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  1. Article ; Online: Fitz-Hugh-Curtis Syndrome: A Diagnosis to Consider in a Woman with Right Upper Quadrant Abdominal Pain without Gallstones.

    Faré, Pietro Benedetto / Allio, Ileana / Monotti, Rita / Foieni, Fabrizio

    European journal of case reports in internal medicine

    2018  Volume 5, Issue 2, Page(s) 743

    Abstract: A young woman presented with right upper quadrant abdominal pain exacerbated by movement and breathing. Extensive evaluation revealed no gallstones or any other specific cause. Urine polymerase chain reaction results for : Learning points: Right upper ...

    Abstract A young woman presented with right upper quadrant abdominal pain exacerbated by movement and breathing. Extensive evaluation revealed no gallstones or any other specific cause. Urine polymerase chain reaction results for
    Learning points: Right upper quadrant pain in a sexually active woman may be due to Fitz-Hugh-Curtis syndrome, a type of localized peritonitis also called perihepatitis.This condition is considered to be a complication of an ascending genital infection leading to pelvic inflammatory disease.Sexually active women with right upper quadrant abdominal pain without gallstones should be tested for
    Language English
    Publishing date 2018-02-22
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2017_000743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pulmonary Complications in a Patient with Common Variable Hypogammaglobulinemia

    Paolo Ghiringhelli / Fabrizio Foieni / Girolamo Sala / Alessandro Diana / Beatrice Valvo / Mariella Ciola / Michele Zaza / Roberto Bertolini / Cinzia Simoni / Lorenzo Bellintani / Andrea Agostinelli / Federica Macchi / Sara Limbiati / Michela Provisione

    Clinical Management Issues, Vol 17, Iss

    2023  Volume 1

    Abstract: Common variable immunodeficiency (CVID) is a rare disorder characterized by primary antibody deficiency leading to hypogammaglobulinemia and increased risk of infections. Pulmonary hypertension (PH) is an unusual complication of CVID and may be ... ...

    Abstract Common variable immunodeficiency (CVID) is a rare disorder characterized by primary antibody deficiency leading to hypogammaglobulinemia and increased risk of infections. Pulmonary hypertension (PH) is an unusual complication of CVID and may be associated with chronic hypoxemic respiratory failure. We described the case of a 47-year-old female patient hospitalized with worsening dyspnea, which had emerged about 10 days before and was associated with productive cough. 26 years before, she was diagnosed with common variable hypogammaglobulinemia, that was treated with intravenous immunoglobulin infusions for at least 20 years. She had suffered from recurrent secondary infections of the respiratory tract with inveterate bronchiectasis, pulmonary hypertension, and chronic respiratory failure. This case suggests that Internal Medicine wards, due to their global vision of the patient, are well suited to manage subjects with serious, complex, and genetically determined pathologies.
    Keywords common variable hypogammaglobulinemia ; respiratory failure ; pulmonary hypertension ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher SEEd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: [A rare case of sepsis from Citrobacter koseri in adults]

    Matteo Pistoia / Mariella Ciola / Girolamo Sala / Fabrizio Foieni / Andrea Agostinelli / Beatrice Valvo / Lorenzo Bellintani / Paolo Ghiringhelli

    Clinical Management Issues, Vol 15, Iss

    2021  Volume 1

    Abstract: We describe the case of a 53-year-old man, recently diagnosed with decompensated type II diabetes mellitus, admitted to our Department for fever, asthenia, and detection of multiple lung abscesses and pulmonary embolism at chest tomography. His clinical ... ...

    Abstract We describe the case of a 53-year-old man, recently diagnosed with decompensated type II diabetes mellitus, admitted to our Department for fever, asthenia, and detection of multiple lung abscesses and pulmonary embolism at chest tomography. His clinical history revealed just a recent orthopedic surgery of osteosynthesis on the left wrist with normal clinical and instrumental post-surgical evolution. Empirical antibiotic therapy with piperacillin/tazobactam and clindamycin was initiated. During hospital stay, swelling and functional impotence in the right knee occurred. They were investigated by arthrocentesis and magnetic resonance, and diagnosed as septic arthritis. Blood culture performed at admission tested positive for Citrobacter koseri on several samples where meropenem was added according to antibiogram. On the other hand, the cultures of bronchoaspirate, pulmonary fine needle aspiration, and arthrocentesis were negative. Antibiotic therapy was administered up to two weeks after discharge and radiological and physical features progressively improved.
    Keywords citrobacter koseri ; septic arthritis ; fever ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher SEEd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Fitz-Hugh-Curtis Syndrome

    Pietro Benedetto Faré / Ileana Allio / Rita Monotti / Fabrizio Foieni

    European Journal of Case Reports in Internal Medicine, Vol 5, Iss

    A Diagnosis to Consider in a Woman with Right Upper Quadrant Abdominal Pain without Gallstones

    2017  Volume 2

    Abstract: A young woman presented with right upper quadrant abdominal pain exacerbated by movement and breathing. Extensive evaluation revealed no gallstones or any other specific cause. Urine polymerase chain reaction results for Chlamydia trachomatis were ... ...

    Abstract A young woman presented with right upper quadrant abdominal pain exacerbated by movement and breathing. Extensive evaluation revealed no gallstones or any other specific cause. Urine polymerase chain reaction results for Chlamydia trachomatis were positive, so the clinical diagnosis of Fitz-Hugh-Curtis syndrome was confirmed. This type of localized peritonitis is thought to be a complication of an ascending genital infection leading to pelvic inflammatory disease. The diagnosis is established on clinical grounds after excluding alternative, more common conditions. Proper antibiotic treatment usually leads to recovery and prevents long-term complications.
    Keywords Medicine ; R
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Derivation and validation of the clinical prediction model for COVID-19.

    Foieni, Fabrizio / Sala, Girolamo / Mognarelli, Jason Giuseppe / Suigo, Giulia / Zampini, Davide / Pistoia, Matteo / Ciola, Mariella / Ciampani, Tommaso / Ultori, Carolina / Ghiringhelli, Paolo

    Internal and emergency medicine

    2020  Volume 15, Issue 8, Page(s) 1409–1414

    Abstract: The epidemic phase of Coronavirus disease 2019 (COVID-19) made the Worldwide health system struggle against a severe interstitial pneumonia requiring high-intensity care settings for respiratory failure. A rationalisation of resources and a specific ... ...

    Abstract The epidemic phase of Coronavirus disease 2019 (COVID-19) made the Worldwide health system struggle against a severe interstitial pneumonia requiring high-intensity care settings for respiratory failure. A rationalisation of resources and a specific treatment path were necessary. The study suggests a predictive model drawing on clinical data gathered by 119 consecutive patients with laboratory-confirmed COVID-19 admitted in Busto Arsizio hospital. We derived a score that identifies the risk of clinical evolution and in-hospital mortality clustering patients into four groups. The study outcomes have been compared across the derivation and validation samples. The prediction rule is based on eight simple patient characteristics that were independently associated with study outcomes. It is able to stratify COVID-19 patients into four severity classes, with in-hospital mortality rates of 0% in group 1, 6-12.5% in group 2, 7-20% in group 3 and 60-86% in group 4 across the derivation and validation sample. The prediction model derived in this study identifies COVID-19 patients with low risk of in-hospital mortality and ICU admission. The prediction model that the study presents identifies COVID-19 patients with low risk of in-hospital mortality and admission to ICU. Moreover, it establishes an intermediate portion of patients that should be treated accurately in order to avoid an unfavourable clinical evolution. A further validation of the model is important before its implementation as a decision-making tool to guide the initial management of patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19 ; Clinical Decision Rules ; Coronavirus Infections/diagnosis ; Coronavirus Infections/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/physiopathology ; Reproducibility of Results ; Risk Assessment/methods ; Risk Assessment/standards ; Risk Assessment/statistics & numerical data ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-09-15
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-020-02480-3
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  6. Article: Derivation and validation of the clinical prediction model for COVID-19

    Foieni, Fabrizio / Sala, Girolamo / Mognarelli, Jason Giuseppe / Suigo, Giulia / Zampini, Davide / Pistoia, Matteo / Ciola, Mariella / Ciampani, Tommaso / Ultori, Carolina / Ghiringhelli, Paolo

    Intern Emerg Med

    Abstract: The epidemic phase of Coronavirus disease 2019 (COVID-19) made the Worldwide health system struggle against a severe interstitial pneumonia requiring high-intensity care settings for respiratory failure. A rationalisation of resources and a specific ... ...

    Abstract The epidemic phase of Coronavirus disease 2019 (COVID-19) made the Worldwide health system struggle against a severe interstitial pneumonia requiring high-intensity care settings for respiratory failure. A rationalisation of resources and a specific treatment path were necessary. The study suggests a predictive model drawing on clinical data gathered by 119 consecutive patients with laboratory-confirmed COVID-19 admitted in Busto Arsizio hospital. We derived a score that identifies the risk of clinical evolution and in-hospital mortality clustering patients into four groups. The study outcomes have been compared across the derivation and validation samples. The prediction rule is based on eight simple patient characteristics that were independently associated with study outcomes. It is able to stratify COVID-19 patients into four severity classes, with in-hospital mortality rates of 0% in group 1, 6-12.5% in group 2, 7-20% in group 3 and 60-86% in group 4 across the derivation and validation sample. The prediction model derived in this study identifies COVID-19 patients with low risk of in-hospital mortality and ICU admission. The prediction model that the study presents identifies COVID-19 patients with low risk of in-hospital mortality and admission to ICU. Moreover, it establishes an intermediate portion of patients that should be treated accurately in order to avoid an unfavourable clinical evolution. A further validation of the model is important before its implementation as a decision-making tool to guide the initial management of patients.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #758227
    Database COVID19

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  7. Article ; Online: Derivation and validation of the clinical prediction model for COVID-19

    Foieni, Fabrizio / Sala, Girolamo / Mognarelli, Jason Giuseppe / Suigo, Giulia / Zampini, Davide / Pistoia, Matteo / Ciola, Mariella / Ciampani, Tommaso / Ultori, Carolina / Ghiringhelli, Paolo

    Internal and Emergency Medicine ; ISSN 1828-0447 1970-9366

    2020  

    Abstract: Abstract The epidemic phase of Coronavirus disease 2019 (COVID-19) made the Worldwide health system struggle against a severe interstitial pneumonia requiring high-intensity care settings for respiratory failure. A rationalisation of resources and a ... ...

    Abstract Abstract The epidemic phase of Coronavirus disease 2019 (COVID-19) made the Worldwide health system struggle against a severe interstitial pneumonia requiring high-intensity care settings for respiratory failure. A rationalisation of resources and a specific treatment path were necessary. The study suggests a predictive model drawing on clinical data gathered by 119 consecutive patients with laboratory-confirmed COVID-19 admitted in Busto Arsizio hospital. We derived a score that identifies the risk of clinical evolution and in-hospital mortality clustering patients into four groups. The study outcomes have been compared across the derivation and validation samples. The prediction rule is based on eight simple patient characteristics that were independently associated with study outcomes. It is able to stratify COVID-19 patients into four severity classes, with in-hospital mortality rates of 0% in group 1, 6–12.5% in group 2, 7–20% in group 3 and 60–86% in group 4 across the derivation and validation sample. The prediction model derived in this study identifies COVID-19 patients with low risk of in-hospital mortality and ICU admission. The prediction model that the study presents identifies COVID-19 patients with low risk of in-hospital mortality and admission to ICU. Moreover, it establishes an intermediate portion of patients that should be treated accurately in order to avoid an unfavourable clinical evolution. A further validation of the model is important before its implementation as a decision-making tool to guide the initial management of patients.
    Keywords Internal Medicine ; Emergency Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s11739-020-02480-3
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progress.

    Cugno, Massimo / Zanichelli, Andrea / Foieni, Fabrizio / Caccia, Sonia / Cicardi, Marco

    Trends in molecular medicine

    2009  Volume 15, Issue 2, Page(s) 69–78

    Abstract: C1 inhibitor (C1-INH, also known as SERPING1) can be deficient in plasma as a result of genetic or acquired conditions, and this causes an episodic, local increase in vascular permeability in the subcutaneous and submucosal layers, identified as ... ...

    Abstract C1 inhibitor (C1-INH, also known as SERPING1) can be deficient in plasma as a result of genetic or acquired conditions, and this causes an episodic, local increase in vascular permeability in the subcutaneous and submucosal layers, identified as angioedema (hereditary or acquired). Bradykinin, the mediator of the increase in vascular permeability, is released on inappropriate activation of the contact system, which is controlled by C1 inhibitor. Therapy aims to reverse or prevent angioedema. Advances in understanding the complex effects of C1-INH deficiency at the molecular level have led to new molecular-targeted approaches. Three new treatments, an inhibitor of kallikrein to prevent bradykinin release, an antagonist of the bradykinin receptor to prevent its action and a recombinant human C1-INH produced in transgenic animals, are under clinical evaluation currently. Here, we review the molecular mechanisms underlying angioedema due to C1-inhibitor deficiency and clinical progress using molecular-targeted interventions.
    MeSH term(s) Angioedema/genetics ; Angioedema/physiopathology ; Angioedema/therapy ; Bradykinin/metabolism ; Capillary Permeability ; Complement C1 Inhibitor Protein/genetics ; Complement C1 Inhibitor Protein/metabolism ; Homeostasis ; Humans ; Kallikreins/antagonists & inhibitors ; Kallikreins/metabolism ; Models, Molecular ; Peptide Hydrolases/chemistry ; Peptide Hydrolases/metabolism ; Protein Structure, Tertiary
    Chemical Substances Complement C1 Inhibitor Protein ; Peptide Hydrolases (EC 3.4.-) ; Kallikreins (EC 3.4.21.-) ; Bradykinin (S8TIM42R2W)
    Language English
    Publishing date 2009-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2008.12.001
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  9. Article ; Online: A case of chest pain and heart failure.

    Scannella, Emanuela / Angaroni, Laura / Coerezza, Anna / Solbiati, Monica / Foieni, Fabrizio / Montano, Nicola

    Internal and emergency medicine

    2011  Volume 7, Issue 3, Page(s) 267–269

    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Cardiomyopathies/diagnosis ; Cardiomyopathies/drug therapy ; Cardiomyopathies/pathology ; Chest Pain/diagnosis ; Chest Pain/drug therapy ; Chest Pain/pathology ; Glucocorticoids/therapeutic use ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Heart Failure/pathology ; Humans ; Male ; Middle Aged ; Sarcoidosis/diagnosis ; Sarcoidosis/drug therapy ; Sarcoidosis/pathology
    Chemical Substances Adrenergic beta-Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Glucocorticoids
    Language English
    Publishing date 2011-05-06
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-011-0595-6
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  10. Article ; Online: A simple endocrinological cause of a complex cardiovascular picture.

    Nataloni, Ilaria Faustina / Ceriani, Elisa / Foieni, Fabrizio / Montano, Nicola / Cicardi, Marco

    Internal and emergency medicine

    2010  Volume 5, Issue 3, Page(s) 269–271

    MeSH term(s) Aged ; Asthenia/etiology ; Bradycardia/etiology ; Dyspnea/drug therapy ; Humans ; Hypothyroidism/complications ; Hypothyroidism/diagnosis ; Male ; Thyroiditis, Autoimmune/complications ; Thyroiditis, Autoimmune/diagnosis ; Thyrotropin/blood ; Thyroxine/blood ; Triiodothyronine/blood
    Chemical Substances Triiodothyronine (06LU7C9H1V) ; Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2010-01-19
    Publishing country Italy
    Document type Case Reports ; Letter
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-009-0343-3
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