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Article: Epigenetic modifications in solid tumor metastasis in people of African ancestry.

Oladipo, Elijah Kolawole / Olufemi, Seun Elijah / Adediran, Daniel Adewole / Adejumo, Isaac Oluseun / Jimah, Esther Moderayo / Oloke, Julius Kola / Udekwu, Chinedum C / Ogunwobi, Olorunseun O

Frontiers in oncology

2024 Volume 14, Page(s) 1325614

Abstract: This review focuses on the critical role of epigenetic modifications in solid tumor metastasis, particularly in people of African ancestry. Epigenetic alterations, such as DNA methylation, histone modifications, alterations in non-coding RNAs, and mRNA ... ...

Abstract	This review focuses on the critical role of epigenetic modifications in solid tumor metastasis, particularly in people of African ancestry. Epigenetic alterations, such as DNA methylation, histone modifications, alterations in non-coding RNAs, and mRNA methylation, significantly influence gene expression, contributing to cancer development and progression. Despite the primary focus on populations of European, American, and Asian descent in most cancer research, this work emphasizes the importance of studying the unique genetic and epigenetic landscapes of African populations for a more inclusive approach in understanding and treating cancer. Insights from this review have the potential to pave the way for the development of effective, tailored treatments, and provide a richer resource for understanding cancer progression and metastasis. Specific focus was placed on the role of DNA methylation, histone modifications, non-coding RNAs, and mRNA methylation in solid tumor metastasis, including how these modifications contribute to the regulation of tumor suppressor genes and oncogenes, influence cellular pathways and signaling, and interact with the immune system. Moreover, this review elaborates on the development of epigenetic-targeted therapeutic strategies and the current advances in this field, highlighting the promising applications of these therapies in improving outcomes for African ancestry populations disproportionately affected by certain types of cancer. Nevertheless, this work acknowledges the challenges that lie ahead, particularly the under-representation of African populations in cancer genomic and epigenomic studies and the technical complications associated with detecting subtle epigenetic modifications. Emphasis is placed on the necessity for more inclusive research practices, the development of more robust and sensitive methods for detecting and interpreting epigenetic changes, and the understanding of the interplay between genetic and epigenetic variations. The review concludes with an optimistic outlook on the future of epigenetic research in People of African ancestry, urging the concerted efforts of researchers, clinicians, funding agencies, and policymakers to extend the benefits of this research to all populations.
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1325614
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Article: Africa (COVID-19) Vaccine Technology Transfer: Where Are We?

Oladipo, Elijah Kolawole / Olufemi, Seun Elijah / Ojo, Taiwo Ooreoluwa / Adediran, Daniel Adewole / Idowu, Akindele Felix / Idowu, Usman Abiodun / Onyeaka, Helen

Life (Basel, Switzerland)

2023 Volume 13, Issue 9

Abstract: The rampant spread of the COVID-19 infection poses a grave and formidable challenge to global healthcare, with particular concern to the inhabitants of the African continent. In response to these pressing concerns, different strategies have been employed ...

Abstract	The rampant spread of the COVID-19 infection poses a grave and formidable challenge to global healthcare, with particular concern to the inhabitants of the African continent. In response to these pressing concerns, different strategies have been employed to combat the emergence of this insidious disease, encompassing crucial measures such as physical distancing, the utilization of face masks, meticulous hand hygiene, and widespread vaccination campaigns. Nevertheless, the economic realities faced by numerous African nations, characterized by their classification as "low-income countries (LICs)", present a formidable barrier to accessing and distributing approved vaccines to their populations. Moreover, it is essential to discuss the hesitancy of the European Union (EU) in releasing intellectual property rights associated with the transfer of vaccine technology to Africa. While the EU has been a key player in global efforts to combat the pandemic, there has been reluctance in sharing valuable knowledge and resources with African countries. This hesitancy raises concerns about equitable vaccine access and the potential for a prolonged health crisis in Africa. This review underscores the urgent imperative and need of establishing localized vaccine development and production facilities within Africa, necessitating the active involvement of governments and collaborative partnerships to achieve this crucial objective. Furthermore, this review advocates for the exploration of viable avenues for the transfer of vaccine technology as a means to facilitate equitable vaccine access across the African continent and also the cruciality and the need for the EU to reconsider its stance and actively engage in transferring vaccine technology to Africa through sharing intellectual property. The EU can contribute to the establishment of localized vaccine production facilities on the continent, which will not only increase vaccine availability but also promote self-sufficiency and resilience in the face of future health emergencies.
Language	English
Publishing date	2023-09-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13091886
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Article ; Online: Whole genomic sequence of Enterobacter sichuanensis AJI 2411 - A plant growth promoting rhizobacteria.

Ajibade, Oluwatosin Akinola / Oladipo, Elijah Kolawole / Kwenda, Stanford / Khumalo, Zamantungwa / Ismail, Arshad / Oloke, Julius Kola / Oyawoye, Olubukola Monisola / Onyeaka, Helen

Gene

2023 Volume 887, Page(s) 147725

Abstract: Enterobacter sichuanensis AJI 2411 is a rhizobacteria displaying plant growth promoting potentials, which was isolated from the rhizosphere of soybeans in Ede, Osun State, Nigeria. The full genome of Enterobacter sichuanensis AJI 2411 was sequenced and ... ...

Abstract	Enterobacter sichuanensis AJI 2411 is a rhizobacteria displaying plant growth promoting potentials, which was isolated from the rhizosphere of soybeans in Ede, Osun State, Nigeria. The full genome of Enterobacter sichuanensis AJI 2411 was sequenced and reported in this study to shed light on the molecular mechanisms that aids the bacteria's plant growth-promoting abilities.
MeSH term(s)	Enterobacter/genetics ; Plant Development/genetics ; Rhizosphere ; Genomics ; Plant Roots/genetics ; Plant Roots/microbiology ; Soil Microbiology
Language	English
Publishing date	2023-08-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147725
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Article ; Online: COVID-19 vaccines and vaccination: how prepared is Africa?

Ariyo, Olumuyiwa Elijah / Oladipo, Elijah Kolawole / Osasona, Oluwadamilola Gideon / Obe, Olumide / Olomojobi, Folakemi

The Pan African medical journal

2021 Volume 39, Page(s) 107

Abstract: The approval of vaccines for emergency use signifies a great milestone to end the COVID-19 pandemic. However, less than 2% of the global vaccines have been administered in Africa, putting the continent in a precarious situation in the eventuality of ... ...

Abstract	The approval of vaccines for emergency use signifies a great milestone to end the COVID-19 pandemic. However, less than 2% of the global vaccines have been administered in Africa, putting the continent in a precarious situation in the eventuality of another wave that may consume its health system. There is still an enormous task in Africa in the face of vaccine nationalism. In most countries, vaccine acquisition and deployment have been suboptimal. Leaving out Africa in the race to achieve global herd immunity may be catastrophic. Stakeholders must continue engagement to ensure a successful deployment of the vaccines on the continent. There is a need to build capacity in Africa for rapid vaccine development and deployment in the long term.
MeSH term(s)	Africa ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/supply & distribution ; Capacity Building ; Global Health ; Humans ; Immunity, Herd ; Vaccination/statistics & numerical data
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-06-04
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2021.39.107.27912
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Article: Bioinformatics Designing and Molecular Modelling of a Universal mRNA Vaccine for SARS-CoV-2 Infection.

Oladipo, Elijah Kolawole / Adeniyi, Micheal Oluwafemi / Ogunlowo, Mercy Temiloluwa / Irewolede, Boluwatife Ayobami / Adekanola, Victoria Oluwapelumi / Oluseyi, Glory Samuel / Omilola, Janet Abisola / Udoh, Anietie Femi / Olufemi, Seun Elijah / Adediran, Daniel Adewole / Olonade, Aanuoluwapo / Idowu, Usman Abiodun / Kolawole, Olatunji M / Oloke, Julius Kola / Onyeaka, Helen

Vaccines

2022 Volume 10, Issue 12

Abstract: At this present stage of COVID-19 re-emergence, designing an effective candidate vaccine for different variants of SARS-CoV-2 is a study worthy of consideration. This research used bioinformatics tools to design an mRNA vaccine that captures all the ... ...

Abstract	At this present stage of COVID-19 re-emergence, designing an effective candidate vaccine for different variants of SARS-CoV-2 is a study worthy of consideration. This research used bioinformatics tools to design an mRNA vaccine that captures all the circulating variants and lineages of the virus in its construct. Sequences of these viruses were retrieved across the six continents and analyzed using different tools to screen for the preferable CD8
Language	English
Publishing date	2022-12-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10122107
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Article: Predicting

Adelusi, Temitope Isaac / Ojo, Taiwo Ooreoluwa / Bolaji, Olawale Quadri / Oyewole, Moyosoluwa Precious / Olaoba, Olamide Tosin / Oladipo, Elijah Kolawole

In silico pharmacology

2023 Volume 12, Issue 1, Page(s) 4

Abstract: Malaria remains a significant public health challenge, with resistance to available drugs necessitating the development of novel therapies targeting invasion-dependent proteins. Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK-1) is ... ...

Abstract	Malaria remains a significant public health challenge, with resistance to available drugs necessitating the development of novel therapies targeting invasion-dependent proteins. Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK-1) is essential for host erythrocyte invasion and parasite asexual development. This study screened a library of 490 compounds using computational methods to identify potential PfCDPK-1 inhibitors. Three compounds; 17-hydroxyazadiradione, Picracin, and Epicatechin-gallate derived from known antimalarial botanicals, showed potent inhibitory effects on PfCDPK-1. These compounds exhibited better binding affinities (-8.8, -9.1, -9.3 kCal/mol respectively), pharmacokinetics, and physicochemical properties than the purported inhibitory standard of PfCDPK-1, Purfalcamine. Molecular dynamics simulations (50 ns) and molecular mechanics analyses confirmed the stability and binding rigidity of these compounds at the active pocket of PfCDPK-1. The results suggest that these compounds are promising pharmacological targets with potential therapeutic effects for malaria treatment/management without undesirable side effects. Therefore, this study provides new insights into the development of effective antimalarial agents targeting invasion-dependent proteins, which could help combat the global malaria burden. Supplementary information: The online version contains supplementary material available at 10.1007/s40203-023-00175-z.
Language	English
Publishing date	2023-12-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2702993-1
ISSN	2193-9616
ISSN	2193-9616
DOI	10.1007/s40203-023-00175-z
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Article ; Online: Immunoinformatics aided design of a peptide‐based kit for detecting Escherichia coli O157:H7 from food sources

Oladipo, Elijah Kolawole / Oluwasegun, Jerry Ayobami / Oladunni, Tolu David / Owoeye, Victoria Oluwakemi / Obisanya, Olukayode Ifeanyi / Olasinde, Oluwatosin Tumininu / Onyeaka, Helen N.

Journal of Food Safety. 2023 Oct., v. 43, no. 5 p.e13073-

2023

Abstract: Food and water‐borne enterohemorrhagic Escherichia coli (EHEC) serotype O157:H7 is a zoonotic bacterium that causes gastroenteritis and other human diseases. It has also been linked to chronic foodborne diseases with high mortality rates worldwide, ... ...

Abstract	Food and water‐borne enterohemorrhagic Escherichia coli (EHEC) serotype O157:H7 is a zoonotic bacterium that causes gastroenteritis and other human diseases. It has also been linked to chronic foodborne diseases with high mortality rates worldwide, particularly in children. Hence, this study was carried out to designed a peptide base kit for quick detection of E. coli in food. A peptide‐based rapid detection kit was designed using an immunoinformatic technique and some antigenic target genes (stx1A, stx2B, escC, fliC, and eae). The antigenic gene sequences retrieved were screened for antigenicity, transmembrane topology, B‐cells and helper T‐cells. Selected epitopes were joined with appropriate linkers to form a chimeric protein which consists of five B‐cell epitopes, five interleukin‐4 (IL‐4) inducer epitopes and five interleukin‐10 (IL‐10) inducer epitopes. The improved and optimized chimeric protein sequence was cloned in‐silico in a suitable expression host, E. coli‐strain K12. The designed peptide refined and validated tertiary structure was molecularly docked with the tertiary structures of each antigenic target gene. The physicochemical properties of the chimeric protein showed that the construct has an amino acid length of 295 amino acids, a molecular weight of 29.876 kiloDalton (kDa), an aliphatic index of 75.05 and an instability index of 14.82 which confers stability. The construct was hydrophilic with a GRAVY value of −0.261 and had a considerable half‐life of 4.4 h (mammalian reticulocytes, in vitro), >20 h (yeast, in vivo) and >10 h (E. coli, in vivo). Conclusively, the final construct has successfully met the design requirements for the development of a lateral flow kit, which has the potential to provide fast and efficient detection of E. coli O157:H7. However, it is the additional validation through the vitro and in vivo techniques needed to confirm that this designed peptide based test kit.
Keywords	B-lymphocytes ; Escherichia coli O157 ; T-lymphocytes ; amino acid sequences ; amino acids ; analytical kits ; bacteria ; computer simulation ; epitopes ; food safety ; gastroenteritis ; genes ; half life ; humans ; hydrophilicity ; immunoinformatics ; interleukin-10 ; interleukin-4 ; molecular weight ; mortality ; rapid methods ; recombinant fusion proteins ; reticulocytes ; serotypes ; topology ; yeasts
Language	English
Dates of publication	2023-10
Publishing place	John Wiley & Sons, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	756159-3
ISSN	1745-4565 ; 0149-6085
ISSN (online)	1745-4565
ISSN	0149-6085
DOI	10.1111/jfs.13073
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Antibodies against human parvovirus B19 in pregnant women in Ogbomoso, Oyo State Nigeria.

Kolawole, Oladipo Elijah / Elukunbi, Awoyelu Hilda / Kola, Oloke Julius

Journal of immunoassay & immunochemistry

2018 Volume 39, Issue 5, Page(s) 551–557

Abstract: Infection caused by Human parvovirus B19 (HPVB19) during pregnancy has been associated with adverse effects on fetus such as intrauterine fetal death but there is dearth information about the seroprevalence and risk factors among pregnant women. This ... ...

Abstract	Infection caused by Human parvovirus B19 (HPVB19) during pregnancy has been associated with adverse effects on fetus such as intrauterine fetal death but there is dearth information about the seroprevalence and risk factors among pregnant women. This study was carried out to determine the incidence of specific IgM antibodies to HPVB19 among pregnant women attending Bowen University Teaching Hospital, Ogbomoso, Oyo State. A total of 185 participants, in the age range 18-49 years, who consented voluntarily after thorough explanation of the purpose of the study were recruited for the study. Specific IgM antibodies were detected using commercially available third-generation ELISA kits. Data on socio-demographic characteristics and potential risk factors were collected using structured questionnaires. Chi-square (χ
MeSH term(s)	Adolescent ; Adult ; Antibody Specificity ; Antigen-Antibody Reactions ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoglobulin M/blood ; Immunoglobulin M/immunology ; Logistic Models ; Middle Aged ; Nigeria ; Parvovirus B19, Human/chemistry ; Parvovirus B19, Human/immunology ; Pregnancy ; Surveys and Questionnaires ; Young Adult
Chemical Substances	Immunoglobulin M
Language	English
Publishing date	2018-09-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2050610-7
ISSN	1532-4230 ; 1532-1819
ISSN (online)	1532-4230
ISSN	1532-1819
DOI	10.1080/15321819.2018.1518877
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Article ; Online: West Nile virus infection in Ogbomoso: serological evidence.

Kolawole, Oladipo Elijah / Kola, Oloke Julius

Journal of immunoassay & immunochemistry

2015 Volume 36, Issue 6, Page(s) 573–578

Abstract: A seroepidemiological study for West Nile virus was carried out in an urban and rural settlements in Ogbomoso for its IgM and IgG. Human sera was obtained and West Nile virus IgM and IgG was determined using Enzyme Linked Immunosorbent Assay technique. ... ...

Abstract	A seroepidemiological study for West Nile virus was carried out in an urban and rural settlements in Ogbomoso for its IgM and IgG. Human sera was obtained and West Nile virus IgM and IgG was determined using Enzyme Linked Immunosorbent Assay technique. Out of 93 subjects tested, 19.4% and 12.9% were positive for IgG and IgM, respectively. Among the urban dwellers, 23.40% were positive for both IgG and IgM, while the rural dwellers had 15.22% for IgG and 2.17% for IgM. Test for pure antibody to West Nile virus revealed that 23.7% had the virus while 8.6% had antibodies that cross reacted for other flaviviruses. Results show that West Nile virus is circulating in Ogbomoso and its environ which might have accounted for malaria like infection in the region.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antibodies, Viral/blood ; Child ; Child, Preschool ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Nigeria/epidemiology ; West Nile Fever/blood ; West Nile Fever/epidemiology ; West Nile virus
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2015
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	2050610-7
ISSN	1532-4230 ; 1532-1819
ISSN (online)	1532-4230
ISSN	1532-1819
DOI	10.1080/15321819.2015.1017105
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Article ; Online: Human papillomavirus in pregnant women at Bowen University Teaching Hospital, Ogbomoso, Nigeria.

Elukunbi, Awoyelu Hilda / Kolawole, Elijah Oladipo / Kola, Julius Oloke / Afolabi, Yetunde O

Journal of immunoassay & immunochemistry

2019 Volume 40, Issue 3, Page(s) 283–288

Abstract: Background: Trans-placental transmission of human papillomavirus infection during pregnancy and burden of cervical cancer is increasing in Nigeria. However, studies on the prevalence of HPV among pregnant women are limited in Ogbomoso.: Materials and ... ...

Abstract	Background: Trans-placental transmission of human papillomavirus infection during pregnancy and burden of cervical cancer is increasing in Nigeria. However, studies on the prevalence of HPV among pregnant women are limited in Ogbomoso. Materials and methods: A total of 93 pregnant women attending the antenatal clinic of Bowen University Teaching hospital in the age range 20-45 years consented for the study. All sera were tested for the presence of IgM antibodies against HPV using a third generation Enzyme-Linked Immunosorbent Assay. Chi-square test was used to assess the association between the socio-demographic variables and HPV status. Statistical significance was set at P ≤ 0.05. Results: The overall seroprevalence of HPV was 5.38% (5/93). The mean age of the study participants was 30.62 ± 5.03 years. The highest prevalence was recorded among the age group 26-35 (6.3%; 4/64) years while the least was recorded among the age group 20-25 (6.7%; 1/15) years. None of the socio-demographic characteristics and potential risk factor considered had statistically significant association with HPV infection (P ˃ 0.05). Conclusion: Awareness and screening of pregnant women should be strengthened among health stakeholders for proper management.
MeSH term(s)	Adult ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoglobulin M/immunology ; Middle Aged ; Nigeria ; Papillomaviridae/immunology ; Pregnancy ; Young Adult
Chemical Substances	Immunoglobulin M
Language	English
Publishing date	2019-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2050610-7
ISSN	1532-4230 ; 1532-1819
ISSN (online)	1532-4230
ISSN	1532-1819
DOI	10.1080/15321819.2019.1583110
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