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Article ; Online: A Case Report of Diabetes in a Patient with Glycogen Storage Disease Type 1a.

Kanemaru, Yoshinori / Harada, Norio / Wada, Naoki / Yasuda, Takuma / Okamura, Emi / Fujii, Toshihito / Ogura, Masahito / Inagaki, Nobuya

Internal medicine (Tokyo, Japan)

2024

Abstract: Glycogen storage disease type 1a (GSD-1a) is a rare congenital disease. Recently, life expectancy with GSD-1a has been improved by its early diagnosis and management. Complications of diabetes with GSD-1a are extremely rare. The optimal treatment for ... ...

Abstract	Glycogen storage disease type 1a (GSD-1a) is a rare congenital disease. Recently, life expectancy with GSD-1a has been improved by its early diagnosis and management. Complications of diabetes with GSD-1a are extremely rare. The optimal treatment for glucose control using this disease combination remains unclear. The existence of GSD-1a and diabetes can cause both hypoglycemia and hyperglycemia, making glucose control especially problematic. In the present report, α-glucosidase inhibitor (α-GI) and dipeptidyl peptidase-4 (DPP-4) inhibitors improved hyperglycemia without symptoms of hypoglycemia in a patient with diabetes and GSD-1a using intermittent continuous glucose monitoring (isCGM).
Language	English
Publishing date	2024-01-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2766-23
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Article ; Online: A Rapid Screening Assay for Clarithromycin-Resistant Mycobacterium avium Complex Using Melting Curve Analysis with Nonfluorescent Labeled Probes.

Aoki, Akira / Jinno, Hideto / Ogawa, Kenji / Nakagawa, Taku / Inagaki, Takayuki / Wajima, Takeaki / Okamoto, Yoshinori / Uchiya, Kei-Ichi

Microbiology spectrum

2023 Volume 11, Issue 1, Page(s) e0432622

Abstract: Mycobacterium avium complex (MAC) thrives in various environments and mainly causes lung disease in humans. Because macrolide antibiotics such as clarithromycin or azithromycin are key drugs for MAC lung disease, the emergence of macrolide-resistant ... ...

Abstract	Mycobacterium avium complex (MAC) thrives in various environments and mainly causes lung disease in humans. Because macrolide antibiotics such as clarithromycin or azithromycin are key drugs for MAC lung disease, the emergence of macrolide-resistant strains prevents the treatment of MAC. More than 95% of macrolide-resistant MAC strains are reported to have a point mutation in 23S rRNA domain V. This study successfully developed a melting curve assay using nonfluorescent labeled probes to detect the MAC mutation at positions 2058 to 2059 of the 23S rRNA gene (AA genotype, clarithromycin susceptible; TA, GA, AG, CA, AC, and AT genotypes, clarithromycin resistant). In the AA-specific probe assay, the melting peak of the DNA fragment of the AA genotype was higher than that of DNA fragments of other genotypes. Melting temperature (
MeSH term(s)	Humans ; Clarithromycin/pharmacology ; Clarithromycin/therapeutic use ; Mycobacterium avium Complex/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Azithromycin/therapeutic use ; Macrolides/therapeutic use ; Microbial Sensitivity Tests ; Drug Therapy, Combination ; Mycobacterium avium-intracellulare Infection/diagnosis ; Mycobacterium avium-intracellulare Infection/drug therapy ; Mycobacterium avium-intracellulare Infection/microbiology ; Drug Resistance, Bacterial/genetics ; Leprostatic Agents/therapeutic use ; Mycobacterium tuberculosis ; Lung Diseases/drug therapy
Chemical Substances	Clarithromycin (H1250JIK0A) ; Anti-Bacterial Agents ; Azithromycin (83905-01-5) ; Macrolides ; Leprostatic Agents
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.04326-22
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Article ; Online: Knockdown of TFAP2E results in rapid G

Sakai, Ryo / Fujiwara, Kyoko / Nagasaki-Maeoka, Eri / Inagaki, Yoshinori / Yamaoka, Bin / Muto-Fujita, Eri / Kamidaki, Yusuke / Koshinaga, Tsugumichi / Uehara, Shuichiro / Takayama, Tadateru / Sato, Shuichi

Oncology letters

2024 Volume 27, Issue 3, Page(s) 128

Abstract: TFAP2E is a member of the activator protein-2 transcription factor family and acts as a tumor suppressor in several types of cancer. Downregulation of TFAP2E expression is significantly associated with a shorter overall survival period in patients with ... ...

Abstract	TFAP2E is a member of the activator protein-2 transcription factor family and acts as a tumor suppressor in several types of cancer. Downregulation of TFAP2E expression is significantly associated with a shorter overall survival period in patients with oral squamous cell carcinoma (OSCC). To evaluate the molecular mechanisms by which TFAP2E suppresses the development or progression of OSCC, the present study investigated the effects of TFAP2E downregulation on OSCC-derived Ca9-22 and HSC-4 cells. The present study demonstrated that small interfering RNA mediated-knockdown of TFAP2E accelerated the proliferation of these OSCC cell lines compared with that in the control group, as determined by the standard water-soluble tetrazolium salt-8 assay. To analyze the cell cycle progression rate, the cell cycle distribution patterns of TFAP2E-knockdown and control cells cultured in the presence of nocodazole, which prevents the completion of mitosis, were analyzed by fluorescence-activated cell sorting at different time points. When analyzing cellular DNA contents, no major differences in cell cycle profiles were observed; however, the rate of increase in cells positive for histone H3 Serine 28 phosphorylation, a standard molecular marker of early M phase, was significantly higher in TFAP2E-knockdown cells than in the control cells. Collectively, these results suggested that TFAP2E may attenuate the proliferation of OSCC cells by regulating G
Language	English
Publishing date	2024-01-29
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2024.14260
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Article ; Online: The Difficulty in Administering Appropriate Antimicrobial Therapy for Stenotrophomonas maltophilia Bacteremia.

Yanai, Mitsuru / Inagaki, Yoshinori / Tokunaga, Tomohiko

Internal medicine (Tokyo, Japan)

2017 Volume 56, Issue 20, Page(s) 2815

Language	English
Publishing date	2017-10-15
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.9016-17
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Article ; Online: Germline MICA Polymorphism Is Associated with the Long-Term Outcomes in Patients Undergoing Hepatectomy for Colorectal Liver Metastases.

Kobayashi, Yuta / Shindoh, Junichi / Nishioka, Yujiro / Inagaki, Yoshinori / Mitsui, Jun / Arita, Junichi / Hasegawa, Kiyoshi

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2020 Volume 24, Issue 9, Page(s) 2137–2139

Language	English
Publishing date	2020-06-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1007/s11605-020-04659-7
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Zs.A 5207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Expression dynamics of HAND1/2 in in vitro human cardiomyocyte differentiation.

Okubo, Chikako / Narita, Megumi / Inagaki, Azusa / Nishikawa, Misato / Hotta, Akitsu / Yamanaka, Shinya / Yoshida, Yoshinori

Stem cell reports

2021 Volume 16, Issue 8, Page(s) 1906–1922

Abstract: Hand1 and Hand2 are transcriptional factors, and knockout mice of these genes show left and right ventricular hypoplasia, respectively. However, their function and expression in human cardiogenesis are not well studied. To delineate their expressions and ...

Abstract	Hand1 and Hand2 are transcriptional factors, and knockout mice of these genes show left and right ventricular hypoplasia, respectively. However, their function and expression in human cardiogenesis are not well studied. To delineate their expressions and assess their functions in human cardiomyocytes (CMs) in vitro, we established two triple-reporter human induced pluripotent stem cell lines that express HAND1
MeSH term(s)	Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Cycle/genetics ; Cell Differentiation/genetics ; Cell Proliferation/genetics ; Cells, Cultured ; Gene Regulatory Networks/genetics ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/metabolism ; RNA Interference ; RNA-Seq/methods ; Time Factors ; Transcriptome/genetics
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; HAND2 protein, human ; Luminescent Proteins ; helix-loop-helix protein, eHAND
Language	English
Publishing date	2021-07-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2720528-9
ISSN	2213-6711 ; 2213-6711
ISSN (online)	2213-6711
ISSN	2213-6711
DOI	10.1016/j.stemcr.2021.06.014
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Article: Evaluation of four computed tomography reconstruction algorithms using a coronary artery phantom.

Sawamura, Shungo / Kato, Shingo / Funama, Yoshinori / Oda, Seitaro / Mochizuki, Harumi / Inagaki, Sayuri / Takeuchi, Yuka / Morioka, Tsubasa / Izumi, Toshiharu / Ota, Yoichiro / Kawagoe, Hironori / Cheng, Shihyao / Nakayama, Naoki / Fukui, Kazuki / Tsutsumi, Takashi / Iwasawa, Tae / Utsunomiya, Daisuke

Quantitative imaging in medicine and surgery

2024 Volume 14, Issue 4, Page(s) 2870–2883

Abstract: Background: Despite advancements in coronary computed tomography angiography (CTA), challenges in positive predictive value and specificity remain due to limited spatial resolution. The purpose of this experimental study was to investigate the effect of ...

Abstract	Background: Despite advancements in coronary computed tomography angiography (CTA), challenges in positive predictive value and specificity remain due to limited spatial resolution. The purpose of this experimental study was to investigate the effect of 2nd generation deep learning-based reconstruction (DLR) on the quantitative and qualitative image quality in coronary CTA. Methods: A vessel model with stepwise non-calcified plaque was scanned using 320-detector CT. Image reconstruction was performed using four techniques: hybrid iterative reconstruction (HIR), model-based iterative reconstruction (MBIR), DLR, and 2nd generation DLR. The luminal peak CT number, contrast-to-noise ratio (CNR), and edge rise slope (ERS) were quantitatively evaluated via profile curve analysis. Two observers qualitatively graded the graininess, lumen sharpness, and overall lumen visibility on the basis of the degree of confidence for the stenosis severity using a five-point scale. Results: The image noise with HIR, MBIR, DLR, and 2nd generation DLR was 23.0, 21.0, 16.9, and 9.5 HU, respectively. The corresponding CNR (25% stenosis) was 15.5, 15.9, 22.1, and 38.3, respectively. The corresponding ERS (25% stenosis) was 203.2, 198.6, 228.9, and 262.4 HU/mm, respectively. Among the four reconstruction methods, the 2nd generation DLR achieved the significantly highest CNR and ERS values. The score of 2nd generation DLR in all evaluation points (graininess, sharpness, and overall lumen visibility) was higher than those of the other methods (overall vessel visibility score, 2.6±0.5, 3.8±0.6, 3.7±0.5, and 4.6±0.5 with HIR, MBIR, DLR, and 2nd generation DLR, respectively). Conclusions: 2nd generation DLR provided better CNR and ERS in coronary CTA than HIR, MBIR, and previous-generation DLR, leading to the highest subjective image quality in the assessment of vessel stenosis.
Language	English
Publishing date	2024-03-27
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-23-1204
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Article ; Online: Assessment of liver function-related mRNA expression and fluorescence imaging in outflow-obstructed regions in rats.

Ito, Daisuke / Kawaguchi, Yoshikuni / Inagaki, Yoshinori / Ito, Kyoji / Mihara, Yuichiro / Kaneko, Junichi / Tanaka, Mariko / Fukayama, Masashi / Kokudo, Norihiro / Hasegawa, Kiyoshi

Surgery today

2022 Volume 53, Issue 4, Page(s) 513–521

Abstract: Purpose: The liver function in outflow-obstructed regions is reportedly impaired; however, the functional decrease has not been quantitatively assessed. We therefore evaluated the uptake of indocyanine green (ICG) into hepatocytes and the mRNA ... ...

Abstract	Purpose: The liver function in outflow-obstructed regions is reportedly impaired; however, the functional decrease has not been quantitatively assessed. We therefore evaluated the uptake of indocyanine green (ICG) into hepatocytes and the mRNA expression associated with the liver function in outflow-obstructed regions using rat models. Methods: A total of 20 rats with the ligation of the right median hepatic vein to induce outflow obstruction were studied. Five rats each were grouped by the time of re-laparotomy, and the fluorescence intensity (FI) values of ICG. The mRNA expression, including that of Albumin, Cytochrome P450 (Cyp) 1a2, Cyp3a1, Cyp7a1, and Gamma-glutamylcysteine synthetase, in outflow-obstructed (mRNA Results: Microscopic fluorescence imaging showed that the FI values were significantly lower in outflow-obstructed regions than in non-outflow-obstructed regions at 12 h, 24 h, and 3 days after ligation of the hepatic vein. The mRNA Conclusions: The liver function in outflow-obstructed regions was impaired in terms of the uptake of ICG and the mRNA expression. Our findings may help estimate the postoperative functional remnant liver volume by considering the decrease in the liver function in outflow-obstructed regions.
MeSH term(s)	Rats ; Animals ; Liver/blood supply ; Hepatic Veins/surgery ; Hepatocytes ; Indocyanine Green/metabolism ; Optical Imaging/methods ; RNA, Messenger/metabolism
Chemical Substances	Indocyanine Green (IX6J1063HV) ; RNA, Messenger
Language	English
Publishing date	2022-10-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1115435-4
ISSN	1436-2813 ; 0941-1291
ISSN (online)	1436-2813
ISSN	0941-1291
DOI	10.1007/s00595-022-02588-3
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Article: Innovative treatment for hepatocellular carcinoma (HCC).

Kaneko, Junichi / Kokudo, Takashi / Inagaki, Yoshinori / Hasegawa, Kiyoshi

Translational gastroenterology and hepatology

2018 Volume 3, Page(s) 78

Abstract: Indocyanine green (ICG) is not new in the field of liver surgery. Early studies performed in the 1980s and 1990s revealed the value of the ICG clearance test in predicting post-hepatectomy morbidity and mortality. ICG clearance and retention tests are ... ...

Abstract	Indocyanine green (ICG) is not new in the field of liver surgery. Early studies performed in the 1980s and 1990s revealed the value of the ICG clearance test in predicting post-hepatectomy morbidity and mortality. ICG clearance and retention tests are crucial for determining precise liver function before liver surgery and offer several benefits for safe surgery. Whereas ICG is well-known and has long history in medicine, recent progress in infrared light technology over the last decade has highlighted another feature of ICG. For example, ICG fluorescence-guided surgery may change the next generation of liver surgery. In the near future, ICG with near-infrared (NIR) light photodynamic therapy (PDT) is expected to become a new treatment method for hepatocellular carcinoma (HCC). Furthermore, several aspects of the mechanisms of ICG accumulation in HCC cells have been revealed by important basic research studies. New imaging technologies and mechanistic findings keep ICG in the spotlight. In this article, we review three recently described topics of ICG which may contribute to the development of innovative and new treatments method for HCC, fluorescence-guided surgery, mechanism of ICG accumulation in HCC cells, PDT for HCC.
Language	English
Publishing date	2018-10-22
Publishing country	China
Document type	Journal Article ; Review
ISSN	2415-1289
ISSN	2415-1289
DOI	10.21037/tgh.2018.10.04
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Article: Real-Time Fluorescence Imaging to Identify Cholangiocarcinoma in the Extrahepatic Biliary Tree Using an Enzyme-Activatable Probe.

Takahashi, Ryugen / Ishizawa, Takeaki / Inagaki, Yoshinori / Tanaka, Mariko / Ogasawara, Akira / Kuriki, Yugo / Fujita, Kyohhei / Kamiya, Mako / Ushiku, Tetsuo / Urano, Yasuteru / Hasegawa, Kiyoshi

Liver cancer

2023 Volume 12, Issue 6, Page(s) 590–602

Abstract: Introduction: Complete resection is the only possible treatment for cholangiocarcinoma in the extrahepatic biliary tree (eCCA), although current imaging modalities are limited in their ability to accurately diagnose longitudinal spread. We aimed to ... ...

Abstract	Introduction: Complete resection is the only possible treatment for cholangiocarcinoma in the extrahepatic biliary tree (eCCA), although current imaging modalities are limited in their ability to accurately diagnose longitudinal spread. We aimed to develop fluorescence imaging techniques for real-time identification of eCCA using an enzyme-activatable probe, which emits fluorescence immediately after activation by a cancer-specific enzyme. Methods: Using lysates and small tissue fragments collected from surgically resected specimens, we selected the most specific probe for eCCA from among 800 enzyme-activatable probes. The selected probe was directly sprayed onto resected specimens and fluorescence images were acquired; these images were evaluated for diagnostic accuracy. We also comprehensively searched for enzymes that could activate the probe, then compared their expression levels in cancer and non-cancer tissues. Results: Analyses of 19 samples (four cancer lysates, seven non-cancer lysates, and eight bile samples) and 54 tissue fragments (13 cancer tissues and 41 non-cancer tissues) revealed that PM-2MeSiR was the most specific fluorophore for eCCA. Fluorescence images of 7 patients were obtained; these images enabled rapid identification of cancerous regions, which closely matched histopathology findings in 4 patients. Puromycin-sensitive aminopeptidase was identified as the enzyme that might activate the probe, and its expression was upregulated in eCCA. Conclusion: Fluorescence imaging with PM-2MeSiR, which may be activated by puromycin-sensitive aminopeptidase, yielded generally high accuracy. This technique may be useful for real-time identification of the spread of eCCA during surgery and endoscopic examinations.
Language	English
Publishing date	2023-04-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2666925-0
ISSN	1664-5553 ; 2235-1795
ISSN (online)	1664-5553
ISSN	2235-1795
DOI	10.1159/000530645
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