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Article ; Online: Hypertension in Wilms tumor.

Hsiao, Wendy / Denburg, Michelle / Laskin, Benjamin

2023 Volume 39, Issue 1, Page(s) 15–24

Abstract: Wilms tumor (WT) represents over 90% of all pediatric kidney tumors. Children with WT often present acutely with hypertension which resolves in the short term after nephrectomy. However, WT survivors have increased long-term risk of hypertension, ... ...

Abstract	Wilms tumor (WT) represents over 90% of all pediatric kidney tumors. Children with WT often present acutely with hypertension which resolves in the short term after nephrectomy. However, WT survivors have increased long-term risk of hypertension, primarily due to decreased nephron mass after nephrectomy, with additional insults from possible exposure to abdominal radiation and nephrotoxic therapies. The diagnosis of hypertension may be improved by ambulatory blood pressure monitoring (ABPM), as several recent single-center studies have shown a substantial proportion of WT survivors with masked hypertension. Current gaps in knowledge include determining which WT patients may benefit from routine screening with ABPM, correlation of casual and ABPM parameters with cardiac abnormalities, and longitudinal assessment of cardiovascular and kidney parameters in relation to appropriate treatment of hypertension. This review aims to summarize the most recent literature on hypertension presentation and management at the time of WT diagnosis as well as the long-term hypertension risk and impact on kidney and cardiovascular outcomes in WT survivors.
MeSH term(s)	Child ; Humans ; Blood Pressure Monitoring, Ambulatory ; Glomerular Filtration Rate/physiology ; Wilms Tumor/complications ; Wilms Tumor/diagnosis ; Wilms Tumor/therapy ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/etiology ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/therapy ; Blood Pressure
Language	English
Publishing date	2023-05-13
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-023-06011-y
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Article ; Online: Lattice Anisotropy, Oxygen Octahedral Rotation and Tunable Magnetic Anisotropy in Patterned SrRuO3 Quantum Structures.

Wang, H / Laskin, G / He, W / Boschker, H / Yi, M / Braun, W / Fenk, B / Srot, V / Mannhart, J / van Aken, P A

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

2023 Volume 29, Issue Supplement_1, Page(s) 1650

Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1385710-1
ISSN	1435-8115 ; 1431-9276
ISSN (online)	1435-8115
ISSN	1431-9276
DOI	10.1093/micmic/ozad067.849
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Article ; Online: Acute physiological comparison of sub-maximal exercise on a novel adapted rowing machine and arm crank ergometry in people with a spinal cord injury.

Sawatzky, Bonita / Herrington, Brandon / Choi, Kevin / Ben Mortenson, W / Borisoff, Jaimie / Sparrey, Carolyn / Laskin, James J

Spinal cord

2022 Volume 60, Issue 8, Page(s) 694–700

Abstract: Study design: Non-randomized crossover trial.: Objectives: The objective of this study was to assess the oxygen uptake during exercise using the Adapted ROWing machine (AROW) compared to the more commonly used Arm Crank Ergometry (ACE) for people ... ...

Abstract	Study design: Non-randomized crossover trial. Objectives: The objective of this study was to assess the oxygen uptake during exercise using the Adapted ROWing machine (AROW) compared to the more commonly used Arm Crank Ergometry (ACE) for people with spinal cord injury/disease (SCI/D) with or without trunk stability. Setting: Canada, Vancouver. Methods: Participants were from a convenience sample of 14 adults with SCI/D (age 21-63 y) which include those with lumbar to low cervical impairments currently exercising at least once per week using cardiovascular exercise equipment at our Physical Activity Research Centre. The interventions were non-randomized steady-state exercise bouts at self-selected low and moderate workloads on the AROW and ACE for 5 min each. Our primary outcomes were the rate of oxygen consumption (mL/kg/min) and the Borg 0-10 Rating Scale of Perceived Exertion (RPE). Results: A repeated measures two-way ANOVA (p < 0.05) indicated that exercising on the AROW resulted significantly greater oxygen consumption and perceived exertion than ACE at similar sub-maximal workloads which may be explained by the differences in efficiency between the devices (Partial eta squared = 0.84, F stat = 48.25; Partial eta squared = 0.86, F stat = 53.54). Conclusions: We have demonstrated that this form of upper extremity exercise had a greater RPE and VO
MeSH term(s)	Adult ; Arm/physiology ; Ergometry ; Exercise/physiology ; Exercise Test/methods ; Humans ; Middle Aged ; Oxygen Consumption/physiology ; Spinal Cord Injuries/therapy ; Water Sports/physiology ; Young Adult
Language	English
Publishing date	2022-02-03
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	1316161-1
ISSN	1476-5624 ; 1362-4393
ISSN (online)	1476-5624
ISSN	1362-4393
DOI	10.1038/s41393-022-00757-2
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Article ; Online: Long-Term Kidney and Cardiovascular Complications in Pediatric Cancer Survivors.

Hsiao, Wendy / Lapite, Ajibike / Faig, Walter / Abdel-Megid, Maya / Carlson, Claire / Hobbie, Wendy / Ginsberg, Jill / Laskin, Benjamin / Denburg, Michelle

The Journal of pediatrics

2022 Volume 255, Page(s) 89–97.e1

Abstract: Objective: The objective of this study was to describe the burden of adverse kidney and hypertension outcomes in patients evaluated by pediatric nephrology in a multidisciplinary survivorship clinic.: Study design: Retrospective chart review of all ... ...

Abstract	Objective: The objective of this study was to describe the burden of adverse kidney and hypertension outcomes in patients evaluated by pediatric nephrology in a multidisciplinary survivorship clinic. Study design: Retrospective chart review of all patients followed up by nephrology in our multidisciplinary survivorship clinic from August 2013 to June 2021. Data included clinic blood pressure, longitudinal ambulatory blood pressure monitoring (ABPM), echocardiography, serum creatinine, and first-morning urine protein/creatinine ratios. For patients with multiple ABPMs, results of initial and most recent ABPMs were compared. Results: Of 422 patients followed in the multidisciplinary cancer survivorship clinic, 130 were seen by nephrology. The median time after therapy completion to first nephrology visit was 8 years. The most common diagnoses were leukemia/myelodysplastic syndrome (27%), neuroblastoma (24%), and Wilms tumor (15%). At the last follow-up, 68% had impaired kidney function, 38% had a clinical diagnosis of hypertension, and 12% had proteinuria. There were 91 ABPMs performed in 55 (42%) patients. Patients with multiple ABPMs (n = 21) had statistically significant reductions in overall median blood pressure loads: systolic initial load 37% vs most recent 10% (P = .005) and diastolic load 36% vs 14% (P = .017). Patients with impaired kidney function were more likely to have received ifosfamide. Patients with hypertension were more likely to have received total body irradiation or allogeneic stem cell transplant. Conclusions: History of leukemia/myelodysplastic syndrome, neuroblastoma, and Wilms tumor was frequent among survivors seen by nephrology. There was significant improvement in cardiovascular measures with increased recognition of hypertension and subsequent treatment.
MeSH term(s)	Humans ; Child ; Cancer Survivors ; Retrospective Studies ; Blood Pressure Monitoring, Ambulatory/methods ; Hypertension/complications ; Blood Pressure ; Survivors ; Wilms Tumor/complications ; Renal Insufficiency/complications ; Kidney Neoplasms/complications ; Kidney Neoplasms/therapy ; Kidney ; Neuroblastoma/complications ; Leukemia ; Myelodysplastic Syndromes/complications
Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2022.10.029
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Article ; Online: Exploring exercise participation and the usability of the adaptive rower and arm crank ergometer through wheelchair users' perspectives.

Wong, Rachel N / Stewart, Ashley L / Sawatzky, Bonita / Laskin, James J / Borisoff, Jaimie / Mattie, Johanne / Sparrey, Carolyn J / Mortenson, W Ben

Disability and rehabilitation

2021 Volume 44, Issue 15, Page(s) 3915–3924

Abstract: Purpose: Arm crank ergometry and adaptive rowing are existing exercise options for wheelchairs users, but not commonly available. This study was conducted to explore exercise participation of wheelchair users, as well as the usability of the adaptive ... ...

Abstract	Purpose: Arm crank ergometry and adaptive rowing are existing exercise options for wheelchairs users, but not commonly available. This study was conducted to explore exercise participation of wheelchair users, as well as the usability of the adaptive rowing ergometer (aROW) and arm crank ergometer (ACE). Methods: This mixed-methods study used a concurrent triangulation design. Following completion of both exercise sessions (5 min each), participants ( Results: Wheelchair users exercised for improved physical and mental health, as well as for functional independence, and community participation; however, lack of accessible equipment was a prominent barrier. Both the aROW and ACE have high usability, but the aROW was perceived as more enjoyable and effective for cardiovascular exercise. Conclusions: The implementation of the aROW into community gyms has the potential to help close the existing gap in inclusive equipment and may help people with disabilities to be more fully included in their community and lead healthier lives.Implications for rehabilitationWheelchair users perceive exercise as a meaningful activity that enhances physical health and risk of disease, functional independence, community participation, and overall social and emotional health.The adapted rowing machine was perceived as highly usable and was felt to be more enjoyable and effective for cardiovascular exercise compared to traditional arm crank ergometers.The adaptive rower provides an additional accessible equipment option for wheelchair users to obtain effective cardiovascular exercise.More available equipment may increase community participation and promote inclusion for wheelchair users.
MeSH term(s)	Arm ; Disabled Persons ; Ergometry ; Humans ; Spinal Cord Injuries ; Wheelchairs
Language	English
Publishing date	2021-03-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1104775-6
ISSN	1464-5165 ; 0963-8288
ISSN (online)	1464-5165
ISSN	0963-8288
DOI	10.1080/09638288.2021.1894245
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Article ; Online: Mass spectrometry imaging of diclofenac and its metabolites in tissues using nanospray desorption electrospray ionization.

Mesa Sanchez, Daniela / Brown, Hilary M / Yin, Ruichuan / Chen, Bingming / Vavrek, Marissa / Cancilla, Mark T / Zhong, Wendy / Shyong, BaoJen / Zhang, Nanyan Rena / Li, Fangbiao / Laskin, Julia

Analytica chimica acta

2022 Volume 1233, Page(s) 340490

Abstract: Glucuronidation is a common phase II metabolic process for drugs and xenobiotics which increases their solubility for excretion. Acyl glucuronides (glucuronides of carboxylic acids) present concerns as they have been implicated in gastrointestinal ... ...

Abstract	Glucuronidation is a common phase II metabolic process for drugs and xenobiotics which increases their solubility for excretion. Acyl glucuronides (glucuronides of carboxylic acids) present concerns as they have been implicated in gastrointestinal toxicity and hepatic failure. Despite the substantial success in the bulk analysis of these species, previous attempts using traditional mass spectrometry imaging (MSI) techniques have completely or partially failed and therefore little is known about their localization in tissues. Herein, we use nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI MSI), an ambient liquid extraction-based ionization technique, as a viable alternative to other MSI techniques to examine the localization of diclofenac, a widely used nonsteroidal anti-inflammatory drug, and its metabolites in mouse kidney and liver tissues. MSI data acquired over a broad m/z range showed low signals of the drug and its metabolites resulting from the low ionization efficiency and substantial signal suppression on the tissue. Significant improvements in the signal-to-noise were obtained using selected ion monitoring (SIM) with m/z windows centered around the low-abundance ions of interest. Using nano-DESI MSI in SIM mode, we observed that diclofenac acyl glucuronide and hydroxydiclofenac are localized to the inner medulla and cortex of the kidney, respectively, which is consistent with the previously reported localization of enzymes that process diclofenac into its respective metabolites. In contrast, a uniform distribution of diclofenac and its metabolites was observed in the liver tissue. Concentration ratios of diclofenac and hydroxydiclofenac calculated from nano-DESI MSI data are generally in agreement to those obtained using liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis. Collectively, our results demonstrate that nano-DESI MSI can be successfully used to image diclofenac and its primary metabolites and derive relative quantitative data from different tissue regions. Our approach will enable a better understanding of metabolic processes associated with diclofenac and other drugs that are difficult to analyze using commercially available MSI platforms.
MeSH term(s)	Animals ; Mice ; Spectrometry, Mass, Electrospray Ionization/methods ; Chromatography, Liquid ; Diclofenac ; Tandem Mass Spectrometry ; Ions ; Anti-Inflammatory Agents
Chemical Substances	Diclofenac (144O8QL0L1) ; Ions ; Anti-Inflammatory Agents
Language	English
Publishing date	2022-10-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2022.340490
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Article: The economic value of liquid biopsy for genomic profiling in advanced non-small cell lung cancer.

Therapeutic advances in medical oncology

2022 Volume 14, Page(s) 17588359221112696

Abstract: Background: Liquid biopsy (LB) can detect actionable genomic alterations in plasma circulating tumor circulating tumor DNA beyond tissue testing (TT) alone in advanced non-small cell lung cancer (NSCLC) patients. We estimated the cost-effectiveness of ... ...

Abstract	Background: Liquid biopsy (LB) can detect actionable genomic alterations in plasma circulating tumor circulating tumor DNA beyond tissue testing (TT) alone in advanced non-small cell lung cancer (NSCLC) patients. We estimated the cost-effectiveness of adding LB to TT in the Canadian healthcare system. Methods: A cost-effectiveness analysis was conducted using a decision analytic Markov model from the Canadian public payer (Ontario) perspective and a 2-year time horizon in patients with treatment-naïve stage IV non-squamous NSCLC and ⩽10 pack-year smoking history. LB was performed using the comprehensive genomic profiling Guardant360™ assay. Standard of care TT for each participating institution was performed. Costs and outcomes of molecular testing by LB + TT were compared to TT alone. Transition probabilities were calculated from the VALUE trial (NCT03576937). Sensitivity analyses were undertaken to assess uncertainty in the model. Results: Use of LB + TT identified actionable alterations in more patients, 68.5 Conclusion: The addition of LB to TT as initial molecular testing of clinically selected patients with advanced NSCLC did not increase system costs and led to more patients receiving appropriate targeted therapy.
Language	English
Publishing date	2022-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2503443-1
ISSN	1758-8359 ; 1758-8340
ISSN (online)	1758-8359
ISSN	1758-8340
DOI	10.1177/17588359221112696
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Article ; Online: Acute Kidney Injury Associated with Late-Onset Neonatal Sepsis: A Matched Cohort Study.

Coggins, Sarah A / Laskin, Benjamin / Harris, Mary Catherine / Grundmeier, Robert W / Passarella, Molly / McKenna, Kristin J / Srinivasan, Lakshmi

The Journal of pediatrics

2020 Volume 231, Page(s) 185–192.e4

Abstract: Objectives: To determine incidence and severity of acute kidney injury (AKI) within 7 days of sepsis evaluation and to assess AKI duration and the association between AKI and 30-day mortality.: Study design: Retrospective, matched cohort study in a ... ...

Abstract	Objectives: To determine incidence and severity of acute kidney injury (AKI) within 7 days of sepsis evaluation and to assess AKI duration and the association between AKI and 30-day mortality. Study design: Retrospective, matched cohort study in a single-center level IV neonatal intensive care unit. Eligible infants underwent sepsis evaluations at ≥72 hours of age during calendar years 2013-2018. Exposed infants (cases) were those with culture-proven sepsis and antimicrobial duration ≥5 days. Nonexposed infants (controls) were matched 1:1 to exposed infants based on gestational and corrected gestational age, and had negative sepsis evaluations with antibiotic durations <48 hours. AKI was defined by modified neonatal Kidney Disease Improving Global Outcomes criteria. Statistical analysis included Mann-Whitney and χ Results: Among 203 episodes of late-onset sepsis, 40 (20%) developed AKI within 7 days after evaluation, and among 193 episodes with negative cultures, 16 (8%) resulted in AKI (P = .001). Episodes of sepsis also led to greater AKI severity, compared with nonseptic episodes (P = .007). The timing of AKI onset and AKI duration did not differ between groups. Sepsis was associated with increased odds of developing AKI (aOR, 3.0; 95% CI, 1.5-6.2; P = .002). AKI was associated with increased 30-day mortality (aOR, 4.5; 95% CI, 1.3-15.6; P = .017). Conclusions: Infants with late-onset sepsis had increased odds of AKI and greater AKI severity within 7 days of sepsis evaluation, compared with age-matched infants without sepsis. AKI was independently associated with increased 30-day mortality. Strategies to mitigate AKI in critically ill neonates with sepsis may improve outcomes.
MeSH term(s)	Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Cohort Studies ; Female ; Humans ; Incidence ; Infant, Newborn ; Male ; Neonatal Sepsis/complications ; Retrospective Studies ; Severity of Illness Index ; Time Factors
Language	English
Publishing date	2020-12-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2020.12.023
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Article ; Online: Pitfalls in the diagnosis of hepatic epithelioid hemangioendothelioma by FNA and needle core biopsy.

Jurczyk, Matthew / Zhu, Bing / Laskin, William / Lin, Xiaoqi

Diagnostic cytopathology

2014 Volume 42, Issue 6, Page(s) 516–520

Abstract: Epithelioid hemangioendothelioma (EHE) of the liver is an extremely rare tumor that masquerades as an epithelial neoplasm and poses significant diagnostic pitfalls for the cytopathologist. This report describes a 64-year-old woman whom on computerized ... ...

Abstract	Epithelioid hemangioendothelioma (EHE) of the liver is an extremely rare tumor that masquerades as an epithelial neoplasm and poses significant diagnostic pitfalls for the cytopathologist. This report describes a 64-year-old woman whom on computerized tomography was found to have multiple peripherally calcified hypodense lesions throughout the liver and an ipsilateral adrenal mass. Fine needle aspiration and needle cores biopsies of the largest liver lesion showed epithelioid cells and spindle cells in fibrous stroma. The epithelioid cells had round or oval, hyperchromatic nuclei with smooth nuclear contours, delicate cytoplasm and indistinct cytoplasmic borders. Rare cells had intracellular vascular lumen containing fragmented or intact red blood cells. The cells were individually dispersed or arranged in nests and vague tubular arrays. No mitotic figures or necrosis were seen. An immunohistochemical profile demonstrated diffuse CD31 and focal CD 34 and nuclear Fli-1 immunoexpression and low Ki-67 proliferative activity (1%) within lesional cells confirming the diagnosis of EHE. The differential diagnosis of EHE which includes cholangiocarcinoma, hepatocellular carcinoma, metastatic carcinoma and melanoma is discussed.
MeSH term(s)	Antigens, CD34/genetics ; Antigens, CD34/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Biopsy, Fine-Needle ; Biopsy, Large-Core Needle ; Diagnostic Errors ; Female ; Hemangioendothelioma, Epithelioid/diagnosis ; Hemangioendothelioma, Epithelioid/pathology ; Humans ; Ki-67 Antigen/genetics ; Ki-67 Antigen/metabolism ; Liver Neoplasms/diagnosis ; Liver Neoplasms/pathology ; Middle Aged ; Platelet Endothelial Cell Adhesion Molecule-1/genetics ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Proto-Oncogene Protein c-fli-1/genetics ; Proto-Oncogene Protein c-fli-1/metabolism
Chemical Substances	Antigens, CD34 ; Biomarkers, Tumor ; FLI1 protein, human ; Ki-67 Antigen ; Platelet Endothelial Cell Adhesion Molecule-1 ; Proto-Oncogene Protein c-fli-1
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632710-2
ISSN	1097-0339 ; 8755-1039
ISSN (online)	1097-0339
ISSN	8755-1039
DOI	10.1002/dc.22943
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Article ; Online: Derivatives of 1,2,4-triazole imines acting as dual iNOS and tumor cell growth inhibitors.

Guillon, Christophe / Vetrano, Anna M / Saxena, Jaya / Hunter, Angela / Verderone, Geraldine / Finetti, Thomas M / Wisnoski, Jeffrey / DeMatteo, Peter W / Rapp, Robert D / Heindel, Ned D / Joseph, Laurie B / Heck, Diane E / Laskin, Jeffrey D

Bioorganic chemistry

2020 Volume 103, Page(s) 104128

Abstract: A set of 4-( ... ...

Abstract	A set of 4-(R
MeSH term(s)	Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Proliferation/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Growth Inhibitors/chemical synthesis ; Growth Inhibitors/chemistry ; Growth Inhibitors/pharmacology ; Imines/chemical synthesis ; Imines/chemistry ; Imines/pharmacology ; Mice ; Molecular Structure ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase Type II/antagonists & inhibitors ; Nitric Oxide Synthase Type II/metabolism ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry ; Triazoles/pharmacology
Chemical Substances	Antineoplastic Agents ; Growth Inhibitors ; Imines ; Triazoles ; 1,2,4-triazole (288-88-0) ; Nitric Oxide (31C4KY9ESH) ; NOS2 protein, human (EC 1.14.13.39) ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
Language	English
Publishing date	2020-07-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2020.104128
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