Article: Design and Structure-Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin.
ACS medicinal chemistry letters
2021 Volume 12, Issue 3, Page(s) 365–372
Abstract: Furin plays an important role in various pathological states, especially in bacterial and viral infections. A detailed understanding of the structural requirements for inhibitors targeting this enzyme is crucial to develop new therapeutic strategies in ... ...
| Abstract | Furin plays an important role in various pathological states, especially in bacterial and viral infections. A detailed understanding of the structural requirements for inhibitors targeting this enzyme is crucial to develop new therapeutic strategies in infectious diseases, including an urgent unmet need for SARS-CoV-2 infection. Previously, we have identified a potent furin inhibitor, peptide Ac-RARRRKKRT- |
|---|---|
| Language | English |
| Publishing date | 2021-02-05 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 1948-5875 |
| ISSN | 1948-5875 |
| DOI | 10.1021/acsmedchemlett.0c00386 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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