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  1. Article ; Online: Cosmetic gynecology-An emerging field for the dermatologist.

    Jindal, Anuradha / Mysore, Venkataram / Mysore, Jayashree Venkataram

    Journal of cosmetic dermatology

    2022  Volume 22, Issue 1, Page(s) 111–118

    Abstract: Introduction: Cosmetic gynecology is an expanding field with a steep rise in awareness and demand for procedures to enhance the aesthetic appearance of female genitalia.: Aim: This article aims to provide an overview of aesthetic gynecology for a ... ...

    Abstract Introduction: Cosmetic gynecology is an expanding field with a steep rise in awareness and demand for procedures to enhance the aesthetic appearance of female genitalia.
    Aim: This article aims to provide an overview of aesthetic gynecology for a practicing dermatologist.
    Methods: A study conducted in India showed a rising trend in the demand of aesthetic vaginal procedures from 3.9% in 2012 to 28.97% in 2015.
    Conclusion: Several aesthetic modalities such as peels, platelet rich plasma, and energy-based devices and surgical modalities have been in use, though serious evidence for efficacy of many of these procedures is lacking.
    MeSH term(s) Female ; Humans ; Gynecology ; Dermatologists ; Rejuvenation ; Vagina ; Cosmetics ; Cosmetic Techniques
    Chemical Substances Cosmetics
    Language English
    Publishing date 2022-11-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15484
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  2. Article ; Online: Recalcitrant skin ulcers in a patient with Papillon-Lefèvre syndrome: an unusual novel presentation.

    Malhi, Kittu / Singh, Sukhdeep / Mustari, Akash P / Bishnoi, Anuradha / Machhua, Sanghamitra / Jindal, Ankur Kumar

    Clinical and experimental dermatology

    2023  Volume 49, Issue 5, Page(s) 512–513

    MeSH term(s) Humans ; Papillon-Lefevre Disease/complications ; Skin Ulcer/pathology ; Skin Ulcer/etiology ; Female ; Male
    Language English
    Publishing date 2023-11-07
    Publishing country England
    Document type Case Reports ; Letter ; Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llad446
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  3. Article ; Online: Downregulation of ATF-4 Attenuates the Endoplasmic Reticulum Stress-Mediated Neuroinflammation and Cognitive Impairment in Experimentally Induced Alzheimer's Disease Model.

    Goswami, Poonam / Akhter, Juheb / Mangla, Anuradha / Suramya, Suramya / Jindal, Garima / Ahmad, Shahzad / Raisuddin, Sheikh

    Molecular neurobiology

    2023  

    Abstract: Protein aggregation is invariably associated with the inflammation as a factor in Alzheimer's disease (AD). We investigated the interaction between downstream factors of endoplasmic reticulum (ER) stress pathway and inflammation, with implications in ... ...

    Abstract Protein aggregation is invariably associated with the inflammation as a factor in Alzheimer's disease (AD). We investigated the interaction between downstream factors of endoplasmic reticulum (ER) stress pathway and inflammation, with implications in cognitive impairment in AD. Amyloid-β (Aβ)
    Language English
    Publishing date 2023-12-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03861-3
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  4. Article ; Online: Modified mask for aesthetic procedures on face during COVID-19 era: Chiseling our armamentarium.

    Noronha, Malcom / Jindal, Anuradha / Mysore, Venkataram

    Dermatologic therapy

    2020  Volume 33, Issue 6, Page(s) e13819

    MeSH term(s) COVID-19/prevention & control ; COVID-19/transmission ; Cosmetic Techniques ; Dermatology/methods ; Humans ; Masks
    Keywords covid19
    Language English
    Publishing date 2020-07-06
    Publishing country United States
    Document type Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.13819
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  5. Article: Hereditary Angioedema: Diagnostic Algorithm and Current Treatment Concepts.

    Jindal, Ankur Kumar / Bishnoi, Anuradha / Dogra, Sunil

    Indian dermatology online journal

    2021  Volume 12, Issue 6, Page(s) 796–804

    Abstract: Hereditary angioedema (HAE) is an uncommon disorder with a global prevalence of approximately 1 in 10,000 to 1 in 50,000 population. This disease is grossly underrecognized in India because of lack of awareness and/or lack of diagnostic facilities. ... ...

    Abstract Hereditary angioedema (HAE) is an uncommon disorder with a global prevalence of approximately 1 in 10,000 to 1 in 50,000 population. This disease is grossly underrecognized in India because of lack of awareness and/or lack of diagnostic facilities. Clinical manifestations include swelling over face, eyes, lips, hands, feet, and genitals, abdominal pain, and life-threatening laryngeal edema. HAE should be suspected in all patients who present with angioedema without wheals and who do not respond to antihistamines and/or steroids. C1 levels, C1-INH levels, and C1-INH function should be checked in all patients suspected to have HAE. C1q levels should be assessed in patients with suspected autoimmune-mediated acquired angioedema. Management of HAE constitutes the treatment of acute attack and short-term and long-term prophylaxis. Because of lack of all first-line recommended medications, the management of HAE in India is a challenging task. Patients are managed using fresh frozen plasma (acute treatment), tranexamic acid, and attenuated androgens (prophylaxis). Even though attenuated androgens have been shown to be effective in the prevention of attacks of HAE, the side effect profile especially in children and in females is a serious concern. Hence, the treatment needs to be individualized considering the risk-benefit ratio of long-term prophylaxis. In this review, we provide an overview of diagnostic strategy for patients with HAE and the current treatment concepts with emphasis on currently available treatment options in resource-constrained settings.
    Language English
    Publishing date 2021-11-22
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2585814-2
    ISSN 2249-5673 ; 2229-5178
    ISSN (online) 2249-5673
    ISSN 2229-5178
    DOI 10.4103/idoj.idoj_398_21
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  6. Article ; Online: Dermatological procedures amidst COVID-19: When and how to resume.

    Jindal, Anuradha / Noronha, Malcom / Mysore, Venkataram

    Dermatologic therapy

    2020  Volume 33, Issue 5, Page(s) e13561

    Abstract: The pandemic of COVID-19 has captivated more than 3 million people across the globe affecting the dermatology practice as well. Due to the novel nature of the virus and concomitant lack of research, standard guidelines have not been set in place ... ...

    Abstract The pandemic of COVID-19 has captivated more than 3 million people across the globe affecting the dermatology practice as well. Due to the novel nature of the virus and concomitant lack of research, standard guidelines have not been set in place regarding the procedures. Currently, due to fear and spread of coronavirus aesthetic practice has taken a seat back. Dermatologic surgeon/aesthetician have to be prepared for the forthcoming alterations in the practice and adjust to the necessary precautionary methods. This articles aims to prepare dermatologist for the upcoming difficulties and precautions to be taken for conducting procedures in amidst of coronavirus.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Dermatology ; Disinfection ; Humans ; Minimally Invasive Surgical Procedures ; N95 Respirators ; SARS-CoV-2 ; Ventilation
    Keywords covid19
    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.13561
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    Zs.A 5181: Show issues Location:
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  7. Article ; Online: Biochemistry of exosomes and their theranostic potential in human diseases.

    Dwivedi, Manish / Ghosh, Diya / Saha, Anwesha / Hasan, Saba / Jindal, Divya / Yadav, Hitendra / Yadava, Anuradha / Dwivedi, Medha

    Life sciences

    2023  Volume 315, Page(s) 121369

    Abstract: Exosomes are classified as special extracellular vesicles in the eukaryotic system having diameters ranging from 30 to 120 nm. These vesicles carry various endogenous molecules including DNA, mRNA, microRNA, circular RNA, and proteins, crucial for ... ...

    Abstract Exosomes are classified as special extracellular vesicles in the eukaryotic system having diameters ranging from 30 to 120 nm. These vesicles carry various endogenous molecules including DNA, mRNA, microRNA, circular RNA, and proteins, crucial for numerous metabolic reactions and can be proposed as therapeutic or diagnostic targets for several disorders. The donor exosomes release their content to recipient cells and further establish the significant intercellular communication showing biological effects by triggering environmental alterations. Exosomes derived from mesenchymal and dendritic cells have demonstrated their therapeutic potential against organ injury. Yet, various intricacies are involved in exosomal transport and its inclusion in cancer and other disease pathogenesis needs to be explored. The exosomes represent profound potential as diagnostic biomarkers and therapeutic carriers in various pathophysiological conditions such as neurodegenerative diseases, chronic cancers, infectious diseases, female reproductive diseases and cardiovascular diseases. In the current study, we demonstrate the advancements in the implication of exosomes as one of the irrefutable prognostic biological targets in human health and diseases.
    MeSH term(s) Female ; Humans ; Cell Communication ; Exosomes/genetics ; Exosomes/metabolism ; Extracellular Vesicles/metabolism ; MicroRNAs/metabolism ; Neoplasms/therapy ; Neoplasms/drug therapy ; Precision Medicine ; Disease/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-01-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.121369
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  8. Article ; Online: Utility of oral mucosa as a substrate for the serodiagnosis of pemphigus: A descriptive analysis.

    Jindal, Anuradha / Rao, Chythra / Pai, Satish B / Rao, Raghavendra

    Indian journal of dermatology, venereology and leprology

    2021  Volume 88, Issue 2, Page(s) 156–161

    Abstract: Background: The indirect immunofluorescence test is useful in the serodiagnosis of pemphigus. As indirect immunofluorescence titers correlate with disease activity in pemphigus, it is often used as a monitoring tool. The sensitivity of indirect ... ...

    Abstract Background: The indirect immunofluorescence test is useful in the serodiagnosis of pemphigus. As indirect immunofluorescence titers correlate with disease activity in pemphigus, it is often used as a monitoring tool. The sensitivity of indirect immunofluorescence depends on the substrate used, and the preferred substrates are monkey esophagus for pemphigus vulgaris and normal human skin for pemphigus foliaceus.
    Aims: We evaluated oral mucosa as a substrate for indirect immunofluorescence in pemphigus.
    Methods: Fifty patients with pemphigus (40 with pemphigus vulgaris and ten with pemphigus foliaceus) and 50 controls were enrolled for study. Demographic and clinical details were recorded and indirect immunofluorescence using two substrates (oral mucosa and normal human skin) was carried out in serial dilution. Desmoglein (Dsg) 1 and 3 enzyme-linked immunosorbent assay was also evaluated simultaneously.
    Results: Indirect immunofluorescence was positive in 40 patients (80%) with oral mucosa substrate and 34 patients (68%) with normal human skin substrate. Circulating antibodies were detected with oral mucosa in 33 (82.5%) of the 40 pemphigus vulgaris patients and in 26 (65%) patients using normal human skin. Antibodies were detected in eight of the ten pemphigus foliaceus patients (80%) with normal human skin and in seven (70%) patients with oral mucosa. Dsg enzyme-linked immunosorbent assay was positive in 45 (90%) patients, and 37 of these were also indirect immunofluorescence positive with oral mucosa. In the five Dsg enzyme-linked immunosorbent assay-negative patients, indirect immunofluorescence with oral mucosa was positive in three.
    Limitations: A comparison of oral mucosa with monkey esophagus could not be performed.
    Conclusion: Oral mucosa is a suitable and sensitive substrate for indirect immunofluorescence in pemphigus. Further studies comparing the sensitivity of indirect immunofluorescence using oral mucosa with monkey esophagus are recommended.
    MeSH term(s) Adult ; Antibodies/metabolism ; Case-Control Studies ; Desmoglein 1/metabolism ; Desmoglein 3/metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Fluorescent Antibody Technique, Indirect ; Humans ; Male ; Mouth Mucosa/metabolism ; Pemphigus/diagnosis
    Chemical Substances Antibodies ; Desmoglein 1 ; Desmoglein 3
    Language English
    Publishing date 2021-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 416068-x
    ISSN 0973-3922 ; 0019-5162 ; 0378-6323
    ISSN (online) 0973-3922
    ISSN 0019-5162 ; 0378-6323
    DOI 10.25259/IJDVL_469_20
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  9. Article ; Online: Intramatricial methotrexate for treatment of resistant acrodermatitis continua of Hallopeau: An alternative in COVID-19.

    Jindal, Anuradha / Ramesh, Sandhiya / Noronha, Malcom / Pai, Kantilatha / Pai, Sathish

    Dermatologic therapy

    2020  Volume 33, Issue 4, Page(s) e13787

    MeSH term(s) Acrodermatitis/diagnosis ; Acrodermatitis/drug therapy ; Acrodermatitis/epidemiology ; Administration, Topical ; Adult ; Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus Infections/epidemiology ; Dermatologic Agents/administration & dosage ; Dose-Response Relationship, Drug ; Female ; Humans ; Methotrexate/administration & dosage ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Skin/pathology
    Chemical Substances Dermatologic Agents ; Methotrexate (YL5FZ2Y5U1)
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.13787
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  10. Article ; Online: Obesity aggravates neuroinflammatory and neurodegenerative effects of bisphenol A in female rats.

    Mangla, Anuradha / Goswami, Poonam / Sharma, Bhaskar / Suramya, Suramya / Jindal, Garima / Javed, Mehjbeen / Saifi, Mohd Anas / Parvez, Suhel / Nag, Tapas Chandra / Raisuddin, Sheikh

    Toxicology mechanisms and methods

    2024  , Page(s) 1–20

    Abstract: Bisphenol A (BPA), a common plasticizer, is categorized as a neurotoxic compound and its impact on individuals exhibits sex-linked variations. Several biological and environmental factors impact the degree of toxicity. Moreover, nutritional factors have ... ...

    Abstract Bisphenol A (BPA), a common plasticizer, is categorized as a neurotoxic compound and its impact on individuals exhibits sex-linked variations. Several biological and environmental factors impact the degree of toxicity. Moreover, nutritional factors have profound influence on toxicity outcome. BPA has been demonstrated to be an obesogen. However, research on the potential role of obesity as a confounding factor in BPA toxicity is lacking. We studied the neurodegenerative effects in high-fat diet (HFD)-induced obese female rats after being exposed with BPA (10 mg/L via drinking water for 90 days). Four groups were taken in this study - Control, HFD, HFD + BPA and BPA. Cognitive function was evaluated through novel object recognition (NOR) test. Inflammatory changes in brain, and changes in hormonal level, lipid profile, glucose tolerance, oxidative stress and antioxidants were also determined. HFD + BPA group rats showed a significant decline in NOR test. The cerebral cortex (CC) of the brain showed increased neurodegenerative changes as measured by microtubule associated protein-2 (MAP-2) accompanied by histopathological confirmation. The increased level of neuroinflammation was demonstrated by microglial activation (Iba-1) and protein expression of nuclear factor- kappa B (NF-КB) in the brain. Obesity also caused significant (
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081252-8
    ISSN 1537-6524 ; 1537-6516 ; 1051-7235
    ISSN (online) 1537-6524
    ISSN 1537-6516 ; 1051-7235
    DOI 10.1080/15376516.2024.2349538
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