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Article ; Online: Discovery of potential FGFR3 inhibitors via QSAR, pharmacophore modeling, virtual screening and molecular docking studies against bladder cancer.

Ganji, Mahmoud / Bakhshi, Shohreh / Shoari, Alireza / Ahangari Cohan, Reza

2023 Volume 21, Issue 1, Page(s) 111

Abstract: Background: Fibroblast growth factor receptor 3 is known as a favorable aim in vast range of cancers, particularly in bladder cancer treatment. Pharmacophore and QSAR modeling approaches are broadly utilized for developing novel compounds for the ... ...

Abstract	Background: Fibroblast growth factor receptor 3 is known as a favorable aim in vast range of cancers, particularly in bladder cancer treatment. Pharmacophore and QSAR modeling approaches are broadly utilized for developing novel compounds for the determination of inhibitory activity versus the biological target. In this study, these methods employed to identify FGFR3 potential inhibitors. Methods: To find the potential compounds for bladder cancer targeting, ZINC and NCI databases were screened. Pharmacophore and QSAR modeling of FGFR3 inhibitors were utilized for dataset screening. Then, with regard to several factors such as Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties and Lipinski's Rule of Five, the recognized compounds were filtered. In further step, utilizing the flexible docking technique, the obtained compounds interactions with FGFR3 were analyzed. Results: The best five compounds, namely ZINC09045651, ZINC08433190, ZINC00702764, ZINC00710252 and ZINC00668789 were selected for Molecular Dynamics (MD) studies. Off-targeting of screened compounds was also investigated through CDD search and molecular docking. MD outcomes confirmed docking investigations and revealed that five selected compounds could make steady interactions with the FGFR3 and might have effective inhibitory potencies on FGFR3. Conclusion: These compounds can be considered as candidates for bladder cancer therapy with improved therapeutic properties and less adverse effects.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Pharmacophore ; Receptor, Fibroblast Growth Factor, Type 3 ; Quantitative Structure-Activity Relationship ; Early Detection of Cancer ; Urinary Bladder Neoplasms/drug therapy
Chemical Substances	Receptor, Fibroblast Growth Factor, Type 3 (EC 2.7.10.1) ; FGFR3 protein, human (EC 2.7.10.1)
Language	English
Publishing date	2023-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-03955-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Synthesis and characterization of Gd

Shariati, Alireza / Ebrahimi, Tahereh / Babadinia, Parva / Shariati, Fatemeh Sadat / Ahangari Cohan, Reza

Scientific reports

2023 Volume 13, Issue 1, Page(s) 4520

Abstract: Magnetic resonance imaging and computed tomography (CT) suffer from low contrast sensitivity and potential toxicity of contrast agents. To overcome these limitations, we developed and tested a new class of dual contrast agents based on polydopamine ... ...

Abstract	Magnetic resonance imaging and computed tomography (CT) suffer from low contrast sensitivity and potential toxicity of contrast agents. To overcome these limitations, we developed and tested a new class of dual contrast agents based on polydopamine nanoparticles (PDA-NPs) that are functionalized and targeted with hyaluronic acid (HA). These nanoparticles (NPs) are chelated with Gd
MeSH term(s)	Humans ; Contrast Media ; Hyaluronic Acid/chemistry ; HEK293 Cells ; Hemolysis ; Magnetic Resonance Imaging/methods ; Nanoparticles/chemistry ; Tomography, X-Ray Computed
Chemical Substances	polydopamine ; gadoterate meglumine (L0ND3981AG) ; Contrast Media ; Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2023-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-31252-0
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Article ; Online: Development of a bivalent protein-based vaccine candidate against invasive pneumococcal diseases based on novel pneumococcal surface protein A in combination with pneumococcal histidine triad protein D.

Afshari, Elnaz / Ahangari Cohan, Reza / Shams Nosrati, Mohammad Sadegh / Mousavi, Seyed Fazlollah

Frontiers in immunology

2023 Volume 14, Page(s) 1187773

Abstract: Extensive efforts have been made toward improving effective strategies for pneumococcal vaccination, focusing on evaluating the potential of multivalent protein-based vaccines and overcoming the limitations of pneumococcal polysaccharide-based vaccines. ... ...

Abstract	Extensive efforts have been made toward improving effective strategies for pneumococcal vaccination, focusing on evaluating the potential of multivalent protein-based vaccines and overcoming the limitations of pneumococcal polysaccharide-based vaccines. In this study, we investigated the protective potential of mice co-immunization with the pneumococcal PhtD and novel rPspA proteins against pneumococcal sepsis infection. The formulations of each antigen alone or in combination were administered intraperitoneally with alum adjuvant into BALB/c mice three times at 14-day intervals. The production of antigen-specific IgG, IgG1 and IgG2a subclasses, and IL-4 and IFN-γ cytokines, were analyzed. Two
MeSH term(s)	Animals ; Mice ; Streptococcus pneumoniae ; Pneumococcal Infections/prevention & control ; Vaccines
Chemical Substances	pneumococcal surface protein A ; histidine triad protein ; Vaccines
Language	English
Publishing date	2023-08-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1187773
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Article ; Online: Critical Aggregation Concentration Can be a Predictor of Doxorubicin Delivery Performance of Self-Assembling Amphiphilic Peptides with Different Hydrophobic Tails.

Zanganeh, Saeed / Firoozpour, Loghman / Salavatipour, Maryam Samareh / Sardari, Soroush / Cohan, Reza Ahangari / Mohajel, Nasir

Journal of pharmaceutical sciences

2024

Abstract: Amphiphilic peptides hold great potential as drug delivery systems. A popular peptide design approach has been to place amino acids in the peptide sequence based on their known properties. On the other hand, the directed discovery approach aims to screen ...

Abstract	Amphiphilic peptides hold great potential as drug delivery systems. A popular peptide design approach has been to place amino acids in the peptide sequence based on their known properties. On the other hand, the directed discovery approach aims to screen a sequence space for a desired property. However, screening amphiphilic peptides for desirable drug delivery properties is not possible without a quantity that is predictive of these properties. We studied the predictive power of critical aggregation concentration (CAC) values on the drug delivery performance of a series of amphiphilic peptides with different hydrophobic tails and close CAC values. The CAC values were predicted by our previously developed model and doxorubicin was used as a model hydrophobic drug. All peptides showed close drug loading, entrapment efficiency, and release profile. They also formed similar spherical particles by assembling in reverse β-sheet arrangements regardless of drug presence. Moreover, the assembled particles were able to accumulate doxorubicin inside ordinary as well as drug-resistant breast cancer cells and enhance its toxicity up to 39 and 17 folds, respectively. It can be concluded that similar drug delivery properties displayed by the peptides can be attributed to their similar hydrophilic-lipophilic balance as reflected in their close CAC values.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	3151-3
ISSN	1520-6017 ; 0022-3549
ISSN (online)	1520-6017
ISSN	0022-3549
DOI	10.1016/j.xphs.2024.02.022
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Article ; Online: In-silico design and evaluation of an epitope-based serotype-independent promising vaccine candidate for highly cross-reactive regions of pneumococcal surface protein A.

Afshari, Elnaz / Cohan, Reza Ahangari / Sotoodehnejadnematalahi, Fattah / Mousavi, Seyed Fazlollah

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 13

Abstract: Background: The pathogenicity of pneumococcus with high morbidity, mortality, and multi-drug resistance patterns has been increasing. The limited coverage of the licensed polysaccharide-based vaccines and the replacement of the non-vaccine serotypes are ...

Abstract	Background: The pathogenicity of pneumococcus with high morbidity, mortality, and multi-drug resistance patterns has been increasing. The limited coverage of the licensed polysaccharide-based vaccines and the replacement of the non-vaccine serotypes are the main reasons for producing a successful serotype-independent vaccine. Pneumococcal surface protein A (PspA) is an extremely important virulence factor and an interesting candidate for conserved protein-based pneumococcal vaccine classified into two prominent families containing five clades. PspA family-elicited immunity is clade-dependent, and the level of the PspA cross-reactivity is restricted to the same family. Methods: To cover and overcome the clade-dependent immunity of the PspAs in this study, we designed and tested a PspA Results: For the first time, this work suggested a novel PspA-based vaccine candidate using immunoinformatics tools. The designed PspA Conclusion: Our findings elucidated the potential application of the PspA
MeSH term(s)	Humans ; Animals ; Mice ; Serogroup ; Pneumococcal Infections/prevention & control ; Epitopes ; Lactoferrin ; Molecular Docking Simulation ; Bacterial Proteins ; Streptococcus pneumoniae ; Pneumococcal Vaccines ; Antibodies ; Antibodies, Bacterial ; Mice, Inbred BALB C
Chemical Substances	pneumococcal surface protein A ; Epitopes ; Lactoferrin (EC 3.4.21.-) ; Bacterial Proteins ; Pneumococcal Vaccines ; Antibodies ; Antibodies, Bacterial
Language	English
Publishing date	2023-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-022-03864-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Indirect optimization of staphylokinase expression level in dicistronic auto-inducible system.

Shariati, Fatemeh Sadat / Keramati, Malihe / Cohan, Reza Ahangari

AMB Express

2022 Volume 12, Issue 1, Page(s) 124

Abstract: Design of experiment (DOE) is a statistical approach for designing, performing, and interpreting a large set of data with the minimum number of tests. In our previous study, we developed a novel Hsp27 SILEX system for production of recombinant proteins. ... ...

Abstract	Design of experiment (DOE) is a statistical approach for designing, performing, and interpreting a large set of data with the minimum number of tests. In our previous study, we developed a novel Hsp27 SILEX system for production of recombinant proteins. In the present study, we optimized indirectly the most effective factors including inoculation load, self-induction temperature, and culture media on autoinduction of staphylokinase (SAK) expression using RSM methodology and fluorometry. The expression level of SAK was assayed at different runs after 6 h incubation at 90 rpm. The results indicated all parameters significantly affect the SAK expression level (p < 0.05). The optimum expression condition was obtained with an inoculation load of 0.05, a temperature of 25 °C, and TB culture medium. The analysis of variance with a R
Language	English
Publishing date	2022-09-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2621432-5
ISSN	2191-0855
ISSN	2191-0855
DOI	10.1186/s13568-022-01464-0
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Article ; Online: Discovery of potential FGFR3 inhibitors via QSAR, pharmacophore modeling, virtual screening and molecular docking studies against bladder cancer

Mahmoud Ganji / Shohreh Bakhshi / Alireza Shoari / Reza Ahangari Cohan

Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-

2023 Volume 22

Abstract: Abstract Background Fibroblast growth factor receptor 3 is known as a favorable aim in vast range of cancers, particularly in bladder cancer treatment. Pharmacophore and QSAR modeling approaches are broadly utilized for developing novel compounds for the ...

Abstract	Abstract Background Fibroblast growth factor receptor 3 is known as a favorable aim in vast range of cancers, particularly in bladder cancer treatment. Pharmacophore and QSAR modeling approaches are broadly utilized for developing novel compounds for the determination of inhibitory activity versus the biological target. In this study, these methods employed to identify FGFR3 potential inhibitors. Methods To find the potential compounds for bladder cancer targeting, ZINC and NCI databases were screened. Pharmacophore and QSAR modeling of FGFR3 inhibitors were utilized for dataset screening. Then, with regard to several factors such as Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties and Lipinski’s Rule of Five, the recognized compounds were filtered. In further step, utilizing the flexible docking technique, the obtained compounds interactions with FGFR3 were analyzed. Results The best five compounds, namely ZINC09045651, ZINC08433190, ZINC00702764, ZINC00710252 and ZINC00668789 were selected for Molecular Dynamics (MD) studies. Off-targeting of screened compounds was also investigated through CDD search and molecular docking. MD outcomes confirmed docking investigations and revealed that five selected compounds could make steady interactions with the FGFR3 and might have effective inhibitory potencies on FGFR3. Conclusion These compounds can be considered as candidates for bladder cancer therapy with improved therapeutic properties and less adverse effects.
Keywords	Bladder cancer ; Drug discovery ; Pharmacophore ; QSAR ; Docking ; Molecular dynamics ; Medicine ; R
Subject code	540
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Anti-angiogenic peptides application in cancer therapy; a review.

Shoari, Alireza / Khodabakhsh, Farnaz / Ahangari Cohan, Reza / Salimian, Morteza / Karami, Elmira

Research in pharmaceutical sciences

2021 Volume 16, Issue 6, Page(s) 559–574

Abstract: Cancer is a disease ... ...

Abstract	Cancer is a disease advanced
Language	English
Publishing date	2021-10-15
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2400156-9
ISSN	1735-9414 ; 1735-5362
ISSN (online)	1735-9414
ISSN	1735-5362
DOI	10.4103/1735-5362.327503
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Article ; Online: Development of Streptococcus equisimilis Group G Mutant Strains with Ability to Produce Low Polydisperse and Low-Molecular-Weight Hyaluronic Acid

Jafari, Bahareh / Keramati, Malihe / Ahangari Cohan, Reza / Atyabi, Seyed Mohammad / Ali Hosseinzadeh, Sara

Iranian biomedical journal

2022 Volume 26, Issue 6, Page(s) 454–462

Abstract: Background: Background: Hyaluronic acid (HA), a natural polymer with wide applications in biomedicine and cosmetics, is mainly produced by Streptococcal fermentation at industrial scale. In the present study, chemical random mutagenesis was used for ... ...

Abstract	Background: Background: Hyaluronic acid (HA), a natural polymer with wide applications in biomedicine and cosmetics, is mainly produced by Streptococcal fermentation at industrial scale. In the present study, chemical random mutagenesis was used for development of Streptococcus equisimilis group G mutant strains with high HA productivity. Methods: Methods: The optimum of the pH of culture condition and cultivation time for HA production by wild strain group G were assessed. At first, two rounds of mutation at different concentrations of NTG was used for mutagenesis. Then, the nonhemolytic and hyaluronidase-negative mutants were screened on the blood and HA agar. HA productivity and molecular weight were determined by carbazole assay, agarose gel electrophoresis and specific staining. Moreover, stability of the high producer mutants was evaluated within 10 generations. Results: Results: The results showed that the wild-type strain produced 1241 ± 2.1 µg/ml of HA at pH 5.5 and 4 hours of cultivation, while the screened mutants showed a 16.1-45.5% increase in HA production. Two mutant strains, named Gm2-120-21-3 (2470 ± 8.1 µg/ml) and Gm2-120-21-4 (2856 ± 4.2 µg/ml), indicated the highest titer and a consistent production. The molecular weight (Mw) of HA for the mutants was less than 160 kDa, considering as a low Mw HA. Conclusion: Conclusion: The mutant strains producing a low polydisperse, as well as low Mw of HA with high titer might be regarded as potential industrial strains for HA production after further safety investigations.
MeSH term(s)	Hyaluronic Acid/chemistry ; Molecular Weight ; Agar ; Streptococcus
Chemical Substances	Hyaluronic Acid (9004-61-9) ; Agar (9002-18-0)
Language	English
Publishing date	2022-11-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2489282-8
ISSN	2008-823X ; 1028-852X
ISSN (online)	2008-823X
ISSN	1028-852X
DOI	10.52547/ibj.3789
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Article: A novel nanobody-based immunocytokine of a mutant interleukin-2 as a potential cancer therapeutic.

Beig Parikhani, Arezoo / Dehghan, Rada / Talebkhan, Yeganeh / Bayat, Elham / Biglari, Alireza / Shokrgozar, Mohammad Ali / Ahangari Cohan, Reza / Mirabzadeh, Esmat / Ajdary, Soheila / Behdani, Mahdi

AMB Express

2024 Volume 14, Issue 1, Page(s) 19

Abstract: The immunotherapeutic application of interleukin-2 (IL-2) in cancer treatment is limited by its off-target effects on different cell populations and insufficient activation of anti-tumor effector cells at the site of the tumor upon tolerated doses. ... ...

Abstract	The immunotherapeutic application of interleukin-2 (IL-2) in cancer treatment is limited by its off-target effects on different cell populations and insufficient activation of anti-tumor effector cells at the site of the tumor upon tolerated doses. Targeting IL-2 to the tumor microenvironment by generating antibody-cytokine fusion proteins (immunocytokine) would be a promising approach to increase efficacy without associated toxicity. In this study, a novel nanobody-based immunocytokine is developed by the fusion of a mutant (m) IL-2 with a decreased affinity toward CD25 to an anti-vascular endothelial growth factor receptor-2 (VEGFR2) specific nanobody, denoted as VGRmIL2-IC. The antigen binding, cell proliferation, IFN-γ-secretion, and cytotoxicity of this new immunocytokine are evaluated and compared to mIL-2 alone. Furthermore, the pharmacokinetic properties are analyzed. Flow cytometry analysis shows that the VGRmIL2-IC molecule can selectively target VEGFR2-positive cells. The results reveal that the immunocytokine is comparable to mIL-2 alone in the stimulation of Primary Peripheral Blood Mononuclear Cells (PBMCs) and cytotoxicity in in vitro conditions. In vivo studies demonstrate improved pharmacokinetic properties of VGRmIL2-IC in comparison to the wild or mutant IL-2 proteins. The results presented here suggest VGRmIL2-IC could be considered a candidate for the treatment of VEGFR2-positive tumors.
Language	English
Publishing date	2024-02-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2621432-5
ISSN	2191-0855
ISSN	2191-0855
DOI	10.1186/s13568-023-01648-2
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