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Article ; Online: Segmental neurofibromatosis

Pratiksha Sonkusale / Sumit Kar / Pooja Bonde / Komal Ramteke

Journal of Mahatma Gandhi Institute of Medical Sciences, Vol 25, Iss 2, Pp 113-

A report of a rare case

2020 Volume 115

Abstract: Neurofibromatosis (NF) is a genetic disorder with an autosomal-dominant inheritance mainly affecting the growth of the cells of the neural tissues. Segmental NF (SNF), a rare variant of NF (NF type V), is characterized by café-au-lait macules and ... ...

Abstract	Neurofibromatosis (NF) is a genetic disorder with an autosomal-dominant inheritance mainly affecting the growth of the cells of the neural tissues. Segmental NF (SNF), a rare variant of NF (NF type V), is characterized by café-au-lait macules and freckles or neurofibromas limited to one segment or one region of the body. A 26-year-old married female presented with asymptomatic café-au-lait macules and freckles involving the left cervical and thoracic region. The lesions did not cross the midline. Family history was not positive. There was no history of consanguineous marriage. There was no systemic involvement. We report this case as a rare entity of NF along with multidermatomal involvement.
Keywords	café-au-lait macules ; neurofibromatosis ; neurofibromatosis type v ; somatic mosaicism ; Medicine ; R ; Other systems of medicine ; RZ201-999
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pregnancy-associated hyperkeratosis of the nipple/areola

Pratiksha Sonkusale / Sumit Kar / Nidhi Yadav / Pooja Bonde

Journal of Mahatma Gandhi Institute of Medical Sciences, Vol 24, Iss 2, Pp 96-

2019 Volume 98

Abstract: Hyperkeratosis of the nipple is an uncommon, benign, asymptomatic, acquired condition of unknown pathogenesis. Most cases are bilateral, although unilateral cases had been reported. Breastfeeding is usually not affected. Physiologic changes of the nipple ...

Abstract	Hyperkeratosis of the nipple is an uncommon, benign, asymptomatic, acquired condition of unknown pathogenesis. Most cases are bilateral, although unilateral cases had been reported. Breastfeeding is usually not affected. Physiologic changes of the nipple and areola during pregnancy include enlargement, hyperpigmentation, secondary areolae, erectile nipples, prominence of veins, striae, and enlargement of the Montgomery glands or tubercles (hypertrophied sebaceous glands). Women with unilateral primary hyperkeratosis of the nipple and/or areola (HNA) may have bilateral disease during pregnancy (secondary HNA). Pregnancy may also produce thicker, darker lesions. Here, we report a case of pregnancy-associated hyperkeratosis of the nipple in a primigravida. We counseled her about the benign nature of the condition and treated her with topical steroids and moisturizers.
Keywords	Hyperkeratosis of the nipple ; pregnancy dermatoses ; verrucous lesion ; Medicine ; R ; Other systems of medicine ; RZ201-999
Subject code	150
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Extrafacial melasma over forearms.

Madke, Bhushan / Kar, Sumit / Yadav, Nidhi / Bonde, Pooja

Indian dermatology online journal

2016 Volume 7, Issue 4, Page(s) 344–345

Language	English
Publishing date	2016-08-10
Publishing country	India
Document type	Journal Article
ZDB-ID	2585814-2
ISSN	2249-5673 ; 2229-5178
ISSN (online)	2249-5673
ISSN	2229-5178
DOI	10.4103/2229-5178.185470
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Article ; Online: Pregnancy-associated hyperkeratosis of nipple/areola

Pratiksha Sonkusale / Sumit Kar / Nidhi Yadav / Pooja Bonde

Medical Journal of Dr. D.Y. Patil Vidyapeeth, Vol 11, Iss 5, Pp 444-

2018 Volume 446

Abstract: Hyperkeratosis of nipple is uncommon, benign, asymptomatic, acquired condition of unknown pathogenesis. Most cases are bilateral, although unilateral cases had been reported. Breastfeeding is usually not affected. Physiologic changes of the nipple and ... ...

Abstract	Hyperkeratosis of nipple is uncommon, benign, asymptomatic, acquired condition of unknown pathogenesis. Most cases are bilateral, although unilateral cases had been reported. Breastfeeding is usually not affected. Physiologic changes of the nipple and areola during pregnancy include enlargement, hyperpigmentation, secondary areolae, erectile nipples, prominence of veins, striae, and enlargement of the Montgomery glands or tubercles (hypertrophied sebaceous glands). Women with unilateral primary hyperkeratosis of the nipple and/or areola may have bilateral disease during pregnancy (secondary hyperkeratosis of the nipple and/or areola). Pregnancy may also produce thicker, darker lesions. Here, we report a case of pregnancy-associated hyperkeratosis of nipple in a primigravida. We counseled her about benign nature of the condition and treated her with topical steroids and moisturizers.
Keywords	Hyperkeratosis of nipple ; pregnancy dermatoses ; verrucous lesion ; Medicine ; R
Subject code	150
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Assessing the viability of Soluplus® self-assembled nanocolloids for sustained delivery of highly hydrophobic lapatinib (anticancer agent): Optimisation and in-vitro characterisation

Bonde, Gunjan Vasant / Ajmal, Gufran / Yadav, Sarita Kumari / Mittal, Pooja / Singh, Juhi / Bakde, Bharati V / Mishra, Brahmeshwar

Colloids and surfaces. 2020 Jan. 01, v. 185

2020

Abstract: Nanocolloids are considered ideal carriers for hydrophobic drugs owing to their core–shell structure. Lapatinib is a potential anti-cancer agent, but its clinical use is limited because of its poor aqueous solubility, thus requiring larger oral doses ... ...

Abstract	Nanocolloids are considered ideal carriers for hydrophobic drugs owing to their core–shell structure. Lapatinib is a potential anti-cancer agent, but its clinical use is limited because of its poor aqueous solubility, thus requiring larger oral doses with the associated toxicity. Thus, in the present study, we fabricated self-assembled nanocolloidal polymeric micelles (LP-PMs) of Soluplus® and Pluronic® F127 by the thin-film hydration method and assessed their delivery potential of the hydrophobic anti-cancer drug lapatinib (LP) and optimised these nanocolloidal polymeric micelles using Quality-by-Design approach. Amorphisation of the drug and no typical incompatibility other than hydrogen bonding in the LP-PMs was confirmed by solid-state characterisation. The LP-PMs exhibited a uniform size of 92.9 ± 4.07 nm, with a 5.06 mV zeta potential and approximately 87% drug encapsulation. The critical micellar concentration (CMC) of Soluplus® decreased from 6.63 × 10−3 to 4.4 × 10−3 mg/mL by incorporating Pluronic® F127. Further, the sustained release of LP from the LP-PMs was confirmed by in-vitro release studies showing 36% and 60% of LP released from the LP-PMs within 48 h in release media of pH 7.4 and pH 5.0, respectively. These results support their capability of preferential release at acidic tumor environment. Their hemocompatibility evidenced by hemolysis below accepted limits and no platelet aggregation with resistance to instant dilution illustrated their admirable blood compatibility and suitability for intravenous administration. The encapsulation of LP inside micelles enhanced the cytotoxicity of LP against SKBr3 breast cancer cells. Further, the LP-PMs were found to be stable over six months when stored at 2–8 °C. These findings indicate the improved potential of nanocolloidal polymeric micelles as promising carriers for the preferential and sustained delivery of hydrophobic anticancer drugs such as lapatinib to tumours.
Keywords	antineoplastic agents ; biocompatibility ; breast neoplasms ; colloids ; cytotoxicity ; encapsulation ; films (materials) ; hemolysis ; hydrogen bonding ; hydrophobicity ; intravenous injection ; micelles ; neoplasm cells ; oral administration ; pH ; platelet aggregation ; polymers ; solubility ; storage temperature ; viability ; zeta potential
Language	English
Dates of publication	2020-0101
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2019.110611
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Formulation and Characterization of Genistein-loaded Nanostructured Lipid Carriers: Pharmacokinetic, Biodistribution and In vitro Cytotoxicity Studies.

Mittal, Pooja / Vrdhan, Harsh / Ajmal, Gufran / Bonde, Gunjan / Kapoor, Ramit / Mishra, Brahmeshwar

Current drug delivery

2018 Volume 16, Issue 3, Page(s) 215–225

Abstract: Background: Genistein (Gen) is a naturally occurring soy isoflavonoid, possessing anticancer, antiproliferation & antioxidant-like properties. The disadvantage of poor solubility and less oral bioavailability restrict its use as a potential anticancer ... ...

Abstract	Background: Genistein (Gen) is a naturally occurring soy isoflavonoid, possessing anticancer, antiproliferation & antioxidant-like properties. The disadvantage of poor solubility and less oral bioavailability restrict its use as a potential anticancer agent. Objectives: The current work was focused on the formulation and characterization of the genistein loaded nanostructured lipid carriers that can entrap enough quantity of the drug which will provide sustained release of the drug for the treatment of ovarian cancer. Methods: The nanostructure lipid carriers of genistein were developed with the aid of solvent emulsification and evaporation technique by employing TPGS as a surfactant. The resultant formulation was characterized by various physicochemical properties. Pharmacokinetics and biodistribution studies were carried out to estimate the mean plasma concentrations of the drug. Percentage cytotoxicity was evaluated by using PA-1 ovarian cancer cell lines. Results: The resultant formulation exhibited a particle size of 130.23 nm, and entrapment efficiency of 94.27 %, & zeta potential of -20.21 mV with unimodal size distribution. Pharmacokinetics and biodistribution studies revealed that the formulation was able to provide sufficient plasma drug concentration for the longer period of time and the drug was more distributed in ovarian cancer tissues. Results of MTT assay concluded that GenNLC were more effective in comparison to pristine Gen. Conclusion: In a nutshell, GenNLC seems to be a superior alternative carrier system for the formulation industry to obtain the higher entrapment with excellent stability of the formulation.
MeSH term(s)	Animals ; Cell Line, Tumor ; Chemistry, Pharmaceutical ; Drug Carriers/administration & dosage ; Drug Carriers/chemistry ; Drug Carriers/pharmacokinetics ; Drug Carriers/toxicity ; Female ; Genistein/administration & dosage ; Genistein/chemistry ; Genistein/pharmacokinetics ; Genistein/toxicity ; Humans ; Lipids/administration & dosage ; Lipids/chemistry ; Lipids/pharmacokinetics ; Lipids/toxicity ; Nanostructures/administration & dosage ; Nanostructures/chemistry ; Nanostructures/toxicity ; Rats, Wistar ; Tissue Distribution
Chemical Substances	Drug Carriers ; Lipids ; Genistein (DH2M523P0H)
Language	English
Publishing date	2018-11-22
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2185284-4
ISSN	1875-5704 ; 1567-2018
ISSN (online)	1875-5704
ISSN	1567-2018
DOI	10.2174/1567201816666181120170137
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Article ; Online: Design, optimization, characterization and in-vivo evaluation of Quercetin enveloped Soluplus®/P407 micelles in diabetes treatment.

Singh, Juhi / Mittal, Pooja / Vasant Bonde, Gunjan / Ajmal, Gufran / Mishra, Brahmeshwar

Artificial cells, nanomedicine, and biotechnology

2018 Volume 46, Issue sup3, Page(s) S546–S555

Abstract: Quercetin (Qu), is a flavonoid known to have anti-diabetic effects owing to its antioxidant property, thus promoting regeneration of the pancreatic islets, ultimately increasing insulin secretion. But the therapeutic application of Qu is hampered by its ... ...

Abstract	Quercetin (Qu), is a flavonoid known to have anti-diabetic effects owing to its antioxidant property, thus promoting regeneration of the pancreatic islets, ultimately increasing insulin secretion. But the therapeutic application of Qu is hampered by its low oral bioavailability and its unfavourable physicochemical characteristics. The present work aimed at formulation of Quercetin loaded Soluplus® micelles (SMs) so as to enhance its bioavailability and provide prolonged release for the management of diabetes. Box-Behnken response surface methodology was employed to optimize the formulation prepared using co-solvent evaporation method. Physicochemical characterization confirmed the nano-spherical nature of Quercetin loaded Soluplus® micelles (Qu-SMs) with average particle size ranging from 85-108nm, encapsulation efficiency of 63-77%. Solid state characterization confirmed the encapsulation of Qu in the micelles without any incompatibilities. Moving forward, the results of in vitro study revealed prolonged and slow release of Qu from the developed formulations. The in vivo pharmacokinetic study revealed improved bioavailability by enveloping the drug in SMs. Moreover, the study performed to evaluate the efficiency in diabetes treatment revealed an enhanced anti-diabetic effect. Thus, Qu-SMs can serve as potential carriers aimed at improving the anti-diabetic property of Qu.
MeSH term(s)	Animals ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Drug Carriers/chemistry ; Drug Carriers/pharmacokinetics ; Drug Carriers/pharmacology ; Drug Design ; Drug Liberation ; Humans ; Male ; Micelles ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacokinetics ; Polyethylene Glycols/pharmacology ; Polyvinyls/chemistry ; Polyvinyls/pharmacokinetics ; Polyvinyls/pharmacology ; Quercetin/chemistry ; Quercetin/pharmacokinetics ; Quercetin/pharmacology ; Rats ; Rats, Wistar
Chemical Substances	Drug Carriers ; Micelles ; Polyvinyls ; polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer ; Polyethylene Glycols (3WJQ0SDW1A) ; Quercetin (9IKM0I5T1E)
Language	English
Publishing date	2018-10-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2723095-8
ISSN	2169-141X ; 2169-1401
ISSN (online)	2169-141X
ISSN	2169-1401
DOI	10.1080/21691401.2018.1501379
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Zs.A 1164: Show issues

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Article ; Online: Assessing the viability of Soluplus® self-assembled nanocolloids for sustained delivery of highly hydrophobic lapatinib (anticancer agent): Optimisation and in-vitro characterisation.

Bonde, Gunjan Vasant / Ajmal, Gufran / Yadav, Sarita Kumari / Mittal, Pooja / Singh, Juhi / Bakde, Bharati V / Mishra, Brahmeshwar

Colloids and surfaces. B, Biointerfaces

2019 Volume 185, Page(s) 110611

Abstract: Nanocolloids are considered ideal carriers for hydrophobic drugs owing to their core-shell structure. Lapatinib is a potential anti-cancer agent, but its clinical use is limited because of its poor aqueous solubility, thus requiring larger oral doses ... ...

Abstract	Nanocolloids are considered ideal carriers for hydrophobic drugs owing to their core-shell structure. Lapatinib is a potential anti-cancer agent, but its clinical use is limited because of its poor aqueous solubility, thus requiring larger oral doses with the associated toxicity. Thus, in the present study, we fabricated self-assembled nanocolloidal polymeric micelles (LP-PMs) of Soluplus® and Pluronic® F127 by the thin-film hydration method and assessed their delivery potential of the hydrophobic anti-cancer drug lapatinib (LP) and optimised these nanocolloidal polymeric micelles using Quality-by-Design approach. Amorphisation of the drug and no typical incompatibility other than hydrogen bonding in the LP-PMs was confirmed by solid-state characterisation. The LP-PMs exhibited a uniform size of 92.9 ± 4.07 nm, with a 5.06 mV zeta potential and approximately 87% drug encapsulation. The critical micellar concentration (CMC) of Soluplus® decreased from 6.63 × 10
MeSH term(s)	Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Colloids/chemistry ; Delayed-Action Preparations/pharmacology ; Drug Delivery Systems ; Drug Liberation ; Humans ; Hydrophobic and Hydrophilic Interactions ; Lapatinib/pharmacology ; Micelles ; Nanoparticles/chemistry ; Particle Size ; Platelet Aggregation/drug effects ; Polyethylene Glycols/pharmacology ; Polymers/chemistry ; Polyvinyls/pharmacology ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	Antineoplastic Agents ; Colloids ; Delayed-Action Preparations ; Micelles ; Polymers ; Polyvinyls ; polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer ; Lapatinib (0VUA21238F) ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2019-10-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2019.110611
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Article ; Online: Biomimetic PCL-gelatin based nanofibers loaded with ciprofloxacin hydrochloride and quercetin: A potential antibacterial and anti-oxidant dressing material for accelerated healing of a full thickness wound.

Ajmal, Gufran / Bonde, Gunjan Vasant / Mittal, Pooja / Khan, Gayasuddin / Pandey, Vivek Kumar / Bakade, Bharati V / Mishra, Brahmeshwar

International journal of pharmaceutics

2019 Volume 567, Page(s) 118480

Abstract: An open wound is highly susceptible to microbial infection leading to elevated level of inflammatory response. For prompt healing, a wound requires a biomimetic dressing material with ideal hydrophilicity and tensile strength, possessing antimicrobial ... ...

Abstract	An open wound is highly susceptible to microbial infection leading to elevated level of inflammatory response. For prompt healing, a wound requires a biomimetic dressing material with ideal hydrophilicity and tensile strength, possessing antimicrobial and antioxidant property. Although PCL-based nanofibers have sufficient tensile strength and biocompatibility, it lacks in terms of optimum hydrophilicity and biodegradation. Therefore, we fabricated a PCL-gelatin based electrospun nanofibers, enriched with quercetin and ciprofloxacin hydrochloride (CH). The average diameter of developed nanofibers was 725.943 ± 201.965 nm, and devoid of chemical interaction between two drugs and polymers. CH and quercetin exhibited biphasic in-vitro release in phosphate buffer (pH 7.4). The in-vitro antibacterial and antioxidant property of scaffolds were evaluated by film-diffusion against Staphylococcus aureus and DPPH assay, respectively. The addition of gelatin along with CH and quercetin enhanced the hydrophilicity (contact angle = 48.8 ± 2.95°) and biodegradation rate of the nanofibers. In-vitro biocompatibility of scaffold was examined by hemocompatibility and fibroblast viability using MTT assay. The results confirm the direct application of scaffold in the wounded area. Further, complete closure of full-thickness wound within 16 days, and regulation of hydroxyproline, SOD and catalase level in granulation tissues following treatment with scaffold, confirmed its application for accelerated wound healing.
MeSH term(s)	Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/chemistry ; Antioxidants/administration & dosage ; Antioxidants/chemistry ; Bandages ; Biomimetics ; Cell Line ; Cell Survival/drug effects ; Ciprofloxacin/administration & dosage ; Ciprofloxacin/chemistry ; Drug Liberation ; Female ; Gelatin/administration & dosage ; Male ; Mice ; Nanofibers/administration & dosage ; Polyesters/administration & dosage ; Quercetin/administration & dosage ; Quercetin/chemistry ; Rats, Wistar ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/growth & development ; Wound Healing/drug effects
Chemical Substances	Anti-Bacterial Agents ; Antioxidants ; Polyesters ; polycaprolactone (24980-41-4) ; Ciprofloxacin (5E8K9I0O4U) ; Gelatin (9000-70-8) ; Quercetin (9IKM0I5T1E)
Language	English
Publishing date	2019-06-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2019.118480
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Zs.A 1409: Show issues

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Article ; Online: Ciprofloxacin HCl and quercetin functionalized electrospun nanofiber membrane: fabrication and its evaluation in full thickness wound healing.

Ajmal, Gufran / Bonde, Gunjan Vasant / Thokala, Sathish / Mittal, Pooja / Khan, Gayasuddin / Singh, Juhi / Pandey, Vivek Kumar / Mishra, Brahmeshwar

Artificial cells, nanomedicine, and biotechnology

2019 Volume 47, Issue 1, Page(s) 228–240

Abstract: Microbial infection and oxidative damage of the fibroblast often results in prolonged and incomplete wound healing. Therefore, there is an increasing demand for a scaffold being effective to prevent any possible infection and neutralize excessively ... ...

Abstract	Microbial infection and oxidative damage of the fibroblast often results in prolonged and incomplete wound healing. Therefore, there is an increasing demand for a scaffold being effective to prevent any possible infection and neutralize excessively released free radicals. Herein, we designed a PCL-based nanofiber loaded with ciprofloxacin hydrochloride (CHL) and quercetin. Developed nanofiber showed the formation of smooth and continuous nanofiber with 101.59 ± 29.18 nm average diameter and entrapping the drugs in amorphous form without any possible physico-chemical interaction between drugs and excipient. High entrapment efficiency (CHL: 92.04% and Que: 94.32%) and prolonged in-vitro release (for 7 days) demonstrated the capability of scaffold to suppress any probable infection and oxidative damage, which was further confirmed by in-vitro antibacterial and antioxidant activity. The biocompatibility of scaffold for direct application to wound site was evaluated through hemocompatibility and cytocompatibility assay. The wound healing efficacies of nanofiber were assessed using full thickness wound model in rats, which displayed accelerated wound healing with complete re-epithelialization and improved collagen deposition within 16 days. In-vivo wound healing finding was further corroborated by SOD, catalase, and hydroxyproline assay. The current study validates the application of ciprofloxacin HCl and quercetin functionalized nanofiber as a potential wound dressing material.
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Ciprofloxacin/chemistry ; Ciprofloxacin/pharmacology ; Collagen/biosynthesis ; Drug Liberation ; Electricity ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Hydroxyproline/metabolism ; Materials Testing ; Membranes, Artificial ; Nanofibers/chemistry ; Oxidative Stress/drug effects ; Quercetin/chemistry ; Quercetin/pharmacology ; Wound Healing/drug effects
Chemical Substances	Anti-Bacterial Agents ; Antioxidants ; Membranes, Artificial ; Ciprofloxacin (5E8K9I0O4U) ; Collagen (9007-34-5) ; Quercetin (9IKM0I5T1E) ; Hydroxyproline (RMB44WO89X)
Language	English
Publishing date	2019-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2723095-8
ISSN	2169-141X ; 2169-1401
ISSN (online)	2169-141X
ISSN	2169-1401
DOI	10.1080/21691401.2018.1548475
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