performance level of effectiveness. Microbial and turbidity reductions generally improved over the filter operating period but showed no trends with filtration rates.
    MeSH term(s) Humans ; Escherichia coli ; Drinking Water ; Chitosan ; Silicon Dioxide ; Water Purification/methods ; Viruses ; Bacteria
    Chemical Substances Drinking Water ; Chitosan (9012-76-4) ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Increased Phase Cone Turnover in 80-250 Hz Bands Occurs in the Epileptogenic Zone During Interictal Periods.

    Ramon, Ceon / Holmes, Mark D

    Frontiers in human neuroscience

    2020  Volume 14, Page(s) 615744

    Abstract: We found that phase cone clustering patterns in EEG ripple bands demonstrate an increased turnover rate in epileptogenic zones compared to adjacent regions. We employed 256 channel EEG data collected in four adult subjects with refractory epilepsy. The ... ...

    Abstract We found that phase cone clustering patterns in EEG ripple bands demonstrate an increased turnover rate in epileptogenic zones compared to adjacent regions. We employed 256 channel EEG data collected in four adult subjects with refractory epilepsy. The analysis was performed in the 80-150 and 150-250 Hz ranges. Ictal onsets were documented with intracranial EEG recordings. Interictal scalp recordings, free of epileptiform patterns, of 240-s duration, were selected for analysis for each subject. The data was filtered, and the instantaneous phase was extracted after the Hilbert transformation. Spatiotemporal contour plots of the unwrapped instantaneous phase with 1.0 ms intervals were constructed using a montage layout of the 256 electrode positions. Stable phase cone patterns were selected based on criteria that the sign of spatial gradient did not change for a minimum of three consecutive time samples and the frame velocity was consistent with known propagation velocities of cortical axons. These plots exhibited increased dynamical formation and dissolution of phase cones in the ictal onset zones, compared to surrounding cortical regions, in all four patients. We believe that these findings represent markers of abnormally increased cortical excitability. They are potential tools that may assist in localizing the epileptogenic zone.
    Language English
    Publishing date 2020-12-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2020.615744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Identifying the Epileptic Network

    Tucker, Don / Holmes, Mark

    2014  

    Abstract: An important area of current research in epilepsy focuses on identifying the specific regions within the brain that are affected in individuals with recurring seizures. The epileptogenic process may result not only in pathology in focal cortical regions, ...

    Abstract An important area of current research in epilepsy focuses on identifying the specific regions within the brain that are affected in individuals with recurring seizures. The epileptogenic process may result not only in pathology in focal cortical regions, but abnormalities in subcortical structures, such as thalamus and basal ganglia, and in intercortical and intracortical connecting white matter pathways. Novel methods of treating refractory epilepsy are urgently needed. The goal of identifying for each affected individual the specific brain regions that are involved offers the promise that novel methods of treatment will one day be developed that specifically target those abnormal regions. Researchers from disparate fields are required to develop and advance this area of research, and this current topic proposes to place a spotlight on the "state of the art" of methods to identify the abnormal networks. Recent work covering a wide variety of disciplines and technologies, including dense array electroencephalography (dEEG), novel methods of analyses of both the interictal dEEG and intracranial EEG (icEEG), magnetoencephalography (MEG), high-resolution magnetic resonance imaging (MRI), functional MRI (fMRI), simultaneous fMRI-EEG, fMRI connectivity measures, simultaneous dEEG-icEEG, and techniques to coregister patient-specific MRI (including white matter pathways) and dEEG, are all examples of areas of research that have contributed to a greater understanding of potential epileptogenic regions. We asked for individuals with expertise in an area of research that expands an understanding of identifying epileptic networks to contribute to this research topic
    Keywords Neurology. Diseases of the nervous system ; Medicine (General)
    Size 1 electronic resource (126 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090218
    ISBN 9782889192960 ; 2889192962
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: A standardized ontology for naming tRNA-derived RNAs based on molecular origin.

    Holmes, Andrew D / Chan, Patricia P / Chen, Qi / Ivanov, Pavel / Drouard, Laurence / Polacek, Norbert / Kay, Mark A / Lowe, Todd M

    Nature methods

    2023  Volume 20, Issue 5, Page(s) 627–628

    MeSH term(s) RNA, Transfer/genetics ; RNA/genetics
    Chemical Substances RNA, Transfer (9014-25-9) ; RNA (63231-63-0)
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 2169522-2
    ISSN 1548-7105 ; 1548-7091
    ISSN (online) 1548-7105
    ISSN 1548-7091
    DOI 10.1038/s41592-023-01813-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6022: Show issues Location:
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  7. Article: Is the foodservice industry perceived as being palatable by those looking to enter it?

    Holmes, Mark Robert / McAdams, Bruce / Gibbs, Chris / D’Angelo, Alexia

    Journal of foodservice business research. 2022 July 04, v. 25, no. 4

    2022  

    Abstract: This research looks to examine attractors and detractors for students looking to enter the hospitality and culinary industries, their perceptions of work/life balance, and their schedule preferences. To accomplish this, surveys were undertaken at 2 ... ...

    Abstract This research looks to examine attractors and detractors for students looking to enter the hospitality and culinary industries, their perceptions of work/life balance, and their schedule preferences. To accomplish this, surveys were undertaken at 2 universities and 6 colleges located in Ontario, Canada. This study found that the long hours, mid shifts, and work-life balance deter students in culinary and hospitality programs from wanting to enter the industry and that there is a preference for four-day workweeks. The paper concludes by discussing the preferences of tomorrow’s workforce, proposing that the foodservice industry should look to offer schedules that will improve employee wellbeing and retention.
    Keywords food service ; labor force ; research ; Ontario
    Language English
    Dates of publication 2022-0704
    Size p. 414-433.
    Publishing place Routledge
    Document type Article
    ZDB-ID 2094789-6
    ISSN 1537-8039 ; 1537-8020
    ISSN (online) 1537-8039
    ISSN 1537-8020
    DOI 10.1080/15378020.2021.1950507
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5835: Show issues

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  8. Article ; Online: Publisher Correction: LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response.

    MacMillan, Sandy / Holmes, Andrew P / Dallas, Mark L / Mahmoud, Amira D / Shipston, Michael J / Peers, Chris / Hardie, D Grahame / Kumar, Prem / Evans, A Mark

    Communications biology

    2022  Volume 5, Issue 1, Page(s) 765

    Language English
    Publishing date 2022-07-29
    Publishing country England
    Document type Published Erratum
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-022-03744-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impulse Oscillometry Versus Spirometry to Detect Bronchiolitis Obliterans Syndrome in Bilateral Lung Transplant Recipients: A Prospective Diagnostic Study.

    Crowhurst, Thomas D / Butler, Jessica A / Bussell, Lauren A / Johnston, Sonya D / Yeung, David / Hodge, Greg / Snell, Greg I / Yeo, Aeneas / Holmes, Mark / Holmes-Liew, Chien-Li

    Transplantation

    2023  Volume 108, Issue 4, Page(s) 1004–1014

    Abstract: ... a median testing interval of 92 d (interquartile range, 62-161). Statistically significant moderate ...

    Abstract Background: Chronic lung allograft dysfunction (CLAD), and especially bronchiolitis obliterans syndrome (BOS), remain dominant causes of morbidity and mortality after lung transplantation. Interest is growing in the forced oscillation technique, of which impulse oscillometry (IOS) is a form, as a tool to improve our understanding of these disorders. However, data remain limited and no longitudinal studies have been published, meaning there is no information regarding any capacity IOS may have for the early detection of CLAD.
    Methods: We conducted a prospective longitudinal study enrolling a consecutive sample of adult bilateral lung transplant recipients with healthy lung allografts or CLAD and performed ongoing paired IOS and spirometry tests on a clinically determined basis. We assessed for correlations between IOS and spirometry and examined any predictive value either modality may hold for the early detection of BOS.
    Results: We enrolled 91 patients and conducted testing for 43 mo, collecting 558 analyzable paired IOS and spirometry tests, with a median of 9 tests per subject (interquartile range, 5-12) and a median testing interval of 92 d (interquartile range, 62-161). Statistically significant moderate-to-strong correlations were demonstrated between all IOS parameters and spirometry, except resistance at 20 Hz, which is a proximal airway measure. No predictive value for the early detection of BOS was found for IOS or spirometry.
    Conclusions: This study presents the first longitudinal data from IOS after lung transplantation and adds considerably to the growing literature, showing unequivocal correlations with spirometry but failing to demonstrate a predictive value for BOS.
    MeSH term(s) Adult ; Humans ; Bronchiolitis Obliterans Syndrome ; Oscillometry/methods ; Prospective Studies ; Longitudinal Studies ; Transplant Recipients ; Lung ; Spirometry ; Bronchiolitis Obliterans/diagnosis ; Bronchiolitis Obliterans/etiology ; Forced Expiratory Volume
    Language English
    Publishing date 2023-12-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
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  10. Article ; Online: The causes of epilepsy: common and uncommon causes in adults and children.

    Holmes, Mark D

    Archives of neurology

    2012  Volume 69, Issue 9, Page(s) 1212–1213

    Language English
    Publishing date 2012-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80049-1
    ISSN 1538-3687 ; 0003-9942
    ISSN (online) 1538-3687
    ISSN 0003-9942
    DOI 10.1001/archneurol.2012.1266
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