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  1. Article ; Online: Elektronenmikroskopie.

    Porubsky, Stefan

    Pathologie (Heidelberg, Germany)

    2023  Volume 44, Issue 2, Page(s) 82–83

    Title translation Electron microscopy.
    Language German
    Publishing date 2023-03-03
    Publishing country Germany
    Document type Editorial
    ISSN 2731-7196
    ISSN (online) 2731-7196
    DOI 10.1007/s00292-023-01185-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Charcot-Leyden-Kristalle und Curschmann-Spiralen.

    Porubsky, Stefan

    Der Pathologe

    2022  Volume 43, Issue 3, Page(s) 171

    Title translation Charcot-Leyden crystals and Curschmann spirals.
    Language German
    Publishing date 2022-04-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 135954-x
    ISSN 1432-1963 ; 0172-8113
    ISSN (online) 1432-1963
    ISSN 0172-8113
    DOI 10.1007/s00292-022-01062-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1543: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Elektronenmikroskopie in der Nephropathologie.

    Porubsky, Stefan

    Pathologie (Heidelberg, Germany)

    2022  Volume 44, Issue 2, Page(s) 84–94

    Abstract: Non-neoplastic kidney diseases represent a broad spectrum of diseases. Although their pathogenesis differs, the histological findings may be similar in terms of conventional morphology. A precise classification of these diseases is a prerequisite for ... ...

    Title translation Electron microscopy in nephropathology.
    Abstract Non-neoplastic kidney diseases represent a broad spectrum of diseases. Although their pathogenesis differs, the histological findings may be similar in terms of conventional morphology. A precise classification of these diseases is a prerequisite for correct therapy and prognostic assessment. In the diagnostic process, the magnification achieved by electron microscopy is essential and cannot be replaced by any other technique. The most frequent diagnostic questions addressed by ultrastructural studies represent (1) alterations of podocytes (e.g., minimal-change disease), (2) changes of the thickness and structure of the glomerular basement membrane (e.g., diabetic glomerulosclerosis or Alport disease), (3) the presence, characteristics and exact localisation of immune complexes (e.g., membranous glomerulonephritis or lupus nephritis), (4) alterations of endothelial cells and capillaries (e.g., thrombotic microangiopathy) and (5) diseases of the tubular cells (e.g., light-chain nephropathy or toxic effects). Therefore, ultrastructural investigations are-together with conventional microscopy and immunohistochemistry (or immunofluorescence)-an integral part of the so-called triple-diagnostics in routine nephropathology.
    MeSH term(s) Humans ; Endothelial Cells/pathology ; Kidney/pathology ; Microscopy, Electron ; Lupus Nephritis/pathology ; Glomerular Basement Membrane/pathology
    Language German
    Publishing date 2022-12-08
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7196
    ISSN (online) 2731-7196
    DOI 10.1007/s00292-022-01164-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ultrastruktur pathologischer Ablagerungen und Zellinklusionen.

    Schröder, Josef A / Porubsky, Stefan

    Pathologie (Heidelberg, Germany)

    2023  Volume 44, Issue 2, Page(s) 95–103

    Abstract: Intra- and extracellular depositions and inclusions occur in a wide range of diseases with exogenous (e.g. infectious, environmental and toxic) or endogenous (e.g. genetic, inflammatory, neoplastic and degenerative) aetiology. The noxious agent and the ... ...

    Title translation Ultrastructure of pathologic deposits and cellular inclusions.
    Abstract Intra- and extracellular depositions and inclusions occur in a wide range of diseases with exogenous (e.g. infectious, environmental and toxic) or endogenous (e.g. genetic, inflammatory, neoplastic and degenerative) aetiology. The noxious agent and the pathogenesis influence the organ of manifestation, the subcellular localisation and the ultrastructural appearance of the depositions. Whereas some of the inclusions like pathogens, foreign material (e.g. asbestos) or microvilli have an almost pathognomonic morphology, other inclusions are present in lower amounts also under normal conditions (e.g. lipid vacuoles and glycogen). Therefore, the interpretation of ultrastructural findings makes a correlation with the histological features and clinical constellation necessary. Auxiliary investigations by electron energy loss spectroscopy (EELS) or electron spectroscopic imaging (ESI) provide additional information about the chemical composition of the material and are therefore especially helpful for the identification of foreign substances. This review focuses on a selection of deposits and inclusions relevant to diagnostic pathology.
    MeSH term(s) Inclusion Bodies/ultrastructure ; Vacuoles ; Microvilli/ultrastructure ; Microscopy, Energy-Filtering Transmission Electron ; Glycogen
    Chemical Substances Glycogen (9005-79-2)
    Language German
    Publishing date 2023-02-07
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7196
    ISSN (online) 2731-7196
    DOI 10.1007/s00292-023-01181-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Benign lesions of the mediastinum.

    Gerber, Tiemo Sven / Porubsky, Stefan

    Histopathology

    2023  Volume 84, Issue 1, Page(s) 183–195

    Abstract: Mediastinal tumours represent a heterogeneous group of entities derived from the manifold structures located in or adjacent to the mediastinum. Due to the occurrence of some of these tumours in characteristic mediastinal compartments, an anatomical ... ...

    Abstract Mediastinal tumours represent a heterogeneous group of entities derived from the manifold structures located in or adjacent to the mediastinum. Due to the occurrence of some of these tumours in characteristic mediastinal compartments, an anatomical subdivision of the mediastinum in the prevascular (anterior), visceral (middle), and paravertebral (posterior) is helpful for the differential diagnosis. Benign anterior mediastinal tumours linked to an enlargement of the thymic gland mainly consist of thymic cysts and several types of thymic hyperplasia: true thymic hyperplasia, rebound hyperplasia, lymphofollicular hyperplasia, and so-called thymic hyperplasia with lymphoepithelial sialadenitis (LESA)-like features. Mature teratomas, ectopic (para)thyroid tissue, and benign thymic tumours such as thymolipoma or thymofibrolipoma represent further typical tumours of the anterior mediastinum. Pericardial, bronchogenic, or oesophageal duplication cysts predominate in the middle mediastinum, whereas neurogenic tumours and myelolipomas are characteristic findings in the posterior compartment. Vascular tumours, lipomas, adenomatoid tumours, Castleman disease, or mediastinitis are further examples of less frequent tumours or tumorous lesions affecting the mediastinum. This review focuses on benign mediastinal lesions with an emphasis on benign tumours of the thymus. Besides histology, characteristic epidemiological and clinical aspects prerequisite for the correct diagnosis and patient management are discussed.
    MeSH term(s) Humans ; Mediastinum/pathology ; Mediastinal Neoplasms/diagnosis ; Mediastinal Neoplasms/pathology ; Thymus Hyperplasia/diagnosis ; Thymus Hyperplasia/pathology ; Hyperplasia/pathology ; Thymus Neoplasms/pathology
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.15088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1328: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Thesis: Einfluss von nativen und oxidativ modifizierten Low-density-Lipoproteinen auf die Genexpression in humanen proximalen Tubulusepithelien in Kultur

    Porubský, Štefan

    Korrelation zu humanen Nierenbiopsien

    2004  

    Author's details vorgelegt von Štefan Porubský
    Language German
    Size 93 Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2004
    HBZ-ID HT016068178
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 E 2109 order for loan Magazin

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  7. Article: Histological Findings in Kidney Biopsies of Patients with Monoclonal Gammopathy-Always a Surprise.

    Klank, David / Hoffmann, Martin / Porubsky, Stefan / Bergner, Raoul

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 8

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-08-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12081912
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  8. Article: Epidemiology of thymomas and thymic carcinomas in the United States and Germany, 1999-2019.

    Gerber, Tiemo Sven / Strobl, Stephanie / Marx, Alexander / Roth, Wilfried / Porubsky, Stefan

    Frontiers in oncology

    2024  Volume 13, Page(s) 1308989

    Abstract: Introduction: Mediastinal tumors, particularly non-neuroendocrine thymic epithelial tumors (TET) are relatively uncommon, posing challenges for extensive epidemiological studies. This study presents a comprehensive analysis of these tumors in the United ...

    Abstract Introduction: Mediastinal tumors, particularly non-neuroendocrine thymic epithelial tumors (TET) are relatively uncommon, posing challenges for extensive epidemiological studies. This study presents a comprehensive analysis of these tumors in the United States (US) and Germany (GER) from 1999 to 2019.
    Methods: Patients aged 0-19 (n=478) and ≥20 years (n=17,459) diagnosed with malignant tumors of the anterior mediastinum were identified from the Surveillance, Epidemiology, and End Results registry (SEER) and the Zentrum für Krebsregisterdaten (ZfKD) databases.
    Results: Among patients aged ≥20 years, TETs accounted for the most prevalent anterior mediastinal tumors (US/GER: 63%/64%), followed by lymphomas (14%/8%). For patients <20 years, predominant tumors included germ cell tumors (42%/14%), lymphomas (38%/53%), and TETs (10%/27%). The overall annual incidence of thymoma was 2.2/2.64 (US/GER) per million inhabitants and for thymic carcinomas 0.48/0.42. The male-to-female ratio was 1:1.09/1.03, and the mean age 59.48 ± 14.89/61.33 ± 13.94. Individuals with thymomas, but not thymic carcinomas, exhibited a 21%/29% significantly heightened risk of developing secondary malignancies compared to controls with non-thymic primary tumors.
    Discussion: This study provides a comparative analysis of anterior mediastinal tumors, particularly TETs, in the US and GER over the past two decades. Furthermore, it highlights a significantly elevated incidence of secondary malignancies in thymoma patients.
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1308989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Neuropathologie I: Muskuläre Erkrankungen.

    Schänzer, Anne / Dittmayer, Carsten / Porubsky, Stefan / Weis, Joachim / Goebel, Hans-Hilmar / Stenzel, Werner

    Pathologie (Heidelberg, Germany)

    2022  Volume 44, Issue 2, Page(s) 104–112

    Abstract: Muscle diseases include hereditary and acquired diseases with clinical manifestation in both childhood and adulthood. The different muscle diseases may have ultrastructural alterations that help us further understand the pathology of the disease. ... ...

    Title translation Neuropathology I: muscular diseases.
    Abstract Muscle diseases include hereditary and acquired diseases with clinical manifestation in both childhood and adulthood. The different muscle diseases may have ultrastructural alterations that help us further understand the pathology of the disease. Specific changes in sarcomere structure help to classify a congenital myopathy. The detection of cellular aggregates supports the classification of myositis. Pathologically altered mitochondria, on the other hand, can occur both in genetic mitochondriopathies but also secondarily in acquired muscle diseases like myositis. Ultrastructural analysis of the myocardium is also helpful in the diagnosis of hereditary cardiomyopathies in childhood. This review article highlights the ultrastructural features of different muscle diseases and pathognomonic findings in specific disease groups.
    MeSH term(s) Humans ; Muscular Diseases/genetics ; Myositis/diagnosis ; Myocardium/pathology ; Sarcomeres/pathology
    Language German
    Publishing date 2022-12-02
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7196
    ISSN (online) 2731-7196
    DOI 10.1007/s00292-022-01163-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Open redo thymectomy for a large recurrent thymoma in a patient with myasthenia gravis: a case report.

    Galata, Christian / Porubsky, Stefan / Dohle, Daniel Sebastian / Karampinis, Ioannis / Stamenovic, Davor / Roessner, Eric Dominic

    Mediastinum (Hong Kong, China)

    2022  Volume 6, Page(s) 8

    Abstract: Thoracoscopic and robotic approaches are becoming increasingly popular for thymoma surgery. Yet open thymectomy must still be mastered today, as it may be the only viable option in challenging cases. In this study, we report a case of an extended local ... ...

    Abstract Thoracoscopic and robotic approaches are becoming increasingly popular for thymoma surgery. Yet open thymectomy must still be mastered today, as it may be the only viable option in challenging cases. In this study, we report a case of an extended local recurrence of myasthenia gravis associated thymoma and a history of previous sternotomy. The mediastinal mass infiltrated the left upper lobe of the lung, the pericardium, and presumably the aortic arch. Although the standard for thymoma resection at our institution is the robotic approach, we performed primary open redo thymectomy in standby of cardiopulmonary bypass in this case. Intraoperatively, bleeding from the aortic arch occurred, which was promptly controlled due to the open approach and due to immediate availability of cardiopulmonary bypass. The patient was transferred to the normal ward on the first postoperative day, was treated according to fast-track principles and recovered well. The pathology revealed a WHO B2:B1 thymoma with negative resection margins. Thymectomy is recommended as the principal treatment for thymoma and is also advised in the case of recurrence. However, there is no evidence regarding the optimal surgical approach. Our case indicates that in the era of minimally invasive thymectomy, the decision to conduct open surgery is wise when the risk of serious bleeding is anticipated or adherence to oncologic principles is challenged by tumor size or growth pattern.
    Language English
    Publishing date 2022-03-25
    Publishing country China
    Document type Case Reports
    ISSN 2522-6711
    ISSN (online) 2522-6711
    DOI 10.21037/med-21-25
    Database MEDical Literature Analysis and Retrieval System OnLINE

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