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  1. Article ; Online: William Cruikshank (1745-1800), anatomist and surgeon, and his illustrious patient, Samuel Johnson.

    McDonald, Stuart W

    Clinical anatomy (New York, N.Y.)

    2015  Volume 28, Issue 7, Page(s) 836–843

    Abstract: ... Arguably, his most famous patient was Samuel Johnson, the celebrated 18th Century man of letters and author ...

    Abstract William Cumberland Cruikshank (1745-1800) was a Scot who from 1771 until his death taught anatomy at the famous school of anatomy in Great Windmill Street, London, founded by William Hunter (1718-1783). Arguably, his most famous patient was Samuel Johnson, the celebrated 18th Century man of letters and author of the first English dictionary. This article, largely drawn from Johnson's correspondence, documents the medical condition that caused Johnson to consult Cruikshank and some of the social links between Johnson, Hunter, and Cruikshank.
    MeSH term(s) Anatomists/history ; Anatomy/history ; England ; Famous Persons ; General Surgery/history ; History, 18th Century ; History, 19th Century ; Humans ; Surgeons/history
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Biography ; Historical Article ; Portraits
    ZDB-ID 1025505-9
    ISSN 1098-2353 ; 0897-3806
    ISSN (online) 1098-2353
    ISSN 0897-3806
    DOI 10.1002/ca.22567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2592: Show issues Location:
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  2. Book ; Online: The Cambridge Introduction to Samuel Beckett

    McDonald, Ronan

    (Cambridge Introductions to Literature)

    2007  

    Abstract: An eloquent and accessible introduction to one of the most important writers of the twentieth ... ...

    Series title Cambridge Introductions to Literature
    Abstract An eloquent and accessible introduction to one of the most important writers of the twentieth century
    Language English
    Size Online-Ressource (152 p.)
    Publisher Cambridge University Press
    Publishing place Cambridge
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780521838566 ; 0521838568
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article ; Online: The HEART Pathway: Just a HEART score permutation or the future of clinical decision rules?

    McDonald, Samuel A / Peterson, Eric D

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2022  Volume 29, Issue 8, Page(s) 1037–1039

    MeSH term(s) Clinical Decision Rules ; Emergency Service, Hospital ; Heart ; Humans
    Language English
    Publishing date 2022-06-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.14542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: The agony of an American wilderness

    McDonald, Samuel A.

    loggers, environmentalists, and the struggle for control of a forgotten forest

    2005  

    Author's details Samuel A. MacDonald
    Keywords Pennsylvania ; Umweltschutz ; Naturschutzgebiet ; Siedlung ; Allegheny Country
    Subject Ökologie ; Umweltvorsorge ; Besiedelung ; Besiedlung ; Siedlungsstätte ; Siedlungsgebiet ; Siedlungen ; Naturreservat ; Wilderness
    Language English
    Size 187 S.
    Publisher Rowman & Littlefield Publ
    Publishing place Lanham u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014257035
    ISBN 0-7425-4157-6 ; 0-7425-4158-4 ; 978-0-7425-4157-3 ; 978-0-7425-4158-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    058/850 available for loan (reading room) Freihandmagazin (U1)

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  5. Article ; Online: Feeding Saccharomyces cerevisiae fermentation postbiotic products alters immune function and the lung transcriptome of preweaning calves with an experimental viral-bacterial coinfection.

    Maina, Teresia W / McDonald, Paiton O / Rani Samuel, Beulah E / Sardi, Maria I / Yoon, Ilkyu / Rogers, Adam / McGill, Jodi L

    Journal of dairy science

    2023  Volume 107, Issue 4, Page(s) 2253–2267

    Abstract: Bovine respiratory disease causes morbidity and mortality in cattle of all ages. Supplementing with postbiotic products from Saccharomyces cerevisiae fermentation (SCFP) has been reported to improve growth and provide metabolic support required for ... ...

    Abstract Bovine respiratory disease causes morbidity and mortality in cattle of all ages. Supplementing with postbiotic products from Saccharomyces cerevisiae fermentation (SCFP) has been reported to improve growth and provide metabolic support required for immune activation in calves. The objective of this study was to determine effects of SCFP supplementation on the transcriptional response to coinfection with bovine respiratory syncytial virus (BRSV) and Pasteurella multocida in the lung using RNA sequencing. Twenty-three calves were enrolled and assigned to 2 treatment groups: control (n = 12) or SCFP-treated (n = 11, fed 1 g/d SmartCare in milk and 5 g/d NutriTek on starter grain; both from Diamond V Mills Inc.). Calves were infected with ∼10
    MeSH term(s) Animals ; Cattle ; Diet/veterinary ; Saccharomyces cerevisiae/metabolism ; Fermentation ; Coinfection/veterinary ; Interleukin-6/metabolism ; Transcriptome ; Lung ; Virus Diseases/metabolism ; Virus Diseases/veterinary ; Immunity ; Cattle Diseases/metabolism
    Chemical Substances Interleukin-6
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2023-23866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Health Claims and Doses of Fish Oil Supplements in the US.

    Assadourian, Joanna N / Peterson, Eric D / McDonald, Samuel A / Gupta, Anand / Navar, Ann Marie

    JAMA cardiology

    2023  Volume 8, Issue 10, Page(s) 984–988

    Abstract: Importance: One in 5 US adults older than 60 years takes fish oil supplements often for heart health despite multiple randomized clinical trials showing no data for cardiovascular benefit for supplement-range doses. Statements on the supplement labels ... ...

    Abstract Importance: One in 5 US adults older than 60 years takes fish oil supplements often for heart health despite multiple randomized clinical trials showing no data for cardiovascular benefit for supplement-range doses. Statements on the supplement labels may influence consumer beliefs about health benefits.
    Objectives: To evaluate health claims made on the labels of fish oil supplements in the US, and to examine doses of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in commonly available formulations.
    Design, setting, and participants: This cross-sectional study used data from labels of on-market fish oil (and nonfish ω-3 fatty acid) supplements obtained from the National Institutes of Health Dietary Supplement Label Database. The study was conducted and data analyzed from February to June 2022.
    Main outcome and measures: The frequency and types of health claims made on fish oil labels (US Food and Drug Administration [FDA]-reviewed qualified health claim vs a structure/function claim) and the organ system referenced were evaluated. The total daily doses of combined EPA and DHA (EPA+DHA) were assessed for supplements from 16 leading manufacturers and retailers.
    Results: Across 2819 unique fish oil supplements, 2082 (73.9%) made at least 1 health claim. Of these, only 399 (19.2%) used an FDA-approved qualified health claim; the rest (1683 [80.8%]) made only structure/function claims (eg, "promotes heart health"). Cardiovascular health claims were the most common (1747 [62.0%]). Across 16 leading brands/manufacturers, 255 fish oil supplements were identified. Among these, substantial variability was found in the daily dose of EPA (median [IQR], 340 [135-647] mg/d), DHA (median [IQR], 270 [140-500] mg/d), and total EPA+DHA (median [IQR], 600 [300-1100] mg/d). Only 24 of 255 supplements (9.4%) evaluated contained a daily dose of 2 g or more EPA+DHA.
    Conclusions: Results of this cross-sectional study suggest that the majority of fish oil supplement labels make health claims, usually in the form of structure/function claims, that imply a health benefit across a variety of organ systems despite a lack of trial data showing efficacy. Significant heterogeneity exists in the daily dose of EPA+DHA in available supplements, leading to potential variability in safety and efficacy between supplements. Increasing regulation of dietary supplement labeling may be needed to prevent consumer misinformation.
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.2424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Technological solution for the assessment and rehabilitation of visuo-cognition in Parkinson's disease.

    Das, Julia / Morris, Rosie / Barry, Gill / Celik, Yunus / Godfrey, Alan / McDonald, Claire / Walker, Richard / Vitorio, Rodrigo / Stuart, Samuel

    Expert review of medical devices

    2023  Volume 20, Issue 4, Page(s) 253–257

    MeSH term(s) Humans ; Parkinson Disease ; Cognition ; Cognition Disorders ; Medicine
    Language English
    Publishing date 2023-03-23
    Publishing country England
    Document type Editorial
    ZDB-ID 2250857-0
    ISSN 1745-2422 ; 1743-4440
    ISSN (online) 1745-2422
    ISSN 1743-4440
    DOI 10.1080/17434440.2023.2192869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6424: Show issues Location:
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  8. Article ; Online: Health-related quality of life, functional outcomes, and complications after sentinel lymph node biopsy and elective neck dissection in early oral cancer: A systematic review.

    McDonald, Christopher / Kent, Samuel / Schache, Andrew / Rogers, Simon / Shaw, Richard

    Head & neck

    2023  Volume 45, Issue 11, Page(s) 2754–2779

    Abstract: Background: Elective neck dissection improves survival in early oral cancer. Sentinel lymph node biopsy may also do this with less morbidity. This systematic review compared health-related quality of life, functional outcomes, and complications after ... ...

    Abstract Background: Elective neck dissection improves survival in early oral cancer. Sentinel lymph node biopsy may also do this with less morbidity. This systematic review compared health-related quality of life, functional outcomes, and complications after sentinel lymph node biopsy and elective neck dissection in early oral cancer.
    Methods: PRISMA guidelines were followed. Thirteen studies met inclusion criteria.
    Results: Results favoring sentinel lymph node biopsy were found in complications, scar length and appearance, length of hospital stay, time to drain removal, and objective shoulder measures at timepoints up to 12 months. Where differences in health-related quality of life were found, methodological issues make their clinical significance questionable.
    Conclusions: Sentinel lymph node biopsy was associated with fewer complications and statistically better outcomes in a number of physical measures. There is as yet no strong evidence to suggest it is associated with better health-related quality of life outcomes. While a number of health-related quality of life outcome measures show promise, their interpretation is hampered by methodological concerns. Further rigorous research is required to address this.
    MeSH term(s) Humans ; Sentinel Lymph Node Biopsy/adverse effects ; Neck Dissection/adverse effects ; Neck Dissection/methods ; Quality of Life ; Lymphatic Metastasis/pathology ; Neoplasm Staging ; Mouth Neoplasms/surgery ; Mouth Neoplasms/pathology ; Lymph Nodes/pathology
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1493: Show issues Location:
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  9. Article ; Online: Impact of Rapid Medical Evaluation on Patient Flow in an Urban Emergency Department.

    Furmaga, Jakub / McDonald, Samuel A

    Journal of medical systems

    2021  Volume 45, Issue 6, Page(s) 63

    Abstract: Rapid Medical Evaluation (RME) is a new Emergency Department (ED) process that initiates testing while patients are in the Waiting Room. Primary goal of this study is to assess the effectiveness of RME pathway on the patient flow through the ED. This was ...

    Abstract Rapid Medical Evaluation (RME) is a new Emergency Department (ED) process that initiates testing while patients are in the Waiting Room. Primary goal of this study is to assess the effectiveness of RME pathway on the patient flow through the ED. This was a retrospective, single site, cohort study of patients presenting to the ED 12 months before (PRE group) and 12 months after (POST group) RME implementation. The POST group was divided into those that underwent RME and those managed using standard care pathway (SCP). Data was collected from Electronic Health Record (EHR) database using SQL and consisted of time stamp data for discrete ED patient events. The following metrics were calculated for all ED encounters: Active ED Room Time, Boarding Time, Total ED Room Time, Total ED Time, and Door-to-Provider Time. Patients undergoing RME on average spent 90-min less in ED Treatment Room compared to SCP group and were evaluated by a provider 151 min earlier than if they had waited for an available ED Treatment Room. Implementation of RME helped reduce time patients spend in ED Treatment Room, improved patient throughput, and decreased Door-to-Provider time during the busiest times in the ED.
    MeSH term(s) Benchmarking ; Cohort Studies ; Emergency Service, Hospital ; Humans ; Length of Stay ; Retrospective Studies
    Language English
    Publishing date 2021-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423488-1
    ISSN 1573-689X ; 0148-5598
    ISSN (online) 1573-689X
    ISSN 0148-5598
    DOI 10.1007/s10916-021-01741-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1426: Show issues Location:
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  10. Article ; Online: Stereotactic Body Radiation Therapy Salvage for Lymph Node Recurrent Prostate Cancer in the Era of PSMA PET Imaging.

    Hayek, Omar E / Rais-Bahrami, Soroush / McDonald, Andrew / Galgano, Samuel J

    Current urology reports

    2023  Volume 24, Issue 10, Page(s) 471–476

    Abstract: Purpose of review: Our understanding of patterns of prostate cancer recurrence after primary treatment of localized disease has significantly evolved since the development of positron emission tomography (PET) agents targeting prostate cancer. ... ...

    Abstract Purpose of review: Our understanding of patterns of prostate cancer recurrence after primary treatment of localized disease has significantly evolved since the development of positron emission tomography (PET) agents targeting prostate cancer. Previously, most biochemical recurrences were not associated with imaging correlates when restaging with computed tomography (CT), magnetic resonance imaging (MRI), or bone scintigraphy and, hence, were typically assumed to represent occult metastases. A rising prostate specific antigen (PSA) after previous local therapy prompting a PET scan showing uptake limited to regional lymph nodes is an increasingly common clinical scenario as advanced prostate cancer imaging becomes more widely utilized. The optimal management strategy for patients who have lymph node recurrent prostate cancer is both unclear and evolving, particularly in terms of local and regionally directed therapies. Stereotactic body radiation therapy (SBRT) utilizes ablative radiation doses with steep gradients to achieve local tumor control while sparing nearby normal tissues. SBRT is an attractive therapeutic modality due to its efficacy, favorable toxicity profile, and flexibility to administer elective doses to areas of potential occult involvement. The purpose of this review is to briefly describe how SBRT is being implemented in the era of PSMA PET for the management of solely lymph node recurrent prostate cancer.
    Recent findings: SBRT has been shown to effectively control individual lymph node tumor deposits within the pelvis and retroperitoneum for prostate cancer and is well-tolerated with a favorable toxicity profile. However, a major limitation thus far has been the lack of prospective trials supporting the use of SBRT for oligometastatic nodal recurrent prostate cancer. As further trials are conducted, its exact role in the treatment paradigm of recurrent prostate cancer will be better established. Although PET-guided SBRT appears feasible and potentially beneficial, there is still considerable uncertainty about the use of elective nodal radiotherapy (ENRT) in patients with nodal recurrent oligometastatic prostate cancer. PSMA PET has undoubtedly advanced imaging of recurrent prostate cancer, revealing anatomic correlates for disease recurrence that previously went undetected. At the same time, SBRT continues to be explored in prostate cancer with feasibility, a favorable risk profile, and satisfactory oncologic outcomes. However, much of the existing literature comes from the pre-PSMA PET era and integration of this novel imaging approach has led to greater focus on new and ongoing clinical trials to rigorously evaluate this approach and compare to other established treatment modalities utilized for oligometastatic, nodal recurrence of prostate cancer.
    MeSH term(s) Male ; Humans ; Radiosurgery ; Positron Emission Tomography Computed Tomography/methods ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/radiotherapy ; Neoplasm Recurrence, Local/pathology ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/pathology ; Positron-Emission Tomography ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Salvage Therapy
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057354-6
    ISSN 1534-6285 ; 1527-2737
    ISSN (online) 1534-6285
    ISSN 1527-2737
    DOI 10.1007/s11934-023-01174-5
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