LIVIVO - Search results -

Search results

Result 1 - 10 of total 127608

Search options

Article ; Online: The Potential Role of the J-T

Vicente, Jose / Strauss, David G / Upreti, Vijay V / Fossler, Michael J / Sager, Philip T / Noveck, Robert

2019 Volume 59, Issue 7, Page(s) 909–914

MeSH term(s)	Animals ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/mortality ; Biomarkers ; Death, Sudden, Cardiac ; Drug Development/standards ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Electrocardiography ; Guidelines as Topic ; Humans ; Pharmacology, Clinical/organization & administration ; Societies, Scientific ; Torsades de Pointes/chemically induced ; Torsades de Pointes/mortality ; United States
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	188980-1
ISSN	1552-4604 ; 0091-2700 ; 0021-9754
ISSN (online)	1552-4604
ISSN	0091-2700 ; 0021-9754
DOI	10.1002/jcph.1411
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uf I Zs.176: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities.

Russell, Magdalena L / Souquette, Aisha / Levine, David M / Schattgen, Stefan A / Allen, E Kaitlynn / Kuan, Guillermina / Simon, Noah / Balmaseda, Angel / Gordon, Aubree / Thomas, Paul G / Matsen, Frederick A / Bradley, Philip

eLife

2022 Volume 11

Abstract: ... determined biases and immune exposures. T cells combine a random V(D)J recombination process with a selection ... Every T cell receptor (TCR) repertoire is shaped by a complex probabilistic tangle of genetically ... from a large human cohort, we infer specific genetic loci associated with V(D)J recombination probabilities ...

Abstract	Every T cell receptor (TCR) repertoire is shaped by a complex probabilistic tangle of genetically determined biases and immune exposures. T cells combine a random V(D)J recombination process with a selection process to generate highly diverse and functional TCRs. The extent to which an individual's genetic background is associated with their resulting TCR repertoire diversity has yet to be fully explored. Using a previously published repertoire sequencing dataset paired with high-resolution genome-wide genotyping from a large human cohort, we infer specific genetic loci associated with V(D)J recombination probabilities using genome-wide association inference. We show that V(D)J gene usage profiles are associated with variation in the
MeSH term(s)	Genetic Loci ; Genome-Wide Association Study ; Genotype ; Humans ; Probability ; Receptors, Antigen, T-Cell/genetics ; V(D)J Recombination/genetics
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2022-03-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.73475
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: PROMIDISα: A T-cell receptor α signature associated with immunodeficiencies caused by V(D)J recombination defects.

Berland, Aurélie / Rosain, Jérémie / Kaltenbach, Sophie / Allain, Vincent / Mahlaoui, Nizar / Melki, Isabelle / Fievet, Alice / Dubois d'Enghien, Catherine / Ouachée-Chardin, Marie / Perrin, Laurence / Auger, Nathalie / Cipe, Funda Erol / Finocchi, Andrea / Dogu, Figen / Suarez, Felipe / Moshous, Despina / Leblanc, Thierry / Belot, Alexandre / Fieschi, Claire /

Boutboul, David / Malphettes, Marion / Galicier, Lionel / Oksenhendler, Eric / Blanche, Stéphane / Fischer, Alain / Revy, Patrick / Stoppa-Lyonnet, Dominique / Picard, Capucine / de Villartay, Jean-Pierre

The Journal of allergy and clinical immunology

2018 Volume 143, Issue 1, Page(s) 325–334.e2

Abstract: Background: V(D)J recombination ensures the diversity of the adaptive immune system ... Although its complete defect causes severe combined immunodeficiency (ie, T: Objective: We aimed at developing ... biomarkers based on analysis of the T-cell receptor (TCR) α repertoire to assist in the diagnosis of patients ...

Abstract	Background: V(D)J recombination ensures the diversity of the adaptive immune system. Although its complete defect causes severe combined immunodeficiency (ie, T Objective: We aimed at developing biomarkers based on analysis of the T-cell receptor (TCR) α repertoire to assist in the diagnosis of patients with primary immunodeficiencies with V(D)J recombination and DNA repair deficiencies. Methods: We used flow cytometric (fluorescence-activated cell sorting) analysis to quantify TCR-Vα7.2-expressing T lymphocytes in peripheral blood and developed PROMIDISα, a multiplex RT-PCR/next-generation sequencing assay, to evaluate a subset of the TCRα repertoire in T lymphocytes. Results: The combined fluorescence-activated cell sorting and PROMIDISα analyses revealed specific signatures in patients with V(D)J recombination-defective primary immunodeficiencies or ataxia telangiectasia/Nijmegen breakage syndromes. Conclusion: Analysis of the TCRα repertoire is particularly appropriate in a prospective way to identify patients with partial immune defects caused by suboptimal V(D)J recombination activity, a DNA repair defect, or both. It also constitutes a valuable tool for the retrospective in vivo functional validation of variants identified through exome or panel sequencing. Its broader implementation might be of interest to assist early diagnosis of patients presenting with hypomorphic DNA repair defects inclined to experience acute toxicity during prehematopoietic stem cell transplantation conditioning.
MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Humans ; Immunologic Deficiency Syndromes/genetics ; Immunologic Deficiency Syndromes/immunology ; Immunologic Deficiency Syndromes/pathology ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Prospective Studies ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Retrospective Studies ; V(D)J Recombination/immunology
Chemical Substances	Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	2018-06-12
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2018.05.028
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.92: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Automated T-wave Delineator Algorithm for J-t

Hosseini, Meisam / Johannesen, Lars / Vicente, Jose / Strauss, David G

Journal of electrocardiology

2016 Volume 49, Issue 6, Page(s) 935–936

Language	English
Publishing date	2016-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	410286-1
ISSN	1532-8430 ; 0022-0736
ISSN (online)	1532-8430
ISSN	0022-0736
DOI	10.1016/j.jelectrocard.2016.09.036
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 701: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

Magdalena L Russell / Aisha Souquette / David M Levine / Stefan A Schattgen / E Kaitlynn Allen / Guillermina Kuan / Noah Simon / Angel Balmaseda / Aubree Gordon / Paul G Thomas / Frederick A Matsen IV / Philip Bradley

eLife, Vol

2022 Volume 11

Abstract	Every T cell receptor (TCR) repertoire is shaped by a complex probabilistic tangle of genetically determined biases and immune exposures. T cells combine a random V(D)J recombination process with a selection process to generate highly diverse and functional TCRs. The extent to which an individual’s genetic background is associated with their resulting TCR repertoire diversity has yet to be fully explored. Using a previously published repertoire sequencing dataset paired with high-resolution genome-wide genotyping from a large human cohort, we infer specific genetic loci associated with V(D)J recombination probabilities using genome-wide association inference. We show that V(D)J gene usage profiles are associated with variation in the TCRB locus and, specifically for the functional TCR repertoire, variation in the major histocompatibility complex locus. Further, we identify specific variations in the genes encoding the Artemis protein and the TdT protein to be associated with biasing junctional nucleotide deletion and N-insertion, respectively. These results refine our understanding of genetically-determined TCR repertoire biases by confirming and extending previous studies on the genetic determinants of V(D)J gene usage and providing the first examples of trans genetic variants which are associated with modifying junctional diversity. Together, these insights lay the groundwork for further explorations into how immune responses vary between individuals.
Keywords	t cell receptor repertoire ; VDJ recombination probabilities ; GWAS ; Artemis ; TdT ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Volcanically-Induced Environmental and Floral Changes Across the Triassic-Jurassic (T-J) Transition

Peixin Zhang / Jing Lu / Minfang Yang / David P. G. Bond / Sarah E. Greene / Le Liu / Yuanfu Zhang / Ye Wang / Ziwei Wang / Shan Li / Longyi Shao / Jason Hilton

Frontiers in Ecology and Evolution, Vol

2022 Volume 10

Abstract: ... a multidisciplinary record of volcanism and environmental change from an expanded Triassic-Jurassic (T-J) transition ... phases during the T-J transition. Each of these can be correlated with large, negative C isotope ... a collapse in land plant diversity during the T-J transition. ...

Abstract	The End-Triassic Mass Extinction (ETME) saw the catastrophic loss of ca. 50% of marine genera temporally associated with emplacement of the Central Atlantic Magmatic Province (CAMP). However, the effects of the ETME on land is a controversial topic. Evaluation of the disparate cause(s) and effects of the extinction requires additional, detailed terrestrial records of these events. Here, we present a multidisciplinary record of volcanism and environmental change from an expanded Triassic-Jurassic (T-J) transition preserved in lacustrine sediments from the Jiyuan Basin, North China. High-resolution chemostratigraphy, palynological, kerogen, and sedimentological data reveal that terrestrial conditions responded to and were defined by large-scale volcanism. The record of sedimentary mercury reveals two discrete CAMP eruptive phases during the T-J transition. Each of these can be correlated with large, negative C isotope excursions (CIE-I of −4.7‰; CIE-II of −2.9‰), significantly reduced plant diversity (with ca. 45 and 44% generic losses, respectively), enhanced wildfire (marked by increased fusinite or charcoal content), and major climatic shifts toward drier and hotter conditions (indicated by the occurrence of calcareous nodules, increased Classopollis pollen content, and PCA analysis). Our results show that CAMP eruptions may have followed a bimodal eruptive model and demonstrate the powerful ability of large-scale volcanism to alter the global C cycle and profoundly affect the climate, in turn leading to enhanced wildfires and a collapse in land plant diversity during the T-J transition.
Keywords	End-Triassic Mass Extinction ; palynology ; volcanism ; paleoenvironment ; paleoclimate ; carbon cycle ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
Subject code	550
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The J to T-peak interval as a biomarker in drug safety studies: A method of accuracy assessment applied to two algorithms.

Chiu, W Brian / de Bie, Johan / Mortara, David W

Journal of electrocardiology

2017 Volume 50, Issue 6, Page(s) 758–761

Abstract: Objectives: To evaluate performance of J-to-T-peak (JTP) measurements of 12-lead ECGs, in a five ... in context of the measurement, e.g. T-wave morphology, autonomic nervous system state.: Results ...

Abstract	Objectives: To evaluate performance of J-to-T-peak (JTP) measurements of 12-lead ECGs, in a five-arm study using drugs with various levels of electrolyte channel block. Methods: The novel evaluation method distinguishes between different aspects of measurement. "Random noise" is the variability among repeated measurements made without changing the conditions. "Context noise" is the variability of changes in context of the measurement, e.g. T-wave morphology, autonomic nervous system state. Results: The average random noise of our RR-corrected JTPc measurements in standard deviations was 3.0 ms and not dependent on the drug. The average context noise was 4.0 ms for ranolazine, verapamil, and placebo, and 8.8 ms for dofetilide and quinidine. Measurement consistency is corroborated by linear fit confidence intervals of baseline- and placebo-corrected JTPc versus drug concentration. Conclusions: Systematic differences were found in JTPc drug response between the Mortara method and published data. Residual signal component in the context noise may influence future study design.
MeSH term(s)	Algorithms ; Biomarkers/analysis ; Electrocardiography/methods ; Heart Conduction System/drug effects ; Humans ; Ion Channels/drug effects ; Phenethylamines/pharmacology ; Potassium Channel Blockers/pharmacology ; Quinidine/pharmacology ; Ranolazine/pharmacology ; Sodium Channel Blockers/pharmacology ; Sulfonamides/pharmacology ; Verapamil/pharmacology
Chemical Substances	Biomarkers ; Ion Channels ; Phenethylamines ; Potassium Channel Blockers ; Sodium Channel Blockers ; Sulfonamides ; Ranolazine (A6IEZ5M406) ; Verapamil (CJ0O37KU29) ; Quinidine (ITX08688JL) ; dofetilide (R4Z9X1N2ND)
Language	English
Publishing date	2017-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	410286-1
ISSN	1532-8430 ; 0022-0736
ISSN (online)	1532-8430
ISSN	0022-0736
DOI	10.1016/j.jelectrocard.2017.07.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 701: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Crystallins, cataract, and dynamic lens proteostasis. A commentary on P.W.N. Schmid, N.C.H. Lim, C. Peters, K.C. Back, B. Bourgeois, F. Pirolt, B. Richter, J. Peschek, O. Puk, O.V. Amarie, C. Dalke, M. Haslbeck, S. Weinkauf, T. Madl, J. Graw, and J. Buchner (2021) Imbalances in the eye lens proteome are linked to cataract formation, Nat. Struct. Mol. Biol.28, 143-151. doi: 10.1038/s41594-020-00543-9.

Grosas, Aidan B / Thorn, David C / Carver, John A

Experimental eye research

2021 Volume 208, Page(s) 108619

Language	English
Publishing date	2021-05-10
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2021.108619
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 163: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Re: Evaluation and Management of the Adolescent Varicocele: T. F. Kolon J Urol 2015; 194: 1194-1201.

Diamond, David A / Kurtz, Michael P

The Journal of urology

2016 Volume 195, Issue 4 Pt 1, Page(s) 1173–1175

MeSH term(s)	Adolescent ; Humans ; Male ; Varicocele
Language	English
Publishing date	2016
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2015.10.170
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui VI Zs.91: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 331: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Localization of CD8 T cell epitope within cardiac myosin heavy chain-α334-352 that induces autoimmune myocarditis in A/J mice.

Massilamany, Chandirasegaran / Gangaplara, Arunakumar / Basavalingappa, Rakesh H / Rajasekaran, Rajkumar A / Khalilzad-Sharghi, Vahid / Han, Zhongji / Othman, Shadi / Steffen, David / Reddy, Jay

International journal of cardiology

2016 Volume 202, Page(s) 311–321

Abstract: ... 352-induced experimental autoimmune myocarditis in A/J mice (H-2a), we discovered that Myhc334-352 ... supposedly a CD4 T cell epitope, also induced antigen-specific CD8 T cells that transfer disease to naive ... animals.: Methods and results: In our efforts to identify the CD8 T cell determinants, we localized ...

Abstract	Background: Cardiac myosin heavy chain-α (Myhc), an intracellular protein expressed in the cardiomyocytes, has been identified as a major autoantigen in cardiac autoimmunity. In our studies with Myhc334-352-induced experimental autoimmune myocarditis in A/J mice (H-2a), we discovered that Myhc334-352, supposedly a CD4 T cell epitope, also induced antigen-specific CD8 T cells that transfer disease to naive animals. Methods and results: In our efforts to identify the CD8 T cell determinants, we localized Myhc338-348 within the full length-Myhc334-352, leading to four key findings. (1) By acting as a dual epitope, Myhc338-348 induces both CD4 and CD8 T cell responses. (2) In a major histocompatibility complex (MHC) class I-stabilization assay, Myhc338-348 was found to bind H-2Dd-but not H-2Kk or H-2Ld-alleles. (3) The CD8 T cell response induced by Myhc338-348 was antigen-specific, as evaluated by MHC class I/H-2Dd dextramer staining. The antigen-sensitized T cells predominantly produced interferon-γ, the critical cytokine of effector cytotoxic T lymphocytes. (4) Myhc338-348 was found to induce myocarditis in immunized animals as determined by histology and magnetic resonance microscopy imaging. Conclusions: Our data provide new insights as to how different immune cells can recognize the same antigen and inflict damage through different mechanisms.
MeSH term(s)	Animals ; Autoimmune Diseases/immunology ; CD8 Antigens/immunology ; Cells, Cultured ; Cytokines/immunology ; Female ; Immunodominant Epitopes/immunology ; Magnetic Resonance Imaging ; Mice ; Mice, Inbred A ; Myocarditis/etiology ; Myocarditis/immunology ; Myosin Heavy Chains/immunology ; Staining and Labeling ; beta 2-Microglobulin/immunology
Chemical Substances	CD8 Antigens ; Cytokines ; Immunodominant Epitopes ; beta 2-Microglobulin ; Myosin Heavy Chains (EC 3.6.4.1)
Language	English
Publishing date	2016-01-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2015.09.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1673: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito