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  1. Article: Genetic Variation in the

    Dimitrakopoulos, Foteinos-Ioannis / Koliou, Georgia-Angeliki / Kotoula, Vassiliki / Papadopoulou, Kyriaki / Markou, Konstantinos / Vlachtsis, Konstantinos / Angouridakis, Nikolaos / Karasmanis, Ilias / Nikolaou, Angelos / Psyrri, Amanda / Visvikis, Anastasios / Kosmidis, Paris / Fountzilas, George / Koutras, Angelos

    Cancers

    2021  Volume 13, Issue 5

    Abstract: Head and neck cancer (HNC) is a significantly heterogeneous disease and includes malignancies arising from different anatomical sites, such as nasopharyngeal cancer (NPC) and laryngeal cancer (LC). In the current study, polymorphisms located in ... ...

    Abstract Head and neck cancer (HNC) is a significantly heterogeneous disease and includes malignancies arising from different anatomical sites, such as nasopharyngeal cancer (NPC) and laryngeal cancer (LC). In the current study, polymorphisms located in angiogenesis- and apoptosis-related genes (
    Language English
    Publishing date 2021-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13051163
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  2. Article ; Online: Tumor Infiltrating Lymphocytes and CD8+ T Cell Subsets as Prognostic Markers in Patients with Surgically Treated Laryngeal Squamous Cell Carcinoma.

    Chatzopoulos, Kyriakos / Kotoula, Vassiliki / Manoussou, Kyriaki / Markou, Konstantinos / Vlachtsis, Konstantinos / Angouridakis, Nikolaos / Nikolaou, Angelos / Vassilakopoulou, Maria / Psyrri, Amanda / Fountzilas, Georgios

    Head and neck pathology

    2019  Volume 14, Issue 3, Page(s) 689–700

    Abstract: To evaluate the prognostic significance of tumor infiltrating lymphocytes (TILs) and of CD8+ T-cell subsets in patients with surgically treated laryngeal squamous cell carcinoma (LSCC), LSCC from 283 patients were examined. TIL density was ... ...

    Abstract To evaluate the prognostic significance of tumor infiltrating lymphocytes (TILs) and of CD8+ T-cell subsets in patients with surgically treated laryngeal squamous cell carcinoma (LSCC), LSCC from 283 patients were examined. TIL density was morphologically assessed on whole sections. CD8+ cell counts/mm
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/immunology ; CD8-Positive T-Lymphocytes/immunology ; Female ; Humans ; Laryngeal Neoplasms/immunology ; Laryngeal Neoplasms/surgery ; Lymphocytes, Tumor-Infiltrating/immunology ; Male ; Middle Aged ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/immunology ; Squamous Cell Carcinoma of Head and Neck/surgery
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2019-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2407834-7
    ISSN 1936-0568 ; 1936-055X
    ISSN (online) 1936-0568
    ISSN 1936-055X
    DOI 10.1007/s12105-019-01101-6
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  3. Article ; Online: Primary neuroendocrine neoplasms of the larynx. A series of 4 cases reported and a review of the literature.

    Angouridakis, Nikolaos / Goudakos, John / Karayannopoulou, Georgia / Triaridis, Stefanos / Nikolaou, Angelos / Markou, Konstantinos

    Head & neck

    2013  Volume 35, Issue 6, Page(s) E187–93

    Abstract: Background: Neuroendocrine tumors are rare neoplasms arising from neural and epithelial origin.: Methods and results: The case records of 4 patients with the diagnosis of neuroendocrine laryngeal tumor were retrospectively reviewed. In this analysis ... ...

    Abstract Background: Neuroendocrine tumors are rare neoplasms arising from neural and epithelial origin.
    Methods and results: The case records of 4 patients with the diagnosis of neuroendocrine laryngeal tumor were retrospectively reviewed. In this analysis of our medical records, we describe a series of 4 men with neuroendocrine laryngeal tumors treated in our department since 1994, including the first extremely aggressive and lethal laryngeal paraganglioma reported in the English-language literature. We also discuss the classification, the macro and microscopical characteristics, clinical and pathologic findings, and treatment of these neoplasms.
    Conclusion: Although neuroendocrine laryngeal tumors account for approximately 1% of all neoplasms in the larynx, its majority represents very aggressive tumors showing a capacity for metastasis and portending poor outcome.
    MeSH term(s) Aged ; Chemoradiotherapy ; Chemotherapy, Adjuvant ; Humans ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/therapy ; Laryngectomy ; Male ; Middle Aged ; Neoplasm Metastasis ; Neuroendocrine Tumors/pathology ; Neuroendocrine Tumors/therapy ; Radiotherapy, Adjuvant ; Retrospective Studies ; Smoking/adverse effects ; Thyroidectomy
    Language English
    Publishing date 2013-06
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.22955
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1493: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Mucogingival overgrowth in a geriatric patient.

    Kafas, Panagiotis / Upile, Tahwinder / Stavrianos, Christos / Angouridakis, Nikolaos / Jerjes, Waseem

    Dermatology online journal

    2010  Volume 16, Issue 8, Page(s) 7

    Abstract: Epulis fissuratum is a pathological condition caused by an ill-fitting denture. The mucogingival hyperplasia may be considered as a reactive condition of the oral mucosa to excessive mechanical pressure on the mucosa. Epulis fissuratum excision is a ... ...

    Abstract Epulis fissuratum is a pathological condition caused by an ill-fitting denture. The mucogingival hyperplasia may be considered as a reactive condition of the oral mucosa to excessive mechanical pressure on the mucosa. Epulis fissuratum excision is a procedure usually done for prosthodontic reasons. The treatment of this benign entity is essential mainly for masticatory reasons. The use of diode laser for epulis removal without infiltrated anesthesia in a conscious geriatric patient is currently under investigation.
    MeSH term(s) Aged ; Dentures/adverse effects ; Female ; Gingival Hyperplasia/etiology ; Gingival Hyperplasia/pathology ; Gingival Hyperplasia/surgery ; Humans ; Lasers, Semiconductor/therapeutic use ; Mouth Mucosa/pathology ; Mouth Mucosa/surgery ; Treatment Outcome
    Language English
    Publishing date 2010
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 1087-2108
    ISSN (online) 1087-2108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Expression of TNFα, IL-6, IL-2 and IL-8 in the Serum of Patients with Idiopathic Sudden Sensorineural Hearing Loss: Possible Prognostic Factors of Response to Corticosteroid Treatment

    Tsinaslanidou, Zinovia / Tsaligopoulos, Miltiadis / Angouridakis, Nikolaos / Vital, Victor / Kekes, Georgios / Constantinidis, Jiannis

    Audiology and Neurotology Extra

    2016  Volume 6, Issue 1, Page(s) 9–19

    Abstract: Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) remains one of the major unsolved otologic emergencies. A viral infection, a systemic inflammatory disorder, as well as physical, mental and metabolic stress can trigger an innate immune ...

    Institution 2nd Department and 1st Department of Otolaryngology Head and Neck Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Abstract Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) remains one of the major unsolved otologic emergencies. A viral infection, a systemic inflammatory disorder, as well as physical, mental and metabolic stress can trigger an innate immune response in the inner ear resulting in ISSNHL. Proinflammatory cytokines play a central role in this cochlear immunological cascade. Objective: To examine the expression of proinflammatory cytokines in the serum of patients with ISSNHL in correlation with the therapeutic outcome of intravenous administration of corticosteroids. Method: Forty-three patients primarily diagnosed with ISSNHL underwent intravenous corticosteroid treatment for 8 days. The expression of tumor necrosis factor-α (TNFα), interleukin-6 (IL-6), interleukin-2 (IL-2) and interleukin-8 (IL-8) was detected with the use of enzyme-linked immunosorbent assay in serum specimens on the 1st and 8th day of treatment and it was correlated with the treatment outcome. Results: TNFα reduction and IL-6 increase strongly correlate with a good therapeutic result [χ2(2) = 13.12, p = 0.001 and χ2(2) = 16.78, p = 0.0001]. IL-8 increase reflects negatively on the outcome, however, not in a statistically significant way. No association was established between IL-2 variations and the therapeutic outcome. Conclusions: TNFα and IL-6 can be used as prognostic factors for the treatment outcome, whereas the prognostic value of IL-8 requires further statistical confirmation.
    Keywords IL-6 ; IL-2 ; IL-8 ; Recovery ; Sudden sensorineural hearing loss ; Proinflammatory cytokines ; TNFα ; Immunological theory
    Language English
    Publishing date 2016-04-05
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Paper ; This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
    ZDB-ID 2677620-0
    ISSN 1664-5537 ; 1664-5537
    ISSN (online) 1664-5537
    ISSN 1664-5537
    DOI 10.1159/000442016
    Database Karger publisher's database

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  6. Article ; Online: Dysaesthesia in the mental nerve distribution triggered by a foreign body: a case report.

    Kafas, Panagiotis / Upile, Tahwinder / Angouridakis, Nikolaos / Stavrianos, Christos / Dabarakis, Nikolaos / Jerjes, Waseem

    Cases journal

    2009  Volume 2, Page(s) 169

    Abstract: Introduction: Foreign bodies' entrapments in the mandibular and submandibular regions are quite common.: Case presentation: We report an unusual case of foreign body (amalgam filling) entrapment over the mental foramen causing dysaesthesia in the ... ...

    Abstract Introduction: Foreign bodies' entrapments in the mandibular and submandibular regions are quite common.
    Case presentation: We report an unusual case of foreign body (amalgam filling) entrapment over the mental foramen causing dysaesthesia in the distribution of the mental nerve. An interesting sign was blue discoloration of the overlaying oral mucosa which was interpreted as amalgam tattooing.
    Conclusion: Surgical removal of the foreign object eliminated the reported symptoms.
    Language English
    Publishing date 2009-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2431132-7
    ISSN 1757-1626 ; 1757-1626
    ISSN (online) 1757-1626
    ISSN 1757-1626
    DOI 10.1186/1757-1626-2-169
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  7. Article ; Online: Dermatofibrosarcoma protuberans with fibrosarcomatous transformation of the head and neck.

    Angouridakis, Nikolaos / Kafas, Panagiotis / Jerjes, Waseem / Triaridis, Stefanos / Upile, Tahwinder / Karkavelas, Georgios / Nikolaou, Angelos

    Head & neck oncology

    2011  Volume 3, Page(s) 5

    Abstract: Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous neoplasm associated with a high cure rate. We present a case of aggressive DFSP with fibrosarcomatous areas in the head and neck. A 28-year-old Mediterranean female presented with a 45-day ... ...

    Abstract Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous neoplasm associated with a high cure rate. We present a case of aggressive DFSP with fibrosarcomatous areas in the head and neck. A 28-year-old Mediterranean female presented with a 45-day history of rapidly growing cutaneous lesion of the face. Surgical biopsy confirmed the diagnosis of DFSP. Subsequently, the patient underwent wide local surgical resection, followed by reconstruction. Histopathology report revealed fibrosarcomatous transformation and the patient underwent adjuvant radiotherapy. The patient continues to be disease free at the 35-month follow-up.Although DFSP behave as non-aggressive malignancy, surgery with complete removal of the affected area is the intervention of choice. Moreover, adjuvant treatment and follow-up of the patient is essential in order to prevent recurrence.
    MeSH term(s) Adult ; Cell Transformation, Neoplastic/pathology ; Dermatofibrosarcoma/diagnosis ; Dermatofibrosarcoma/pathology ; Dermatofibrosarcoma/surgery ; Disease Progression ; Female ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/surgery ; Humans ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery
    Language English
    Publishing date 2011-02-04
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2473460-3
    ISSN 1758-3284 ; 1758-3284
    ISSN (online) 1758-3284
    ISSN 1758-3284
    DOI 10.1186/1758-3284-3-5
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  8. Article ; Online: Screening for EGFR Mutations in Patients with Head and Neck Cancer Treated with Gefitinib on a Compassionate-Use Program: A Hellenic Cooperative Oncology Group Study.

    Murray, Samuel / Bobos, Mattheos / Angouridakis, Nikolaos / Nikolaou, Angelos / Linardou, Helena / Razis, Evangelia / Fountzilas, George

    Journal of oncology

    2011  Volume 2010, Page(s) 709678

    Abstract: Background and Aim. EGFR is commonly expressed in cancers of the head and neck (H and N), and anti-EGFR agents have demonstrated improvements in outcomes (TTP and OS). The aim of this study was to determine EGFR gene status in H and N cancer patients ... ...

    Abstract Background and Aim. EGFR is commonly expressed in cancers of the head and neck (H and N), and anti-EGFR agents have demonstrated improvements in outcomes (TTP and OS). The aim of this study was to determine EGFR gene status in H and N cancer patients treated with gefitinib and to correlate mutational status with clinico-pathological data and response. Patients and Methods. Patients with histologically confirmed H and N cancer having failed prior treatment for advanced disease entered this compassionate-use-program. Nineteen patients received gefitinib. EGFR expression was assessed by IHC, gene copy number by FISH, and mutation analysis was conducted for EGFR (18-21), KRAS, BRAF (V600E), and HER-2 exon 20. An additional TKI naive cohort of 73 patients was also screened. Results. Mutations were detected in 6/19 patients (3× EGFR, 1× KRAS, and 2× HER2-exon 20). There were no significant differences in TTP or OS for patients with somatic EGFR mutations. No BRAF mutations were detected. Conclusions. The incidence of EGFR mutations in H and N cancer in this study was 5.3%. No statistically relevant correlations between mutation or gene gain and response or survival were observed. Due to the limited number of patients and low incidence of genetic aberrations in the genes analyzed, additional studies are warranted.
    Language English
    Publishing date 2011-01-03
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2461349-6
    ISSN 1687-8469 ; 1687-8450
    ISSN (online) 1687-8469
    ISSN 1687-8450
    DOI 10.1155/2010/709678
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  9. Conference proceedings: Olfaktorische Funktion bei allergischer Rhinitis

    Yakinthou, Anna / Angouridakis, Nikolaos / Constantinidis, Jannis

    2006  , Page(s) 06hnod328

    Event/congress 77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.; Mannheim; Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 2006
    Keywords Medizin, Gesundheit
    Publishing date 2006-04-24
    Publisher German Medical Science; Düsseldorf, Köln
    Document type Conference proceedings
    Database German Medical Science

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  10. Conference proceedings: Einfluss der chirurgischen Erweiterung der oberen Atemwege bei OSAS Patienten auf die Plasma Zytokine

    Constantinidis, Jannis / Ereliadis, Stefanos / Angouridakis, Nikolaos / Angouridaki, Christina

    2006  , Page(s) 06hnod608

    Event/congress 77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.; Mannheim; Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 2006
    Keywords Medizin, Gesundheit
    Publishing date 2006-04-24
    Publisher German Medical Science; Düsseldorf, Köln
    Document type Conference proceedings
    Database German Medical Science

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