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  1. Article: Update Herpes zoster (2 DFP-Punkte)

    Müllegger, Robert

    Arzt & Praxis

    2015  Volume 69, Issue 1017, Page(s) 15

    Language German
    Document type Article
    ZDB-ID 1224197-0
    ISSN 0048-5128
    Database Current Contents Medicine

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  2. Article ; Online: S2k guideline: Diagnosis and therapy of localized scleroderma.

    Kreuter, Alexander / Moinzadeh, Pia / Kinberger, Maria / Horneff, Gerd / Worm, Margitta / Werner, Ricardo N / Hammacher, Andreas / Krieg, Thomas / Wenzel, Jörg / Oeschger, Michael / Weibel, Lisa / Müllegger, Robert / Hunzelmann, Nicolas

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2024  Volume 22, Issue 4, Page(s) 605–620

    Abstract: The updated S2k guideline deals with the diagnosis and therapy of localized scleroderma (LoS). LoS represents a spectrum of sclerotic skin diseases in which, depending on the subtype and localisation, structures such as adipose tissue, muscles, joints, ... ...

    Abstract The updated S2k guideline deals with the diagnosis and therapy of localized scleroderma (LoS). LoS represents a spectrum of sclerotic skin diseases in which, depending on the subtype and localisation, structures such as adipose tissue, muscles, joints, and bones may also be affected. Involvement of internal organs or progression to systemic sclerosis does not occur. LoS can be classified into four main forms: limited, generalized, linear, and mixed forms, with some additional subtypes. For cases of limited skin involvement, the guideline primarily recommends therapy with topical corticosteroids. UV therapy can also be recommended. In subtypes with severe skin or musculoskeletal involvement, systemic therapy with methotrexate is recommended. During the active phase of the disease, systemic glucocorticosteroids can be used additionally. In cases of methotrexate and steroid refractory courses, contraindications, or intolerance, mycophenolate mofetil, mycophenolic acid, or abatacept can be considered as second-line systemic therapies. In the case of linear LoS, autologous adipose-derived stem cell transplantation can also be performed for correcting soft tissue defects.
    MeSH term(s) Humans ; Methotrexate/therapeutic use ; Scleroderma, Localized/diagnosis ; Scleroderma, Localized/therapy ; Skin ; Dermatologic Agents/therapeutic use ; Mycophenolic Acid/therapeutic use
    Chemical Substances Methotrexate (YL5FZ2Y5U1) ; Dermatologic Agents ; Mycophenolic Acid (HU9DX48N0T)
    Language English
    Publishing date 2024-03-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: [No title information]

    Kreuter, Alexander / Moinzadeh, Pia / Kinberger, Maria / Horneff, Gerd / Worm, Margitta / Werner, Ricardo N / Hammacher, Andreas / Krieg, Thomas / Wenzel, Jörg / Oeschger, Michael / Weibel, Lisa / Müllegger, Robert / Hunzelmann, Nicolas

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2024  Volume 22, Issue 4, Page(s) 605–621

    Title translation S2k‐Leitlinie: Diagnostik und Therapie der zirkumskripten Sklerodermie.
    MeSH term(s) Humans ; Scleroderma, Localized/diagnosis
    Language German
    Publishing date 2024-04-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15328_g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: DNA repair enzymes in sunscreens and their impact on photoageing-A systematic review.

    Luze, Hanna / Nischwitz, Sebastian Philipp / Zalaudek, Iris / Müllegger, Robert / Kamolz, Lars Peter

    Photodermatology, photoimmunology & photomedicine

    2020  Volume 36, Issue 6, Page(s) 424–432

    Abstract: ... attributed to ultraviolet irradiation (UV-R). Photoprotection by conventional sunscreens is exclusively ... These enzymes are capable of identifying and removing UV-R-induced dimeric photoproducts. Clinical studies ...

    Abstract Background: DNA damage is one of the main factors responsible for photoageing and is predominantly attributed to ultraviolet irradiation (UV-R). Photoprotection by conventional sunscreens is exclusively prophylactic, and of no value, once DNA damage has occurred. As a result, the demand for DNA repair mechanisms inhibiting, reversing or delaying the pathologic events in UV-exposed skin has sparked research on anti-photoageing and strategies to improve the effect of conventional sunscreens. This review provides an overview of recent developments in DNA repair enzymes used in sunscreens and their impact on photoageing.
    Methods: A systematic review of the literature, up to March 2019, was conducted using the electronic databases, PubMed and Web of Science. Quality assessment was carried out using the Newcastle-Ottawa scale (NOS) to ensure inclusion of adequate quality studies only (NOS > 5).
    Results: Out of the 352 publications, 52 were considered relevant to the key question and included in the present review. Two major enzymes were found to play a major role in DNA damage repair in sunscreens: photolyase and T4 endonuclease V. These enzymes are capable of identifying and removing UV-R-induced dimeric photoproducts. Clinical studies revealed that sunscreens with liposome-encapsulated types of photolyase and/or T4 endonuclease V can enhance these repair mechanisms.
    Conclusion: There is a lack of randomized controlled trials demonstrating the efficacy of DNA repair enzymes on photoageing, or a superiority of sunscreens with DNA repair enzymes compared to conventional sunscreens. Further studies are mandatory to further reveal pathogenic factors of photoageing and possible therapeutic strategies against it.
    MeSH term(s) Animals ; DNA Damage ; DNA Repair/drug effects ; Deoxyribodipyrimidine Photo-Lyase/pharmacology ; Deoxyribonuclease (Pyrimidine Dimer)/pharmacology ; Humans ; Skin Aging/radiation effects ; Sunscreening Agents/chemistry ; Sunscreening Agents/pharmacology ; Ultraviolet Rays/adverse effects ; Viral Proteins/pharmacology
    Chemical Substances Sunscreening Agents ; Viral Proteins ; endonuclease V, phage T4 (EC 3.1.21.7) ; Deoxyribonuclease (Pyrimidine Dimer) (EC 3.1.25.1) ; Deoxyribodipyrimidine Photo-Lyase (EC 4.1.99.3)
    Language English
    Publishing date 2020-08-27
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 1028855-7
    ISSN 1600-0781 ; 0108-9684 ; 0905-4383
    ISSN (online) 1600-0781
    ISSN 0108-9684 ; 0905-4383
    DOI 10.1111/phpp.12597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online ; Conference proceedings: Die Abteilung für Dermatologie in Wiener Neustadt feiert ihr einjähriges Bestehen.

    Müllegger, Robert

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2007  Volume 5, Issue 5, Page(s) 444

    Title translation The Division of Dermatology in Viennese Neustadt celebration of its first year of existence.
    MeSH term(s) Austria ; Clinical Trials as Topic/trends ; Dermatology/trends ; Societies, Medical/trends ; Venereology/trends
    Language German
    Publishing date 2007-05
    Publishing country Germany
    Document type Congresses
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/j.1610-0387.2007.07027.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pityriasis rosea in der Schwangerschaft: Eine Fallserie und Literaturübersicht.

    Wenger-Oehn, Lena / Graier, Thomas / Ambros-Rudolph, Christina / Müllegger, Robert / Bittighofer, Christina / Wolf, Peter / Hofer, Angelika

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2022  Volume 20, Issue 7, Page(s) 953–960

    Language English
    Publishing date 2022-07-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14763_g
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  7. Article ; Online: Pityriasis rosea in pregnancy: A case series and literature review.

    Wenger-Oehn, Lena / Graier, Thomas / Ambros-Rudolph, Christina / Müllegger, Robert / Bittighofer, Christina / Wolf, Peter / Hofer, Angelika

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2022  Volume 20, Issue 7, Page(s) 953–959

    Abstract: Background and objective: Pityriasis rosea (PR), a common skin disease in young adults, may adversely affects the course of pregnancy and the unborn child.: Patients and methods: Data from forty-six pregnant women with PR seen in the dermatological ... ...

    Abstract Background and objective: Pityriasis rosea (PR), a common skin disease in young adults, may adversely affects the course of pregnancy and the unborn child.
    Patients and methods: Data from forty-six pregnant women with PR seen in the dermatological university clinic between 2003 and 2018 were analyzed and compared with patient data (n = 53) from previously published studies to determine the incidence and risk factors for an unfavorable pregnancy outcome after PR infection.
    Results: Unfavorable pregnancy outcomes (defined as miscarriage, preterm delivery before week 37 of gestation, or birth weight < 2,500 g) were significantly less frequent in our study population than in a pooled cohort obtained from previously published studies (10.9 % vs. 39.6 %; P = 0.0012). Analysis of pooled data from our study and from previous studies revealed that the week of pregnancy at onset of PR was inversely associated with an unfavorable outcome (odds ratio [OR] = 0.937; 95 % CI 0.883 to 0.993). In addition, duration of PR (OR = 1.432; 95 % CI 1.129 to 1.827), additional extracutaneous symptoms (OR = 4.112; 95 % CI 1.580 to 10.23), and widespread rash distribution (OR 5.203, 95 % CI 1.702 to 14.89) were directly associated with unfavorable outcome.
    Conclusion: In most cases, PR does not influence pregnancy or birth outcomes.
    MeSH term(s) Cohort Studies ; Female ; Humans ; Incidence ; Infant, Newborn ; Pityriasis Rosea/diagnosis ; Pityriasis Rosea/epidemiology ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/epidemiology ; Risk Factors ; Young Adult
    Language English
    Publishing date 2022-05-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14763
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  8. Article ; Online: Skin infections in pregnancy.

    Müllegger, Robert R / Häring, Nina S / Glatz, Martin

    Clinics in dermatology

    2016  Volume 34, Issue 3, Page(s) 368–377

    Abstract: A wide array of infectious diseases can occur in pregnancy. Their acquisition, clinical presentation, and course during gestation may be altered due to an impairment of the maternal cellular immunity. Some infectious diseases can lead to serious ... ...

    Abstract A wide array of infectious diseases can occur in pregnancy. Their acquisition, clinical presentation, and course during gestation may be altered due to an impairment of the maternal cellular immunity. Some infectious diseases can lead to serious consequences for the mother or the offspring, including congenital malformations. This review describes in detail the clinical presentation, course, management, and associated maternal and fetal risks of selected viral (varicella-zoster virus infections, condylomata acuminata), fungal (candida vulvovaginitis), bacterial (Lyme borreliosis), and parasitic (scabies) infections. The treatment options are critically reviewed. First-line therapies include acyclovir and varicella-zoster virus immunoglobulin for varicella-zoster virus infections, surgical modalities for genital warts, topical clotrimazole and oral fluconazole for Candida vulvovaginitis, amoxicillin and cefuroxime for Lyme borreliosis, and permethrin for scabies. A synopsis of maternal and fetal risks of other important infections is also included.
    MeSH term(s) Candidiasis, Vulvovaginal/drug therapy ; Candidiasis, Vulvovaginal/transmission ; Cesarean Section ; Chickenpox/complications ; Chickenpox/congenital ; Chickenpox/drug therapy ; Chickenpox/transmission ; Condylomata Acuminata/therapy ; Female ; Fetal Diseases/microbiology ; Herpes Zoster/drug therapy ; Herpes Zoster/transmission ; Humans ; Infectious Disease Transmission, Vertical/prevention & control ; Lyme Disease/complications ; Lyme Disease/drug therapy ; Pregnancy ; Pregnancy Complications, Infectious/microbiology ; Pregnancy Complications, Infectious/therapy ; Pregnancy Complications, Parasitic/drug therapy ; Pregnancy Outcome ; Scabies/drug therapy ; Skin Diseases, Infectious/microbiology ; Skin Diseases, Infectious/therapy ; Skin Diseases, Infectious/transmission
    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1064149-x
    ISSN 1879-1131 ; 0738-081X
    ISSN (online) 1879-1131
    ISSN 0738-081X
    DOI 10.1016/j.clindermatol.2016.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Fixed food eruption caused by quinine in a 54-year-old female patient.

    Sommer, Christian / Zikeli, Martin / Müllegger, Robert

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2017  Volume 15, Issue 4, Page(s) 449–450

    MeSH term(s) Analgesics, Non-Narcotic/adverse effects ; Drug Eruptions ; Exanthema/chemically induced ; Female ; Humans ; Middle Aged ; Quinine/adverse effects
    Chemical Substances Analgesics, Non-Narcotic ; Quinine (A7V27PHC7A)
    Language English
    Publishing date 2017-03-15
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.12893
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  10. Article ; Online: Fixed food eruption durch Chinin bei einer 54-jährigen Patientin.

    Sommer, Christian / Zikeli, Martin / Müllegger, Robert

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2017  Volume 15, Issue 4, Page(s) 448–450

    Language English
    Publishing date 2017-04-04
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.12893_g
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