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  1. Article ; Online: Wie wichtig ist heute noch eine akademische Karriere in der Medizin? Eine Befragung von Medizinstudierenden in Deutschland: Ergebnisse des Studienarms XIII der KARiMED-Studie.

    Sorg, Heiko / Ehlers, Jan P / Zupanic, Michaela / Salehi, Irsa / G G Sorg, Christian

    Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen

    2023  Volume 177, Page(s) 73–81

    Abstract: Objective: Academic careers still play a significant role in medicine. Although the doctorate remains interesting for many students, there are no data available from medical students, for example, with regard to the interest in habilitation. In parallel, ...

    Title translation How important is an academic career in medicine today? A survey among medical students in Germany: Results of study arm XIII of the KARiMED study.
    Abstract Objective: Academic careers still play a significant role in medicine. Although the doctorate remains interesting for many students, there are no data available from medical students, for example, with regard to the interest in habilitation. In parallel, a good work-life/family balance is a key career element for young medical professionals. The aim was to obtain an up-to-date opinion on the academic career of medical students.
    Methodology: Using an online survey, medical students of all semesters in Germany were questioned on the topics of academic career, mentoring, and work-life balance from October 2017 to December 2018. For this purpose, the medical students were invited by e-mail to participate and answer an anonymized online questionnaire.
    Results: A total of 1,775 participants from all 38 German medical faculties (68.3% female; age 23.3 ± 4.0 years) were included. Almost half of the participants could envision working in a branch office after graduation. While a professional career appeared important to a clear majority (70.8%), leisure time was rated as even more important (84.3%), and work-life balance clearly prioritized personal life (41.2%) over career (9.6%). Acquiring a title was rated as important to one's career by 53.6%. However, while the acquisition of a doctorate was still an option for 88.0% of the respondents, the situation is significantly different for academic titles following a successful habilitation. Although the significance of a habilitation is rated as high to very high (66.1%), the titles of assistant professor ("yes": 13.0%), associate professor (6.0%) or university professor (7.0%) are much less likely to be considered by medical students and are therefore rated as "maybe" and "no". Nevertheless, almost 60% wished for better information and advice in their future field of work.
    Conclusion: Careers in medicine are undergoing a transformation where better compatibility of leisure/family and work is no longer the sole focus. On the contrary, work-life blending is sought, as a connection between work and life. Changes are therefore necessary for professional and especially academic careers in order to make working in science and research attractive again.
    MeSH term(s) Humans ; Female ; Young Adult ; Adult ; Male ; Germany ; Students, Medical ; Career Choice ; Medicine ; Surveys and Questionnaires
    Language German
    Publishing date 2023-02-24
    Publishing country Netherlands
    Document type English Abstract ; Journal Article
    ZDB-ID 2412512-X
    ISSN 2212-0289 ; 1865-9217
    ISSN (online) 2212-0289
    ISSN 1865-9217
    DOI 10.1016/j.zefq.2022.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cognitive disorders in childhood epilepsy: a comparative longitudinal study using administrative healthcare data.

    Sorg, Anna-Lisa / von Kries, Rüdiger / Borggraefe, Ingo

    Journal of neurology

    2022  Volume 269, Issue 7, Page(s) 3789–3799

    Abstract: Objective: The study aimed to assess the risk of cognitive impairment in patients with epilepsy, the impact of age of epilepsy onset on cognition and the temporal relationship of epilepsy onset and intellectual impairment.: Methods: This longitudinal ...

    Abstract Objective: The study aimed to assess the risk of cognitive impairment in patients with epilepsy, the impact of age of epilepsy onset on cognition and the temporal relationship of epilepsy onset and intellectual impairment.
    Methods: This longitudinal study analyzed birth cohorts and followed-up children born 2005-2007 up to the age of ten using administrative healthcare data of about 8.9 million members insured by the statutory health insurance "BARMER" in Germany. We compared prevalence of cognitive impairment (ICD-code F7*) in children with epilepsy (ICD-code G40) to controls, and calculated relative risks by age groups at onset of epilepsy and assessed differences in relation to the temporal sequence of the diagnoses.
    Results: Of the 142,563 pre-pubertal children included in the analysis, 2728 (1.9%) had an epilepsy diagnosis within the first 10 years of life. 17.4% (475/2728) of children with epilepsy had a diagnosis of cognitive impairment compared to 1.7% (2309/139835) in controls. The relative risk for cognitive impairment compared to age-matched controls was 10.5 (95% CI 9.6, 11.6) and was highest in epilepsy cases with seizure manifestation within the first 2 years of life compared to older children. The prevalence of cognitive impairment before epilepsy diagnosis was slightly increased compared to controls, while it was increased by a factor of nine in children diagnosed with cognitive impairment in the year of onset of epilepsy or afterwards.
    Conclusions: Pre-pubertal children with epilepsy have a ten-fold higher risk for intellectual impairment compared to age-matched controls. This risk inversely correlates with the age of epilepsy manifestation. Cognitive impairment was diagnosed after epilepsy manifestation in the majority of patients.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Cognition ; Cognition Disorders/diagnosis ; Cognition Disorders/epidemiology ; Cognition Disorders/etiology ; Delivery of Health Care ; Epilepsy/epidemiology ; Epilepsy/psychology ; Humans ; Longitudinal Studies
    Language English
    Publishing date 2022-02-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-022-11008-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Die Ödemkrankheit des Schweines

    Sorg, Ingrid

    Isolierung, Reinigung und Charakterisierung der Fimbrien 107 von Escherichia coli 0139:K12(B):H1

    1992  

    Author's details von Ingrid Sorg
    Size II, 55 S. : Ill.
    Publishing country Switzerland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zürich, Univ., Diss., 1992
    Note Zsfassung in engl. Sprache
    HBZ-ID HT004993028
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  4. Article: Kognition bei Epilepsien im Kindes- und Jugendalter

    Borggraefe, Ingo / Sorg, Anna Lisa / Cornell, Sonia

    Kinder- und Jugendmedizin

    2022  Volume 22, Issue 05, Page(s) 341–350

    Abstract: Kognitive Einschränkungen sind bei etwa jedem fünften Kind mit einer Epilepsie vorhanden. Ein besonders hohes Risiko besteht bei früher Epilepsiemanifestation. Die Ursache der Epilepsie beeinflusst neben anderen Faktoren das Ausmaß der kognitiven ... ...

    Abstract Kognitive Einschränkungen sind bei etwa jedem fünften Kind mit einer Epilepsie vorhanden. Ein besonders hohes Risiko besteht bei früher Epilepsiemanifestation. Die Ursache der Epilepsie beeinflusst neben anderen Faktoren das Ausmaß der kognitiven Einschränkungen am stärksten. Die Erkennung von kognitiven Einschränkungen bei Kindern mit Epilepsie kann Auswirkungen auf entsprechende Förderkonzepte und Lebenswege für die betroffenen Kinder haben. Ferner muss erkannt werden, ob die medikamentöse Behandlung der Anfälle zu einer eingeschränkten kognitiven Leistungsfähigkeit beiträgt. In einigen Fällen können frühzeitige epilepsiechirurgische Eingriffe, sofern der Patient dafür infrage kommt, einen kognitiven Abbau aufhalten.
    Language German
    Publishing date 2022-11-01
    Publisher Georg Thieme Verlag KG,
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2223494-9
    ISSN 2567-577X ; 1617-0288
    ISSN (online) 2567-577X
    ISSN 1617-0288
    DOI 10.1055/a-1920-1831
    Database Thieme publisher's database

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  5. Article: Kognition bei Epilepsien im Kindes- und Jugendalter

    Borggraefe, Ingo / Sorg, Anna Lisa / Cornell, Sonia

    Kinder- und Jugendmedizin

    2022  Volume 22, Issue 5, Page(s) 341–350

    Abstract: Kognitive Einschränkungen sind bei etwa jedem fünften Kind mit einer Epilepsie vorhanden. Ein besonders hohes Risiko besteht bei früher Epilepsiemanifestation. Die Ursache der Epilepsie beeinflusst neben anderen Faktoren das Ausmaß der kognitiven ... ...

    Title translation Cognition in childhood and adolescent epilepsies. (DeepL)
    Abstract Kognitive Einschränkungen sind bei etwa jedem fünften Kind mit einer Epilepsie vorhanden. Ein besonders hohes Risiko besteht bei früher Epilepsiemanifestation. Die Ursache der Epilepsie beeinflusst neben anderen Faktoren das Ausmaß der kognitiven Einschränkungen am stärksten. Die Erkennung von kognitiven Einschränkungen bei Kindern mit Epilepsie kann Auswirkungen auf entsprechende Förderkonzepte und Lebenswege für die betroffenen Kinder haben. Ferner muss erkannt werden, ob die medikamentöse Behandlung der Anfälle zu einer eingeschränkten kognitiven Leistungsfähigkeit beiträgt. In einigen Fällen können frühzeitige epilepsiechirurgische Eingriffe, sofern der Patient dafür infrage kommt, einen kognitiven Abbau aufhalten. (c) Thieme. All rights reserved.
    Keywords Cognitive Ability ; Cognitive Impairment ; Diagnosis ; Diagnostik ; Drug Therapy ; Epidemiologie ; Epidemiology ; Epilepsie ; Epilepsy ; Epileptic Seizures ; Epileptische Anfälle ; Kognitive Beeinträchtigung ; Kognitive Fähigkeiten ; Medikamentöse Therapie ; Pediatrics ; Pädiatrie
    Language German
    Document type Article
    ZDB-ID 2045632-3
    ISSN 1617-0288
    ISSN 1617-0288
    DOI 10.1055/a-1920-1831
    Database PSYNDEX

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  6. Article ; Online: New-Onset Paranoia in an Elderly Woman With Bipolar Disorder: Differential Diagnosis, Evaluation, and Treatment.

    Paudel, Shreedhar / Vyas, Chirag M / Peay, Celeste / Sorg, Emily / Abuali, Inas / Stern, Theodore A

    The primary care companion for CNS disorders

    2022  Volume 24, Issue 4

    Abstract: The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service ... ...

    Abstract The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry.
    MeSH term(s) Aged ; Bipolar Disorder/complications ; Bipolar Disorder/diagnosis ; Bipolar Disorder/therapy ; Diagnosis, Differential ; Female ; Hospitals, General ; Humans ; Mental Disorders/therapy ; Paranoid Disorders/complications ; Paranoid Disorders/diagnosis ; Paranoid Disorders/therapy ; Psychiatry ; Referral and Consultation
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2675414-9
    ISSN 2155-7780 ; 2155-7780
    ISSN (online) 2155-7780
    ISSN 2155-7780
    DOI 10.4088/PCC.21f03141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Perineuronal nets in the rat medial prefrontal cortex alter hippocampal-prefrontal oscillations and reshape cocaine self-administration memories.

    Wingert, Jereme C / Ramos, Jonathan D / Reynolds, Sebastian X / Gonzalez, Angela E / Rose, R Mae / Hegarty, Deborah M / Aicher, Sue A / Bailey, Lydia G / Brown, Travis E / Abbas, Atheir I / Sorg, Barbara A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The medial prefrontal cortex (mPFC) is a major contributor to relapse to cocaine in humans and to reinstatement behavior in rodent models of cocaine use disorder. Output from the mPFC is modulated by parvalbumin (PV)-containing fast-spiking interneurons, ...

    Abstract The medial prefrontal cortex (mPFC) is a major contributor to relapse to cocaine in humans and to reinstatement behavior in rodent models of cocaine use disorder. Output from the mPFC is modulated by parvalbumin (PV)-containing fast-spiking interneurons, the majority of which are surrounded by perineuronal nets (PNNs). Here we tested whether chondroitinase ABC (ABC)- mediated removal of PNNs prevented the acquisition or reconsolidation of a cocaine self-administration memory. ABC injections into the dorsal mPFC prior to training attenuated the acquisition of cocaine self-administration. Also, ABC given 3 days prior to but not 1 hr after memory reactivation blocked cue-induced reinstatement. However, reduced reinstatement was present only in rats given a
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.05.577568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Structural basis for selective AMPylation of Rac-subfamily GTPases by

    Dietz, Nikolaus / Huber, Markus / Sorg, Isabel / Goepfert, Arnaud / Harms, Alexander / Schirmer, Tilman / Dehio, Christoph

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 12

    Abstract: Small GTPases of the Ras-homology (Rho) family are conserved molecular switches that control fundamental cellular activities in eukaryotic cells. As such, they are targeted by numerous bacterial toxins and effector proteins, which have been intensively ... ...

    Abstract Small GTPases of the Ras-homology (Rho) family are conserved molecular switches that control fundamental cellular activities in eukaryotic cells. As such, they are targeted by numerous bacterial toxins and effector proteins, which have been intensively investigated regarding their biochemical activities and discrete target spectra; however, the molecular mechanism of target selectivity has remained largely elusive. Here we report a bacterial effector protein that selectively targets members of the Rac subfamily in the Rho family of small GTPases but none in the closely related Cdc42 or RhoA subfamilies. This exquisite target selectivity of the FIC domain AMP-transferase Bep1 from
    MeSH term(s) Amino Acid Sequence ; Bacterial Proteins/metabolism ; Bartonella ; Binding Sites ; Membrane Proteins/metabolism ; Models, Molecular ; Multigene Family ; Protein Binding ; Protein Conformation ; Protein Processing, Post-Translational ; Structure-Activity Relationship ; rac GTP-Binding Proteins/chemistry ; rac GTP-Binding Proteins/genetics ; rac GTP-Binding Proteins/metabolism
    Chemical Substances Bacterial Proteins ; Membrane Proteins ; rac GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2023245118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Negative symptoms, striatal dopamine and model-free reward decision-making in schizophrenia.

    Brandl, Felix / Knolle, Franziska / Avram, Mihai / Leucht, Claudia / Yakushev, Igor / Priller, Josef / Leucht, Stefan / Ziegler, Sibylle / Wunderlich, Klaus / Sorg, Christian

    Brain : a journal of neurology

    2022  Volume 146, Issue 2, Page(s) 767–777

    Abstract: Negative symptoms, such as lack of motivation or social withdrawal, are highly prevalent and debilitating in patients with schizophrenia. Underlying mechanisms of negative symptoms are incompletely understood, thereby preventing the development of ... ...

    Abstract Negative symptoms, such as lack of motivation or social withdrawal, are highly prevalent and debilitating in patients with schizophrenia. Underlying mechanisms of negative symptoms are incompletely understood, thereby preventing the development of targeted treatments. We hypothesized that in patients with schizophrenia during psychotic remission, impaired influences of both model-based and model-free reward predictions on decision-making ('reward prediction influence', RPI) underlie negative symptoms. We focused on psychotic remission, because psychotic symptoms might confound reward-based decision-making. Moreover, we hypothesized that impaired model-based/model-free RPIs depend on alterations of both associative striatum dopamine synthesis and storage (DSS) and executive functioning. Both factors influence RPI in healthy subjects and are typically impaired in schizophrenia. Twenty-five patients with schizophrenia with pronounced negative symptoms during psychotic remission and 24 healthy controls were included in the study. Negative symptom severity was measured by the Positive and Negative Syndrome Scale negative subscale, model-based/model-free RPI by the two-stage decision task, associative striatum DSS by 18F-DOPA positron emission tomography and executive functioning by the symbol coding task. Model-free RPI was selectively reduced in patients and associated with negative symptom severity as well as with reduced associative striatum DSS (in patients only) and executive functions (both in patients and controls). In contrast, model-based RPI was not altered in patients. Results provide evidence for impaired model-free reward prediction influence as a mechanism for negative symptoms in schizophrenia as well as for reduced associative striatum dopamine and executive dysfunction as relevant factors. Data suggest potential treatment targets for patients with schizophrenia and pronounced negative symptoms.
    MeSH term(s) Humans ; Schizophrenia/diagnostic imaging ; Dopamine ; Tomography, X-Ray Computed ; Psychotic Disorders/diagnostic imaging ; Reward
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-07-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awac268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Early postoperative weight loss predicts nadir weight and weight regain after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass.

    Pokala, Bhavani / Hernandez, Edward / Giannopoulos, Spyridon / Athanasiadis, Dimitrios I / Timsina, Lava / Sorg, Nikki / Makhecha, Keith / Madduri, Sathvik / Stefanidis, Dimitrios

    Surgical endoscopy

    2022  Volume 37, Issue 6, Page(s) 4934–4941

    Abstract: Background: Weight regain (WR) post bariatric surgery affects almost 20% of patients. It has been theorized that a complex interplay between physiologic adaptations and epigenetic mechanisms promotes WR in obesity, however, reliable predictors have not ... ...

    Abstract Background: Weight regain (WR) post bariatric surgery affects almost 20% of patients. It has been theorized that a complex interplay between physiologic adaptations and epigenetic mechanisms promotes WR in obesity, however, reliable predictors have not been identified. Our study examines the relationship between early postoperative weight loss (WL), nadir weight (NW), and WR following laparoscopic Roux-en-Y gastric bypass (LRYGB) and sleeve gastrectomy (LSG).
    Methods: A retrospective review of prospectively collected data was conducted for LRYGB or LSG patients from 2012 to 2016. Demographics, preoperative BMI, procedure type, and postoperative weight at 6, 12, 24, 36, and 48 months were recorded. WR was defined as > 20% increase from NW. Univariate and multivariate linear and logistic regression models were used to determine the association between early postoperative WL with NW and WR at 4 years.
    Results: Thousand twenty-six adults were included (76.8% female, mean age 44.9 ± 11.9 years, preoperative BMI 46.1 ± 8); 74.6% had LRYGB and 25.3% had LSG. Multivariable linear regression models showed that greater WL was associated with lower NW at 6 months (Coef - 2.16; 95% CI - 2.51, - 1.81), 1 year (Coef - 2.33; 95% CI - 2.58, - 2.08), 2 years (Coef - 2.04; 95% CI - 2.25, - 1.83), 3 years (Coef - 1.95; 95% CI - 2.14, - 1.76), and 4 years (Coef - 1.89; 95% CI - 2.10, - 1.68), p ≤ 0.001. WR was independently associated with increased WL between 6 months and 1 year (Coef 1.59; 95% CI 1.05,2.14; p ≤ 0.001) and at 1 year (Coef 1.24; 95% CI 0.84,1.63;p ≤ 0.001) postoperatively. The multivariable logistic regression model showed significantly increased risk of WR at 4 years for patients with greater WL at 6 months (OR 1.20, 95% CI 1.08,1.33; p = 0.001) and 1 year (OR 1.14; 95% CI 1.06,1.23; p ≤ 0.001).
    Conclusion: Our findings demonstrate that higher WL at 6 and 12 months post bariatric surgery may be risk factors for WR at 4 years. Surgeons may need to follow patients with high early weight loss more closely and provide additional treatment options to maximize their long-term success.
    MeSH term(s) Adult ; Humans ; Female ; Middle Aged ; Male ; Gastric Bypass/methods ; Obesity, Morbid/surgery ; Gastroplasty/methods ; Body Mass Index ; Gastrectomy/methods ; Laparoscopy/methods ; Retrospective Studies ; Weight Gain ; Weight Loss/physiology ; Treatment Outcome ; Postoperative Complications/etiology ; Postoperative Complications/surgery
    Language English
    Publishing date 2022-09-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-022-09658-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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