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  1. AU=Amico Patrizia
  2. AU="Kojev, Aslan"
  3. AU="Zhiyu Wang"
  4. AU="Shannon C Peyton"
  5. AU="Shiltsev, V."
  6. AU="Edward S. Debnam"
  7. AU="Freeston, Sarah L"
  8. AU="Bertolucci, S."
  9. AU="de Barros, Rosires M B"
  10. AU="Carr, Crystal C"
  11. AU="Davies, Mark Lloyd"
  12. AU=St Gelais Corine
  13. AU=Engstrom Malitta
  14. AU="Hongo, Akane"
  15. AU="Krykorková, I"
  16. AU=Yan Bing
  17. AU="Nakos, Konstantinos"
  18. AU="Schreiner, Ryan"
  19. AU=Pltz T
  20. AU="Akhmanova, Anna" AU="Akhmanova, Anna"
  21. AU="Goretsky, Anton"
  22. AU="Cordoza, Makayla L"
  23. AU=Midoux Patrick AU=Midoux Patrick
  24. AU="Mundt, H M"
  25. AU=Tsivitse Susan

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  1. Artikel ; Online: The gut microbiota in adults with chronic intestinal failure.

    Pironi, Loris / D'Amico, Federica / Guidetti, Mariacristina / Brigidi, Patrizia / Sasdelli, Anna Simona / Turroni, Silvia

    Clinical nutrition (Edinburgh, Scotland)

    2024  Band 43, Heft 6, Seite(n) 1331–1342

    Abstract: Objective: Fecal microbiota was investigated in adult patients with chronic intestinal failure (CIF) due to short bowel syndrome (SBS) with jejunocolonic anastomosis (SBS-2). Few or no data are available on SBS with jejunostomy (SBS-1) and CIF due to ... ...

    Abstract Objective: Fecal microbiota was investigated in adult patients with chronic intestinal failure (CIF) due to short bowel syndrome (SBS) with jejunocolonic anastomosis (SBS-2). Few or no data are available on SBS with jejunostomy (SBS-1) and CIF due to intestinal dysmotility (DYS) or mucosal disease (MD). We profiled the fecal microbiota of various pathophysiological mechanisms of CIF.
    Methods: Cross-sectional study on 61 adults with CIF (SBS-1 30, SBS-2 17, DYS 8, MD 6). Fecal samples were collected and profiled by 16S rRNA amplicon sequencing. Healthy controls (HC) were selected from pre-existing cohorts, matched with patients by sex and age.
    Results: Compared to HC, SBS-1, SBS-2 and MD patients showed lower alpha diversity; no difference was found for DYS. In beta diversity analysis, SBS-1, SBS-2 and DYS groups segregated from HC and from each other. Taxonomically, the CIF groups differed from HC even at the phylum level. In particular, CIF patients' microbiota was dominated by Lactobacillaceae and Enterobacteriaceae, while depleted in typical health-associated taxa belonging to Lachnospiraceae and Ruminococcaceae. Notably, compositional peculiarities of the CIF groups emerged. Furthermore, in the SBS groups, the microbiota profile differed according to the amount of parenteral nutrition required and the duration of CIF.
    Conclusions: CIF patients showed marked intestinal dysbiosis with microbial signatures specific to the pathophysiological mechanism of CIF as well as to the severity and duration of SBS.
    Sprache Englisch
    Erscheinungsdatum 2024-04-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2024.04.018
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  2. Artikel ; Online: Gut microbiota in relation to frailty and clinical outcomes.

    D'Amico, Federica / Barone, Monica / Brigidi, Patrizia / Turroni, Silvia

    Current opinion in clinical nutrition and metabolic care

    2023  Band 26, Heft 3, Seite(n) 219–225

    Abstract: Purpose of review: The gut microbiota is involved in several aspects of host health and disease, but its role is far from fully understood. This review aims to unveil the role of our microbial community in relation to frailty and clinical outcomes.: ... ...

    Abstract Purpose of review: The gut microbiota is involved in several aspects of host health and disease, but its role is far from fully understood. This review aims to unveil the role of our microbial community in relation to frailty and clinical outcomes.
    Recent findings: Ageing, that is the continuous process of physiological changes that begin in early adulthood, is mainly driven by interactions between biotic and environmental factors, also involving the gut microbiota. Indeed, our gut microbial counterpart undergoes considerable compositional and functional changes across the lifespan, and ageing-related processes may be responsible for - and due to - its alterations during elderhood. In particular, a dysbiotic gut microbiota in the elderly population has been associated with the development and progression of several age-related disorders.
    Summary: Here, we first provide an overview of the lifespan trajectory of the gut microbiota in both health and disease. Then, we specifically focus on the relationship between gut microbiota and frailty syndrome, that is one of the major age-related burdens. Finally, examples of microbiome-based precision interventions, mainly dietary, prebiotic and probiotic ones, are discussed as tools to ameliorate the symptoms of frailty and its overlapping conditions (e.g. sarcopenia), with the ultimate goal of actually contributing to healthy ageing and hopefully promoting longevity.
    Mesh-Begriff(e) Humans ; Aged ; Adult ; Gastrointestinal Microbiome/physiology ; Frailty ; Frail Elderly ; Sarcopenia ; Aging/physiology
    Sprache Englisch
    Erscheinungsdatum 2023-03-03
    Erscheinungsland England
    Dokumenttyp Review ; Journal Article
    ZDB-ID 1460178-3
    ISSN 1473-6519 ; 1363-1950
    ISSN (online) 1473-6519
    ISSN 1363-1950
    DOI 10.1097/MCO.0000000000000926
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  3. Artikel ; Online: Make It Less

    Mengoli, Mariachiara / Barone, Monica / Fabbrini, Marco / D'Amico, Federica / Brigidi, Patrizia / Turroni, Silvia

    Genes

    2022  Band 13, Heft 12

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    Sprache Englisch
    Erscheinungsdatum 2022-11-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13122200
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  4. Artikel ; Online: Bifidobacterium

    Procaccianti, Giorgia / Roggiani, Sara / Conti, Gabriele / Brigidi, Patrizia / Turroni, Silvia / D'Amico, Federica

    Microbiome research reports

    2023  Band 2, Heft 3, Seite(n) 24

    Abstract: The gut microbiome has received a crescendo of attention in recent years due to myriad influences on human pathophysiology, including cancer. Anticancer therapy research is constantly looking for new hints to improve response to therapy while reducing ... ...

    Abstract The gut microbiome has received a crescendo of attention in recent years due to myriad influences on human pathophysiology, including cancer. Anticancer therapy research is constantly looking for new hints to improve response to therapy while reducing the risk of relapse. In this scenario, Bifidobacterium, which inhabits the gut microbial ecosystem (especially that of children) and is considered a health-associated microbe, has emerged as a key target to assist anticancer treatments for a better prognosis. However, some researchers have recently hypothesized an unfavorable role of Bifidobacterium spp. in anticancer immunochemotherapy, leading to some confusion in the field. This narrative review summarizes the current knowledge on the role of Bifidobacterium spp. in relation to anticancer treatments, discussing the pros and cons of its presence in the gut microbiome of cancer patients. The current intervention strategies based on the administration of probiotic strains of Bifidobacterium are then discussed. Finally, the need to conduct further studies, especially functional ones, is underlined to provide robust experimental evidence, especially on the underlying molecular mechanisms, and thus resolve the controversies on this microbe for the long-term success of immunochemotherapy.
    Sprache Englisch
    Erscheinungsdatum 2023-07-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2771-5965
    ISSN (online) 2771-5965
    DOI 10.20517/mrr.2023.23
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  5. Artikel ; Online: Weight loss trend after bariatric surgery in a population of obese patients.

    Palumbo, Patrizia / Banchelli, Federico / Miloro, Clelia / Toschi, Patrizia Federica / Mecheri, Fouzia / Gabriele, Silvia / Pantaleoni, Monica / D'Amico, Roberto / Menozzi, Renata

    Clinical nutrition ESPEN

    2023  Band 57, Seite(n) 58–64

    Abstract: Background and aims: Bariatric Surgery (BS) is a therapeutic option in patients with severe obesity whose non-surgical techniques have failed. No work has previously explored trajectories of weight loss and how long this was maintained. Aim of study is ... ...

    Abstract Background and aims: Bariatric Surgery (BS) is a therapeutic option in patients with severe obesity whose non-surgical techniques have failed. No work has previously explored trajectories of weight loss and how long this was maintained. Aim of study is to describe effect of BS and nutritional intervention on body weight trend in patients with obesity.
    Methods: 792 patients who underwent BS from 1996 to 2021 were included. The Protocol provides Laparoscopic Sleeve Gastrectomy (LSG), Vertical Gastroplasty (VBG) and Roux-en-Y Gastric Bypass (GB). %Total Weight Loss (%TWL) and %Excess Weight Loss (%EWL) were evaluated in three cohort of patients. Cumulative incidence of clinical goal after surgery was calculated at two and five years after BS.
    Results: At two years of follow-up, average %TWL and %EWL were 31.2% (95% CI = 29.0-33.4%) and 71% (95% CI = 65.4-76.5%) for VBG, 34.7% (95% CI = 33.8-35.6%) and 78.0% (95% CI = 75.9-89.1%) for GB and 33.8% (95% CI = 32.5-35.1%) and 68.8% (95% CI = 66.1-71.6%) for LSG. At two years from surgery the cumulative incidence of clinical goal was 70.7% (95% CI = 59.1-79.1%) for VBG, 86.4% (95% CI = 82.4-89.6%) for GB and 83.4% (95% CI = 76.0-87.1%) for LSG. At five years from surgery, average % TWL and % EWL were 22.5% (95% CI = 10.2-34.8%) and 58.2% (95% CI = 28.4-88.1%) for VBG, 31.8% (95% CI = 30.2-33.3%) and 70.8% (95% CI = 67.5-74.1%) for GB and 29.5% (95% CI = 26.2-32.8%) and 62.0% (95% CI = 53.4-70.6%) for LSG respectively. At five years after having reached clinical goal the share of people who were able to maintain their weight was 49.5% (95% CI = 30.8-79.6%) for VBG, 69.5% (95% CI = 58.3-82.8%) for GB and 55.9% (95% CI = 42.1-74.3%) for LSG. The median time of clinical goal maintaining was 4.8 years for VBG (95% CI lower limit = 4.1), 6.6 years for GB (95% CI lower limit = 6.2) and 5.3 years for LSG (95% CI lower limit = 4.8).
    Conclusions: Our work confirm effectiveness of BS in patients with obesity and show that who do not reach clinical goal within 2 years, hardly will reach it later and suggest necessity for a medium and long-term follow-up to prevent weight regain.
    Mesh-Begriff(e) Humans ; Bariatric Surgery ; Obesity/complications ; Obesity/surgery ; Obesity, Morbid/surgery ; Gastric Bypass ; Weight Loss
    Sprache Englisch
    Erscheinungsdatum 2023-06-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2023.06.015
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  6. Artikel ; Online: Gut microbiome-micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?

    Barone, Monica / D'Amico, Federica / Brigidi, Patrizia / Turroni, Silvia

    BioFactors (Oxford, England)

    2022  Band 48, Heft 2, Seite(n) 307–314

    Abstract: Micronutrients, namely, vitamins and minerals, are necessary for the proper functioning of the human body, and their deficiencies can have dramatic short- and long-term health consequences. Among the underlying causes, certainly a reduced dietary intake ... ...

    Abstract Micronutrients, namely, vitamins and minerals, are necessary for the proper functioning of the human body, and their deficiencies can have dramatic short- and long-term health consequences. Among the underlying causes, certainly a reduced dietary intake and/or poor absorption in the gastrointestinal tract play a key role in decreasing their bioavailability. Recent evidence from clinical and in vivo studies suggests an increasingly important contribution from the gut microbiome. Commensal microorganisms can in fact regulate the levels of micronutrients, both by intervening in the biosynthetic processes and by modulating their absorption. This short narrative review addresses the pivotal role of the gut microbiome in influencing the bioavailability of vitamins (such as A, B, C, D, E, and K) and minerals (calcium, iron, zinc, magnesium, and phosphorous), as well as the impact of these micronutrients on microbiome composition and functionality. Personalized microbiome-based intervention strategies could therefore constitute an innovative tool to counteract micronutrient deficiencies by modulating the gut microbiome toward an eubiotic configuration capable of satisfying the needs of our organism, while promoting general health.
    Mesh-Begriff(e) Biological Availability ; Gastrointestinal Microbiome ; Humans ; Micronutrients ; Minerals ; Vitamins
    Chemische Substanzen Micronutrients ; Minerals ; Vitamins
    Sprache Englisch
    Erscheinungsdatum 2022-03-16
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 59230-4
    ISSN 1872-8081 ; 0951-6433
    ISSN (online) 1872-8081
    ISSN 0951-6433
    DOI 10.1002/biof.1835
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  7. Artikel ; Online: Gut microbiota resilience and recovery after anticancer chemotherapy.

    Roggiani, Sara / Mengoli, Mariachiara / Conti, Gabriele / Fabbrini, Marco / Brigidi, Patrizia / Barone, Monica / D'Amico, Federica / Turroni, Silvia

    Microbiome research reports

    2023  Band 2, Heft 3, Seite(n) 16

    Abstract: Although research on the role of the gut microbiota (GM) in human health has sharply increased in recent years, what a "healthy" gut microbiota is and how it responds to major stressors is still difficult to establish. In particular, anticancer ... ...

    Abstract Although research on the role of the gut microbiota (GM) in human health has sharply increased in recent years, what a "healthy" gut microbiota is and how it responds to major stressors is still difficult to establish. In particular, anticancer chemotherapy is known to have a drastic impact on the microbiota structure, potentially hampering its recovery with serious long-term consequences for patients' health. However, the distinguishing features of gut microbiota recovery and non-recovery processes are not yet known. In this narrative review, we first investigated how gut microbiota layouts are affected by anticancer chemotherapy and identified potential gut microbial recovery signatures. Then, we discussed microbiome-based intervention strategies aimed at promoting resilience,
    Sprache Englisch
    Erscheinungsdatum 2023-05-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2771-5965
    ISSN (online) 2771-5965
    DOI 10.20517/mrr.2022.23
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  8. Artikel ; Online: Pharmacomicrobiomics in Anticancer Therapies: Why the Gut Microbiota Should Be Pointed Out.

    Conti, Gabriele / D'Amico, Federica / Fabbrini, Marco / Brigidi, Patrizia / Barone, Monica / Turroni, Silvia

    Genes

    2022  Band 14, Heft 1

    Abstract: Anticancer treatments have shown a variable therapeutic outcome that may be partly attributable to the activity of the gut microbiota on the pathology and/or therapies. In recent years, microbiota-drug interactions have been extensively investigated, but ...

    Abstract Anticancer treatments have shown a variable therapeutic outcome that may be partly attributable to the activity of the gut microbiota on the pathology and/or therapies. In recent years, microbiota-drug interactions have been extensively investigated, but most of the underlying molecular mechanisms still remain unclear. In this review, we discuss the relationship between the gut microbiota and some of the most commonly used drugs in oncological diseases. Different strategies for manipulating the gut microbiota layout (i.e., prebiotics, probiotics, antibiotics, and fecal microbiota transplantation) are then explored in order to optimize clinical outcomes in cancer patients. Anticancer technologies that exploit tumor-associated bacteria to target tumors and biotransform drugs are also briefly discussed. In the field of pharmacomicrobiomics, multi-omics strategies coupled with machine and deep learning are urgently needed to bring to light the interaction among gut microbiota, drugs, and host for the development of truly personalized precision therapies.
    Mesh-Begriff(e) Humans ; Gastrointestinal Microbiome ; Probiotics/therapeutic use ; Prebiotics ; Microbiota ; Neoplasms/drug therapy
    Chemische Substanzen Prebiotics
    Sprache Englisch
    Erscheinungsdatum 2022-12-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14010055
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Age-related diseases, therapies and gut microbiome: A new frontier for healthy aging.

    Barone, Monica / D'Amico, Federica / Rampelli, Simone / Brigidi, Patrizia / Turroni, Silvia

    Mechanisms of ageing and development

    2022  Band 206, Seite(n) 111711

    Abstract: The gut microbiome is undoubtedly a key modulator of human health, which can promote or impair homeostasis throughout life. This is even more relevant in old age, when there is a gradual loss of function in multiple organ systems, related to growth, ... ...

    Abstract The gut microbiome is undoubtedly a key modulator of human health, which can promote or impair homeostasis throughout life. This is even more relevant in old age, when there is a gradual loss of function in multiple organ systems, related to growth, metabolism, and immunity. Several studies have described changes in the gut microbiome across age groups up to the extreme limits of lifespan, including maladaptations that occur in the context of age-related conditions, such as frailty, neurodegenerative diseases, and cardiometabolic diseases. The gut microbiome can also interact bi-directionally with anti-age-related disease therapies, being affected and in turn influencing their efficacy. In this framework, the development of integrated microbiome-based intervention strategies, aimed at favoring a eubiotic configuration and trajectory, could therefore represent an innovative approach for the promotion of healthy aging and the achievement of longevity.
    Mesh-Begriff(e) Frailty ; Gastrointestinal Microbiome ; Healthy Aging ; Humans ; Longevity ; Microbiota
    Sprache Englisch
    Erscheinungsdatum 2022-07-20
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2022.111711
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    Zs.A 1012: Hefte anzeigen Standort:
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  10. Artikel ; Online: A new device for remote monitoring of vital parameters in acromegalic patients: pilot study.

    Costa, Denise / D'Amico, Tania / Mercuri, Valeria / Schiaffini, Riccardo / Gargiulo, Patrizia

    Endocrine, metabolic & immune disorders drug targets

    2022  

    Abstract: Introduction: Acromegaly is a rare disease which results from growth hormone (GH) excess. Diabetes mellitus, hypertension, cardiomyopathy and obstructive sleep apnoea syndrome (OSAS) are frequent complications.: Aim of the study: Identify a useful ... ...

    Abstract Introduction: Acromegaly is a rare disease which results from growth hormone (GH) excess. Diabetes mellitus, hypertension, cardiomyopathy and obstructive sleep apnoea syndrome (OSAS) are frequent complications.
    Aim of the study: Identify a useful system to obtain a reliable remote monitoring of glucose and the most important vital parameters in the acromegalic subjects.
    Patients and methods: Sixteen acromegalic patients (from 30 to 73 years old) were enrolled. We provided an health monitor devices to the patients for continuous acquisition of physiological signals including twelve-lead electrocardiography (EKG) and nocturnal SpO2. At the same time, we applied on the same patients the blinded continuous glucose monitoring system (CGMS).
    Results: The lowest saturation peaks at night (<80%) were achieved in patients with a known diagnosis of OSAS. A positive correlation was demonstrated between the lowest oxygen saturation values and the CGM peaks (pV <0,0001) and between the average values of oxygen saturation and CGM (pV<0,0003). Patients with a previous diagnosis of OSAS, obtained by polysomnography, showed on the multiparametric monitor recordings superimposable to their known condition. Instead we noticed a discordance in the two EKG recording: the wireless mode showed an irregular rhythm in 5/16 patients, which was not confirmed by the recording mode with cables.
    Conclusion: The health monitor device associated with CGM may be a new useful and versatile tool for fragile patients who can self-manage remote monitoring, and for physicians who can obtain real-time information for the clinical and therapeutic management of patients. It is also a useful tool for the follow-up of patients with OSAS.Moreover, once the interference of the OSAS is excluded, the CGM allows us to obtain a more reliable and accurate diagnosis of DM.
    Sprache Englisch
    Erscheinungsdatum 2022-05-16
    Erscheinungsland United Arab Emirates
    Dokumenttyp Journal Article
    ZDB-ID 2228325-0
    ISSN 2212-3873 ; 1871-5303
    ISSN (online) 2212-3873
    ISSN 1871-5303
    DOI 10.2174/1871530322666220516161753
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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