Article: Deoxyribonucleotides: the unusual chemistry and biochemistry of DNA precursors.
2004 Volume 33, Issue 4, Page(s) 225–233
Abstract: Deoxyribonucleotides, monomers of macromolecular DNA and the chemical matter of genes, have received surprisingly little attention among chemists and molecular biologists alike, although their origin, properties, and mechanism of enzyme-catalyzed ... ...
Abstract | Deoxyribonucleotides, monomers of macromolecular DNA and the chemical matter of genes, have received surprisingly little attention among chemists and molecular biologists alike, although their origin, properties, and mechanism of enzyme-catalyzed formation bear unique chemical traits which are the basis of DNA replication. Apart from providing insights in bioorganic free radical chemistry, present interest in deoxyribonucleotides stems from the expected demand of hundreds of kilograms per year for DNA chips and antisense constructs used in gene therapy, difficult to produce by conventional methods. A novel approach towards deoxyribonucleotide, and hence DNA formation in a putative primordial 'RNA world' has also recently emerged. |
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MeSH term(s) | Animals ; Biomimetics ; Catalysis ; DNA/chemistry ; DNA/isolation & purification ; DNA Replication ; DNA, Antisense/chemical synthesis ; Deoxyribonucleotides/biosynthesis ; Deoxyribonucleotides/chemistry ; Deoxyribose/chemistry ; Evolution, Molecular ; Genetic Therapy ; Nucleic Acid Precursors/chemistry ; Nucleic Acid Precursors/metabolism ; Oligonucleotide Array Sequence Analysis ; Oxidation-Reduction ; Ribonucleotide Reductases/chemistry ; Ribonucleotide Reductases/classification ; Ribonucleotide Reductases/metabolism |
Chemical Substances | DNA, Antisense ; Deoxyribonucleotides ; Nucleic Acid Precursors ; Deoxyribose (533-67-5) ; DNA (9007-49-2) ; Ribonucleotide Reductases (EC 1.17.4.-) |
Language | English |
Publishing date | 2004-05-10 |
Publishing country | England |
Document type | Journal Article ; Review |
ZDB-ID | 1472875-8 |
ISSN | 1460-4744 ; 0306-0012 |
ISSN (online) | 1460-4744 |
ISSN | 0306-0012 |
DOI | 10.1039/a907361b |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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