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Book: Mohs micrographic surgery

Snow, Stephen N. / Mikhail, George R.

2004

Author's details	Stephen N. Snow ; George R. Mikhail
Keywords	Microsurgery / methods ; Skin Neoplasms / surgery
Language	English
Size	XIX, 436 S. : zahlr. Ill., graph Darst.
Edition	2. ed.
Publisher	Univ. of Wisconsin Press
Publishing place	Madison, Wis
Publishing country	United States
Document type	Book
HBZ-ID	HT014373826
ISBN	0-299-20470-7 ; 978-0-299-20470-9
Database	Catalogue ZB MED Medicine, Health

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Article: Tick Densities and Infection Prevalence on Coastal Islands in Massachusetts, USA: Establishing a Baseline.

Snow, Allison A / Pearson, Patrick / Xu, Guang / Allen, David N / Santamaria, Roberto / Rich, Stephen M

Insects

2023 Volume 14, Issue 7

Abstract: Tick-borne diseases and a tick-induced red meat allergy have become increasingly common in the northeastern USA and elsewhere. At the scale of local communities, few studies have documented tick densities or infection levels to characterize current ... ...

Abstract	Tick-borne diseases and a tick-induced red meat allergy have become increasingly common in the northeastern USA and elsewhere. At the scale of local communities, few studies have documented tick densities or infection levels to characterize current conditions and provide a baseline for further monitoring. Using the town of Nantucket, MA, as a case study, we recorded tick densities by drag sampling along hiking trails in nature preserves on two islands. Nymphal blacklegged ticks (
Language	English
Publishing date	2023-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662247-6
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects14070628
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Article ; Online: Tick Densities and Infection Prevalence on Coastal Islands in Massachusetts, USA: Establishing a Baseline

Snow, Allison A. / Pearson, Patrick / Xu, Guang / Allen, David N. / Santamaria, Roberto / Rich, Stephen M.

Insects. 2023 July 12, v. 14, no. 7

2023

Abstract	Tick-borne diseases and a tick-induced red meat allergy have become increasingly common in the northeastern USA and elsewhere. At the scale of local communities, few studies have documented tick densities or infection levels to characterize current conditions and provide a baseline for further monitoring. Using the town of Nantucket, MA, as a case study, we recorded tick densities by drag sampling along hiking trails in nature preserves on two islands. Nymphal blacklegged ticks (Ixodes scapularis Say) were most abundant at shadier sites and least common in grasslands and scrub oak thickets (Quercus ilicifolia). Lone star ticks (Amblyomma americanum L.) were common on Tuckernuck Island and rare on Nantucket Island, while both tick species were more numerous in 2021 compared to 2020 and 2022. We tested for pathogens in blacklegged nymphs at five sites over two years. In 2020 and 2021, infection levels among the four Nantucket Island sites averaged 10% vs. 19% for Borrelia burgdorferi, 11% vs. 15% for Babesia microti, and 17% (both years) for Anaplasma phagocytophilum, while corresponding levels were significantly greater on Tuckernuck in 2021. Our site-specific, quantitative approach represents a practical example of how potential exposure to tick-borne diseases can be monitored on a local scale.
Keywords	Amblyomma americanum ; Anaplasma phagocytophilum ; Babesia microti ; Borrelia burgdorferi ; Ixodes scapularis ; Quercus ilicifolia ; case studies ; hypersensitivity ; quantitative analysis ; red meat ; shrublands ; ticks ; Massachusetts
Language	English
Dates of publication	2023-0712
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2662247-6
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects14070628
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Significance of Basal Cell Carcinomas Exhibiting Intravascular Invasion.

Bae, Edward / Breen, Catherine / Vidal, Eduardo / Anderson-Dockter, Heidi / Snow, Stephen N / Liu, Rosemarie H / Longley, Bruce Jack / Iwamoto, Satori

The American Journal of dermatopathology

2023 Volume 45, Issue 7, Page(s) 448–453

Abstract: Abstract: Intravascular invasion of tumor cells can be associated with metastasis in many cancers. Basal cell carcinomas (BCCs), however, rarely metastasize; therefore, the clinical impact of intravascularly invasive BCC (IVBCC) is currently unclear. ... ...

Abstract	Abstract: Intravascular invasion of tumor cells can be associated with metastasis in many cancers. Basal cell carcinomas (BCCs), however, rarely metastasize; therefore, the clinical impact of intravascularly invasive BCC (IVBCC) is currently unclear. Because of these facts and the rarity of IVBCC, questions have arisen on whether IVBCC truly exists. We present 4 cases of IVBCC: one case with obvious tumor islands within immunolabeled blood vessels in the context of advanced disease and 3 cases found incidentally during Mohs micrographic surgery. We discuss the difficulty in studying IVBCC, the idea that it could be due to artifact, and the lack of direct clinical-pathological correlation. Given these challenges, we propose diagnostic criteria for IVBCC to decrease ambiguity for pathological diagnosis. Such criteria may facilitate further studies on the clinical significance of IVBCC.
MeSH term(s)	Humans ; Skin Neoplasms/pathology ; Carcinoma, Basal Cell/pathology ; Mohs Surgery
Language	English
Publishing date	2023-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	448469-1
ISSN	1533-0311 ; 0193-1091
ISSN (online)	1533-0311
ISSN	0193-1091
DOI	10.1097/DAD.0000000000002452
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Keeping the power on to home medical devices.

Bean, Richard / Snow, Stephen / Glencross, Mashhuda / Viller, Stephen / Horrocks, Neil

PloS one

2020 Volume 15, Issue 7, Page(s) e0235068

Abstract: Advances in digital health technologies have revolutionised home medical care. Yet many home medical devices (HMEDs, which includes devices referred to as 'life support equipment') rely upon a stable and resilient electricity supply. For users of HMEDs, ... ...

Abstract	Advances in digital health technologies have revolutionised home medical care. Yet many home medical devices (HMEDs, which includes devices referred to as 'life support equipment') rely upon a stable and resilient electricity supply. For users of HMEDs, interruptions to electricity supply can compromise treatment, well-being or survival. This paper addresses a challenge critical to the continued innovation in digital health technologies: the reliable supply of electricity. We bridge the current gap between electricity networks and digital health technologies through a novel method for the remote detection of the phase (that is, which part of the network that each house is connected to), in order to eliminate avoidable interruptions to supply for HMED users. We present an unsupervised phase identification algorithm capable of remote phase detection at scale, and without transformer data. This method translates data insights into actionable energy provision for HMED users and other vulnerable customers, enables more accurate management and planning, and improves electricity reliability which is critical for HMED users and the continued advances in digital health technologies.
MeSH term(s)	Algorithms ; Electricity ; Equipment and Supplies/standards ; Home Care Services/standards ; Humans
Language	English
Publishing date	2020-07-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0235068
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The dynamicity of acute ozone-induced systemic leukocyte trafficking and adrenal-derived stress hormones.

Henriquez, Andres R / Williams, Wanda / Snow, Samantha J / Schladweiler, Mette C / Fisher, Cynthia / Hargrove, Marie M / Alewel, Devin / Colonna, Catherine / Gavett, Stephen H / Miller, Colette N / Kodavanti, Urmila P

Toxicology

2021 Volume 458, Page(s) 152823

Abstract: Ozone exposure induces neuroendocrine stress response, which causes lymphopenia. It was hypothesized that ozone-induced increases in stress hormones will temporally follow changes in circulating granulocytes, monocytes- and lymphocyte subpopulations. The ...

Abstract	Ozone exposure induces neuroendocrine stress response, which causes lymphopenia. It was hypothesized that ozone-induced increases in stress hormones will temporally follow changes in circulating granulocytes, monocytes- and lymphocyte subpopulations. The goal of this study was to chronicle the changes in circulating stress hormones, cytokines, and leukocyte trafficking during 4 h exposure to ozone. Male Wistar Kyoto rats were exposed to air or ozone (0.4 or 0.8 ppm) for 0.5, 1, 2, or 4 h. After each time point, circulating stress hormones, cytokines, and lung gene expression were assessed along with live and apoptotic granulocytes, monocytes (classical and non-classical), and lymphocytes (B, T
MeSH term(s)	Adrenal Cortex Hormones/metabolism ; Air Pollutants/toxicity ; Air Pollution/adverse effects ; Animals ; Apoptosis/drug effects ; Cytokines/metabolism ; Gene Expression Regulation ; Granulocytes/drug effects ; Leukocytes/drug effects ; Lung/metabolism ; Lymphocytes/drug effects ; Male ; Monocytes/drug effects ; Ozone/toxicity ; Rats ; Rats, Inbred WKY ; Spleen/cytology ; Spleen/drug effects ; T-Lymphocytes
Chemical Substances	Adrenal Cortex Hormones ; Air Pollutants ; Cytokines ; Ozone (66H7ZZK23N)
Language	English
Publishing date	2021-05-26
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	184557-3
ISSN	1879-3185 ; 0300-483X
ISSN (online)	1879-3185
ISSN	0300-483X
DOI	10.1016/j.tox.2021.152823
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Zs.A 888: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Quality Improvement of Primary Care Provider Communication on Hospital Discharge.

Goodrich, Nathaniel / Dolter, Stephen / Snow, Joseph / Stoolman, Sharon / Kerns, Ellen / McCulloh, Russell

Hospital pediatrics

2021 Volume 11, Issue 10, Page(s) 1050–1056

Abstract: Background and objectives: Effective communication between inpatient and primary care providers (PCPs) is important for safe transition of care for hospitalized patients. In 2017, communication with PCPs was prioritized for the pediatric hospital ... ...

Abstract	Background and objectives: Effective communication between inpatient and primary care providers (PCPs) is important for safe transition of care for hospitalized patients. In 2017, communication with PCPs was prioritized for the pediatric hospital medicine division. Our primary aim was to improve documented attempted communication with PCPs within 72 hours of discharge from 41% to at least 60% by January 1, 2018, and maintain this performance through 2019. Methods: This study included all inpatient encounters discharged by a pediatric hospital medicine provider from March 2017 to April 2020. An electronic health record phrase debuted March 2017. Successful documentation was defined as any attempt to contact the PCP, regardless of whether actual communication occurred. Group and individual audit and feedback occurred in July 2017 to April 2020. Provider communication was financially incentivized in July 2018 to June 2019. An annotated P-chart for the proportion of encounters with documented PCP communication occurring within 72 hours was established. Special-cause variation was determined by using Shewhart rules. Results: The mean proportion of encounters with documented PCP communication increased from 41% at baseline (March 2017 through July 2017) to 60% in August 2017 and 66% in December 2017. After the financial incentive was removed in July 2019, documentation decreased to 54%. Phone calls with clinic staff were the most common communication method (40% to 71%). Direct conversations with the PCP occurred rarely (0% to 3%). Conclusions: Even when coupled with audit and feedback with EHR interventions, our work suggests that shifting to external financial motivation may hinder sustainability of behavior change to improve attempted documented PCP communication.
MeSH term(s)	Child ; Communication ; Health Personnel ; Hospitals, Pediatric ; Humans ; Patient Discharge ; Quality Improvement
Language	English
Publishing date	2021-09-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2154-1671
ISSN (online)	2154-1671
DOI	10.1542/hpeds.2020-004804
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Drivers behind Residential Electricity Demand Fluctuations Due to COVID-19 Restrictions

Snow, Stephen / Bean, Richard / Glencross, Mashhuda / Horrocks, Neil

2020

Keywords	General Computer Science ; covid19
Publishing date	2020-11-02
Publisher	MDPI AG
Publishing country	au
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome.

Walitt, Brian / Singh, Komudi / LaMunion, Samuel R / Hallett, Mark / Jacobson, Steve / Chen, Kong / Enose-Akahata, Yoshimi / Apps, Richard / Barb, Jennifer J / Bedard, Patrick / Brychta, Robert J / Buckley, Ashura Williams / Burbelo, Peter D / Calco, Brice / Cathay, Brianna / Chen, Li / Chigurupati, Snigdha / Chen, Jinguo / Cheung, Foo /

Chin, Lisa M K / Coleman, Benjamin W / Courville, Amber B / Deming, Madeleine S / Drinkard, Bart / Feng, Li Rebekah / Ferrucci, Luigi / Gabel, Scott A / Gavin, Angelique / Goldstein, David S / Hassanzadeh, Shahin / Horan, Sean C / Horovitz, Silvina G / Johnson, Kory R / Govan, Anita Jones / Knutson, Kristine M / Kreskow, Joy D / Levin, Mark / Lyons, Jonathan J / Madian, Nicholas / Malik, Nasir / Mammen, Andrew L / McCulloch, John A / McGurrin, Patrick M / Milner, Joshua D / Moaddel, Ruin / Mueller, Geoffrey A / Mukherjee, Amrita / Muñoz-Braceras, Sandra / Norato, Gina / Pak, Katherine / Pinal-Fernandez, Iago / Popa, Traian / Reoma, Lauren B / Sack, Michael N / Safavi, Farinaz / Saligan, Leorey N / Sellers, Brian A / Sinclair, Stephen / Smith, Bryan / Snow, Joseph / Solin, Stacey / Stussman, Barbara J / Trinchieri, Giorgio / Turner, Sara A / Vetter, C Stephenie / Vial, Felipe / Vizioli, Carlotta / Williams, Ashley / Yang, Shanna B / Nath, Avindra

Nature communications

2024 Volume 15, Issue 1, Page(s) 907

Abstract: Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous ... ...

Abstract	Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit PI-ME/CFS participants with matched controls to conduct deep phenotyping. Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical conditioning. Immune profiling suggested chronic antigenic stimulation with increase in naïve and decrease in switched memory B-cells. Alterations in gene expression profiles of peripheral blood mononuclear cells and metabolic pathways were consistent with cellular phenotypic studies and demonstrated differences according to sex. Together these clinical abnormalities and biomarker differences provide unique insight into the underlying pathophysiology of PI-ME/CFS, which may guide future intervention.
MeSH term(s)	Humans ; Fatigue Syndrome, Chronic/metabolism ; Leukocytes, Mononuclear/metabolism ; Communicable Diseases/metabolism ; Biomarkers/metabolism ; Phenotype
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45107-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: BMS-986012, an Anti-Fucosyl-GM1 Monoclonal Antibody as Monotherapy or in Combination With Nivolumab in Relapsed/Refractory SCLC: Results From a First-in-Human Phase 1/2 Study.

Chu, Quincy / Leighl, Natasha B / Surmont, Veerle / van Herpen, Carla / Sibille, Anne / Markman, Ben / Clarke, Stephen / Juergens, Rosalyn A / Rivera, Mirelis Acosta / Andelkovic, Vladimir / Rudin, Charles M / Snow, Stephanie / Kim, Dong-Wan / Sanatani, Michael / Lin, Hongxia / Sanghavi, Kinjal / Tannenbaum-Dvir, Sarah / Basciano, Paul / Lathers, Deanne /

Urbanska, Katarzyna / Kollia, Georgia / He, Chunsheng / DiPiero, Andrew / Liu, Yu / Ready, Neal

JTO clinical and research reports

2022 Volume 3, Issue 11, Page(s) 100400

Abstract: ... Patients (BMS-986012 monotherapy, n = 77; BMS-986012 + nivolumab, n = 29) were predominantly of male sex ... line systemic therapy (99%). The most common treatment-related adverse event was pruritus (n = 95 [90 ... Grade 4 treatment-related adverse events were reported in 2% (n = 2) of patients. The objective response ...

Abstract	Introduction: Fucosyl-GM1 is a monosialoganglioside with limited expression in healthy tissues and high expression on SCLC cells. BMS-986012 is a nonfucosylated, first-in-class, fully human immunoglobulin G1 monoclonal antibody that binds to fucosyl-GM1. Methods: CA001-030 is a phase 1/2, first-in-human study of BMS-986012 as monotherapy or in combination with nivolumab for adults with relapsed or refractory SCLC. Safety is the primary end point. Additional end points include objective response rate, duration of response, progression-free survival, pharmacokinetics, and overall survival. Results: Patients (BMS-986012 monotherapy, n = 77; BMS-986012 + nivolumab, n = 29) were predominantly of male sex (58%), 63 years old (mean), current or past tobacco users (97%), and treated previously with first-line systemic therapy (99%). The most common treatment-related adverse event was pruritus (n = 95 [90%]). Grade 4 treatment-related adverse events were reported in 2% (n = 2) of patients. The objective response rate (95% confidence interval [CI]) was higher with BMS-986012 plus nivolumab (38% [20.7%-57.7%]) than with monotherapy (4% [0.8%-11.0%]). Median (95% CI) duration of response with BMS-986012 plus nivolumab was 26.4 (4.4-not reached) months. Progression-free survival (95% CI) at 24 weeks with monotherapy and BMS-986012 plus nivolumab was 12.2% (6.0%-20.7%) and 39.3% (21.7%-56.5%), respectively. The pharmacokinetics profile of monotherapy and BMS-986012 plus nivolumab suggested dose proportionality across the tested dose range. Median overall survival (95% CI) with monotherapy and BMS-986012 plus nivolumab was 5.4 (4.0-7.3) and 18.7 (8.2-37.3) months, respectively. Conclusions: BMS-986012 in combination with nivolumab represents a well-tolerated, potential new therapy for relapsed or refractory SCLC. BMS-986012 is currently being explored in combination with carboplatin, etoposide, and nivolumab as a first-line therapy in extensive-stage SCLC (NCT04702880).
Language	English
Publishing date	2022-08-27
Publishing country	United States
Document type	Journal Article
ISSN	2666-3643
ISSN (online)	2666-3643
DOI	10.1016/j.jtocrr.2022.100400
Database	MEDical Literature Analysis and Retrieval System OnLINE

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