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  1. Book ; Online: Pathogenesis and treatment of chronic pruritus

    Kwatra, Shawn G.

    2020  

    Author's details ed. Shawn G. Kwatra
    Language English
    Size 1 Online-Ressource (vii, 146 Seiten), Illustrationen, Diagramme
    Publisher MDPI
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT020868499
    ISBN 978-3-03943-101-4 ; 9783039431007 ; 3-03943-101-3 ; 3039431005
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Pathogenesis and Treatment of Chronic Pruritus

    Kwatra, Shawn G.

    2020  

    Keywords Medicine ; dupilumab ; IL-4 ; IL-13 ; pruritus ; chronic pruritus of unknown origin ; prurigo nodularis ; uremic pruritus ; lichen planus ; eosinophilic dermatosis of hematologic malignancy ; chronic pruritus ; mirtazapine ; chronic ; itch ; refractory ; treatment ; noradrenergic ; serotonergic ; antihistaminergic ; antidepressant ; skin ; atopic dermatitis ; ceramide ; pine tar ; drug-induced ; medication-related ; epidemiology ; inpatient ; disease burden ; national inpatient sample ; medical dermatology ; systematic review ; prurigo ; nodularis ; atopic ; dermatitis ; race ; gender ; comorbidities ; demographics ; pediatric ; children ; malignancy ; cancer ; neoplasm ; ion channels ; cell signaling ; Cav3.2 calcium channel ; RT-PCR ; wounds ; itch in wounds ; itch management ; aprepitant ; erlotinib ; EGFR ; epidermal growth factor receptor ; NK1R ; neurokinin1-receptor ; mycosis fungoides ; psoriasis ; associations ; lymphomatoid papulosis ; lymphoma ; racial differences ; nodular prurigo ; neuropathy ; therapeutic ; pathogenesis
    Size 1 electronic resource (144 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046738
    ISBN 9783039431014 ; 3039431013
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Prurigo Nodularis.

    Kwatra, Shawn G

    JAMA dermatology

    2022  Volume 158, Issue 3, Page(s) 336

    MeSH term(s) Humans ; Prurigo/diagnosis
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2021.5307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Breaking the Itch-Scratch Cycle in Prurigo Nodularis.

    Kwatra, Shawn G

    The New England journal of medicine

    2020  Volume 382, Issue 8, Page(s) 757–758

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Humans ; Prurigo ; Pruritus
    Chemical Substances Antibodies, Monoclonal, Humanized ; nemolizumab (GN465U8B72)
    Language English
    Publishing date 2020-02-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1916733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Neuropathic pruritus.

    Kwatra, Shawn G / Kambala, Anusha / Dong, Xinzhong

    The Journal of allergy and clinical immunology

    2023  Volume 152, Issue 1, Page(s) 36–38

    MeSH term(s) Humans ; Pruritus/drug therapy ; Antipruritics
    Chemical Substances Antipruritics
    Language English
    Publishing date 2023-04-23
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prurigo Nodularis: New insights into pathogenesis and novel therapeutics.

    Liao, Viviane / Cornman, Hannah L / Ma, Emily / Kwatra, Shawn G

    The British journal of dermatology

    2024  

    Abstract: Prurigo nodularis (PN) is an inflammatory skin condition characterized by intensely pruritic nodules on the skin. PN patients suffer from an intractable itch-scratch cycle leading to impaired sleep, psychosocial distress, and a significant disruption in ... ...

    Abstract Prurigo nodularis (PN) is an inflammatory skin condition characterized by intensely pruritic nodules on the skin. PN patients suffer from an intractable itch-scratch cycle leading to impaired sleep, psychosocial distress, and a significant disruption in quality of life. The pathogenesis of PN is associated with immune and neural dysregulation, mediated by inflammatory cytokines (such as IL-4, -13, -17, -22, and -31) and neuropeptides (such as substance P and calcitonin gene-related peptide). There is a role for type 2 inflammation in PN in addition to Th17 and Th22-mediated inflammation. The neuroimmune feedback loop in PN involves neuropeptides released from nerve fibers that cause vasodilation and further recruitment of inflammatory cells. Inflammatory cells, particularly mast cells and eosinophils, degranulate and release neurotoxins, as well as nerve growth factor, which may contribute to the neuronal hyperplasia seen in the dermis of PN patients and neural sensitization. Recent studies have also indicated underlying genetic susceptibility to PN in addition to environmental factors, the existence of various disease endotypes centered around degrees of Type 2 inflammation or underlying myelopathy or spinal disc disease, and significant race and ethnicity-based differences with African-Americans having densely fibrotic skin lesions. Dupilumab became the first FDA approved therapeutic for PN, and there are several other agents currently in development. The anti-IL-31RA inhibitor nemolizumab is in late stage development with positive phase 3 data reported. In addition, the oral JAK1 inhibitors, abrocitinib and povorcitinib, are in phase 2 trials while a topical JAK1/2 inhibitor, ruxolitinib, is in phase 3 studies.
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljae052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Treatment of pyoderma gangrenosum with apremilast monotherapy.

    Bordeaux, Zachary A / Kwatra, Shawn G / West, Cameron E

    JAAD case reports

    2022  Volume 30, Page(s) 8–10

    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2022.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Understanding racial disparities in prurigo nodularis.

    Sutaria, Nishadh / Semenov, Yevgeniy R / Kwatra, Shawn G

    Journal of the American Academy of Dermatology

    2022  Volume 87, Issue 3, Page(s) e111–e112

    MeSH term(s) Humans ; Neurodermatitis ; Prurigo ; Pruritus
    Language English
    Publishing date 2022-05-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2022.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Emerging Research in Chronic Pruritus: From Bedside to Bench and Back Again.

    Williams, Kyle A / Kwatra, Shawn G

    Medicines (Basel, Switzerland)

    2020  Volume 7, Issue 5

    Abstract: ... ...

    Abstract This
    Language English
    Publishing date 2020-04-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2777965-8
    ISSN 2305-6320
    ISSN 2305-6320
    DOI 10.3390/medicines7050024
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  10. Article ; Online: No increased risk of postoperative adverse events in total joint replacement patients with hidradenitis suppurativa.

    Cornman, Hannah L / Kambala, Anusha / Nandi, Tina R / Kwatra, Shawn G / Nandi, Sumon

    Clinical and experimental dermatology

    2024  

    Abstract: There is concern for increased risk of adverse events, particularly periprosthetic joint infection (PJI), following total joint replacement (TJR) in patients with hidradenitis suppurativa (HS) due to compromised skin barrier and bacterial colonization of ...

    Abstract There is concern for increased risk of adverse events, particularly periprosthetic joint infection (PJI), following total joint replacement (TJR) in patients with hidradenitis suppurativa (HS) due to compromised skin barrier and bacterial colonization of lesions. We used TriNetX health research database to identify TJR patients with (n = 1,760) and without (n = 1,760) HS matched by age, sex, race, and risk factors for PJI. Multivariate analysis was performed and revealed that 90-day risk of PJI, re-operation, wound dehiscence, delayed wound healing, emergency room visits, and readmission were not increased among HS patients who underwent TJR. Given these findings, dermatologists and orthopaedists should not defer TJR access for HS patients, as risk of postoperative complications is not prohibitive.
    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llae032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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