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  1. Article ; Online: Dental Public Health Landscape: Challenges, Technological Innovation and Opportunities in the 21st Century and COVID-19 Pandemic.

    Mascitti, Marco / Campisi, Giuseppina

    International journal of environmental research and public health

    2020  Volume 17, Issue 10

    Abstract: In response to the 2008 economic and financial crisis and to its effects on healthcare systems, dental care has become unaffordable for many people, and a huge number of patients worldwide are avoiding or skipping necessary dental treatments [ ... ]. ...

    Abstract In response to the 2008 economic and financial crisis and to its effects on healthcare systems, dental care has become unaffordable for many people, and a huge number of patients worldwide are avoiding or skipping necessary dental treatments [...].
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Inventions ; Pandemics ; Pneumonia, Viral ; Public Health ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country Switzerland
    Document type Editorial ; Comment
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph17103636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of periodontitis on circulating cell-free DNA levels as a measure of cardiovascular disease.

    Isola, Gaetano / Polizzi, Alessandro / Mascitti, Marco / Santonocito, Simona / Ronsivalle, Vincenzo / Cicciù, Marco / Pesce, Paolo

    Clinical oral investigations

    2023  Volume 27, Issue 11, Page(s) 6855–6863

    Abstract: Objectives: The present study aims to assess the serum circulating cell-free (cfDNA) concentrations in patients with periodontitis and cardiovascular disease (CVD) and to evaluate the impact of periodontitis on circulating cfDNA levels and the ... ...

    Abstract Objectives: The present study aims to assess the serum circulating cell-free (cfDNA) concentrations in patients with periodontitis and cardiovascular disease (CVD) and to evaluate the impact of periodontitis on circulating cfDNA levels and the confounding factors that might mediated the possible relationship.
    Materials and methods: Healthy controls (n=30) and patients with CVD (n=31), periodontitis (n=31), and periodontitis + CVD (n=30) were enrolled in the present study. All subjects underwent regular periodontal examination and blood sampling and cfDNA evaluation. The analysis of the plasma cfDNA concentrations was performed using a dsDNA Assay Kit.
    Results: In comparison with healthy controls and CVD patients, periodontitis and periodontitis+CVD exhibited significantly higher expression of circulating cfDNA (p<0.05). There was a positive correlation among plasma cfDNA and clinical attachment loss (CAL) (p=0.019), high sensitivity C-reactive protein (hs-CRP) (p=0.027), and periodontal inflamed surface area (PISA) (p=0.003). Furthermore, the multivariate regression analysis evidenced that PISA (p<0.001), hs-CRP (p=0.014), and full-mouth bleeding score (FMBS) (p=0.004) were significant predictors of circulating cfDNA concentrations.
    Conclusions: The results of the study highlighted that the periodontitis and periodontitis + CVD group showed higher circulating cfDNA expression in comparison with healthy controls and CVD patients. Moreover, the extent of periodontitis was correlated with the increased cfDNA levels and represented a significant predictor of the increased circulating cfDNA concentrations.
    Clinical relevance: Unbalanced circulating cfDNA concentrations have been indicated to represent a possible risk of CVD and endothelial dysfunction. Periodontitis and periodontitis + CVD patients showed higher circulating cfDNA expression; moreover, the extent of periodontitis significantly predicted higher circulating cfDNA concentrations, suggesting the potential increased risk of developing CVD in periodontitis patients.
    MeSH term(s) Humans ; Cardiovascular Diseases ; C-Reactive Protein/analysis ; Periodontitis/complications ; Cell-Free Nucleic Acids ; Multivariate Analysis
    Chemical Substances C-Reactive Protein (9007-41-4) ; Cell-Free Nucleic Acids
    Language English
    Publishing date 2023-10-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1364490-7
    ISSN 1436-3771 ; 1432-6981
    ISSN (online) 1436-3771
    ISSN 1432-6981
    DOI 10.1007/s00784-023-05300-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tongue "heart" ulcer from bisphosphonate.

    Mascitti, Marco / Santarelli, Andrea

    Journal of dental sciences

    2018  Volume 13, Issue 3, Page(s) 182–183

    Language English
    Publishing date 2018-07-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2018.06.003
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  4. Article: Molecules and Biomaterial Technologies Affecting Stem Cell Differentiation.

    Muzio, Lorenzo Lo / Mascitti, Marco / La Noce, Marcella / Posa, Francesca / Kudo, Yasusei / Cirillo, Nicola

    Stem cells international

    2022  Volume 2022, Page(s) 9783430

    Language English
    Publishing date 2022-04-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 2573856-2
    ISSN 1687-9678 ; 1687-966X
    ISSN (online) 1687-9678
    ISSN 1687-966X
    DOI 10.1155/2022/9783430
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  5. Article ; Online: Dental Public Health Landscape

    Marco Mascitti / Giuseppina Campisi

    International Journal of Environmental Research and Public Health, Vol 17, Iss 3636, p

    Challenges, Technological Innovation and Opportunities in the 21st Century and COVID-19 Pandemic

    2020  Volume 3636

    Abstract: In response to the 2008 economic and financial crisis and to its effects on healthcare systems, dental care has become unaffordable for many people, and a huge number of patients worldwide are avoiding or skipping necessary dental treatments [.] ...

    Abstract In response to the 2008 economic and financial crisis and to its effects on healthcare systems, dental care has become unaffordable for many people, and a huge number of patients worldwide are avoiding or skipping necessary dental treatments [.]
    Keywords n/a ; Medicine ; R ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Dental Public Health Landscape: Challenges, Technological Innovation and Opportunities in the 21st Century and COVID-19 Pandemic

    Mascitti, Marco / Campisi, Giuseppina

    Int. j. environ. res. public health (Online)

    Abstract: In response to the 2008 economic and financial crisis and to its effects on healthcare systems, dental care has become unaffordable for many people, and a huge number of patients worldwide are avoiding or skipping necessary dental treatments [ ... ]. ...

    Abstract In response to the 2008 economic and financial crisis and to its effects on healthcare systems, dental care has become unaffordable for many people, and a huge number of patients worldwide are avoiding or skipping necessary dental treatments [...].
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #327058
    Database COVID19

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  7. Article ; Online: Dental Public Health Landscape

    Mascitti, Marco / Campisi, Giuseppina

    Challenges, Technological Innovation and Opportunities in the 21st Century and COVID-19 Pandemic

    2020  

    Abstract: editorial Dental Public Health Landscape: Challenges, Technological Innovation and Opportunities in the 21st Century and COVID-19 ... ...

    Abstract editorial Dental Public Health Landscape: Challenges, Technological Innovation and Opportunities in the 21st Century and COVID-19 Pandemic
    Keywords Dental ; Public Health,Challenges ; Technological Innovation ; Opportunities ; COVID-19 Pandemic ; covid19
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A Systematic Review on Nerve-Related Adverse Effects following Mandibular Nerve Block Anesthesia.

    Aquilanti, Luca / Mascitti, Marco / Togni, Lucrezia / Contaldo, Maria / Rappelli, Giorgio / Santarelli, Andrea

    International journal of environmental research and public health

    2022  Volume 19, Issue 3

    Abstract: Inferior alveolar nerve (IAN) block injections are commonly used in clinical practice, but they are not free from complications. The aim of the present systematic review is to assess the nerve-related adverse effects of IAN block anesthesia. A structured ...

    Abstract Inferior alveolar nerve (IAN) block injections are commonly used in clinical practice, but they are not free from complications. The aim of the present systematic review is to assess the nerve-related adverse effects of IAN block anesthesia. A structured and systematic search was performed on the major electronic databases (PubMed, Cochrane Library, Web of Science, Scopus and CINAHL) for studies published in English until 30 September 2021. A total of 131 articles were identified through database searching using combinations of keywords. Fifteen papers were included and assessed for eligibility. Overall, nerve damage following an IAN block anesthesia injection is a rare occurrence, probably due to the direct nerve trauma of the needle, a neurotoxic effect of the used anesthetic solution and/or a combination of them. From a medico-legal point of view, a balanced discussion prior to nerve block anesthesia should be pursued in order to avoid patients' reluctance to undergo necessary dental treatment due to the remote eventuality of nerve injury.
    MeSH term(s) Anesthetics, Local/toxicity ; Humans ; Injections ; Mandible ; Mandibular Nerve ; Nerve Block/adverse effects
    Chemical Substances Anesthetics, Local
    Language English
    Publishing date 2022-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19031627
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  9. Article ; Online: Identification of BRAF V600E mutation in odontogenic tumors by high-performance MALDI-TOF analysis.

    Togni, Lucrezia / Zizzi, Antonio / Mazzucchelli, Roberta / Santarelli, Andrea / Rubini, Corrado / Mascitti, Marco

    International journal of oral science

    2022  Volume 14, Issue 1, Page(s) 22

    Abstract: Odontogenic tumors are rare lesions with unknown etiopathogenesis. Most of them are benign, but local aggressiveness, infiltrative potential, and high recurrence rate characterize some entities. The MAP-kinase pathway activation can represent a primary ... ...

    Abstract Odontogenic tumors are rare lesions with unknown etiopathogenesis. Most of them are benign, but local aggressiveness, infiltrative potential, and high recurrence rate characterize some entities. The MAP-kinase pathway activation can represent a primary critical event in odontogenic tumorigenesis. Especially, the BRAF V600E mutation has been involved in 80-90% of ameloblastic lesions, offering a biological rationale for developing new targeted therapies. The study aims to evaluate the BRAF V600E mutation in odontogenic lesions, comparing three different detection methods and focusing on the Sequenom MassARRAY System. 81 surgical samples of odontogenic lesions were subjected to immunohistochemical analysis, Sanger Sequencing, and Matrix-Assisted Laser Desorption/Ionization-Time of Flight mass spectrometry (Sequenom). The BRAF V600E mutation was revealed only in ameloblastoma samples. Moreover, the presence of BRAF V600E was significantly associated with the mandibular site (ρ = 0.627; P value <0.001) and the unicystic histotype (ρ = 0.299, P value <0.001). However, any significant difference of 10-years disease-free survival time was not revealed. Finally, Sequenom showed to be a 100% sensitive and 98.1% specific, suggesting its high-performance diagnostic accuracy. These results suggest the MAP-kinase pathway could contribute to ameloblastic tumorigenesis. Moreover, they could indicate the anatomical specificity of the driving mutations of mandibular ameloblastomas, providing a biological rational for developing new targeted therapies. Finally, the high diagnostic accuracy of Sequenom was confirmed.
    MeSH term(s) Ameloblastoma/genetics ; Ameloblastoma/pathology ; Carcinogenesis ; Humans ; Mitogen-Activated Protein Kinases/genetics ; Mutation ; Odontogenic Tumors/genetics ; Odontogenic Tumors/pathology ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/metabolism ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
    Chemical Substances BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2022-04-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2569849-7
    ISSN 2049-3169 ; 1674-2818
    ISSN (online) 2049-3169
    ISSN 1674-2818
    DOI 10.1038/s41368-022-00170-8
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  10. Article ; Online: A Reciprocal Link between Oral, Gut Microbiota during Periodontitis: The Potential Role of Probiotics in Reducing Dysbiosis-Induced Inflammation.

    Di Stefano, Mattia / Santonocito, Simona / Polizzi, Alessandro / Mauceri, Rodolfo / Troiano, Giuseppe / Lo Giudice, Antonino / Romano, Alessandra / Mascitti, Marco / Isola, Gaetano

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: Human body is colonized by a florid microbial community of bacteria, archaea, fungi, protists, helminths, and viruses, known as microbiota, which co-evolves with the host and influences its health through all stages of its life. It is well known that ... ...

    Abstract Human body is colonized by a florid microbial community of bacteria, archaea, fungi, protists, helminths, and viruses, known as microbiota, which co-evolves with the host and influences its health through all stages of its life. It is well known that oral microorganisms form highly structurally and functionally organized multi-species biofilms and establish a network of complex mutual inter-species interactions having a primary function in synergy, signaling, or antagonism. This ecological model allows the microorganisms to increase their resistance to antimicrobial agents and settle a balanced microbes-host symbiotic relationship that ensures oral and global health status in humans. The host-associated microbiome is an important factor in human health and disease. Therefore, to develop novel diagnostic, therapeutic, and preventive strategies, microbiome's functions and the reciprocal interactions every microbiome entertains with other microbial communities in the human body are being investigated. This review provides an analysis of the literature about the close connection between the two largest microbial communities in humans: the oral and the gut microbiomes. Furthermore, it focuses on how the alteration of their microbial and functional characteristics can lead to and reciprocally influence the onset of both oral and intestinal microbiome-associated illness, along with the potential role of probiotics in ameliorating inflammation and microbial dysbiosis.
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Dysbiosis ; Microbiota ; Periodontitis/drug therapy ; Periodontitis/microbiology ; Inflammation ; Probiotics/therapeutic use
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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