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Article: Effects of Huang-Lian-Jie-Du Decoction on Oxidative Stress and AMPK-SIRT1 Pathway in Alzheimer's Disease Rat.

Gu, Xinru / Zhao, Haiyu / Zhou, Junyi / Zhou, Yanyan / Wei, Xiaolu / Wang, Hongjie / Bian, Baolin / Yang, Jian / Ren, Wei / Si, Nan

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 6212907

Abstract: Huang-Lian-Jie-Du Decoction (HLJDD), traditional Chinese medicine (TCM), is proven to have ...

Abstract	Huang-Lian-Jie-Du Decoction (HLJDD), traditional Chinese medicine (TCM), is proven to have ameliorative effects on learning and memory deficits of Alzheimer's disease (AD). The current study aims to reveal the underlying mechanism of HLJDD in the treatment of AD by simultaneous determination on the regulation of HLJDD on oxidative stress, neurotransmitters, and AMPK-SIRT1 pathway in AD. AD model rat was successfully established by injection of D-galactose and A
Language	English
Publishing date	2020-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/6212907
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pharmacokinetic-Pharmacodynamic Analysis on Inflammation Rat Model after Oral Administration of Huang Lian Jie Du Decoction.

Ren, Wei / Zuo, Ran / Wang, Yao-Nan / Wang, Hong-Jie / Yang, Jian / Xin, Shao-Kun / Han, Ling-Yu / Zhao, Hai-Yu / Han, Shu-Yan / Gao, Bo / Hu, Hao / Hu, Yuan-Jia / Bian, Bao-Lin / Si, Nan

PloS one

2016 Volume 11, Issue 6, Page(s) e0156256

Abstract: Huang-Lian-Jie-Du Decoction (HLJDD) is a classical Traditional Chinese Medicine (TCM) formula ...

Abstract	Huang-Lian-Jie-Du Decoction (HLJDD) is a classical Traditional Chinese Medicine (TCM) formula with heat-dissipating and detoxifying effects. It is used to treat inflammation-associated diseases. However, no systematic pharmacokinetic (PK) and pharmacodynamic (PD) data concerning the activity of HLJDD under inflammatory conditions is available to date. In the present study, the concentration-time profiles and the hepatic clearance rates (HCR) of 41 major components in rat plasma in response to the oral administration of a clinical dose of HLJDD were investigated by LC-QqQ-MS using a dynamic multiple reaction monitoring (DMRM) method. Additionally, the levels of 7 cytokines (CKs) in the plasma and the body temperature of rats were analyzed. Furthermore, a PK-PD model was established to describe the time course of the hemodynamic and anti-inflammatory effects of HLJDD. As one of the three major active constituents in HLJDD, iridoids were absorbed and eliminated more easily and quickly than alkaloids and flavonoids. Compared with the normal controls, the flavonoids, alkaloids and iridoids in inflamed rats exhibited consistently changing trends of PK behaviors, such as higher bioavailability, slower elimination, delays in reaching the maximum concentration (Tmax) and longer substantivity. The HCR of iridoids was different from that of alkaloids and flavonoids in inflamed rats. Furthermore, excellent pharmacodynamic effects of HLJDD were observed in inflamed rats. The levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1β, IL-10, and macrophage inflammatory protein-2 (MIP-2) and body temperature significantly decreased after the administration of HLJDD. Based on PK-PD modeling with the three-phase synchronous characterization of time-concentration-effect, flavonoids exhibited one mechanism of action in the anti-inflammatory process, while iridoids and alkaloids showed another mechanism of action. Taken together, the results demonstrated that HLJDD may restrain inflammation synergistically via its major constituents (alkaloids, flavonoids and iridoids). A correlation between the exposure concentration of different types of compounds and their anti-inflammatory effects in the body was shown. This study provides a comprehensive understanding of the anti-inflammatory activity of HLJDD.
MeSH term(s)	Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Chromatography, Liquid ; Cytokines/blood ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/pharmacology ; Inflammation/blood ; Inflammation/drug therapy ; Male ; Mass Spectrometry ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Cytokines ; Drugs, Chinese Herbal ; oren gedoku to
Language	English
Publishing date	2016-06-09
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0156256
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis using omics analysis.

Pan, Hudan / Zheng, Yanfang / Liu, Zhongqiu / Yuan, Zhongwen / Ren, Rutong / Zhou, Hua / Xie, Ying / Liu, Liang

Frontiers of medicine

2019 Volume 13, Issue 5, Page(s) 564–574

Abstract: ... are complex and remain unclear. Guan-Jie-Kang (GJK), a prescription modified from "Wu Tou Decoction ...

Abstract	Traditional Chinese medicine (TCM) formulas have attracted increasing attention worldwide in the past few years for treating complex disease including rheumatoid arthritis. However, their mechanisms are complex and remain unclear. Guan-Jie-Kang (GJK), a prescription modified from "Wu Tou Decoction," was found to significantly relieve arthritis symptoms in rats with adjuvant-induced arthritis after 30-day treatment, especially in the 24 g/kg/day group. By analyzing 1749 targets related to 358 compounds in the five herbs of GJK, we identified the possible anti-arthritis pathways of GJK, including the calcium signaling and metabolic pathways. Bone damage levels were assessed by micro-computed tomography, and greater bone protective effect was observed with GJK treatment than with methotrexate. Receptor activator of nuclear factor κB ligand (RANKL)-RANK signaling, which is related to calcium signaling, was significantly regulated by GJK. Moreover, a target metabolomics assay of serum was conducted; 17 metabolic biomarkers showed significant correlations with treatment. An integrated pathway analysis revealed that pyruvate metabolism, purine metabolism, and glycolysis metabolism were significantly associated with the effects of GJK in arthritis treatment. Thus, this study establishes a new omics analytical method integrated with bioinformatics analysis for elucidating the multi-pathway mechanisms of TCM.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Arthritis, Experimental/blood ; Arthritis, Experimental/drug therapy ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/drug therapy ; Biomarkers/blood ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Male ; Metabolomics ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; X-Ray Microtomography
Chemical Substances	Anti-Inflammatory Agents ; Biomarkers ; Drugs, Chinese Herbal ; wu-tou
Language	English
Publishing date	2019-05-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2617113-2
ISSN	2095-0225 ; 2095-0217
ISSN (online)	2095-0225
ISSN	2095-0217
DOI	10.1007/s11684-018-0676-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of Huang-Lian-Jie-Du Decoction on Oxidative Stress and AMPK-SIRT1 Pathway in Alzheimer’s Disease Rat

Xinru Gu / Haiyu Zhao / Junyi Zhou / Yanyan Zhou / Xiaolu Wei / Hongjie Wang / Baolin Bian / Jian Yang / Wei Ren / Nan Si

Evidence-Based Complementary and Alternative Medicine, Vol

2020 Volume 2020

Abstract: Huang-Lian-Jie-Du Decoction (HLJDD), traditional Chinese medicine (TCM), is proven to have ...

Abstract	Huang-Lian-Jie-Du Decoction (HLJDD), traditional Chinese medicine (TCM), is proven to have ameliorative effects on learning and memory deficits of Alzheimer’s disease (AD). The current study aims to reveal the underlying mechanism of HLJDD in the treatment of AD by simultaneous determination on the regulation of HLJDD on oxidative stress, neurotransmitters, and AMPK-SIRT1 pathway in AD. AD model rat was successfully established by injection of D-galactose and Aβ25-35-ibotenic acid. Morris Water Maze (MWM) test was used to evaluate the success of AD modelling. On this basis, an advanced technique with UPLC-QqQ MS/MS was built up and applied to determine the levels of 8 neurotransmitters in rat plasma. Significant alternation in methionine, glutamine, and tryptophan was observed in AD rats’ plasma after the administration of HLJDD, relative to the model group. Meanwhile, HLJDD could upregulate the levels of SOD, GSH-Px, AMPK, and SIRT1 and downregulate the content of MDA in the peripheral system of the AD rats. The underlying therapeutic mechanism of HLJDD for the treatment of AD was associated with alleviating oxidation stress, inflammation, neurotransmitters, and energy metabolism. These data provide solid foundation for the potential use of HLJDD to treat AD.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pharmacokinetic-Pharmacodynamic Analysis on Inflammation Rat Model after Oral Administration of Huang Lian Jie Du Decoction.

Wei Ren / Ran Zuo / Yao-Nan Wang / Hong-Jie Wang / Jian Yang / Shao-Kun Xin / Ling-Yu Han / Hai-Yu Zhao / Shu-Yan Han / Bo Gao / Hao Hu / Yuan-Jia Hu / Bao-Lin Bian / Nan Si

PLoS ONE, Vol 11, Iss 6, p e

2016 Volume 0156256

Abstract: Huang-Lian-Jie-Du Decoction (HLJDD) is a classical Traditional Chinese Medicine (TCM) formula ...

Abstract	Huang-Lian-Jie-Du Decoction (HLJDD) is a classical Traditional Chinese Medicine (TCM) formula with heat-dissipating and detoxifying effects. It is used to treat inflammation-associated diseases. However, no systematic pharmacokinetic (PK) and pharmacodynamic (PD) data concerning the activity of HLJDD under inflammatory conditions is available to date. In the present study, the concentration-time profiles and the hepatic clearance rates (HCR) of 41 major components in rat plasma in response to the oral administration of a clinical dose of HLJDD were investigated by LC-QqQ-MS using a dynamic multiple reaction monitoring (DMRM) method. Additionally, the levels of 7 cytokines (CKs) in the plasma and the body temperature of rats were analyzed. Furthermore, a PK-PD model was established to describe the time course of the hemodynamic and anti-inflammatory effects of HLJDD. As one of the three major active constituents in HLJDD, iridoids were absorbed and eliminated more easily and quickly than alkaloids and flavonoids. Compared with the normal controls, the flavonoids, alkaloids and iridoids in inflamed rats exhibited consistently changing trends of PK behaviors, such as higher bioavailability, slower elimination, delays in reaching the maximum concentration (Tmax) and longer substantivity. The HCR of iridoids was different from that of alkaloids and flavonoids in inflamed rats. Furthermore, excellent pharmacodynamic effects of HLJDD were observed in inflamed rats. The levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1β, IL-10, and macrophage inflammatory protein-2 (MIP-2) and body temperature significantly decreased after the administration of HLJDD. Based on PK-PD modeling with the three-phase synchronous characterization of time-concentration-effect, flavonoids exhibited one mechanism of action in the anti-inflammatory process, while iridoids and alkaloids showed another mechanism of action. Taken together, the results demonstrated that HLJDD may restrain inflammation synergistically via its major constituents (alkaloids, flavonoids and iridoids). A correlation between the exposure concentration of different types of compounds and their anti-inflammatory effects in the body was shown. This study provides a comprehensive understanding of the anti-inflammatory activity of HLJDD.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Metabolic fate analysis of Huang-Lian-Jie-Du Decoction in rat urine and feces by LC-IT-MS combining with LC-FT-ICR-MS: a feasible strategy for the metabolism study of Chinese medical formula.

Zuo, Ran / Ren, Wei / Bian, Bao-Lin / Wang, Hong-Jie / Wang, Yao-Nan / Hu, Hao / Zhao, Hai-Yu / Si, Nan

Xenobiotica; the fate of foreign compounds in biological systems

2016 Volume 46, Issue 1, Page(s) 65–81

Abstract: 1. Huang-Lian-Jie-Du Decoction (HLJDD) is widely used for the treatment of hypertension, diabetes ...

Abstract	1. Huang-Lian-Jie-Du Decoction (HLJDD) is widely used for the treatment of hypertension, diabetes, inflammation and neural system diseases in clinic. In the present study, the comprehensive metabolic profile of HLJDD was demonstrated reliably and rapidly followed by the metabolic pathway analysis of six typical pure compounds (four alkaloids, one flavonoid and one iridoid) in HLJDD using LC-IT-MS combined with high resolution LC-FT-ICR-MS. 2. Totally, 85 compounds, including 32 prototype components and 53 biotransformed metabolites were detected and characterized in the urine and feces after oral administration of HLJDD and six pure compounds to rats, respectively. Among them, 17 prototypes were identified definitely with standard references. 3. Hydroxylation, demethylation and glucuronidation reactions of alkaloids, as well as glucuronidation and sulfonation reactions of iridoids and flavonoids, were observed as the major metabolic pathways of HLJDD. Flavonoids, iridoids and their metabolites were mainly excreted from urine. However, amount of alkaloids were detected in feces. 4. In general, the distinctive metabolic process of three kinds of representative components in HLJDD was clarified. The in vivo metabolic network of HLJDD was demonstrated. Meanwhile, the investigation of representative pure compounds in metabolic study provided a valuable strategy to elucidate the full-scale metabolic fate of HLJDD. This might be helpful to understand the in vivo mechanism of Traditional Chinese medicine (TCM).
MeSH term(s)	Alkaloids/urine ; Animals ; Chromatography, Liquid/methods ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/metabolism ; Feces/chemistry ; Flavonoids/urine ; Male ; Mass Spectrometry/methods ; Metabolic Networks and Pathways ; Metabolome ; Rats, Sprague-Dawley ; Reference Standards ; Urine/chemistry
Chemical Substances	Alkaloids ; Drugs, Chinese Herbal ; Flavonoids ; oren gedoku to
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120287-x
ISSN	1366-5928 ; 0049-8254
ISSN (online)	1366-5928
ISSN	0049-8254
DOI	10.3109/00498254.2015.1048541
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 782: Show issues

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Book: Shi jie shi ye xia de "Zhongguo mo shi"

Ren, Wenjie

yi liao lian he ti mo shi de shi jian tan suo yu guan li chuang xin

2014

Author's details	Ren Wenjie zhu
MeSH term(s)	Delivery of Health Care
Language	Chinese
Size	2, 4, 354 pages :, illustrations, portrait
Edition	Di 1 ban.
Document type	Book
ISBN	9787307138445 ; 7307138441
Database	Catalogue of the US National Library of Medicine (NLM)

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Book ; Thesis: The prevalence of somatic symptom disorder (SSD) with predominant pain in China

Ren, Jie

2022

Author's details	vorgelegt 2021 von Jie Ren
Keywords	Psychosomatik ; China
Subject	Psychosomatische Medizin ; Somatopsychologie
Language	English
Size	6, 86 Blätter, Illustrationen, Diagramme
Publishing place	Freiburg im Breisgau
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Albert-Ludwigs-Universität Freiburg im Breisgau, 2022
HBZ-ID	HT021691863
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2023 E 64	order for loan	Magazin

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Article: Kui jie qing in the treatment of chronic non-specific ulcerative colitis.

Wang, B / Ren, S / Feng, W / Zhong, Z / Qin, C

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

1997 Volume 17, Issue 1, Page(s) 10–13

MeSH term(s)	Administration, Rectal ; Adolescent ; Adult ; Aged ; Colitis, Ulcerative/drug therapy ; Diagnosis, Differential ; Drug Combinations ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Male ; Medicine, Chinese Traditional ; Middle Aged
Chemical Substances	Drug Combinations ; Drugs, Chinese Herbal
Language	English
Publishing date	1997-03
Publishing country	China
Document type	Journal Article
ZDB-ID	603186-9
ISSN	0254-6272 ; 0255-2922
ISSN (online)	0254-6272
ISSN	0255-2922
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.B 2564: Show issues

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Book: Mian yi xue wen da tu jie

Chen, Ren

1982

Author's details	Chen Ren, Wang Zhen, bian hui
MeSH term(s)	Allergy and Immunology
Language	Chinese
Size	9, 178 p. :, ill.
Publisher	Ren min wei sheng chu ban she
Publishing place	Beijing Shi
Document type	Book
Note	Title translated: Questions and answers in immunology, illustrated.
Database	Catalogue of the US National Library of Medicine (NLM)

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