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  1. Article ; Online: Detection of Hemosiderin-Laden Macrophages in Bronchoalveolar Lavage Fluid of COVID-19 Patients: Is Perls Stain a Potential Indicator of Oxidative Alveolar Damage?

    Drak Alsibai, Kinan

    Acta cytologica

    2020  Volume 64, Issue 6, Page(s) 617–619

    MeSH term(s) Betacoronavirus ; Bronchoalveolar Lavage Fluid ; COVID-19 ; Coloring Agents ; Coronavirus Infections ; Hemosiderin/metabolism ; Humans ; Macrophages/metabolism ; Oxidative Stress ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Coloring Agents ; Hemosiderin (9011-92-1)
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 80003-x
    ISSN 1938-2650 ; 0001-5547
    ISSN (online) 1938-2650
    ISSN 0001-5547
    DOI 10.1159/000508020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 358: Show issues Location:
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  2. Article ; Online: Expression of angiotensin-converting enzyme 2 and proteases in COVID-19 patients: A potential role of cellular FURIN in the pathogenesis of SARS-CoV-2.

    Drak Alsibai, Kinan

    Medical hypotheses

    2020  Volume 143, Page(s) 109893

    Abstract: Recently, a mini-review was published in the Medical Hypotheses journal by Usul Afsar entitled 2019-nCoV-SARS-CoV-2 (COVID-19) infection: Cruciality of Furin and relevance with cancer. Previous studies have pointed out that disruption of the proteolytic ... ...

    Abstract Recently, a mini-review was published in the Medical Hypotheses journal by Usul Afsar entitled 2019-nCoV-SARS-CoV-2 (COVID-19) infection: Cruciality of Furin and relevance with cancer. Previous studies have pointed out that disruption of the proteolytic cleavage of proteins can promote infectious and non-infectious diseases. The last few weeks have been marked by an important revelation concerning the pathophysiology of SARS-CoV-2. This new coronavirus disease (COVID-19) is a highly contagious and transmissible acute respiratory infectious disorder. SARS-CoV-2 is composed of RNA-dependent RNA polymerase and structural proteins including Spike protein (S protein). Interestingly, the FURIN, one of the proproteins of the convertase family, plays a crucial role in the maturation of viral glycoproteins. In addition, many viruses including coronaviruses, exploit FURIN for the activation of their glycoproteins. Recent data indicate that SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2. Subsequently, the S protein is cleaved by transmembrane protease serine 2 with the help of FURIN which facilitates the entry of the virus into the cell after binding. Furthermore, it seems that FURIN is implicated in the pathogenesis of SARS-CoV-2 and potentially in the increased rates of human-to-human transmission.
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Betacoronavirus/pathogenicity ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/enzymology ; Coronavirus Infections/etiology ; Coronavirus Infections/immunology ; Furin/genetics ; Furin/physiology ; Host Microbial Interactions/physiology ; Humans ; Immune Tolerance ; Immunity, Cellular ; Pandemics ; Peptidyl-Dipeptidase A/physiology ; Pneumonia, Viral/enzymology ; Pneumonia, Viral/etiology ; Pneumonia, Viral/immunology ; Receptors, Virus/physiology ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/physiology ; T-Lymphocytes/immunology ; T-Lymphocytes/physiology ; Virus Internalization
    Chemical Substances Receptors, Virus ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; FURIN protein, human (EC 3.4.21.75) ; Furin (EC 3.4.21.75)
    Keywords covid19
    Language English
    Publishing date 2020-05-30
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1132: Show issues Location:
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  3. Article ; Online: SARS-CoV-2 and

    Aissaoui, Houari / Louvel, Dominique / Drak Alsibai, Kinan

    Journal of clinical tuberculosis and other mycobacterial diseases

    2021  Volume 24, Page(s) 100247

    Abstract: Tuberculosis is a treatable and curable bacterial disease caused ... ...

    Abstract Tuberculosis is a treatable and curable bacterial disease caused by
    Language English
    Publishing date 2021-05-27
    Publishing country England
    Document type Case Reports
    ISSN 2405-5794
    ISSN (online) 2405-5794
    DOI 10.1016/j.jctube.2021.100247
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  4. Article: Detection of Hemosiderin-Laden Macrophages in Bronchoalveolar Lavage Fluid of COVID-19 Patients: Is Perls Stain a Potential Indicator of Oxidative Alveolar Damage?

    Drak Alsibai, Kinan

    Acta Cytol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32506059
    Database COVID19

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  5. Article ; Online: Expression of angiotensin-converting enzyme 2 and proteases in COVID-19 patients

    Drak Alsibai, Kinan

    Medical Hypotheses

    A potential role of cellular FURIN in the pathogenesis of SARS-CoV-2

    2020  Volume 143, Page(s) 109893

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109893
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Detection of Hemosiderin-Laden Macrophages in Bronchoalveolar Lavage Fluid of COVID-19 Patients

    Drak Alsibai, Kinan

    Acta Cytologica

    Is Perls Stain a Potential Indicator of Oxidative Alveolar Damage?

    2020  Volume 64, Issue 6, Page(s) 617–619

    Keywords Pathology and Forensic Medicine ; Histology ; General Medicine ; covid19
    Language English
    Publisher S. Karger AG
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 80003-x
    ISSN 1938-2650 ; 0001-5547
    ISSN (online) 1938-2650
    ISSN 0001-5547
    DOI 10.1159/000508020
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Chromoblastomycosis in French Guiana: Epidemiology and Practices, 1955-2023.

    Valentin, Julie / Grotta, Geoffrey / Muller, Thibaut / Bourgeois, Pieter / Drak Alsibai, Kinan / Demar, Magalie / Couppie, Pierre / Blaizot, Romain

    Journal of fungi (Basel, Switzerland)

    2024  Volume 10, Issue 3

    Abstract: Chromoblastomycosis (CBM) is a chronic neglected fungal disease, usually met in tropical areas. French Guiana is a South American territory with limited epidemiological data. This retrospective study concerned all patients with CBM proven by at least one ...

    Abstract Chromoblastomycosis (CBM) is a chronic neglected fungal disease, usually met in tropical areas. French Guiana is a South American territory with limited epidemiological data. This retrospective study concerned all patients with CBM proven by at least one paraclinical examination and diagnosed in French Guiana between 1950 and 2023. In total, 23 patients were included, mostly males (87%) of Creole origin, living in the coastal region (87%) and involved in outdoor occupations (74%). Lesions were mostly observed on the lower limbs (78.3%), with a median time to diagnosis of four years. Laboratory tests included positive direct microscopic examinations (78.3%) and mycological cultures (69.6%), identifying 14 cases of
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof10030168
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  8. Article ; Online: Fungal Density in Lobomycosis in French Guiana: A Proposal for a New Clinico-Histological and Therapeutic Classification.

    Grotta, Geoffrey / Couppie, Pierre / Demar, Magalie / Drak Alsibai, Kinan / Blaizot, Romain

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 10

    Abstract: Background: Lobomycosis is a rare cutaneous tropical neglected disease caused by the fungal agent : Methods: All cases of lobomycosis diagnosed in French Guiana between 1959 and 2022 were included. We looked for associations between the occurrence of ...

    Abstract Background: Lobomycosis is a rare cutaneous tropical neglected disease caused by the fungal agent
    Methods: All cases of lobomycosis diagnosed in French Guiana between 1959 and 2022 were included. We looked for associations between the occurrence of relapses and the clinic-histological form.
    Results: 31 patients diagnosed with lobomycosis were included. An epidemiological shift was observed in the 2000s as Brazilian patients became the most important ethnic group. Gold mining, forestry and fishing/sailing were reported as professional exposures. New histological features, such as inflammatory "rosettes" formations were described. We describe two clinic-histological patterns: a major form (high fungal density and/or multifocal lesions) and a minor form (low fungal density, unifocal lesions, association with fewer relapses).
    Conclusions: The changing epidemiology of lobomycosis in French Guiana is characterized by a shift towards Brazilian patients, mostly gold miners. Minor forms should be treated with surgery, major forms with a combination of surgery followed by nultiple drug therapy (MDT) or posaconazole.
    Language English
    Publishing date 2023-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9101005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Leprosy in French Guiana, 2015 to 2021: Dynamics of a Persistent Public Health Problem.

    Petiot, Aurore / Drak Alsibai, Kinan / Dossou, Carmelita / Couppie, Pierre / Blaizot, Romain

    Acta dermato-venereologica

    2023  Volume 103, Page(s) adv6246

    Abstract: A resurgence of leprosy as a public health problem in French Guiana was reported over the period 2007 to 2014, particularly among Brazilians gold miners. Prolonged multidrug therapy and reversal reactions represent a therapeutic challenge. The objective ... ...

    Abstract A resurgence of leprosy as a public health problem in French Guiana was reported over the period 2007 to 2014, particularly among Brazilians gold miners. Prolonged multidrug therapy and reversal reactions represent a therapeutic challenge. The objective of this study was to assess the evolution of leprosy in this European overseas territory. All patients with leprosy confirmed in histopathology between 1 January 2015 and 31 December 2021 were included. A total of 86 patients were included, including 64 new cases and 22 previously diagnosed cases. Sixty patients (70%) were male, 6 cases were paediatric. Brazilian gold miners represented 44.1% of reported occupations (15/34). Maroons represented the second community (13 patients, 15%). Multibacillary and paucibacillary forms were found in 53 (71%) and 22 (29%) patients, respectively. The annual prevalence never exceeded the threshold of 1/10,000. The mean incidence and prevalence were significantly lower than during the period 2007 to 2014 (p < 0.0001). Reversal reactions were found in 29 patients and almost always required a long course of steroids. Infliximab allowed a reduction in the length of treatment with steroids in 2/2 cases. In conclusion, the prevalence of leprosy has decreased significantly in French Guiana, but remains driven by the population of illegal gold miners. Anti-tumour necrosis factor (anti-TNF) drugs represent a promising option in the management of reversal reactions.
    MeSH term(s) Humans ; Male ; Child ; Female ; Public Health ; French Guiana/epidemiology ; Drug Therapy, Combination ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Leprostatic Agents/therapeutic use ; Leprosy/diagnosis ; Leprosy/drug therapy ; Leprosy/epidemiology ; Gold
    Chemical Substances Tumor Necrosis Factor Inhibitors ; Leprostatic Agents ; Gold (7440-57-5)
    Language English
    Publishing date 2023-05-05
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/actadv.v103.6246
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    Ui VI Zs.101: Show issues Location:
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  10. Article: Nutritional and Socioeconomic Determinants of Overweight and Obesity in the French Amazon: The Health Barometer Study.

    Massicard, Mickael / Drak Alsibai, Kinan / Nacher, Mathieu / Sabbah, Nadia

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 849718

    Abstract: Objectives: French Guiana is a multicultural overseas territory where obesity is a major public health problem. This study aimed to highlight the nutritional and socioeconomic determinants of overweight and obesity in different populations in French ... ...

    Abstract Objectives: French Guiana is a multicultural overseas territory where obesity is a major public health problem. This study aimed to highlight the nutritional and socioeconomic determinants of overweight and obesity in different populations in French Guiana.
    Methods: A two-stage random sample of 1390 individuals aged 15 to 75 years was surveyed by telephone, and the participants were initially screened for diabetes. Logistic regression was fitted on the sample to adjust for potential confounding factors.
    Results: Overweight and obesity were found in 54.7% of the respondents, a higher proportion than in mainland France. There was a significant body image discrepancy in our population, with a higher risk of obesity among single women, often immigrants from the non-French Caribbean and South America, unemployed or low education.
    Conclusions: The main factors associated with obesity were being a precariousness immigrant; there was often a mismatch between body image and overweight/obesity, which is a major obstacle to the improvement of dietary behaviors and lifestyle. This information provides operational clues as to where to act and the necessary adaptations to attempt to modify behaviors in a culturally-adapted manner.
    MeSH term(s) Female ; Humans ; Life Style ; Obesity/epidemiology ; Overweight/epidemiology ; Prevalence ; Socioeconomic Factors
    Language English
    Publishing date 2022-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.849718
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