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  1. Article ; Online: Profile EpicentRx, Inc.

    Oronsky, Bryan

    Human vaccines & immunotherapeutics

    2023  Volume 19, Issue 1, Page(s) 2184963

    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2023.2184963
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6967: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Commentary on oncolytic viruses: past, present, and future.

    Larson, Christopher / Oronsky, Bryan / Reid, Tony R

    Journal for immunotherapy of cancer

    2023  Volume 11, Issue 12

    Abstract: Whither oncolytic viruses? From the peak of their popularity in the early 2000s, when the ONYX-015 adenovirus had just entered the clinic, and then again in 2015 when the Food and Drug Administration-approved talimogene laherparepvec (also known as ... ...

    Abstract Whither oncolytic viruses? From the peak of their popularity in the early 2000s, when the ONYX-015 adenovirus had just entered the clinic, and then again in 2015 when the Food and Drug Administration-approved talimogene laherparepvec (also known as OncoVEX
    MeSH term(s) United States ; Humans ; Oncolytic Viruses/genetics ; Melanoma/therapy ; Oncolytic Virotherapy
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2023-007905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Predicting the Abscopal Phenomenon-Letter to the Editor.

    Conley, Anthony P / Oronsky, Bryan / Caroen, Scott / Larson, Chris / Reid, Tony

    Molecular cancer therapeutics

    2024  Volume 23, Issue 2, Page(s) 248–249

    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Letter
    ZDB-ID 2063563-1
    ISSN 1538-8514 ; 1535-7163
    ISSN (online) 1538-8514
    ISSN 1535-7163
    DOI 10.1158/1535-7163.MCT-23-0399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5750: Show issues Location:
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  4. Article ; Online: What Exactly Is Inflammation (and What Is It Not?).

    Oronsky, Bryan / Caroen, Scott / Reid, Tony

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: In medicine, inflammation is a fuzzy, overused word first coined by the Romans, the intended meaning and precise definition of which varies according to the person and the clinical context. It tends to carry a negative connotation as a response gone awry, ...

    Abstract In medicine, inflammation is a fuzzy, overused word first coined by the Romans, the intended meaning and precise definition of which varies according to the person and the clinical context. It tends to carry a negative connotation as a response gone awry, like a raging, out-of-control wildfire that requires immediate control and containment lest it destroy all in its path; however, frequently overlooked or lost in the shuffle is the primordial importance of inflammation to health and survival. The precise definition of inflammation matters for several reasons, not least because of the over-liberal use of anti-inflammatory drugs to inhibit inflammation, which may, contrary to prevailing dogma that all inflammation is harmful, act counterproductively to prevent restitutio ad integrum. Using fire as a central analogy, this overview attempts to define inflammation, the better to determine how to manage it, i.e., whether to fan its flames, let it burn out, or suppress it entirely.
    Language English
    Publishing date 2022-11-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232314905
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  5. Article: AdAPT-001, an oncolytic adenovirus armed with a TGF-β trap, overcomes

    Larson, Christopher / Oronsky, Bryan / Reid, Tony

    American journal of cancer research

    2022  Volume 12, Issue 7, Page(s) 3141–3147

    Abstract: Monoclonal antibodies targeting the programmed cell death protein-1/programmed cell death-ligand 1 (PD-1/PD-L1) and cytotoxic T lymphocyte-associated protein-4 (CTLA-4) axes have permanently changed the therapeutic landscape for multiple tumor types ... ...

    Abstract Monoclonal antibodies targeting the programmed cell death protein-1/programmed cell death-ligand 1 (PD-1/PD-L1) and cytotoxic T lymphocyte-associated protein-4 (CTLA-4) axes have permanently changed the therapeutic landscape for multiple tumor types previously associated with a dismal prognosis such as melanoma, non-small cell lung cancer, renal cell carcinoma, bladder cancer, head and neck squamous cell carcinoma, MSI-high colorectal carcinoma, Merkel cell carcinoma, and Hodgkin lymphoma. However, only a subset of patients initially benefits from these inhibitors, and increasing clinical experience indicates that in a substantial proportion of initial responders, lethal secondary resistance ultimately develops months or years later. In this paper we evaluated combination therapy with a Phase 1 oncolytic adenovirus called AdAPT-001, armed with a TGF-β "trap" that binds to and neutralizes the immunosuppressive cytokine, TGF-β, and a checkpoint inhibitor, anti-PD-L1, in PD-L1 resistant tumors. The study, which was performed in an immunocompetent syngeneic ADS-12 mouse model, demonstrated that the combination of AdAPT-001 with PD-L1 blockade reversed PD-L1 resistance, potentially representing a future paradigm shift for patients that are primarily or secondarily resistant to checkpoint inhibitors.
    Language English
    Publishing date 2022-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
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  6. Article ; Online: Could nucleocapsid be a next-generation COVID-19 vaccine candidate - author's reply.

    Oronsky, Bryan / Larson, Christopher / Caroen, Scott / Reid, Tony R

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2022  Volume 125, Page(s) 227

    MeSH term(s) Humans ; COVID-19 Vaccines ; COVID-19/prevention & control ; SARS-CoV-2 ; Nucleocapsid
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-11-05
    Publishing country Canada
    Document type Letter ; Comment
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2022.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article: The small molecule NLRP3 inhibitor RRx-001 potentiates regorafenib activity and attenuates regorafenib-induced toxicity in mice bearing human colorectal cancer xenografts.

    Reid, Tony / Oronsky, Bryan / Abrouk, Nacer / Caroen, Scott / Cabrales, Pedro

    American journal of cancer research

    2022  Volume 12, Issue 4, Page(s) 1912–1918

    Abstract: The multi-kinase inhibitor Regorafenib, approved for the treatment of metastatic colorectal cancer, is poorly tolerated with a Grade 3/4 drug related adverse event rate of 54% resulting in frequent dose reductions and discontinuations. RRx-001 is a ... ...

    Abstract The multi-kinase inhibitor Regorafenib, approved for the treatment of metastatic colorectal cancer, is poorly tolerated with a Grade 3/4 drug related adverse event rate of 54% resulting in frequent dose reductions and discontinuations. RRx-001 is a minimally toxic NLRP3 inhibitor small molecule with macrophage-repolarizing properties in Phase 3 clinical trials. Studies have demonstrated the inhibitory impact of M2 macrophages on the activity of tyrosine kinases, suggesting that the repolarization of macrophages by RRx-001 may enhance the activity of TKIs. The purpose of these experiments was to determine whether RRx-001 demonstrated
    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
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  8. Article: RRx-001: a chimeric triple action NLRP3 inhibitor, Nrf2 inducer, and nitric oxide superagonist.

    Oronsky, Bryan / Takahashi, Lori / Gordon, Richard / Cabrales, Pedro / Caroen, Scott / Reid, Tony

    Frontiers in oncology

    2023  Volume 13, Page(s) 1204143

    Abstract: RRx-001 is a shape shifting small molecule with Fast Track designation for the prevention/amelioration of chemoradiation-induced severe oral mucositis (SOM) in newly diagnosed Head and Neck cancer. It has been intentionally developed or "engineered" as a ...

    Abstract RRx-001 is a shape shifting small molecule with Fast Track designation for the prevention/amelioration of chemoradiation-induced severe oral mucositis (SOM) in newly diagnosed Head and Neck cancer. It has been intentionally developed or "engineered" as a chimeric single molecular entity that targets multiple redox-based mechanisms. Like an antibody drug conjugate (ADC), RRx-001 contains, at one end a "targeting" moiety, which binds to the NLRP3 inflammasome and inhibits it as well as Kelch-like ECH-associated protein 1 (KEAP1), the negative regulator of Nrf2, and, at the other end, a conformationally constrained, dinitro containing 4 membered ring, which fragments under conditions of hypoxia and reduction to release therapeutically active metabolites i.e., the payload. This "payload", which is delivered specifically to hypoperfused and inflamed areas, includes nitric oxide, nitric oxide related species and carbon-centered radicals. As observed with ADCs, RRx-001 contains a backbone amide "linker" attached to a binding site, which correlates with the F
    Language English
    Publishing date 2023-05-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1204143
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  9. Article ; Online: Superficial Venous-Associated Inflammation from Direct IV Administration of RRx-001 in Rats.

    Caroen, Scott / Oronsky, Bryan / Reid, Tony / Pandher, Karamjeet / Lopez, Alric

    International journal of medical sciences

    2022  Volume 19, Issue 11, Page(s) 1628–1630

    Abstract: RRx-001 is a small molecule NLRP3 inflammasome inhibitor with anti-CD47 and antiangiogenic/vascular normalization properties in a Phase 3 clinical trial that has been designated as a drug-device combination by the FDA. In the Phase 1 first-in-man dose ... ...

    Abstract RRx-001 is a small molecule NLRP3 inflammasome inhibitor with anti-CD47 and antiangiogenic/vascular normalization properties in a Phase 3 clinical trial that has been designated as a drug-device combination by the FDA. In the Phase 1 first-in-man dose escalation clinical trial, where RRx-001 was given by direct intravenous (IV) infusion, the main adverse event was a sterile painful infusion phlebitis (IP). Less pain was experienced when RRx-001 was infused at a slower rate over multiple hours which was impractical on an outpatient basis. In Phase 2, for reasons of convenience and safety, RRx-001 was co-administered with an aliquot of autologous blood from an
    MeSH term(s) Animals ; Azetidines ; Hemoglobins/metabolism ; Inflammasomes ; Inflammation/chemically induced ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nitro Compounds ; Phlebitis ; Rats ; Rats, Wistar
    Chemical Substances Azetidines ; Hemoglobins ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nitro Compounds ; RRx-001
    Language English
    Publishing date 2022-09-21
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.76615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Patent and Marketing Exclusivities 101 for Drug Developers.

    Oronsky, Bryan / Caroen, Scott / Brinkhaus, Franck / Reid, Tony / Stirn, Meaghan / Kumar, Raj

    Recent patents on biotechnology

    2023  Volume 17, Issue 3, Page(s) 257–270

    Abstract: Despite an ever-increasing need for newer, safer, more effective, and more affordable therapies to treat a multitude of diseases and conditions, drug development takes too long, costs too much, and is too uncertain to be undertaken without the conferment ...

    Abstract Despite an ever-increasing need for newer, safer, more effective, and more affordable therapies to treat a multitude of diseases and conditions, drug development takes too long, costs too much, and is too uncertain to be undertaken without the conferment of exclusionary rights or entry barriers to motivate and sustain investment in it. These entry barriers take the form of patents that protect intellectual property and marketing exclusivity provisions that are provided by statute. This review focuses on the basic ins and outs of regulatory and patent exclusivities for which new chemical entities (NCEs), referring to never-before approved drugs with an entirely new active ingredient, are eligible and uses RRx-001, a small molecule aerospace-derived NCE in development for the treatment of cancer, radiation toxicity, and diseases of the NLR family pyrin domain containing 3 (NLRP3) inflammasome, as a "real world" example. This is intended as a '101-type' of primer; its aim is to help developers of original pharmaceuticals navigate the maze of patents, other IP regulations, and statutory exclusivities in major markets so that they can make proper use of them.
    MeSH term(s) Humans ; Patents as Topic ; Neoplasms ; Marketing ; Azetidines ; Drug Industry
    Chemical Substances Azetidines
    Language English
    Publishing date 2023-01-13
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ISSN 2212-4012
    ISSN (online) 2212-4012
    DOI 10.2174/1872208317666230111105223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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