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  1. Article: Evaluation of the Antibacterial Activity of New Dermaseptin Derivatives against

    Haddad, Houda / Mejri, Radhia / de Araujo, Alyne Rodrigues / Zaïri, Amira

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 2

    Abstract: Nosocomial infections represent one of the biggest health problems nowadays. ...

    Abstract Nosocomial infections represent one of the biggest health problems nowadays.
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17020171
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  2. Article: Effect of Zinc Oxide Nanoparticles on Liver Functions in Albino Mice.

    Al-Ragi, Majida Jumahh / Karieb, Sahar S / Fathallah, Neila / Zaïri, Amira

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54822

    Abstract: Background: An alarming number of zinc oxide nanoparticles (ZnO-NPs) have leaked into the environment, endangering the tissues of many living creatures, due to the recent surge in their use in several items. Through intra-peritoneal injection, this ... ...

    Abstract Background: An alarming number of zinc oxide nanoparticles (ZnO-NPs) have leaked into the environment, endangering the tissues of many living creatures, due to the recent surge in their use in several items. Through intra-peritoneal injection, this research intends to examine the impact of ZnO-NPs on the hepatic and gastrointestinal structures of male albino mice.
    Method: For seven and 14 days, animals were given 0.1 ml of 100 and 200 mg kg-1 of 50 nm-size ZnO-NPs, respectively. In contrast, those in the control group were given only water and food.
    Result: The results demonstrated that the treated mice's livers underwent functional changes and histological damage. After seven and 14 days, there was a notable rise in the average levels of the glutamate-oxaloacetate transaminase and glutamate-pyruvate transaminase enzymes in comparison to the control group (p≤0.05). Concentration time determines the magnitude of this impact. When enzyme levels vary, it means the liver isn't working properly. Histological changes in the liver, such as necrosis, destruction of hepatocyte membranes, widening of sinusoidal spaces and vacuolation of their cytoplasm, vascular congestion, and an increased number of Kupffer cells, were induced in mice treated with ZnO-NPs at two studied concentrations (100 and 200 mg/kg) for seven and 14 days, respectively. These effects were time-dose-dependent, according to the results of hematoxylin-eosin staining of liver tissue images.
    Language English
    Publishing date 2024-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: HPLC-DAD Analysis and Investigation of Biological Properties of the Leaves of

    Nouir, Sahar / Laouani, Aicha / Loghmari, Ahmed / Bouassida, Khaireddine / Slim, Raoudha / Bouhajeb, Rim / Hasni, Yosra / Saguem, Khaled / Ouni, Bouraoui / Zaïri, Amira

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 12

    Abstract: Globularia ... ...

    Abstract Globularia alypum
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16121726
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  4. Article: Phytochemical profile, cytotoxic, antioxidant, and allelopathic potentials of aqueous leaf extracts of

    Zaïri, Amira / Nouir, Sahar / Zarrouk, Amira / Haddad, Houda / Khélifa, Améni / Achour, Lotfi

    Food science & nutrition

    2020  Volume 8, Issue 9, Page(s) 4805–4813

    Abstract: Although bioactivities ... ...

    Abstract Although bioactivities of
    Language English
    Publishing date 2020-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.1755
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  5. Article ; Online: Phytochemical Analysis and Evaluation of the Antioxidant, Antiproliferative, Antibacterial, and Antibiofilm Effects of

    Nouir, Sahar / Dbeibia, Amal / Bouhajeb, Rim / Haddad, Houda / Khélifa, Amani / Achour, Lotfi / Ghardallou, Mariem / Zaïri, Amira

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 10

    Abstract: Globularia ... ...

    Abstract Globularia alypum
    MeSH term(s) Antioxidants/chemistry ; Plant Extracts/chemistry ; Staphylococcus aureus ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/analysis ; Phytochemicals/pharmacology ; Phytochemicals/analysis ; Plant Leaves/chemistry ; Biofilms ; Plantaginaceae ; Microbial Sensitivity Tests
    Chemical Substances Antioxidants ; Plant Extracts ; Anti-Bacterial Agents ; Phytochemicals
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28104019
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article ; Online: HPLC-DAD Analysis and Investigation of Biological Properties of the Leaves of Globularia alypum (L.), Infusion Extract

    Sahar Nouir / Aicha Laouani / Ahmed Loghmari / Khaireddine Bouassida / Raoudha Slim / Rim Bouhajeb / Yosra Hasni / Khaled Saguem / Bouraoui Ouni / Amira Zaïri

    Pharmaceuticals, Vol 16, Iss 12, p

    2023  Volume 1726

    Abstract: Globularia alypum L. (GA) belonging to the Globulariaceae family is a Mediterranean plant which is widely used in traditional Tunisian medicine. The aim of this study was to investigate the phytochemical composition, antioxidant, anti-arthritic, ... ...

    Abstract Globularia alypum L. (GA) belonging to the Globulariaceae family is a Mediterranean plant which is widely used in traditional Tunisian medicine. The aim of this study was to investigate the phytochemical composition, antioxidant, anti-arthritic, antiproliferative, antibacterial and antibiofilm potential of aqueous GA leaf extracts (AGAL). Quantitative analyses of the different constituents of extracts were evaluated by high-performance liquid chromatography with photodiode-array detection (HPLC-DAD). Spectrophotometric methods and chemical tests were used for antioxidant and anti-arthritic activities. The antiproliferative study was evaluated using colorectal cancer SW620 cells, while the antibacterial assessment and analysis of the antibiofilm effects were determined by the microdilution method and the crystal violet assay, respectively. AGAL extracts presented several components, mainly Nepetin-7-Glucoside and trans-ferrulic acid. The results showed that they had an important antioxidant (IC 50 = 0.34; 0.38 and 1.20 mg/mL) and anti-arthritic (IC 50 = 2.94 mg/mL) properties, and these effects are displayed in a dose-dependent manner. In addition, this extract demonstrated significant antiproliferative (IC 50 = 50 µg/mL), antibacterial (MIC = 6.25 mg/mL and MBC = 6.25 mg/mL), and antibiofilm (59.70% at 25 mg/mL) properties especially against S. aureus . The results achieved confirm the important role of this plant as a source of therapeutic activities.
    Keywords Globularia alypum L ; HPLC-DAD ; antioxidant activity ; anti-arthritic activity ; antiproliferative effect ; antibacterial and antibiofilm activities ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 540
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Analysis of Pathogens of Urinary Tract Infections Associated with Indwelling Double-J Stents and Their Susceptibility to

    Bouassida, Khaireddine / Marzouk, Manel / Nouir, Sahar / Ghammem, Rim / Sahtout, Wissal / Ghardallou, Meriam / Fathallah, Neila / Boukadida, Jalel / Jaidane, Mehdi / Slim, Raoudha / Zaïri, Amira

    Pharmaceutics

    2023  Volume 15, Issue 10

    Abstract: Ureteral double-J stents are frequently used to prevent urinary obstruction. They can develop bacterial colonization and encrustation, which leads to persistent infections that seldom respond to antibiotic treatment. Thus, the goal of this study was to ... ...

    Abstract Ureteral double-J stents are frequently used to prevent urinary obstruction. They can develop bacterial colonization and encrustation, which leads to persistent infections that seldom respond to antibiotic treatment. Thus, the goal of this study was to evaluate the local spectrum of bacterial pathogens and their susceptibility to natural compounds. A total of 59 double-J ureteral stents from 59 consecutive patients were examined. The samples were inoculated on agar culture mediums. Extracts of
    Language English
    Publishing date 2023-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15102496
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  8. Article: Factors influencing bacterial colonization of double J ureteral stents: a prospective study.

    Bouassida, Khaireddine / Marzouk, Manel / Ben Saad, Hamda / Khalfaoui, Najd / Jaidane, Mehdi / Boukadida, Jalel / Zairi, Amira

    Annals of medicine and surgery (2012)

    2023  Volume 86, Issue 1, Page(s) 153–158

    Abstract: Background: To investigate the microorganisms responsible for double J stent (DJS) colonization, bacteriuria, and the drug susceptibility of the isolates. We also tried to determine factors associated with stent colonization, such as indwelling time, ... ...

    Abstract Background: To investigate the microorganisms responsible for double J stent (DJS) colonization, bacteriuria, and the drug susceptibility of the isolates. We also tried to determine factors associated with stent colonization, such as indwelling time, sex, age, and comorbidities.
    Materials and methods: This study is a prospective analysis of patients following DJS ablation. A total of 155 patients from our institution were enrolled in this study between January 2023 and May 2023. Bladder urine was collected in a sterile container prior to stent removal for bacteriological exam. The removed stents were divided into three parts: top (Renal), middle (Ureteral), and bottom (Bladder); 3 cm pieces from each part were taken and placed in a sterile test tube for bacteriological investigation.
    Results: The mean age of patients with positive stent culture was 61.17±12.82 versus 55.94±10.32 when stent culture is negative, which is statistically significant
    Conclusion: Indwelling time is the only unanimous factor of stent colonization in literature, so we recommend using DJS only if necessary and to remove it as soon as possible.
    Language English
    Publishing date 2023-11-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000001477
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  9. Article ; Online: Chemical composition, Fatty acids profile and Biological properties of Thymus capitatus (L.) Hoffmanns, essential Oil.

    Zaïri, Amira / Nouir, Sahar / Zarrouk, Amira / Haddad, Houda / Khélifa, Amani / Achour, Lotfi / Tangy, Frédéric / Chaouachi, Maher / Trabelsi, Mounir

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 20134

    Abstract: T. capitatus is widely used in traditional medicine in Tunisia. The main goal of this study was to evaluate the phytochemical composition, the fatty acids profile, the antioxidant, antibacterial, and antifungal activities as well as the cytotoxic ... ...

    Abstract T. capitatus is widely used in traditional medicine in Tunisia. The main goal of this study was to evaluate the phytochemical composition, the fatty acids profile, the antioxidant, antibacterial, and antifungal activities as well as the cytotoxic potential of the essential oil (EO) of this plant. The identification and the quantification of the different constituents of the tested EO was determined by gas chromatography-mass spectrometry (GC-MS). Antioxidant activities were evaluated by spectrophotometric methods and chemical tests. HCT 116 cells were used to evaluate the cytotoxic effect of the EO. The microdilution method was conducted to evaluate the antibacterial activity. Poisoned food method was used to test the antifungal activities against fungi species such Aspergillus niger and Aspergillus flavus. The EO presented several components, mainly monoterpenes. Results revealed that T. capitatus EO is not cytotoxic and showed excellent antioxidant activity with a dose dependent manner. Regarding antimicrobial activity, T. capitatus EO was efficient against all tested bacteria and fungi.
    MeSH term(s) Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Bacteria/drug effects ; Cell Line ; Dose-Response Relationship, Drug ; Fatty Acids/chemistry ; Fungi/drug effects ; Humans ; Microbial Sensitivity Tests ; Oils, Volatile/analysis ; Oils, Volatile/chemistry ; Oils, Volatile/pharmacology ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Thymus Plant/chemistry
    Chemical Substances Anti-Infective Agents ; Antineoplastic Agents, Phytogenic ; Antioxidants ; Fatty Acids ; Oils, Volatile ; Phytochemicals ; Plant Extracts
    Language English
    Publishing date 2019-12-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-56580-y
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  10. Article ; Online: Hemodynamic profile of pulmonary arterial hypertension in a Tunisian center.

    Jamoussi, Amira / Ben Mrad, Nacef / Rachdi, Emna / Jarraya, Fatma / Zairi, Sarra / Ben Romdhane, Kais / Besbes, Mohamed / Ayed, Samia / Ben Khelil, Jalila

    La Tunisie medicale

    2023  Volume 101, Issue 10, Page(s) 751–755

    Abstract: Introduction: Pulmonary hypertension (PH) management can only be conceived in a specialized center. We aimed to report the experience of a Tunisian ICU about PH invasive hemodynamic exploration and to describe consequent therapeutic decisions.: ... ...

    Abstract Introduction: Pulmonary hypertension (PH) management can only be conceived in a specialized center. We aimed to report the experience of a Tunisian ICU about PH invasive hemodynamic exploration and to describe consequent therapeutic decisions.
    Methods: Retrospective descriptive study including all patients admitted to the medical ICU of Abderrahmen Mami Hospital for right heart catheterization (RHC), between 2005 and 2019 as part of the investigation of PH. Patients' characteristics, procedure safety and arising therapeutic decisions were then reported.
    Results: Forty patients were admitted for hemodynamic evaluation. RHC confirmed PH in 31 patients and exploration was then completed with NO reactivity test. Mean age was 41.3±15 years, gender ratio M/F was 1.06. PH was classified into: group 1 (n=13), group 2 (n=14), group 4 (n=2) and group 5 (n=2). NO vasoreactivity test was positive in 50% of post-capillary PH and in 28% of pre-capillary PH. The therapeutic decision following the reversibility test was: prescription of calcium channel blockers (n=5), a specific pulmonary vasodilator (n=10), operability (n=6), heart-lung transplant (n=3) and therapeutic abstention (n=7). Two minor complications were reported.
    Conclusion: The medical ICU in Abderrahmen Mami Hospital represents an experienced team in hemodynamic investigations despite low annual RHC number. NO reactivity test is an indispensable tool that enables important decisions during PH management.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Pulmonary Arterial Hypertension/complications ; Retrospective Studies ; Hemodynamics ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/epidemiology ; Hypertension, Pulmonary/therapy ; Cardiac Catheterization/adverse effects ; Hypertension/complications
    Language English
    Publishing date 2023-10-05
    Publishing country Tunisia
    Document type Journal Article
    ZDB-ID 128627-4
    ISSN 2724-7031 ; 0041-4131
    ISSN (online) 2724-7031
    ISSN 0041-4131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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