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Article ; Online: Methodological caveats regarding "Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant".

Mulugeta, Surafel / Weaver, Timothy E / Beers, Michael F

2022 Volume 59, Issue 3

MeSH term(s)	Humans ; Mutation ; Protein C ; Surface-Active Agents
Chemical Substances	Protein C ; Surface-Active Agents
Language	English
Publishing date	2022-03-31
Publishing country	England
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.02974-2021
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Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 292: Show issues

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Article ; Online: E-cigarettes and Youth: The Known, the Unknown, and Implications for Stakeholders.

Yammine, Luba / Tovar, Maria / Yammine, Nastassia Anna / Becker, Cabrina / Weaver, Michael F

Journal of addiction medicine

2024

Abstract: Abstract: Despite the decline in the prevalence of e-cigarette use among youth during the coronavirus disease 2019 pandemic, more than 2.5 million of US high and middle schoolers are still using e-cigarettes. Furthermore, those who use e-cigarettes are ... ...

Abstract	Abstract: Despite the decline in the prevalence of e-cigarette use among youth during the coronavirus disease 2019 pandemic, more than 2.5 million of US high and middle schoolers are still using e-cigarettes. Furthermore, those who use e-cigarettes are starting at a younger age and are using them more intensely, reflecting, at least in part, a high addiction liability of modern e-cigarettes. Beyond addiction, accumulating evidence suggests that, in the short-term, e-cigarettes are associated with cardiovascular and pulmonary effects, whereas the long-term effects of e-cigarette use are yet to be established. The aim of this review is to synthesize current knowledge on e-cigarette use among youth, including established and potential risks and efforts to date to curb youth exposure to e-cigarettes. In addition, we provide recommendations for health care providers, researchers, and other stakeholders to address this significant public health issue.
Language	English
Publishing date	2024-03-18
Publishing country	Netherlands
Document type	Journal Article
ISSN	1935-3227
ISSN (online)	1935-3227
DOI	10.1097/ADM.0000000000001304
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Article ; Online: Feasibility of Exenatide, a GLP-1R Agonist, for Treating Cocaine Use Disorder: A Case Series Study.

Yammine, Luba / Balderas, Jessica C / Weaver, Michael F / Schmitz, Joy M

Journal of addiction medicine

2023 Volume 17, Issue 4, Page(s) 481–484

Abstract: Cocaine use remains a serious public health problem associated with a marked increase in overdose deaths in the past decade. No medications have yet been proven to be effective for the treatment of cocaine use disorder (CUD). Among the highly promising ... ...

Abstract	Cocaine use remains a serious public health problem associated with a marked increase in overdose deaths in the past decade. No medications have yet been proven to be effective for the treatment of cocaine use disorder (CUD). Among the highly promising medications have been glucagon-like peptide 1 receptor agonists (GLP-1RA) that are currently used for the treatment of type 2 diabetes mellitus and weight management. Preclinically, GLP-1RAs have been shown to attenuate cocaine self-administration, however, this has not yet been demonstrated in a human laboratory study. The GLP-1RA extended-release exenatide is given as a once-weekly injection, which may be clinically advantageous for addressing medication nonadherence among individuals with CUD. Here, we assess feasibility and safety by reporting on 3 cases of patients with CUD who received 6 weeks of exenatide 2 mg subcutaneously once-weekly in an open-label fashion, along with standard individual drug counseling. We observed excellent attendance and compliance, along with positive end-of-study satisfaction ratings. The medication was well tolerated and without unexpected or severe adverse events. Results for cocaine use and related clinical effects were more mixed, yet encouraging. Future empirical testing of exenatide for treating CUD should utilize a randomized controlled trial design and longer treatment duration.
MeSH term(s)	Humans ; Exenatide/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/chemically induced ; Hypoglycemic Agents/adverse effects ; Feasibility Studies ; Peptides/adverse effects ; Venoms/adverse effects ; Glycated Hemoglobin ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/therapeutic use
Chemical Substances	Exenatide (9P1872D4OL) ; Hypoglycemic Agents ; Peptides ; Venoms ; Glycated Hemoglobin ; Glucagon-Like Peptide-1 Receptor
Language	English
Publishing date	2023-02-17
Publishing country	Netherlands
Document type	Journal Article
ISSN	1935-3227
ISSN (online)	1935-3227
DOI	10.1097/ADM.0000000000001147
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Article ; Online: Use of Direct Oral Anticoagulants Among Patients With Hip Fracture Is Not an Indication to Delay Surgical Intervention.

Brameier, Devon T / Tischler, Eric H / Ottesen, Taylor D / McTague, Michael F / Appleton, Paul T / Harris, Mitchel B / Weaver, Michael J / Suneja, Nishant

Journal of orthopaedic trauma

2024 Volume 38, Issue 3, Page(s) 148–154

MeSH term(s)	Humans ; Female ; Aged ; Aged, 80 and over ; Retrospective Studies ; Hip Fractures/complications ; Hip Fractures/surgery ; Reoperation ; Drainage ; Anticoagulants/therapeutic use
Chemical Substances	Anticoagulants
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	639099-7
ISSN	1531-2291 ; 0890-5339
ISSN (online)	1531-2291
ISSN	0890-5339
DOI	10.1097/BOT.0000000000002753
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Zs.A 2234: Show issues

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Article ; Online: Racial and Ethnic Minority Patients Have Increased Complication Risks When Undergoing Surgery While Not Meeting Clinical Guidelines.

Liimakka, Adriana P / Amen, Troy B / Weaver, Michael J / Shah, Vivek M / Lange, Jeffrey K / Chen, Antonia F

The Journal of bone and joint surgery. American volume

2024

Abstract: Background: Clinical guidelines for performing total joint arthroplasty (TJA) have not been uniformly adopted in practice because research has suggested that they may foster inequities in surgical access, potentially disadvantaging minority ... ...

Abstract	Background: Clinical guidelines for performing total joint arthroplasty (TJA) have not been uniformly adopted in practice because research has suggested that they may foster inequities in surgical access, potentially disadvantaging minority sociodemographic groups. The aim of this study was to assess whether undergoing TJA without meeting clinical guidelines affects complication risk and leads to disparities in postoperative outcomes. Methods: This retrospective cohort study evaluated the records of 11,611 adult patients who underwent primary TJA from January 1, 2010, to December 31, 2020, at an academic hospital network. Based on self-reported race and ethnicity, 89.5% of patients were White, 3.5% were Black, 2.9% were Hispanic, 1.3% were Asian, and 2.8% were classified as other. Patients met institutional guidelines for undergoing TJA if they had a hemoglobin A1c of <8.0% and a body mass index of <40 kg/m2 and were not currently smoking. A logistic regression model was utilized to identify factors associated with complications, and a mixed-effects model was utilized to identify factors associated with not meeting guidelines for undergoing TJA. Results: During the study period, 11% (1,274) of the 11,611 adults who underwent primary TJA did not meet clinical guidelines. Compared with the group who met guidelines, the group who did not had higher proportions of Black patients (3.2% versus 6.0%; p < 0.001) and Hispanic patients (2.7% versus 4.6%; p < 0.001). An increased risk of not meeting guidelines at the time of surgery was demonstrated among Black patients (odds ratio [OR], 1.60 [95% confidence interval (CI), 1.22 to 2.10]; p = 0.001) and patients insured by Medicaid (OR, 1.75 [95% CI, 1.26 to 2.44]; p = 0.001) or Medicare (OR, 1.22 [95% CI, 1.06 to 1.41]; p = 0.007). Patients who did not meet guidelines had a higher risk of reoperation than those who met guidelines (7.7% [98] versus 5.9% [615]; p = 0.017), including a higher risk of infection-related reoperation (3.1% [40] versus 1.4% [147]; p < 0.001). Conclusions: We found that patients who underwent TJA despite not meeting institutional preoperative criteria had a higher risk of postoperative complications. These patients were more likely to be from racial and ethnic minority groups, to have a lower socioeconomic status, and to have Medicare or Medicaid insurance. These findings underscore the need for surgery-related shared decision-making that is informed by evidence-based guidelines in order to reduce complication burden. Level of evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	220625-0
ISSN	1535-1386 ; 0021-9355
ISSN (online)	1535-1386
ISSN	0021-9355
DOI	10.2106/JBJS.23.00706
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Uk I Zs.58/1: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 464: Show issues

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Article ; Online: Sociodemographic Factors and Intestinal Microbiome Development in Preterm, Very Low Birth Weight Infants.

Desorcy-Scherer, Katelyn / Lamberti, Monica F Torrez / Weaver, Michael / Lorca, Graciela L / Parker, Leslie A

American journal of perinatology

2023

Abstract: Objective: Preterm very low birth weight (VLBW) infants are at risk for intestinal morbidities and dysbiotic development of the intestinal microbiome. Despite the influence of sociodemographic factors on premature infant health outcomes, whether they ... ...

Abstract	Objective: Preterm very low birth weight (VLBW) infants are at risk for intestinal morbidities and dysbiotic development of the intestinal microbiome. Despite the influence of sociodemographic factors on premature infant health outcomes, whether they shape the intestinal microbiome early in life is not clear. The objective was to explore the associations between race, sex, and socioeconomic status and the intestinal microbiome of VLBW infants during the first 4 weeks of life. Study design: This was a secondary analysis of data from an ongoing randomized trial of 79 infants ≤30 weeks' gestation and ≤1,500 g. Stool samples were collected at week 1 through week 4, frozen to -80°C and analyzed by 16S rRNA sequencing of the V4 region using Illumina MiSeq. Reads were analyzed to measure α and β diversity as well as relative abundance of bacteria in the intestinal microbiome. Results: Of the 79 infants, 63 had at least one sample available. Twenty-three (37%) of infants were African American, 30 (48%) were male, and 44 (71%) had Medicaid insurance. There were no statistically significant (<0.05) differences in α diversity or β diversity, and the differential abundance analysis suggests limited patterns of distinction in the intestinal microbiome between non-African American and African American infants, male and female infants, and infants with maternal private or Medicaid insurance. Conclusion: Our results suggest race, sex, and socioeconomic status shape colonization of specific microorganisms to a limited extent. Future studies should confirm these findings and determine clinical relevance through further study of differentially abundant microorganisms and additional factors contributing to colonization patterns. Key points: · Diversity of the gut microbiome was similar between infants of varying race, sex, and socioeconomic status.. · We observed sociodemographic-linked differences in colonization of individual taxa.. · Further study is required to confirm these results and the clinical relevance of these findings..
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/s-0043-1769793
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Zs.A 1929: Show issues

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Article ; Online: Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth.

Samuel, Michael S / Lopez, Jose I / McGhee, Ewan J / Croft, Daniel R / Strachan, David / Timpson, Paul / Munro, June / Schröder, Ewald / Zhou, Jing / Brunton, Valerie G / Barker, Nick / Clevers, Hans / Sansom, Owen J / Anderson, Kurt I / Weaver, Valerie M / Olson, Michael F

Cancer cell

2024 Volume 42, Issue 2, Page(s) 317

Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2078448-X
ISSN	1878-3686 ; 1535-6108
ISSN (online)	1878-3686
ISSN	1535-6108
DOI	10.1016/j.ccell.2023.12.014
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Zs.A 5650: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 104: Show issues

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Article ; Online: Prescription Sedative Misuse and Abuse.

Weaver, Michael F

The Yale journal of biology and medicine

2015 Volume 88, Issue 3, Page(s) 247–256

Abstract: Sedatives are widely prescribed for anxiety or insomnia and include benzodiazepines, selective benzodiazepine receptor subtype agonists (z-drugs), and barbiturates. These sedatives are controlled substances due to their potential for misuse and abuse. ... ...

Abstract	Sedatives are widely prescribed for anxiety or insomnia and include benzodiazepines, selective benzodiazepine receptor subtype agonists (z-drugs), and barbiturates. These sedatives are controlled substances due to their potential for misuse and abuse. Misuse is often self-medication (chemical coping) of psychological symptoms in ways unauthorized by the prescriber, usually as dose escalation leading to requests for early refills. Sedatives are abused for euphoric effects, which may have dangerous consequences. Some sedative overdoses can be treated with flumazenil, a reversal agent, along with supportive care. Sedative withdrawal syndrome is treated by tapering the sedative and may require hospitalization. Long-term treatment of sedative addiction requires counseling, often with the help of an addiction-treatment professional.
MeSH term(s)	Antidotes/administration & dosage ; Combined Modality Therapy/methods ; Directive Counseling/methods ; Evidence-Based Medicine ; Female ; Flumazenil/administration & dosage ; Humans ; Middle Aged ; Prescription Drug Misuse/prevention & control ; Self Medication/adverse effects ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/etiology ; Substance-Related Disorders/therapy ; Treatment Outcome
Chemical Substances	Antidotes ; Flumazenil (40P7XK9392)
Language	English
Publishing date	2015-09-03
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	200515-3
ISSN	1551-4056 ; 0044-0086
ISSN (online)	1551-4056
ISSN	0044-0086
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Ua VI Zs.197: Show issues

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Article: Outcomes of associated both-column acetabular fractures with and without a posterior wall fracture- A retrospective observational cohort study.

Reahl, G Bradley / McTague, Michael F / Suneja, Nishant / Weaver, Michael J / Smith, Malcolm / von Keudell, Arvind G

Journal of orthopaedics

2023 Volume 36, Page(s) 132–136

Abstract: Aims & objectives: Our study sought to determine if posterior wall (PW) involvement in associated both-column acetabular fractures (ABCAFs) is associated with different clinical outcomes, primarily rate of conversion to total hip arthroplasty (THA), in ... ...

Abstract	Aims & objectives: Our study sought to determine if posterior wall (PW) involvement in associated both-column acetabular fractures (ABCAFs) is associated with different clinical outcomes, primarily rate of conversion to total hip arthroplasty (THA), in comparison to ABCAFs with no PW involvement. Materials & methods: This retrospective observational cohort study was performed at two academic Level 1 trauma centers. Two study groups were identified. The first study group consisted of 18 patients who sustained an ABCAF with PW involvement (+PW). The second study group consisted of 26 patients who sustained an ABCAF with no PW involvement (-PW). All patients achieved a minimum 12-months of follow-up and/or received a THA conversion procedure at a time remote to their index open reduction internal fixation (ORIF) procedure. The primary outcome of this study was subsequent conversion to THA on the injured hip. The secondary outcome was the presence of post-operative pain at ≥6 months and/or complications. Results: No difference in rate of conversion to THA between + PW (n = 4, 22.2%) and -PW (n = 3, 11.5%) groups was demonstrated (p = 0.419). Similarly, no differences were seen between groups regarding complication rate (p = 0.814) and post-operative pain (p = 0.142). Conclusion: Involvement of the PW does not appear to create worse clinical outcomes in comparison to no involvement in ABCAFs particularly as it relates to ipsilateral joint replacement.
Language	English
Publishing date	2023-01-04
Publishing country	India
Document type	Journal Article
ZDB-ID	2240839-3
ISSN	0972-978X
ISSN	0972-978X
DOI	10.1016/j.jor.2023.01.001
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Article ; Online: Comparison of firocoxib and meloxicam for pain mitigation in goats undergoing surgical castration.

Weeder, Mikaela M / Kleinhenz, Michael D / Reppert, Emily J / Weaver, Leslie F / Johnson, Blaine T / Leslie, Alyssa A / Smith, Kristen J / Curtis, Andrew K / Fritz, Bailey R / Coetzee, Johann F

Journal of the American Veterinary Medical Association

2024 Volume 262, Issue 4, Page(s) 498–505

Abstract: Objective: This study sought to determine whether firocoxib (FIRO) or meloxicam (MEL) was effective at providing analgesia after surgical castration in goats.: Animals: 18 intact male crossbred goats (6 to 8 months old) were enrolled with a mean ... ...

Abstract	Objective: This study sought to determine whether firocoxib (FIRO) or meloxicam (MEL) was effective at providing analgesia after surgical castration in goats. Animals: 18 intact male crossbred goats (6 to 8 months old) were enrolled with a mean weight of 32.6 (± 2.9) kg. Methods: Surgical castration was done under injectable anesthesia by a licensed veterinarian. Twelve bucks were surgically castrated and given either FIRO (n = 6) or MEL (n = 6). Six bucks served as controls (CNTLs) and were not castrated. Outcome measurements included visual analogue scale, infrared thermography, plasma cortisol, plasma substance P, and kinetic gait analysis. All outcome measurements were obtained at -24, 4, 8, 24, 48, and 72 hours. Results: All 3 treatments were significantly different from each other at the 24- and 48-hour time points, with MEL animals having lower visual analogue scale scores when compared to FIRO animals; CNTL animals exhibited the lowest plasma cortisol levels (3.19 ng/mL; 95% CI, -1.21 to 7.59 ng/mL) followed by FIRO (7.45 ng/mL; 95% CI, 3.10 to 11.80 ng/mL) and MEL (10.24 ng/mL; 95% CI, 5.87 to 14.60 ng/mL). FIRO had an average mean decrease in gait velocity change (-54.17 cm/s; 95% CI, -92.99 to -15.35 cm/s), while MEL had an increase in gait velocity when compared to baseline values (14.54 cm/s; 95% CI, -24.27 to 53.36 cm/s). Control animals had an average mean of -3.06 cm/s (95% CI, -41.88 to 35.75 cm/s). Clinical relevance: Results from this study showed that there were some analgesic effects from administering MEL when compared to bucks that received a placebo treatment (CNTL).
MeSH term(s)	Male ; Animals ; Meloxicam/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Hydrocortisone ; Goats ; Thiazines/therapeutic use ; Thiazoles/therapeutic use ; Orchiectomy/veterinary ; Orchiectomy/methods ; Pain/veterinary ; Sulfones ; 4-Butyrolactone/analogs & derivatives
Chemical Substances	Meloxicam (VG2QF83CGL) ; firocoxib (Y6V2W4S4WT) ; Anti-Inflammatory Agents, Non-Steroidal ; Hydrocortisone (WI4X0X7BPJ) ; Thiazines ; Thiazoles ; Sulfones ; 4-Butyrolactone (OL659KIY4X)
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	390811-2
ISSN	1943-569X ; 0003-1488
ISSN (online)	1943-569X
ISSN	0003-1488
DOI	10.2460/javma.23.10.0575
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