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Article ; Online: Similar Prevalence of Plasmodium falciparum and Non-P. falciparum Malaria Infections among Schoolchildren, Tanzania

2023 Volume 29, Issue 6, Page(s) 1143–1153

Abstract: Achieving malaria elimination requires considering both Plasmodium falciparum and non-P. falciparum ... had P. falciparum, 24% had P. ovale spp., 4% had P. malariae, and 0.3% had P. vivax infections. Most ... 91%) schoolchildren with P. ovale infections had low parasite densities; 64% of P. ovale infections ...

Abstract	Achieving malaria elimination requires considering both Plasmodium falciparum and non-P. falciparum infections. We determined prevalence and geographic distribution of 4 Plasmodium spp. by performing PCR on dried blood spots collected within 8 regions of Tanzania during 2017. Among 3,456 schoolchildren, 22% had P. falciparum, 24% had P. ovale spp., 4% had P. malariae, and 0.3% had P. vivax infections. Most (91%) schoolchildren with P. ovale infections had low parasite densities; 64% of P. ovale infections were single-species infections, and 35% of those were detected in low malaria endemic regions. P. malariae infections were predominantly (73%) co-infections with P. falciparum. P. vivax was detected mostly in northern and eastern regions. Co-infections with >1 non-P. falciparum species occurred in 43% of P. falciparum infections. A high prevalence of P. ovale infections exists among schoolchildren in Tanzania, underscoring the need for detection and treatment strategies that target non-P. falciparum species.
MeSH term(s)	Humans ; Child ; Plasmodium falciparum/genetics ; Prevalence ; Tanzania/epidemiology ; Coinfection/epidemiology ; Plasmodium malariae ; Malaria/epidemiology ; Malaria, Falciparum/epidemiology ; Malaria, Falciparum/parasitology ; Malaria, Vivax/parasitology
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2906.221016
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Article ; Online: Highly selective adsorption of p-xylene over other C

Yoon, Ji Woong / Lee, Ji Sun / Piburn, Graham W / Cho, Kyoung Ho / Jeon, Keonghee / Lim, Hyung-Kyu / Kim, Hyungjun / Jun, Chul-Ho / Humphrey, Simon M / Krishna, Rajamani / Chang, Jong-San

Dalton transactions (Cambridge, England : 2003)

2017

Abstract: ... showed high sorption capacity and high adsorption selectivity for p-xylene over the corresponding m- and ... CUK-1 is found to strongly favour p-xylene adsorption because p-xylene molecules undergo well-defined ...

Abstract	High quality crystalline Co-CUK-1 can be synthesized rapidly and efficiently by a microwave-assisted method. The resulting microporous coordination material is a highly effective adsorbent for the separation of xylene isomers and ethylbenzene, as demonstrated here through sorption isotherm analysis, Ideal Adsorbed Solution Theory (IAST) calculations, and grand canonical Monte Carlo (GCMC) simulations. Co-CUK-1 showed high sorption capacity and high adsorption selectivity for p-xylene over the corresponding m- and o-isomers, and ethylbenzenes. According to the data obtained from IAST and GCMC simulations, the Co-CUK-1 is found to strongly favour p-xylene adsorption because p-xylene molecules undergo well-defined molecular packing in the 1-D channels; by comparison, the packing efficiencies of o-xylene, m-xylene and ethylbenzene are significantly lower, as is evidenced by lower saturation capacities.
Language	English
Publishing date	2017-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c7dt03304d
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Article ; Online: Corrigendum to 'ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation' [Molecular Metabolism 25 (2019) p.83-94].

Stöckli, Jacqueline / Zadoorian, Armella / Cooke, Kristen C / Deshpande, Vinita / Yau, Belinda / Herrmann, Gaia / Kebede, Melkam A / Humphrey, Sean J / James, David E

Molecular metabolism

2021 Volume 48, Page(s) 101219

Language	English
Publishing date	2021-03-26
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	2708735-9
ISSN	2212-8778 ; 2212-8778
ISSN (online)	2212-8778
ISSN	2212-8778
DOI	10.1016/j.molmet.2021.101219
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Book: Rang & Dale's pharmacology

Ritter, James M. / Rang, H. P.

2024

Title variant	Pharmacology
Author's details	James M. Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEwan, Emma Robinson James Fullerton
Keywords	Medicine ; Pharmacology ; Pharmakologie, Toxikologie ; Basic Science ; Medical Education
Language	English
Dates of publication	2024-2024
Size	xvii, 850 Seiten, Illustrationen, 2400 Gramm
Edition	Tenth edition
Publisher	Elsevier
Publishing place	London
Publishing country	Great Britain
Document type	Book
Note	Zugang zur Online-Ausgabe über Code
HBZ-ID	HT030336823
ISBN	978-0-323-87395-6 ; 9780323873963 ; 0-323-87395-2 ; 0323873960
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2023 A 1100	available for loan (reading room)	Lesesaal EG
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Article ; Online: P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

Bart Spronck / Marcos Latorre / Sameet Mehta / Alexander W. Caulk / Abhay B. Ramachandra / Sae-Il Murtada / Alexia Rojas / Chang-Sun He / Bo Jiang / Mo Wang / Matthew R. Bersi / George Tellides / Jay D. Humphrey

Artery Research, Vol 26, Iss Supplement

2020 Volume 1

Abstract: ... thickness increase, p = 0.022). CD45+ cell density was markedly higher in hypertensive C57BL/6J than 129SvEv ... aortas (p = 0.001), while vasoconstrictive responses to AngII (causing a wall stress decrease Δσ) were ... greater in 129SvEv than C57BL/6J mice, both before (Δσ = −8 vs. −24%, p = 0.023) and after (Δσ = −24 vs ...

Abstract	Background: Many genetic mutations affect aortic structure and function in mice, but little is known about the influence of background strain. We compared the biomechanical, structural, and gene expression responses of C57BL/6J and 129SvEv aortas to angiotensin II (AngII)-induced hypertension. Methods: After AngII infusion (14-day, 1000 ng/kg/min) and euthanasia, excised thoracic aortas were characterized functionally using isobaric vasoactive and cyclic passive stiffness tests. Immunohistochemistry quantified medial/adventitial composition and infiltration of pan-inflammatory CD45+ cells. RNA sequencing-based gene ontology, wall stress analyses, and growth and remodeling (G&R) simulations were performed to complement our mechanical findings. Results: Baseline aortic geometry, composition, and biomechanical properties, as well as AngII-induced blood pressure increases (+34% vs. +32%, systolic), were similar across strains. Yet, AngII-induced aortic remodeling differed dramatically, with gross maladaptive, fibrotic remodeling (exuberant medial/adventitial thickening) in C57BL/6J but not in 129SvEv mice (+89% vs. +12% thickness increase, p = 0.022). CD45+ cell density was markedly higher in hypertensive C57BL/6J than 129SvEv aortas (p = 0.001), while vasoconstrictive responses to AngII (causing a wall stress decrease Δσ) were greater in 129SvEv than C57BL/6J mice, both before (Δσ = −8 vs. −24%, p = 0.023) and after (Δσ = −24 vs. −46%, p < 0.001) hypertension. Gene expression, stress analyses, and G&R simulations reinforced the emergent hypothesis that mechanical stress-mediated immune processes promote maladaptive remodeling while smooth muscle contractile processes reduce wall stress and thereby protect against fibrosis (Figure). Conclusions: Differentially expressed mechano-sensitive genes play key roles in the distinct hypertensive aortic remodeling in C57BL/6J and 129SvEv mice and must be considered when comparing studies in different background strains.
Keywords	Stiffness ; smooth muscle ; inflammation ; Specialties of internal medicine ; RC581-951 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
Subject code	572
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: P.20 Evolving Structure-Function Correlates during Aortic Maturation and Aging

Cristina Cavinato / Jay D Humphrey

Artery Research, Vol 26, Iss Supplement

2020 Volume 1

Abstract: Introduction: Unraveling aortic cellular and extracellular microstructural and mechanical mechanisms triggered to maintain homeostasis in murine aortae during maturation and aging is fundamental to better understand remodeling in human arteriopathies [1]. ...

Abstract	Introduction: Unraveling aortic cellular and extracellular microstructural and mechanical mechanisms triggered to maintain homeostasis in murine aortae during maturation and aging is fundamental to better understand remodeling in human arteriopathies [1]. Methods: This study, combining ex-vivo extension-inflation testing [2], multiphoton microscopy and optical histology, aimed to quantify multiple microstructural parameters of primary extracellular components – collagen, elastic lamellae – and cells – endothelial, smooth muscle and adventitia cells – of the aorta with a dynamic and multiregional 3D approach. The analysis focused on the quantification and correlation of the histo-mechanical properties of the thoracic aorta as a function of age from 21 days to 1 year after birth, that is, from the time of weaning to maturation and therefore the natural aging. The parameters quantifying the three-dimensional microstructural phenomena of deposition, remodeling and removal of aortic components under pressure and stretch conditions equivalent to those in vivo were layer thicknesses, straightening, alignment and thickness of collagen bundles, number and size of elastic lamellae, density and alignment of the different vascular cells. Results: Changing dynamics at different ages were characterized, such as the smooth muscle cell population reduction and hypertrophy with the interlamellar widening from an intermediate age. Significant correlations indicated the fundamental role of both cells and deposited extracellular proteins such as the reduction in endothelial and smooth muscle cell densities but also the increase in straightness and thickness of collagen bundles in relation to the increase in circumferential and axial stiffness of the aortic wall. FigureMicrostructure-mechanics correlates.
Keywords	Microstructure function ; mechanics cells ; Specialties of internal medicine ; RC581-951 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
Subject code	610
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Use of Lateral Flow Immunoassay to Characterize SARS-CoV-2 RBD-Specific Antibodies and Their Ability to React with the UK, SA and BR P.1 Variant RBDs.

Tan, Enqing / Frew, Erica / Cooper, Jeff / Humphrey, John / Holden, Matthew / Mand, Amanda Restell / Li, Jun / Anderson, Shaya / Bi, Ming / Hatler, Julia / Person, Anthony / Mortari, Frank / Gould, Kevin / Barry, Shelly

Diagnostics (Basel, Switzerland)

2021 Volume 11, Issue 7

Abstract: ... antibody did not neutralize the South African (SA) and Brazilian P.1 (BR P.1) RBDs. The antibody escaped ... by the SA and BR P.1 RBDs retained binding activity to SA and BR P.1 RBDs but was unable to induce ...

Abstract	Identifying anti-spike antibodies that exhibit strong neutralizing activity against current dominant circulating variants, and antibodies that are escaped by these variants, has important implications in the development of therapeutic and diagnostic solutions and in improving understanding of the humoral response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We characterized seven anti-SARS-CoV-2 receptor binding domain (RBD) antibodies for binding activity, pairing capability, and neutralization activity to SARS-CoV-2 and three variant RBDs via lateral flow immunoassays. The results allowed us to group these antibodies into three distinct epitope bins. Our studies showed that two antibodies had broadly potent neutralizing activity against SARS-CoV-2 and these variant RBDs and that one antibody did not neutralize the South African (SA) and Brazilian P.1 (BR P.1) RBDs. The antibody escaped by the SA and BR P.1 RBDs retained binding activity to SA and BR P.1 RBDs but was unable to induce neutralization. We demonstrated that lateral flow immunoassay could be a rapid and effective tool for antibody characterization, including epitope classification and antibody neutralization kinetics. The potential contributions of the mutations (N501Y, E484K, and K417N/T) contained in these variants' RBDs to the antibody pairing capability, neutralization activity, and therapeutic antibody targeting strategy are discussed.
Language	English
Publishing date	2021-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics11071190
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Article ; Online: Corrigendum to ‘ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation’ [Molecular Metabolism 25 (2019) p.83–94]

Jacqueline Stöckli / Armella Zadoorian / Kristen C. Cooke / Vinita Deshpande / Belinda Yau / Gaia Herrmann / Melkam A. Kebede / Sean J. Humphrey / David E. James

Molecular Metabolism, Vol 48, Iss , Pp 101219- (2021)

2021

Keywords	Internal medicine ; RC31-1245
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Use of Lateral Flow Immunoassay to Characterize SARS-CoV-2 RBD-Specific Antibodies and Their Ability to React with the UK, SA and BR P.1 Variant RBDs

Enqing Tan / Erica Frew / Jeff Cooper / John Humphrey / Matthew Holden / Amanda Restell Mand / Jun Li / Shaya Anderson / Ming Bi / Julia Hatler / Anthony Person / Frank Mortari / Kevin Gould / Shelly Barry

Diagnostics, Vol 11, Iss 7, p

2021 Volume 1190

Abstract	Identifying anti-spike antibodies that exhibit strong neutralizing activity against current dominant circulating variants, and antibodies that are escaped by these variants, has important implications in the development of therapeutic and diagnostic solutions and in improving understanding of the humoral response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We characterized seven anti-SARS-CoV-2 receptor binding domain (RBD) antibodies for binding activity, pairing capability, and neutralization activity to SARS-CoV-2 and three variant RBDs via lateral flow immunoassays. The results allowed us to group these antibodies into three distinct epitope bins. Our studies showed that two antibodies had broadly potent neutralizing activity against SARS-CoV-2 and these variant RBDs and that one antibody did not neutralize the South African (SA) and Brazilian P.1 (BR P.1) RBDs. The antibody escaped by the SA and BR P.1 RBDs retained binding activity to SA and BR P.1 RBDs but was unable to induce neutralization. We demonstrated that lateral flow immunoassay could be a rapid and effective tool for antibody characterization, including epitope classification and antibody neutralization kinetics. The potential contributions of the mutations (N501Y, E484K, and K417N/T) contained in these variants’ RBDs to the antibody pairing capability, neutralization activity, and therapeutic antibody targeting strategy are discussed.
Keywords	COVID-19 ; SARS-CoV-2 variant ; lateral flow immunoassay ; spike protein ; receptor binding domain (RBD) ; neutralizing antibody ; Medicine (General) ; R5-920
Subject code	570
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Nitro End Groups: Remarkable Vibrational Reporters for Charge Transfer in the Excited States of Oligo(p-phenyleneethynylene)-Bridged Donor–Acceptor Dyads

Kubicki, Jacek / Lorenc, Maciej / Cochelin, Pierre / Mongin, Olivier / Amar, Anissa / Boucekkine, Abdou / Gaje, Arnold / Humphrey, Mark G / Morshedi, Mahbod / Lorenzen, Sabine / Rauch, Florian / Scheufler, Charlotte / Marder, Todd B / Paul, Frédéric

Journal of physical chemistry. 2020 Apr. 10, v. 124, no. 18

2020

Abstract: The D−π–A dyads [(n-Hex)2N(1,4-C6H4)]C≡C[(1,4-C6H4)NO2] (1) and [(n-Hex)2N(1,4-C6H4)]C≡C(1,4-C6H4)C≡C[(1,4-C6H4)NO2] (2) have been studied by ultrafast time-resolved infrared absorption spectroscopy. After excitation into their singlet charge-transfer ( ... ...

Abstract	The D−π–A dyads [(n-Hex)2N(1,4-C6H4)]C≡C[(1,4-C6H4)NO2] (1) and [(n-Hex)2N(1,4-C6H4)]C≡C(1,4-C6H4)C≡C[(1,4-C6H4)NO2] (2) have been studied by ultrafast time-resolved infrared absorption spectroscopy. After excitation into their singlet charge-transfer (1CT) state, a fast decay (ca. 6 ps for 1 and 1 ps for 2) of the initially populated singlet state into a ground state (major pathway) and a longer lived excited state (possibly the triplet state) is observed. The nitro and alkyne groups were used as vibrational reporters to probe the changes induced by the charge-transfer process. For the first time, we confirm experimentally that these changes are consistent with expectations based on the traditional valence-bond representations of the CT states of these push–pull chromophores. An almost identical charge transfer takes place in the two dyads, despite π-bridges of different lengths between the donor and acceptor groups. Complementary DFT calculations support the experimental assignments and have helped clarify the photophysical behavior of 1 and 2.
Keywords	alkynes ; infrared spectroscopy ; physical chemistry
Language	English
Dates of publication	2020-0410
Size	p. 9755-9764.
Publishing place	American Chemical Society
Document type	Article
ISSN	1932-7455
DOI	10.1021/acs.jpcc.0c01532
Database	NAL-Catalogue (AGRICOLA)

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