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Article: Changes in the Localization of Polyamine Spermidine in the Rat Retina with Age.

Ríos, David S / Malpica-Nieves, Christian J / Díaz-García, Amanda / Eaton, Misty J / Skatchkov, Serguei N

2023 Volume 11, Issue 4

Abstract: Polyamines (PAs) in the nervous system has a key role in regeneration and aging. Therefore, we investigated age-related changes in the expression of PA spermidine (SPD) in the rat retina. Fluorescent immunocytochemistry was used to evaluate the ... ...

Abstract	Polyamines (PAs) in the nervous system has a key role in regeneration and aging. Therefore, we investigated age-related changes in the expression of PA spermidine (SPD) in the rat retina. Fluorescent immunocytochemistry was used to evaluate the accumulation of SPD in retinae from rats of postnatal days 3, 21, and 120. Glial cells were identified using glutamine synthetase (GS), whereas DAPI, a marker of cell nuclei, was used to differentiate between retinal layers. SPD localization in the retina was strikingly different between neonates and adults. In the neonatal retina (postnatal day 3-P3), SPD is strongly expressed in practically all cell types, including radial glia and neurons. SPD staining showed strong co-localization with the glial marker GS in Müller Cells (MCs) in the outer neuroblast layer. In the weaning period (postnatal day 21-P21), the SPD label was strongly expressed in all MCs, but not in neurons. In early adulthood (postnatal day 120-P120), SPD was localized in MCs only and was co-localized with the glial marker GS. A decline in the expression of PAs in neurons was observed with age while glial cells accumulated SPD after the differentiation stage (P21) and during aging in MC cellular endfoot compartments.
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11041008
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Article: The effect of the size of gold nanoparticle contrast agents on CT imaging of the gastrointestinal tract and inflammatory bowel disease.

Rosario-Berríos, Derick N / Pang, Amanda / Liu, Leening P / Maidment, Portia S N / Kim, Johoon / Yoon, Seokyoung / Nieves, Lenitza M / Mossburg, Katherine / Adezio, Andrew / Noel, Peter / Lennon, Elizabeth M / Cormode, David P

bioRxiv : the preprint server for biology

2024

Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD). CT imaging with contrast agents is commonly used for visualizing the gastrointestinal (GI) tract in UC patients. CT is a common imaging modality for evaluating IBD, especially in ... ...

Abstract	Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD). CT imaging with contrast agents is commonly used for visualizing the gastrointestinal (GI) tract in UC patients. CT is a common imaging modality for evaluating IBD, especially in patients with acute abdominal pain presenting to emergency departments. CT's major limitation lies in its lack of specificity for imaging UC, as the commonly used agents are not well-suited for inflamed areas. Recent studies gastrointestinal tract (GIT) in UC. Further systemic research is needed to explore novel contrast agents that can specifically image disease processes in this disease setting.
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.20.576354
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Article ; Online: Right Versus Left Cuff Position for Upper Airway Stimulation.

Arambula, Alexandra M / Bon-Nieves, Antonio / Alapati, Rahul / Wei, Johnny / Wagoner, Sarah / Lawrence, Amelia / Renslo, Bryan / Rouse, David / Larsen, Christopher

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2024 Volume 170, Issue 4, Page(s) 1183–1189

Abstract: Objective: Upper airway stimulation (UAS) is a treatment option for obstructive sleep apnea in which electrical stimulation is applied to the hypoglossal nerve. Nerve branches that control tongue protrusion are located inferiorly. Due to positioning, ... ...

Abstract	Objective: Upper airway stimulation (UAS) is a treatment option for obstructive sleep apnea in which electrical stimulation is applied to the hypoglossal nerve. Nerve branches that control tongue protrusion are located inferiorly. Due to positioning, left-sided implants are typically placed with an inferiorly oriented electrode cuff (L-down) as opposed to superiorly on the right (R-up). In this study, we assess the impact of left- versus right-sided UAS on patient outcomes. Study design: Retrospective cohort study. Setting: Tertiary Academic Medical Center. Methods: Patients who underwent UAS implantation between 2016 and 2021 with an L-down or R-up oriented cuff as confirmed by X-ray were included. Data were collected retrospectively. Most recent sleep study variables were used for analysis. Results: A total of 190 patients met the inclusion criteria. The average age was 61.0 ± 11.0 years, with 55 (28.9%) females. L-down orientation was present in 21 (11.1%) patients vs 169 (88.9%) R-up. Indications for L-down included hunting/shooting (n = 15), prior radiation/surgery (n = 4), central port (n = 1), and brachial plexus injury (n = 1). Adherence was higher among L-down patients (47.1 vs 41.0 hours use/week, P = .037) in univariate analysis, with a similar time to adherence data collection (4.4 vs 4.2 months, P = .612), though this finding was not maintained in the multivariate regression analysis. Decrease in apnea-hypopnea index (21.3 vs 22.8, P = .734), treatment success (76.5% vs 84.0%, P = .665), functional threshold (1.5 vs 1.6, P = .550), therapeutic amplitude (2.3 vs 2.4, P = .882), and decrease in Epworth Sleepiness Scale (4.9 vs 2.6, P = .060) were not significantly different between cohorts. Conclusion: This study is the first to examine the orientation of the UAS electrode cuff concerning the electrodes' natural position and the potential effect on postoperative outcomes. Our study found no significantly different treatment outcomes between the L-down versus R-up cohort, with the exception of device adherence, which was significantly higher in the L-down group on univariate analysis though not on multivariate analysis. Future studies with larger patient cohorts are needed to further investigate this potential relationship between treatment outcomes and electrode cuff orientation.
MeSH term(s)	Female ; Humans ; Middle Aged ; Aged ; Male ; Retrospective Studies ; Electric Stimulation Therapy ; Nose ; Larynx ; Sleep Apnea, Obstructive/surgery ; Treatment Outcome ; Hypoglossal Nerve
Language	English
Publishing date	2024-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1002/ohn.668
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Ul II Zs.83/a: Show issues

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Article ; Online: Visual snow syndrome in patients with migraine: widening the clinical spectrum of the syndrome with permanent and episodic manifestations.

González-Ávila, Carmen / García-Azorín, David / Mínguez-Olaondo, Ane / Rubio-Flores, Laura / Lamas, Raquel / Nieves-Castellanos, Candela / López-Bravo, Alba / Muñoz-Vendrell, Albert / Campoy, Sergio / Sebastian-Valles, Fernando / Quintas, Sonia

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2024

Abstract: Purpose: Migraine is the comorbidity most frequently associated with visual snow syndrome (VSS), but the prevalence of VSS in patients with migraine (PWM) has not been studied. Our objective was to evaluate the frequency of VSS in PWM and to analyze if ... ...

Abstract	Purpose: Migraine is the comorbidity most frequently associated with visual snow syndrome (VSS), but the prevalence of VSS in patients with migraine (PWM) has not been studied. Our objective was to evaluate the frequency of VSS in PWM and to analyze if symptoms of VSS happened in a permanent or episodic manner (eVSS) in this population. Methods: We conducted a multicenter observational cross-sectional study. PWM was recruited from headache units, and a survey about the presence of visual snow symptoms was administered. The frequency and characteristics of patients that met current VSS criteria were analyzed. Demographic and clinical features of patients with VSS, eVSS, and PWM with no visual snow were compared. Results: A total of 217 PWM were included. Seventeen patients (7.8%) met the VSS criteria. VSS patients had visual aura more frequently (58.8% vs. 31%; p = 0.019) and a higher MIDAS score (96.6 vs. 47.7; p = 0.014). Fifty-eight PWM (26.7%) showed visual snow and associated features in an episodic way and were classified as eVSS. Patients with VSS showed a tendency towards a higher frequency of visual symptoms than patients with eVSS (p > 0.05). No statistically significant differences in sociodemographic characteristics and comorbid conditions were found between VSS and eVSS. Conclusion: The prevalence of VSS in PWM may be higher than that described for the general population. Some PWM may present similar visual symptoms to patients with VSS but in an episodic manner. Our study reinforces the observation that the clinical spectrum of visual snow is likely to be broader than previously described.
Language	English
Publishing date	2024-03-27
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-024-07483-y
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Article ; Online: Trends in the Utilization of Surgical Modalities for the Treatment of Drug-Resistant Epilepsy: A Comprehensive 10-Year Analysis Using the National Inpatient Sample.

Ghaith, Abdul Karim / El-Hajj, Victor Gabriel / Sanchez-Garavito, Jesus E / Zamanian, Cameron / Ghanem, Marc / Bon-Nieves, Antonio / Chen, Baibing / Drees, Cornelia N / Miller, David / Parker, Jonathon J / Almeida, Joao Paulo / Elmi-Terander, Adrian / Tatum, William / Middlebrooks, Erik H / Bydon, Mohamad / Van-Gompel, Jamie J / Lundstrom, Brian N / Grewal, Sanjeet S

Neurosurgery

2024

Abstract: Background and objectives: Epilepsy is considered one of the most prevalent and severe chronic neurological disorders worldwide. Our study aims to analyze the national trends in different treatment modalities for individuals with drug-resistant epilepsy ...

Abstract	Background and objectives: Epilepsy is considered one of the most prevalent and severe chronic neurological disorders worldwide. Our study aims to analyze the national trends in different treatment modalities for individuals with drug-resistant epilepsy and investigate the outcomes associated with these procedural trends in the United States. Methods: Using the National Inpatient Sample database from 2010 to 2020, patients with drug-resistant focal epilepsy who underwent laser interstitial thermal therapy (LITT), open surgical resection, vagus nerve stimulation (VNS), or responsive neurostimulation (RNS) were identified. Trend analysis was performed using piecewise joinpoint regression. Propensity score matching was used to compare outcomes between 10 years prepandemic before 2020 and the first peak of the COVID-19 pandemic. Results: This study analyzed a total of 33 969 patients with a diagnosis of drug-resistant epilepsy, with 3343 patients receiving surgical resection (78%), VNS (8.21%), RNS (8%), and LITT (6%). Between 2010 and 2020, there was an increase in the use of invasive electroencephalography monitoring for seizure zone localization (P = .003). There was an increase in the use of LITT and RNS (P < .001), while the use of surgical resection and VNS decreased over time (P < .001). Most of these patients (89%) were treated during the pre-COVID pandemic era (2010-2019), while a minority (11%) underwent treatment during the COVID pandemic (2020). After propensity score matching, the rate of pulmonary complications, postprocedural hematoma formation, and mortality were slightly higher during the pandemic compared with the prepandemic period (P = .045, P = .033, and P = .026, respectively). Conclusion: This study indicates a relative decrease in the use of surgical resections, as a treatment for drug-resistant focal epilepsy. By contrast, newer, minimally invasive surgical approaches including LITT and RNS showed gradual increases in usage.
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1227/neu.0000000000002811
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Zs.A 1424: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Suspected ovarian teratoma with a simple X-ray.

Buendía López, Susana / Peláez Mata, David José / Martín Boizas, Ruth / Sanz Villa, Nieves

Anales de pediatria

2023 Volume 99, Issue 6, Page(s) 451–452

MeSH term(s)	Female ; Humans ; X-Rays ; Ovarian Neoplasms/diagnostic imaging ; Radiography ; Teratoma/diagnostic imaging
Language	English
Publishing date	2023-11-04
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2830901-7
ISSN	2341-2879 ; 2341-2879
ISSN (online)	2341-2879
ISSN	2341-2879
DOI	10.1016/j.anpede.2023.08.017
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Article ; Online: S-SCAM inhibits Axin-dependent synaptic function of GSK3β in a sex-dependent manner.

Kearney, Gillian / Grau, David / Nieves Torres, Damaris / Shin, Seung Min / Lee, Sang H

Scientific reports

2022 Volume 12, Issue 1, Page(s) 4090

Abstract: S-SCAM/MAGI-2 gene duplication is associated with schizophrenia (SCZ). S-SCAM overexpression ... in the forebrain induces SCZ-like phenotypes in a transgenic (Tg) mouse model. Interestingly, S-SCAM Tg mice show ... the sex-specific deficits remain unknown. Here we report that S-SCAM Tg mice have male-specific deficits ...

Abstract	S-SCAM/MAGI-2 gene duplication is associated with schizophrenia (SCZ). S-SCAM overexpression in the forebrain induces SCZ-like phenotypes in a transgenic (Tg) mouse model. Interestingly, S-SCAM Tg mice show male-specific impairments in synaptic plasticity and working memory. However, mechanisms underlying the sex-specific deficits remain unknown. Here we report that S-SCAM Tg mice have male-specific deficits in synaptic GSK3β functions, as shown by reduced synaptic protein levels and increased inhibitory phosphorylation of GSK3β. This GSK3β hyper-phosphorylation was associated with increased CaMKII activities. Notably, synaptic levels of Axin1, to which GSK3β binds in competition with S-SCAM, were also reduced in male S-SCAM Tg mice. We demonstrated that Axin-binding is required for the S-SCAM overexpression-induced synaptic GSK3β reduction. Axin stabilization using XAV939 rescued the GSK3β deficits and restored the temporal activation of GSK3β during long-term depression in S-SCAM overexpressing neurons. Interestingly, synaptic Axin2 levels were increased in female S-SCAM Tg mice. Female sex hormone 17β-estradiol increased Axin2 expression and increased synaptic GSK3β levels in S-SCAM overexpressing neurons. These results reveal the role of S-SCAM in controlling Axin-dependent synaptic localization of GSK3β. Moreover, our studies point out the pathological relevance of GSK3β hypofunction found in humans and contribute to understanding the molecular underpinnings of sex differences in SCZ.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Animals ; Axin Protein/genetics ; Axin Protein/metabolism ; Female ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Guanylate Kinases/genetics ; Male ; Mice ; Neuronal Plasticity ; Neurons/metabolism ; Sex Factors ; Signal Transduction/physiology
Chemical Substances	Adaptor Proteins, Signal Transducing ; Axin Protein ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Guanylate Kinases (EC 2.7.4.8) ; Magi2 protein, mouse (EC 2.7.4.8)
Language	English
Publishing date	2022-03-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-08220-1
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Article ; Online: Urinary Metabolomic Profile of Youth at Risk of Chronic Kidney Disease in Nicaragua.

Hall, Samantha M / Raines, Nathan H / Ramirez-Rubio, Oriana / Amador, Juan José / López-Pilarte, Damaris / O'Callaghan-Gordo, Cristina / Gil-Redondo, Rubén / Embade, Nieves / Millet, Oscar / Peng, Xiaojing / Vences, Selene / Keogh, Sinead A / Delgado, Iris S / Friedman, David J / Brooks, Daniel R / Leibler, Jessica H

Kidney360

2023 Volume 4, Issue 7, Page(s) 899–908

MeSH term(s)	Humans ; Adolescent ; Nicaragua/epidemiology ; Renal Insufficiency, Chronic/epidemiology ; Kidney ; Urinary Tract
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ISSN	2641-7650
ISSN (online)	2641-7650
DOI	10.34067/KID.0000000000000129
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Article ; Online: Prevalence and Economic Burden of Malnutrition Diagnosis Among Patients Presenting to United States Emergency Departments.

Lanctin, David P / Merced-Nieves, Francheska / Mallett, Renee M / Arensberg, Mary Beth / Guenter, Peggi / Sulo, Suela / Platts-Mills, Timothy F

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

2020 Volume 28, Issue 3, Page(s) 325–335

Abstract: ... prevalence and economic burden of diagnosed malnutrition among patients presenting to U.S. EDs.: Methods ... in U.S. EDs, the economic burden of malnutrition is substantial in this care setting ...

Abstract	Background: Malnutrition is a potentially remediable condition that when untreated contributes to poor health and economic outcomes. While assessment of malnutrition risk is improving, its identification rate and economic burden in emergency departments (EDs) is largely unknown. We sought to determine prevalence and economic burden of diagnosed malnutrition among patients presenting to U.S. EDs. Methods: This is a retrospective analysis of Healthcare Cost and Utilization Project Nationwide Emergency Department Sample data. Malnutrition prevalence was confirmed via International Classification of Diseases, 9th Edition, diagnosis codes. The economic burden was assessed by comparing probability of hospitalization and the average total charges between propensity-score matched visits with and without a malnutrition diagnosis. Results: Data from 238 million ED visits between 2006 and 2014 were analyzed. Over this period, the prevalence of diagnosed malnutrition increased for all demographic categories assessed. For older adults (≥65 years), the prevalence increased from 2.5% (2006) to 3.6% (2014). Older age, high-income community residence, Western region, urban areas, and Medicare coverage were associated with higher diagnosis prevalence. Malnutrition diagnosis was associated with a 4.23 (95% confidence interval [CI] = 3.93 to 4.55) times higher odds of hospitalization and $21,892 higher mean total charges (95% CI = $19,593 to $24,192). Conclusions: While malnutrition is currently diagnosed at a low rate in U.S. EDs, the economic burden of malnutrition is substantial in this care setting. Given the potential for systematic malnutrition screening and treatment protocols to alleviate this burden, future research is warranted.
MeSH term(s)	Aged ; Cost of Illness ; Emergency Service, Hospital ; Hospitalization ; Humans ; Malnutrition/diagnosis ; Malnutrition/epidemiology ; Medicare ; Prevalence ; Retrospective Studies ; United States/epidemiology
Language	English
Publishing date	2020-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1329813-6
ISSN	1553-2712 ; 1069-6563
ISSN (online)	1553-2712
ISSN	1069-6563
DOI	10.1111/acem.13887
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Zs.A 4479: Show issues

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Article ; Online: Anti-SARS-CoV-2-specific antibodies in human breast milk following SARS-CoV-2 infection during pregnancy: a prospective cohort study.

Fernández-Buhigas, Irene / Rayo, Nieves / Silos, Julia Cuesta / Serrano, Berta / Ocón-Hernández, Olga / Leung, Bo Wah / Delgado, Juan Luis / Fernández, David Sánchez-Nieves / Valle, Silvia / De Miguel, Laura / Silgado, Aroa / Tanoira, Ramón Perez / Rolle, Valeria / Santacruz, Belén / Gil, Maria M / Poon, Liona C

International breastfeeding journal

2024 Volume 19, Issue 1, Page(s) 5

Abstract: Background: While the presence of SARS-CoV-2 in human breast milk is contentious, anti-SARS-CoV-2 antibodies have been consistently detected in human breast milk. However, it is uncertain when and how long the antibodies are present.: Methods: This ... ...

Abstract	Background: While the presence of SARS-CoV-2 in human breast milk is contentious, anti-SARS-CoV-2 antibodies have been consistently detected in human breast milk. However, it is uncertain when and how long the antibodies are present. Methods: This was a prospective cohort study including all consecutive pregnant women with confirmed SARS-CoV-2 infection during pregnancy, recruited at six maternity units in Spain and Hong Kong from March 2020 to March 2021. Colostrum (day of birth until day 4 postpartum) and mature milk (day 7 postpartum until 6 weeks postpartum) were prospectively collected, and paired maternal blood samples were also collected. Colostrum samples were tested with rRT-PCR-SARS-CoV-2, and skimmed acellular milk and maternal sera were tested against SARS-CoV-2 specific immunoglobulin M, A, and G reactive to receptor binding domain of SARS-CoV-2 spike protein 1 to determine the presence of immunoglobulins. Then, we examined how each immunoglobulin type in the colostrum was related to the time of infection by logistic regression analysis, the concordance between these immunoglobulins in the colostrum, maternal serum, and mature milk by Cohen's kappa statistic, and the relationship between immunoglobulin levels in mature milk and colostrum with McNemar. Results: One hundred eighty-seven pregnant women with confirmed SARS-CoV-2 infection during pregnancy or childbirth were recruited and donated the milk and blood samples. No SARS-CoV-2 was found in the human breast milk. Immunoglobulin A, G, and M were present in 129/162 (79·6%), 5/163 (3·1%), and 15/76 (19·7%) colostrum samples and in 17/62 (27·42%), 2/62 (3·23%) and 2/62 (3·23%) mature milk samples, respectively. Immunoglobulin A was the predominant immunoglobulin found in breast milk, and its levels were significantly higher in the colostrum than in the mature milk (p-value < 0.001). We did not find that the presence of immunoglobulins in the colostrum was associated with their presence in maternal, the severity of the disease, or the time when the infection had occurred. Conclusions: Since anti-SARS-CoV-2 antibodies are found in the colostrum irrespective of the time of infection during pregnancy, but the virus itself is not detected in human breast milk, our study found no indications to withhold breastfeeding, taking contact precautions when there is active disease.
MeSH term(s)	Humans ; Female ; Pregnancy ; Milk, Human/chemistry ; COVID-19 ; Breast Feeding ; Prospective Studies ; SARS-CoV-2 ; Antibodies, Viral/analysis ; Immunoglobulin A/analysis ; Pregnancy Complications, Infectious ; Spike Glycoprotein, Coronavirus
Chemical Substances	spike protein, SARS-CoV-2 ; Antibodies, Viral ; Immunoglobulin A ; Spike Glycoprotein, Coronavirus
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2227239-2
ISSN	1746-4358 ; 1746-4358
ISSN (online)	1746-4358
ISSN	1746-4358
DOI	10.1186/s13006-023-00605-w
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