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  1. Article ; Online: COVID-19 and diabetes - where are we now?

    Groß, Rüdiger / Kleger, Alexander

    Nature metabolism

    2022  

    Language English
    Publishing date 2022-11-11
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-022-00691-w
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  2. Book ; Online ; Thesis: Extracellular vesicles in human body fluids as innate antiviral factors

    Groß, Rüdiger Martin [Verfasser]

    2022  

    Author's details Rüdiger Martin Groß
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universität Ulm
    Publishing place Ulm
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Book ; Thesis: Korrelationanalytische Untersuchungen zum Verhalten des Blutdrucks und der Herzfrequenz prä-, intra- und postoperativ unter Verwendung verschiedener Meßmethoden

    Groß, Rüdiger

    1991  

    Author's details vorgelegt von Rüdiger Groß
    Size 117 S. : Ill., zahlr. graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Franfurt a.M., Univ., Diss., 1992
    HBZ-ID HT004555741
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Detection of SARS-CoV-2 in Human Breast Milk.

    Groß, Rüdiger / Conzelmann, Carina / Münch, Jan / Müller, Janis A

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2610, Page(s) 129–135

    Abstract: Certain viral pathogens can be shed into the human breast milk and cause infections in the infant upon breastfeeding. Thus, it is important to clarify whether viral RNA as well as infectious virus can be found in breast milk. The complexity of this body ... ...

    Abstract Certain viral pathogens can be shed into the human breast milk and cause infections in the infant upon breastfeeding. Thus, it is important to clarify whether viral RNA as well as infectious virus can be found in breast milk. The complexity of this body fluid poses several challenges for viral RNA isolation and detection of infectious virus. We here provide a protocol that allowed the identification of SARS-CoV-2 RNA in breast milk and the isolation of infectious virus after the virus has been artificially spiked into milk samples.
    MeSH term(s) Infant ; Female ; Humans ; SARS-CoV-2 ; Milk, Human ; COVID-19 ; RNA, Viral ; Breast Feeding
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2022-12-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2895-9_11
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  5. Article ; Online: ACE2-EGFR-MAPK signaling contributes to SARS-CoV-2 infection.

    Engler, Melanie / Albers, Dan / Von Maltitz, Pascal / Groß, Rüdiger / Münch, Jan / Cirstea, Ion Cristian

    Life science alliance

    2023  Volume 6, Issue 9

    Abstract: SARS-CoV-2 triggered the most severe pandemic of recent times. To enter into a host cell, SARS-CoV-2 binds to the angiotensin-converting enzyme 2 (ACE2). However, subsequent studies indicated that other cell membrane receptors may act as virus-binding ... ...

    Abstract SARS-CoV-2 triggered the most severe pandemic of recent times. To enter into a host cell, SARS-CoV-2 binds to the angiotensin-converting enzyme 2 (ACE2). However, subsequent studies indicated that other cell membrane receptors may act as virus-binding partners. Among these receptors, the epidermal growth factor receptor (EGFR) was hypothesized not only as a spike protein binder, but also to be activated in response to SARS-CoV-2. In our study, we aim at dissecting EGFR activation and its major downstream signaling pathway, the mitogen-activated signaling pathway (MAPK), in SARS-CoV-2 infection. Here, we demonstrate the activation of EGFR-MAPK signaling axis by the SARS-CoV-2 spike protein and we identify a yet unknown cross talk between ACE2 and EGFR that regulated ACE2 abundance and EGFR activation and subcellular localization, respectively. By inhibiting the EGFR-MAPK activation, we observe a reduced infection with either spike-pseudotyped particles or authentic SARS-CoV-2, thus indicating that EGFR serves as a cofactor and the activation of EGFR-MAPK contributes to SARS-CoV-2 infection.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2/metabolism ; Angiotensin-Converting Enzyme 2/metabolism ; Peptidyl-Dipeptidase A/metabolism ; ErbB Receptors/metabolism
    Chemical Substances spike protein, SARS-CoV-2 ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ErbB Receptors (EC 2.7.10.1) ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-07-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202201880
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  6. Article ; Online: Presenting the Compendium Isotoporum Medii Aevi, a Multi-Isotope Database for Medieval Europe.

    Cocozza, Carlo / Cirelli, Enrico / Groß, Marcus / Teegen, Wolf-Rüdiger / Fernandes, Ricardo

    Scientific data

    2022  Volume 9, Issue 1, Page(s) 354

    Abstract: Here we present the Compendium Isotoporum Medii Aevi (CIMA), an open-access database gathering more than 50,000 isotopic measurements for bioarchaeological samples located within Europe and its margins, and dating between 500 and 1500 CE. This multi- ... ...

    Abstract Here we present the Compendium Isotoporum Medii Aevi (CIMA), an open-access database gathering more than 50,000 isotopic measurements for bioarchaeological samples located within Europe and its margins, and dating between 500 and 1500 CE. This multi-isotope (δ
    Language English
    Publishing date 2022-06-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-022-01462-8
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  7. Article ; Online: Heterologous DNA-prime/protein-boost immunization with a monomeric SARS-CoV-2 spike antigen redundantizes the trimeric receptor-binding domain structure to induce neutralizing antibodies in old mice.

    Pflumm, Dominik / Seidel, Alina / Klein, Fabrice / Groß, Rüdiger / Krutzke, Lea / Kochanek, Stefan / Kroschel, Joris / Münch, Jan / Stifter, Katja / Schirmbeck, Reinhold

    Frontiers in immunology

    2023  Volume 14, Page(s) 1231274

    Abstract: A multitude of alterations in the old immune system impair its functional integrity. Closely related, older individuals show, for example, a reduced responsiveness to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines. However, ... ...

    Abstract A multitude of alterations in the old immune system impair its functional integrity. Closely related, older individuals show, for example, a reduced responsiveness to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines. However, systematic strategies to specifically improve the efficacy of vaccines in the old are missing or limited to simple approaches like increasing the antigen concentration or injection frequencies. We here asked whether the intrinsic, trimeric structure of the SARS-CoV-2 spike (S) antigen and/or a DNA- or protein-based antigen delivery platform affects priming of functional antibody responses particularly in old mice. The used S-antigens were primarily defined by the presence/absence of the membrane-anchoring TM domain and the closely interlinked formation/non-formation of a trimeric structure of the receptor binding domain (S-RBD). Among others, we generated vectors expressing prefusion-stabilized, cell-associated (TM
    MeSH term(s) Animals ; Mice ; Antibodies, Neutralizing ; SARS-CoV-2 ; COVID-19 ; Vaccines, DNA ; Blood Group Antigens ; Immunization
    Chemical Substances Antibodies, Neutralizing ; Vaccines, DNA ; Blood Group Antigens
    Language English
    Publishing date 2023-09-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1231274
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  8. Article ; Online: SARS-CoV-2-Infektion des Verdauungstrakts – Experimentelle Ansätze einer Organoid-basierten in vitro Modellierung.

    Hentschel, Viktoria / Groß, Rüdiger / Krüger, Jana / Münch, Jan / Müller, Martin / Kleger, Alexander

    Zeitschrift fur Gastroenterologie

    2021  Volume 59, Issue 11, Page(s) 1205–1213

    Abstract: SARS-CoV-2 is a novel human pathogenic coronavirus whose predilection for the respiratory tract has given rise to a rapid pandemic spread via airborne particles. Organ-specific susceptibility is substantially determined by the density of cell surface ... ...

    Title translation SARS-CoV-2 and the digestive tract - Organoids to model gastrointestinal infection.
    Abstract SARS-CoV-2 is a novel human pathogenic coronavirus whose predilection for the respiratory tract has given rise to a rapid pandemic spread via airborne particles. Organ-specific susceptibility is substantially determined by the density of cell surface expression of ACE2, which is exploited by viral spike protein as a receptor molecule to mediate adhesion and, thus, to permit internalization of the viral genome into the host cell. Based on an ample data set derived from clinical studies and case reports, evidence suggests that distinct cell populations of the digestive and olfactory-gustatory system are equally equipped with membrane-bound ACE2, rendering them "vulnerable" to SARS-CoV-2. Numerous reports on concomitant gastrointestinal complaints and laboratory abnormalities are thought to reflect a relevant degree of organ dysfunction and underscore the tropism of SARS-CoV-2 for the digestive tract. Organoids are three-dimensional
    MeSH term(s) COVID-19 ; Communicable Diseases ; Gastrointestinal Tract ; Humans ; Organoids ; SARS-CoV-2 ; Virus Internalization
    Language German
    Publishing date 2021-07-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0172-8504 ; 0044-2771
    ISSN (online) 1439-7803
    ISSN 0172-8504 ; 0044-2771
    DOI 10.1055/a-1500-8420
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    Zs.A 111: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
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  9. Article ; Online: Zika virus replication in glioblastoma cells: electron microscopic tomography shows 3D arrangement of endoplasmic reticulum, replication organelles, and viral ribonucleoproteins.

    Wieland, Johannes / Frey, Stefan / Rupp, Ulrich / Essbauer, Sandra / Groß, Rüdiger / Münch, Jan / Walther, Paul

    Histochemistry and cell biology

    2021  Volume 156, Issue 6, Page(s) 527–538

    Abstract: Structural changes of two patient-derived glioblastoma cell lines after Zika virus infection were investigated using scanning transmission electron tomography on high-pressure-frozen, freeze-substituted samples. In Zika-virus-infected cells, Golgi ... ...

    Abstract Structural changes of two patient-derived glioblastoma cell lines after Zika virus infection were investigated using scanning transmission electron tomography on high-pressure-frozen, freeze-substituted samples. In Zika-virus-infected cells, Golgi structures were barely visible under an electron microscope, and viral factories appeared. The cytosol outside of the viral factories resembled the cytosol of uninfected cells. The viral factories contained largely deranged endoplasmic reticulum (ER), filled with many so-called replication organelles consisting of a luminal vesicle surrounded by the ER membrane. Viral capsids were observed in the vicinity of the replication organelles (cell line #12537 GB) or in ER cisternae at large distance from the replication organelles (cell line #15747 GB). Near the replication organelles, we observed many about 100-nm-long filaments that may represent viral ribonucleoprotein complexes (RNPs), which consist of the RNA genome and N protein oligomers. In addition, we compared Zika-virus-infected cells with cells infected with a phlebovirus (sandfly fever Turkey virus). Zika virions are formed in the ER, whereas phlebovirus virions are assembled in the Golgi apparatus. Our findings will help to understand the replication cycle in the virus factories and the building of the replication organelles in glioblastoma cells.
    MeSH term(s) Electron Microscope Tomography ; Endoplasmic Reticulum/metabolism ; Glioblastoma/metabolism ; Glioblastoma/virology ; Humans ; Organelles/metabolism ; Ribonucleoproteins/metabolism ; Tumor Cells, Cultured ; Virus Replication ; Zika Virus/metabolism
    Chemical Substances Ribonucleoproteins
    Language English
    Publishing date 2021-09-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1222930-1
    ISSN 1432-119X ; 0301-5564 ; 0948-6143
    ISSN (online) 1432-119X
    ISSN 0301-5564 ; 0948-6143
    DOI 10.1007/s00418-021-02028-2
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  10. Article ; Online: Towards the direct detection of viral materials at the surface of protective face masks via infrared spectroscopy.

    Schorer, Vanessa / Haas, Julian / Stach, Robert / Kokoric, Vjekoslav / Groß, Rüdiger / Muench, Jan / Hummel, Tim / Sobek, Harald / Mennig, Jan / Mizaikoff, Boris

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 2309

    Abstract: The ongoing COVID-19 pandemic represents a considerable risk for the general public and especially for health care workers. To avoid an overloading of the health care system and to control transmission chains, the development of rapid and cost-effective ... ...

    Abstract The ongoing COVID-19 pandemic represents a considerable risk for the general public and especially for health care workers. To avoid an overloading of the health care system and to control transmission chains, the development of rapid and cost-effective techniques allowing for the reliable diagnosis of individuals with acute respiratory infections are crucial. Uniquely, the present study focuses on the development of a direct face mask sampling approach, as worn (i.e., used) disposable face masks contain exogenous environmental constituents, as well as endogenously exhaled breath aerosols. Optical techniques-and specifically infrared (IR) molecular spectroscopic techniques-are promising tools for direct virus detection at the surface of such masks. In the present study, a rapid and non-destructive approach for monitoring exposure scenarios via medical face masks using attenuated total reflection infrared spectroscopy is presented. Complementarily, IR external reflection spectroscopy was evaluated in comparison for rapid mask analysis. The utility of a face mask-based sampling approach was demonstrated by differentiating water, proteins, and virus-like particles sampled onto the mask. Data analysis using multivariate statistical algorithms enabled unambiguously classifying spectral signatures of individual components and biospecies. This approach has the potential to be extended towards the rapid detection of SARS-CoV-2-as shown herein for the example of virus-like particles which are morphologically equivalent to authentic virus-without any additional sample preparation or elaborate testing equipment at laboratory facilities. Therefore, this strategy may be implemented as a routine large-scale monitoring routine, e.g., at health care institutions, nursing homes, etc. ensuring the health and safety of medical personnel.
    MeSH term(s) Masks/virology ; SARS-CoV-2/isolation & purification ; Spectrophotometry, Infrared
    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-06335-z
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